Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.

Common Emulsifier Combination Skin Feeling Research and Recommendation

Emulsifier is an important component of emulsified skin care BASE(matrix),and the common influencing factors affecting the skin feel of BASE are:emollient,thickeners,and emulsifier.The choice of emulsifier is crucial to the skin feel of cosmetics.In this paper,12 classical emulsifiers were selected and 13 combinations of them were made.Thirteen creams were designed using the same formulation structure,their physicochemical indexes were determined,and their skin feel was tested and evaluated using five expert panel scores,with the test site being the hand.Physicochemical parameters included pH and viscosity.Skin feel indicators include:stickiness,silkiness,whiteheads,greasiness at the end of application,absorption,softness after use,etc.The BASE formulations of the creams were tested and evaluated by five experts.Recommendations were also made for the selection of emulsifier combinations in the design of cream BASE formulations.

THE FEELING THOUGHT PROCESS DURING QIGONG

Setting one’s mind at complete rest dur-ing Qigong requires a process which includesadjustment of the body,breathing andmind,with adjustment of mind as most im-portant.As adjustment of the mind may beregarded as the thought process,we may saythat the thought process is the key to put-ring one’s mind at complete rest.

初绽·遇见新我——FEELING品牌发布会在京举办

6月7日,由青岛嘉乐兴贸易有限公司主办的2016FEELING品牌发布会在北京举行。中国家用纺织品行业协会秘书长李杰、青岛新亚太集团总裁常大勇、青岛嘉乐兴贸易有限公司(以下简称"嘉乐兴")销售总监孟祥杰等百余位嘉宾出席了活动。本次活动基于FEELING品牌发布,分别对FEELING和比华利·保罗两个不同定位的家纺品牌进行了重点介绍。

Serum 17β-estradiol and oral dryness feeling in menopause

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

Study on Prediction and Application of Human Body Feeling Temperature

[ Objective] The study aimed to forecast human body feeling temperature. [ Method] Using air temperature data outside shutter boxes of cement and asphalt underlying surface at 1.5 m and conventional observation data from 2008 to 2010 as well as T639 and Japan numerical forecast product, the characteristics of the minimum temperature in winter half year and the maximum temperature in summer half year in Changzhou were analyzed, and the prediction equation of the maximum temperature from May to September as well as year-round comfort prediction index were es- tablished. Moreover, the announcement platform of human body feeling temperature was developed to forecast it. [ Result] There remained a tiny discrepancy in the winter minimum temperature between inside and outside shutter box, and clays with the minimum temperature difference lower than 2 ℃ accounted for 94.3% of total days. However, the summer maximum temperature difference between inside and outside shutter box was larger, and days with the maximum temperature difference higher than 2 ℃ accounted for 82.0%, while the maximum difference was 5.5 ℃. The prediction accuracy of the inside maximum temperature was 78%. Wind was considered as the primary factor based on the effective temperature, and comfort index forecast and service were determined based on human feelings, dress, meteorological care and so forth. Both human body feel- ing temperature and comfort index forecast were released in the temperature forecast service. [ Condusion] The prediction of human body feeling temperature could provide scientific references for people＇s dress and traveling in daily life.

Empirical Study on the Empowerment of Families Raising Children with Severe Motor and Intellectual Disabilities in Japan: The Association with Positive Feelings towards Child Rearing

Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing.

Negative feelings experienced by people with mental disorder in the workplace: A qualitative study

Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.

How Do We Have Feelings?

For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has become known as the “hard problem of consciousness” and has been the subject of many publications. Although lots of answers have been proposed, none has been completely satisfactory. The focus of most of these studies has been on the neuronal structures and activities. Experiential consciousness emerges from neural processes, but it has not been explained with models that have been based solely on the electro-mechanical aspects of the processes. There must be some other dynamic features of neuronal activity to explain the emergence of experiential consciousness. I argue that a likely answer to the dilemma resides in the added dimension of the neurochemistry of the brain that has, so far, received little attention.

The Impact of Coronavirus on Staff Nurses’ Feeling While Giving Direct Care to COVID-19 Patients in Various COVID Facilities

Background: Nurses are very important frontline health care professionals as they spend more time with patients than other professionals. This is even more so at this critical time of the COVID-19 pandemic. The nursing profession is facing great challenges in coping with the pandemic as they are more vulnerable to exposure and infection with the disease. Kuwait is not spared from the global pandemic which has put the health sector under immense pressure. Because COVID-19 is highly transmissible and deadly, it poses a huge health risk to nurses and has a huge impact on their cognitive, emotional, behavioural and physical dimensions. Aim: The study aims to explore the positive and negative emotions and feelings of staff nurses while giving care to COVID-19 patients. Materials and Methods: A descriptive cross-sectional study was carried out. 300 nurses from different general hospitals, field hospitals, and quarantine facilities in Kuwait participated in the study. A questionnaire was used to collect the data. Results: The findings show that for the cognitive evaluation, 72% were moderately affected, for the emotional evaluation 51.3% and 44% were moderately and mildly affected respectively, for the behavioural evaluation, 66.7% were severely affected, and for the physical evaluation, 43.3% and 31.7% were moderately and severely affected respectively. Prolonged working hours has a highly significant negative correlation to emotional (r −0.165), behavioral (r −0.177) and physical (r −0.155) dimension of the nurses at 0.01 level using Spearman’s correlation. Conclusion: The study concluded that the COVID-19 pandemic has affected the psychophysical dimensions of staff nurses.

Feeling the Pulse of the World

Dizziness from preoccupation with the 20th century robbed us of the time to contemplate the 21st century. This is a well-known dictum early back in the 1960s by the late French strategist Raymond Aron. Now the new century is upon us. What were believed to be irrelevant then have turned out into hot topics these days. An early warning for the unfolding century, the September 11 events represent but only a

An Interpretation of Jane Eyre's Feeling of Inferiority at Gateshead in Jane Eyre

Jane Eyre has been the focus of numerous critics and scholars since its publication in 1847 and they have made a great contribution to the study of Jane Eyre, exploring it from different perspectives. Most of critics and readers regard Jane Eyre as an independent and brave feminism fighter to challenge the tradition in Victorian period while they tend to pay less attention to the invisible side of Jane Eyre. Jane Eyre is not always so brave and strong and confident to face her life, which can be discovered from her language and behavior when she confronts conflicts. This is Jane Eyre's feeling of inferiority. From the perspective of Alfred Adler's individual psychology, this thesis studies Jane Eyre's feeling of inferiority at Gateshead.

胡一郎的故事:No feeling

入了这行,就要有点行业中人的样子。 胡一郎决定为自己的网上购物破身,就在今晚。有本叫做《网络价值》的书,最近在圈里被谈论甚广,而且只在网上有,因此成为胡一郎网上购物的第一目标。

That Restless Feeling

Mrs.Feldmeyer found her inher bedroom crying.She stood inthe doorway and said seriously,“Icame over to borrow your vacuumcleaner,Carolyn. Mine’s broken.The door was open,so I just walkedin.What on earth is the matter?”Carolyn sat up and dried

The Missing of Emotional Feelings in the Translation of Ci Works——A Comparison between Yulingling and Its Translation

Yulinling is a famous piece of Ci by Liu Yong of the Song Dynasty.It is one long-cherished classical in lamenting the sorrow of departure.The author pictures a gloomy scene of separation:the cold autumn,the long corridor,the misty sea and the lonely boat,all the scenes depicting the sorrow and unwillingness of the separation between the two who are in deep love.The translator translated it into Eng lish in order to express his depressive feelings but he did not convey the depressive meaning of the original Ci in full extend.He lost some of the intentional feelings of the original in his translation.Through the comparison between Yulingling and its translation,the paper dis cusses the missing of emotional feelings in the translation of Ci works.