The reccnt Alcatel Lucent failure is an example of how many mergers run into considerable implementing difficulties in the months following their launch. Despite promising perspectives,no coherent whole seems to come ...The reccnt Alcatel Lucent failure is an example of how many mergers run into considerable implementing difficulties in the months following their launch. Despite promising perspectives,no coherent whole seems to come out of the merger,just as anticipated synergies have a hard time materializing.展开更多
Purpose: Fixed-combination medication to treat glaucoma can reduce intraocular pressure (IOP) without negative effects of concomitant medication. Tafluprost/timolol fixed-combination ophthalmic solution (TTFC) has bee...Purpose: Fixed-combination medication to treat glaucoma can reduce intraocular pressure (IOP) without negative effects of concomitant medication. Tafluprost/timolol fixed-combination ophthalmic solution (TTFC) has been reported to show similar effectiveness in lowering IOP, compared with concomitant use of its component drugs, tafluprost and timolol. However, the difference in IOP-lowering effects between TTFC and concomitant use of tafluprost and gel-forming timolol is unknown. Hence, we conducted this switching study from tafluprost and gel-forming timolol to TTFC in glaucoma patients undergoing multi-drug therapy. Design: Multi-center, open-label, interventional clinical study. Methods: Twenty-eight patients (28 eyes;safety analysis set) with primary open-angle glaucoma and ocular hypertension, who had completed the 4-week-concomitant phase of tafluprost and gel-forming timolol, were treated for 8 weeks with TTFC. IOP, adherence, ocular surface safety, and the usability of ophthalmic solution were compared before and after switching. This study was approved by the ethics committees of Kitasato University Hospital and all other study sites. All patients provided written informed consent to participate. Results: IOP at 8 weeks after switching was significantly lower than before switching (P = 0.0001) in the efficacy analysis set (n = 24). The self-reported adherence rate remained high after switching;moreover, there was no meaningful change in ocular surface safety. Patient questionnaires regarding usability of medication revealed that 85.7% of patients preferred their instillation prescription after switching, including TTFC. Among the safety analysis set (n = 28), no adverse events were reported in relation to the study drug. Conclusion: TTFC showed greater IOP reduction than concomitant therapy. Thus, TTFC may be a better option in glaucoma patients than concomitant therapy.展开更多
This paper takes the escapement plate of a mechanical pendulum clock as an example,analyses the design of combination form cutter hob for special profile gears, selection of parameters and calculation for tooth profil...This paper takes the escapement plate of a mechanical pendulum clock as an example,analyses the design of combination form cutter hob for special profile gears, selection of parameters and calculation for tooth profile coordinates and discusses the grinding of cutter hob tooth profile on optical contour grinder.展开更多
A restricted combination is a kind of language phenomena.It is important in language.It is relatively-stationary phrase.Though it is conposed of more than one word,its meaning isn't only literal meaning expressed ...A restricted combination is a kind of language phenomena.It is important in language.It is relatively-stationary phrase.Though it is conposed of more than one word,its meaning isn't only literal meaning expressed by the words,but holistic.The whole isn't equal to the part.In the process of understanding restricted combinations,holistic congnition can play an important role.展开更多
文摘The reccnt Alcatel Lucent failure is an example of how many mergers run into considerable implementing difficulties in the months following their launch. Despite promising perspectives,no coherent whole seems to come out of the merger,just as anticipated synergies have a hard time materializing.
文摘Purpose: Fixed-combination medication to treat glaucoma can reduce intraocular pressure (IOP) without negative effects of concomitant medication. Tafluprost/timolol fixed-combination ophthalmic solution (TTFC) has been reported to show similar effectiveness in lowering IOP, compared with concomitant use of its component drugs, tafluprost and timolol. However, the difference in IOP-lowering effects between TTFC and concomitant use of tafluprost and gel-forming timolol is unknown. Hence, we conducted this switching study from tafluprost and gel-forming timolol to TTFC in glaucoma patients undergoing multi-drug therapy. Design: Multi-center, open-label, interventional clinical study. Methods: Twenty-eight patients (28 eyes;safety analysis set) with primary open-angle glaucoma and ocular hypertension, who had completed the 4-week-concomitant phase of tafluprost and gel-forming timolol, were treated for 8 weeks with TTFC. IOP, adherence, ocular surface safety, and the usability of ophthalmic solution were compared before and after switching. This study was approved by the ethics committees of Kitasato University Hospital and all other study sites. All patients provided written informed consent to participate. Results: IOP at 8 weeks after switching was significantly lower than before switching (P = 0.0001) in the efficacy analysis set (n = 24). The self-reported adherence rate remained high after switching;moreover, there was no meaningful change in ocular surface safety. Patient questionnaires regarding usability of medication revealed that 85.7% of patients preferred their instillation prescription after switching, including TTFC. Among the safety analysis set (n = 28), no adverse events were reported in relation to the study drug. Conclusion: TTFC showed greater IOP reduction than concomitant therapy. Thus, TTFC may be a better option in glaucoma patients than concomitant therapy.
文摘This paper takes the escapement plate of a mechanical pendulum clock as an example,analyses the design of combination form cutter hob for special profile gears, selection of parameters and calculation for tooth profile coordinates and discusses the grinding of cutter hob tooth profile on optical contour grinder.
基金one of the reseach results of scientific research project in Shanghai University of Engineering Science A Study of English and Chinese Restricted Combinations in Phrase Structures(A-0501-12-30)
文摘A restricted combination is a kind of language phenomena.It is important in language.It is relatively-stationary phrase.Though it is conposed of more than one word,its meaning isn't only literal meaning expressed by the words,but holistic.The whole isn't equal to the part.In the process of understanding restricted combinations,holistic congnition can play an important role.
