Hyper-and multi-spectral image fusion is an important technology to produce hyper-spectral and hyper-resolution images,which always depends on the spectral response function andthe point spread function.However,few wo...Hyper-and multi-spectral image fusion is an important technology to produce hyper-spectral and hyper-resolution images,which always depends on the spectral response function andthe point spread function.However,few works have been payed on the estimation of the two degra-dation functions.To learn the two functions from image pairs to be fused,we propose a Dirichletnetwork,where both functions are properly constrained.Specifically,the spatial response function isconstrained with positivity,while the Dirichlet distribution along with a total variation is imposedon the point spread function.To the best of our knowledge,the neural network and the Dirichlet regularization are exclusively investigated,for the first time,to estimate the degradation functions.Both image degradation and fusion experiments demonstrate the effectiveness and superiority of theproposed Dirichlet network.展开更多
A generalized form of the error function, Gp(x)=pΓ(1/p)∫0xe−tpdt, which is directly associated with the gamma function, is evaluated for arbitrary real values of p>1and 0x≤+∞by employing a fast-converging power...A generalized form of the error function, Gp(x)=pΓ(1/p)∫0xe−tpdt, which is directly associated with the gamma function, is evaluated for arbitrary real values of p>1and 0x≤+∞by employing a fast-converging power series expansion developed in resolving the so-called Grandi’s paradox. Comparisons with accurate tabulated values for well-known cases such as the error function are presented using the expansions truncated at various orders.展开更多
BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate ...BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate the effectiveness of laparoscopic minimally invasive surgery as an alternative to traditional open surgery for gastric cancer,focusing on its potential to reduce trauma,accelerate recovery,and achieve comparable oncological out-comes.METHODS This study retrospectively analyzed 203 patients with gastric cancer who underwent surgery at the Shanghai Health Medical College Affiliated Chongming Hospital from January 2020 to December 2023.The patients were divided into two groups:Minimally invasive surgery group(n=102),who underwent laparoscopic gastrectomy,and open surgery group(n=101),who underwent traditional open gastrectomy.We compared surgical indicators(surgical incision size,intraop-erative blood loss,surgical duration,and number of lymph nodes dissected),recovery parameters(time to first flatus,time to start eating,time to ambulation,and length of hospital stay),immune function(levels of IgA,IgG,and IgM),intestinal barrier function(levels of D-lactic acid and diamine oxidase),and stress response(levels of C-reactive protein,interleukin-6,and procalcitonin).RESULTS The minimally invasive surgery group demonstrated significantly better outcomes in terms of surgical indicators,including smaller incisions,less blood loss,shorter surgery time,and more lymph nodes dissected(P<0.05 for all).Recovery was also faster in the minimally invasive surgery group,with earlier return of bowel function,earlier initiation of diet,quicker mobilization,and shorter hospital stays(P<0.05 for all).Furthermore,patients in the minimally invasive surgery group had better preserved immune function,superior intestinal barrier function,and a less pronounced stress response postoperatively(P<0.05 for all).CONCLUSION Laparoscopic minimally invasive surgery for gastric cancer not only provides superior surgical indicators and faster recovery but also offers advantages in preserving immune function,protecting intestinal barrier function,and mitigating the stress response compared to traditional open surgery.These findings support the broader adoption of laparoscopic techniques in the management of gastric cancer.展开更多
A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fra...A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.展开更多
In this paper, we study a modified Leslie-Gower predator-prey model with Smith growth subject to homogeneous Neumann boundary condition, in which the functional response is the Crowley-Martin functional response term....In this paper, we study a modified Leslie-Gower predator-prey model with Smith growth subject to homogeneous Neumann boundary condition, in which the functional response is the Crowley-Martin functional response term. Firstly, for ODE model, the local stability of equilibrium point is given. And by using bifurcation theory and selecting suitable bifurcation parameters, we find many kinds of bifurcation phenomena, including Transcritical bifurcation and Hopf bifurcation. For the reaction-diffusion model, we find that Turing instability occurs. Besides, it is proved that Hopf bifurcation exists in the model. Finally, numerical simulations are presented to verify and illustrate the theoretical results.展开更多
BACKGROUND In the perioperative period of biliary surgery,various factors can induce the release of a large number of inflammatory factors,leading to an imbalance in proinflammatory and anti-inflammatory responses and...BACKGROUND In the perioperative period of biliary surgery,various factors can induce the release of a large number of inflammatory factors,leading to an imbalance in proinflammatory and anti-inflammatory responses and resulting in gastrointestinal(GI)dysfunction.Enhanced Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative recovery.It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery,both of which are the basis and key for perioperative care and postoperative recovery.AIM To better understand the effects of Modified Xiao-Cheng-Qi decoction(MXD)on inflammatory response and GI function in the perioperative management of cholelithiasis and their correlation.METHODS This was a prospective randomized placebo-controlled trial,in which 162 patients who received biliary tract surgery were randomly assigned to three groups:MXD group,XD group,and placebo-control group.The observed parameters included frequency of bowel sounds,time of first flatus and defecation,time of diet,and amount of activity after surgery.The serum levels of C-reactive protein(CRP),interleukin(IL)-6,IL-10,serum amyloid A protein(SAA),and substance P were measured by the enzyme-linked immunosorbent assay.Then,the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and inflammation.RESULTS Compared to the placebo-control,improvements in GI function were observed in the MXD groups including reduced incidence of nausea,vomiting,and bloating;and earlier first exhaust time,first defecation time,and feeding time after surgery(P<0.05).On the 1st and 2nd d after surgery,IL-6,CRP and SAA levels in MXD group were lower than that in placebo control,but substance P level was higher,compared to the control(P<0.05).Functional diarrhea occurred in both MXD and XD groups without any other adverse effects,toxic reactions,and allergic reactions.Diarrhea was relieved after the discontinuation of the investigational remedies.Bowel sounds at 12 h after surgery,the occurring time of the first flatus,first defecation,postoperative liquid diet and semiliquid diet were significantly correlated with levels of IL-6,CRP,SAA and substance P on second day after surgery(P<0.05).CONCLUSION Treatment with MXD can relieve inflammatory response and improve GI function after surgery.Moreover,there are significant correlations between them.Furthermore,it does not cause serious adverse reactions.展开更多
Temperature response functions have been developed to investigate sensor design and divertor heat flux estimation in magnetically confined plasmas. The time-dependent heat flux can be derived by fitting the response f...Temperature response functions have been developed to investigate sensor design and divertor heat flux estimation in magnetically confined plasmas. The time-dependent heat flux can be derived by fitting the response function to experimental thermocouple(TC) data. Because the TC signals have a time delay to transit events such as discharge start or confinement transition, the time delay is taken into account in a temperature response function. Such a function accurately describes the signal from each TC channel with time delay in a sensor test using a neutral beam injection. Measurement for commercial TCs shows that the time delay is caused by the finite heat capacity of TC wire and contact heat resistance between TC and target surface.展开更多
Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical sig...Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body temperature.Immune cells,notably neutrophils and macrophages,play key roles in orchestrating this response.The delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory cascade.While acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune diseases.Understanding these mechanisms is vital for developing therapeutic strategies and managing chronic diseases.展开更多
To investigate the effects of self-memory diffusion on predator-prey models, we consider a predator-prey model with Bazykin functional response of self- memory diffusion. The uniqueness, boundedness, positivity, exist...To investigate the effects of self-memory diffusion on predator-prey models, we consider a predator-prey model with Bazykin functional response of self- memory diffusion. The uniqueness, boundedness, positivity, existence and stability of equilibrium point of the model are studied. In this paper, the uniqueness of the solution is discussed under the non-negative initial function and Neumann boundary conditions satisfying a specific space. The boundness of the solution is proved by the comparison principle of parabolic equations, and the positivity of the solution is proved by the strong maximum principle of parabolic equations. Hurwitz criterion and Lyapunov function construction are used to analyze the local stability and global stability of feasible equilibrium points. The results show that the system solution is unique non-negative and bounded. The model is unstable at the trivial equilibrium point E0 and the boundary equilibrium point E1, and the condition of whether the positive equilibrium point E2 is stable under certain conditions is given.展开更多
A predator-prey model with linear capture term Holling-II functional response was studied by using differential equation theory. The existence and the stabilities of non-negative equilibrium points of the model were d...A predator-prey model with linear capture term Holling-II functional response was studied by using differential equation theory. The existence and the stabilities of non-negative equilibrium points of the model were discussed. The results show that under certain limited conditions, these two groups can maintain a balanced position, which provides a theoretical reference for relevant departments to make decisions on ecological protection.展开更多
A novel inverted generalized gamma(IGG)distribution,proposed for data modelling with an upside-down bathtub hazard rate,is considered.In many real-world practical situations,when a researcher wants to conduct a compar...A novel inverted generalized gamma(IGG)distribution,proposed for data modelling with an upside-down bathtub hazard rate,is considered.In many real-world practical situations,when a researcher wants to conduct a comparative study of the life testing of items based on cost and duration of testing,censoring strategies are frequently used.From this point of view,in the presence of censored data compiled from the most well-known progressively Type-Ⅱ censoring technique,this study examines different parameters of the IGG distribution.From a classical point of view,the likelihood and product of spacing estimation methods are considered.Observed Fisher information and the deltamethod are used to obtain the approximate confidence intervals for any unknown parametric function of the suggestedmodel.In the Bayesian paradigm,the same traditional inferential approaches are used to estimate all unknown subjects.Markov-Chain with Monte-Carlo steps are considered to approximate all Bayes’findings.Extensive numerical comparisons are presented to examine the performance of the proposed methodologies using various criteria of accuracy.Further,using several optimality criteria,the optimumprogressive censoring design is suggested.To highlight how the proposed estimators can be used in practice and to verify the flexibility of the proposed model,we analyze the failure times of twenty mechanical components of a diesel engine.展开更多
To improve the resilience of a distribution system against extreme weather,a fuel-based distributed generator(DG)allocation model is proposed in this study.In this model,the DGs are placed at the planning stage.When a...To improve the resilience of a distribution system against extreme weather,a fuel-based distributed generator(DG)allocation model is proposed in this study.In this model,the DGs are placed at the planning stage.When an extreme event occurs,the controllable generators form temporary microgrids(MGs)to restore the load maximally.Simultaneously,a demand response program(DRP)mitigates the imbalance between the power supply and demand during extreme events.To cope with the fault uncertainty,a robust optimization(RO)method is applied to reduce the long-term investment and short-term operation costs.The optimization is formulated as a tri-level defenderattacker-defender(DAD)framework.At the first level,decision-makers work out the DG allocation scheme;at the second level,the attacker finds the optimal attack strategy with maximum damage;and at the third level,restoration measures,namely distribution network reconfiguration(DNR)and demand response are performed.The problem is solved by the nested column and constraint generation(NC&CG)method and the model is validated using an IEEE 33-node system.Case studies validate the effectiveness and superiority of the proposed model according to the enhanced resilience and reduced cost.展开更多
For a set S of real numbers, we introduce the concept of S-almost automorphic functions valued in a Banach space. It generalizes in particular the space of Z-almost automorphic functions. Considering the space of S-al...For a set S of real numbers, we introduce the concept of S-almost automorphic functions valued in a Banach space. It generalizes in particular the space of Z-almost automorphic functions. Considering the space of S-almost automorphic functions, we give sufficient conditions of the existence and uniqueness of almost automorphic solutions of a differential equation with a piecewise constant argument of generalized type. This is done using the Banach fixed point theorem.展开更多
The magnetic flux in a permanent magnet transverse flux generator(PMTFG) is three-dimensional(3D), therefore, its efficacy is evaluated using 3D magnetic field analysis. Although the 3D finite-element method(FEM) is h...The magnetic flux in a permanent magnet transverse flux generator(PMTFG) is three-dimensional(3D), therefore, its efficacy is evaluated using 3D magnetic field analysis. Although the 3D finite-element method(FEM) is highly accurate and reliable for machine simulation, it requires a long computation time, which is crucial when it is to be used in an iterative optimization process. Therefore, an alternative to 3DFEM is required as a rapid and accurate analytical technique. This paper presents an analytical model for PMTFG analysis using winding function method. To obtain the air gap MMF distribution, the excitation magneto-motive force(MMF) and the turn function are determined based on certain assumptions. The magnetizing inductance, flux density, and back-electro-magnetomotive force of the winding are then determined. To assess the accuracy of the proposed method, the analytically calculated parameters of the generator are compared to those obtained by a 3D-FEM. The presented method requires significantly shorter computation time than the 3D-FEM with comparable accuracy.展开更多
Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers ar...Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers are renowned for their good mechanical properties,abundance,and short cycle growth.As beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic foundation.Three different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the thickness.The elastic properties of the composite are determined with the law of mixture.Employing Hamilton’s principle,the governing equations of motion are obtained.The generalized differential quadrature method(GDQM)is then applied to the equations to obtain the results.The achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam change.Furthermore,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber distribution.Eventually,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.展开更多
Tool condition monitoring(TCM)is a key technology for intelligent manufacturing.The objective is to monitor the tool operation status and detect tool breakage so that the tool can be changed in time to avoid significa...Tool condition monitoring(TCM)is a key technology for intelligent manufacturing.The objective is to monitor the tool operation status and detect tool breakage so that the tool can be changed in time to avoid significant damage to workpieces and reduce manufacturing costs.Recently,an innovative TCM approach based on sensor data modelling and model frequency analysis has been proposed.Different from traditional signal feature-based monitoring,the data from sensors are utilized to build a dynamic process model.Then,the nonlinear output frequency response functions,a concept which extends the linear system frequency response function to the nonlinear case,over the frequency range of the tooth passing frequency of the machining process are extracted to reveal tool health conditions.In order to extend the novel sensor data modelling and model frequency analysis to unsupervised condition monitoring of cutting tools,in the present study,a multivariate control chart is proposed for TCM based on the frequency domain properties of machining processes derived from the innovative sensor data modelling and model frequency analysis.The feature dimension is reduced by principal component analysis first.Then the moving average strategy is exploited to generate monitoring variables and overcome the effects of noises.The milling experiments of titanium alloys are conducted to verify the effectiveness of the proposed approach in detecting excessive flank wear of solid carbide end mills.The results demonstrate the advantages of the new approach over conventional TCM techniques and its potential in industrial applications.展开更多
BACKGROUND Kidney function loss or renal insufficiency indicated by elevated creatinine levels and/or an estimated glomerular filtration rate(eGFR)<60 mL/minute/1.73 m²at presentation in patients with primary ...BACKGROUND Kidney function loss or renal insufficiency indicated by elevated creatinine levels and/or an estimated glomerular filtration rate(eGFR)<60 mL/minute/1.73 m²at presentation in patients with primary focal segmental glomerulosclerosis(FSGS)is commonly seen as a poor prognostic marker for kidney survival.However,a pre>vious study from our center suggested this may be due to hemodynamic factors.AIM To observe the clinical and biochemical parameters,treatment response,kidney survival,and overall outcomes of adult patients with primary FSGS presenting with kidney function insufficiency.METHODS This retrospective observational study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from January 1995 to December 2017.During this period,401 biopsy-proven primary FSGS patients were identified,of which 98(24.4%)presented with kidney function loss or renal insufficiency defined as eGFR<60 mL/minute/1.73 m²at presentation and were studied in detail.RESULTS Among the 98 patients with renal function loss on presentation,the mean age was 30.9 years±13.6 years with a male-to-female ratio of 2.5:1.The mean serum creatinine level was 2.2 mg/dL±1.3 mg/dL and mean eGFR 37.1 mL/minute/1.73 m2±12.8 mL/minute/1.73 m2.The mean 24-hour urinary protein excretion was 5.9 g/day±4.0 g/day,and the mean serum albumin was 2.1 g/dL±1.0 g/dL(median:1.5 g/dL).The mean systolic blood pressure(BP)was 132.7 mmHg±19.8 mmHg,and the mean diastolic BP was 87.4 mmHg±12.7 mmHg.Steroid treatment was given to 81(82.6%)of 98 patients for an average duration of 19.9 weeks±14.4 weeks,with a mean total steroid dose of 4.4 g±1.5 g.Treatment response showed that 20(24.6%)patients achieved complete remission,9(11.1%)achieved partial remission,and 52(64.1%)did not respond.The baseline eGFR was significantly lower in the non-responsive group(P=0.006).The distribution of FSGS variants was also significantly different among steroid-responsive and non-responsive groups(P=0.012).CONCLUSION Renal function loss in FSGS patients at presentation does not necessarily indicate irreversible kidney function loss and a significant number of patients respond to appropriate treatment of the underlying disease.展开更多
Finite dement formulations are used to simulate the evolution of the elastoplastic response of functionally graded cemented carbides (FGCC) due to thermal loading. The geometry of specimens is an axisymmetric solid ...Finite dement formulations are used to simulate the evolution of the elastoplastic response of functionally graded cemented carbides (FGCC) due to thermal loading. The geometry of specimens is an axisymmetric solid cylinder with a two-dimensional gradient. The elastoplastic constitutive relationship is developed by constraint factors. Numerical results show that compressive stresses occur in the surface zone and tensile stresses in the cobalt rich zone when the temperature drops from the initial stress-free temperature of 800 to 0℃. The maximum value of the surface compressive stress is 254 MPa and the maximum value of the tensile stress is 252 MPa in the cobalt rich zones. When the cobalt concentration difference in the specimens is equal to or greater than 0.3, there is pronounced plastic flow in cobalt rich zone. When the temperature heats up from 0 to 800 ℃, the total plastic strain reaches 0.001 4. Plastic flow has a significant effect on the reduction of thermal stress concentration.展开更多
基金the Postdoctoral ScienceFoundation of China(No.2023M730156)the NationalNatural Foundation of China(No.62301012).
文摘Hyper-and multi-spectral image fusion is an important technology to produce hyper-spectral and hyper-resolution images,which always depends on the spectral response function andthe point spread function.However,few works have been payed on the estimation of the two degra-dation functions.To learn the two functions from image pairs to be fused,we propose a Dirichletnetwork,where both functions are properly constrained.Specifically,the spatial response function isconstrained with positivity,while the Dirichlet distribution along with a total variation is imposedon the point spread function.To the best of our knowledge,the neural network and the Dirichlet regularization are exclusively investigated,for the first time,to estimate the degradation functions.Both image degradation and fusion experiments demonstrate the effectiveness and superiority of theproposed Dirichlet network.
文摘A generalized form of the error function, Gp(x)=pΓ(1/p)∫0xe−tpdt, which is directly associated with the gamma function, is evaluated for arbitrary real values of p>1and 0x≤+∞by employing a fast-converging power series expansion developed in resolving the so-called Grandi’s paradox. Comparisons with accurate tabulated values for well-known cases such as the error function are presented using the expansions truncated at various orders.
基金Shanghai Chongming District Sustainable Development Science and Technology Innovation Action Plan,No.CKY2020-11.
文摘BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate the effectiveness of laparoscopic minimally invasive surgery as an alternative to traditional open surgery for gastric cancer,focusing on its potential to reduce trauma,accelerate recovery,and achieve comparable oncological out-comes.METHODS This study retrospectively analyzed 203 patients with gastric cancer who underwent surgery at the Shanghai Health Medical College Affiliated Chongming Hospital from January 2020 to December 2023.The patients were divided into two groups:Minimally invasive surgery group(n=102),who underwent laparoscopic gastrectomy,and open surgery group(n=101),who underwent traditional open gastrectomy.We compared surgical indicators(surgical incision size,intraop-erative blood loss,surgical duration,and number of lymph nodes dissected),recovery parameters(time to first flatus,time to start eating,time to ambulation,and length of hospital stay),immune function(levels of IgA,IgG,and IgM),intestinal barrier function(levels of D-lactic acid and diamine oxidase),and stress response(levels of C-reactive protein,interleukin-6,and procalcitonin).RESULTS The minimally invasive surgery group demonstrated significantly better outcomes in terms of surgical indicators,including smaller incisions,less blood loss,shorter surgery time,and more lymph nodes dissected(P<0.05 for all).Recovery was also faster in the minimally invasive surgery group,with earlier return of bowel function,earlier initiation of diet,quicker mobilization,and shorter hospital stays(P<0.05 for all).Furthermore,patients in the minimally invasive surgery group had better preserved immune function,superior intestinal barrier function,and a less pronounced stress response postoperatively(P<0.05 for all).CONCLUSION Laparoscopic minimally invasive surgery for gastric cancer not only provides superior surgical indicators and faster recovery but also offers advantages in preserving immune function,protecting intestinal barrier function,and mitigating the stress response compared to traditional open surgery.These findings support the broader adoption of laparoscopic techniques in the management of gastric cancer.
基金Supported by the National Natural Science Foundation of China(Grant No.11801342)the Natural Science Foundation of Shaanxi Province(Grant No.2023-JC-YB-043).
文摘A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.
文摘In this paper, we study a modified Leslie-Gower predator-prey model with Smith growth subject to homogeneous Neumann boundary condition, in which the functional response is the Crowley-Martin functional response term. Firstly, for ODE model, the local stability of equilibrium point is given. And by using bifurcation theory and selecting suitable bifurcation parameters, we find many kinds of bifurcation phenomena, including Transcritical bifurcation and Hopf bifurcation. For the reaction-diffusion model, we find that Turing instability occurs. Besides, it is proved that Hopf bifurcation exists in the model. Finally, numerical simulations are presented to verify and illustrate the theoretical results.
文摘BACKGROUND In the perioperative period of biliary surgery,various factors can induce the release of a large number of inflammatory factors,leading to an imbalance in proinflammatory and anti-inflammatory responses and resulting in gastrointestinal(GI)dysfunction.Enhanced Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative recovery.It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery,both of which are the basis and key for perioperative care and postoperative recovery.AIM To better understand the effects of Modified Xiao-Cheng-Qi decoction(MXD)on inflammatory response and GI function in the perioperative management of cholelithiasis and their correlation.METHODS This was a prospective randomized placebo-controlled trial,in which 162 patients who received biliary tract surgery were randomly assigned to three groups:MXD group,XD group,and placebo-control group.The observed parameters included frequency of bowel sounds,time of first flatus and defecation,time of diet,and amount of activity after surgery.The serum levels of C-reactive protein(CRP),interleukin(IL)-6,IL-10,serum amyloid A protein(SAA),and substance P were measured by the enzyme-linked immunosorbent assay.Then,the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and inflammation.RESULTS Compared to the placebo-control,improvements in GI function were observed in the MXD groups including reduced incidence of nausea,vomiting,and bloating;and earlier first exhaust time,first defecation time,and feeding time after surgery(P<0.05).On the 1st and 2nd d after surgery,IL-6,CRP and SAA levels in MXD group were lower than that in placebo control,but substance P level was higher,compared to the control(P<0.05).Functional diarrhea occurred in both MXD and XD groups without any other adverse effects,toxic reactions,and allergic reactions.Diarrhea was relieved after the discontinuation of the investigational remedies.Bowel sounds at 12 h after surgery,the occurring time of the first flatus,first defecation,postoperative liquid diet and semiliquid diet were significantly correlated with levels of IL-6,CRP,SAA and substance P on second day after surgery(P<0.05).CONCLUSION Treatment with MXD can relieve inflammatory response and improve GI function after surgery.Moreover,there are significant correlations between them.Furthermore,it does not cause serious adverse reactions.
基金partially performed with the support and under the auspices of the NIFS Collaborative Research Program(Nos.NIFS20KLPR051,NIFS20KUHL099 and NIFS20KUGM153)。
文摘Temperature response functions have been developed to investigate sensor design and divertor heat flux estimation in magnetically confined plasmas. The time-dependent heat flux can be derived by fitting the response function to experimental thermocouple(TC) data. Because the TC signals have a time delay to transit events such as discharge start or confinement transition, the time delay is taken into account in a temperature response function. Such a function accurately describes the signal from each TC channel with time delay in a sensor test using a neutral beam injection. Measurement for commercial TCs shows that the time delay is caused by the finite heat capacity of TC wire and contact heat resistance between TC and target surface.
文摘Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body temperature.Immune cells,notably neutrophils and macrophages,play key roles in orchestrating this response.The delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory cascade.While acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune diseases.Understanding these mechanisms is vital for developing therapeutic strategies and managing chronic diseases.
文摘To investigate the effects of self-memory diffusion on predator-prey models, we consider a predator-prey model with Bazykin functional response of self- memory diffusion. The uniqueness, boundedness, positivity, existence and stability of equilibrium point of the model are studied. In this paper, the uniqueness of the solution is discussed under the non-negative initial function and Neumann boundary conditions satisfying a specific space. The boundness of the solution is proved by the comparison principle of parabolic equations, and the positivity of the solution is proved by the strong maximum principle of parabolic equations. Hurwitz criterion and Lyapunov function construction are used to analyze the local stability and global stability of feasible equilibrium points. The results show that the system solution is unique non-negative and bounded. The model is unstable at the trivial equilibrium point E0 and the boundary equilibrium point E1, and the condition of whether the positive equilibrium point E2 is stable under certain conditions is given.
文摘A predator-prey model with linear capture term Holling-II functional response was studied by using differential equation theory. The existence and the stabilities of non-negative equilibrium points of the model were discussed. The results show that under certain limited conditions, these two groups can maintain a balanced position, which provides a theoretical reference for relevant departments to make decisions on ecological protection.
基金funded by the Deanship of Scientific Research and Libraries,Princess Nourah bint Abdulrahman University,through the Program of Research Project Funding after Publication,Grant No.(RPFAP-34-1445).
文摘A novel inverted generalized gamma(IGG)distribution,proposed for data modelling with an upside-down bathtub hazard rate,is considered.In many real-world practical situations,when a researcher wants to conduct a comparative study of the life testing of items based on cost and duration of testing,censoring strategies are frequently used.From this point of view,in the presence of censored data compiled from the most well-known progressively Type-Ⅱ censoring technique,this study examines different parameters of the IGG distribution.From a classical point of view,the likelihood and product of spacing estimation methods are considered.Observed Fisher information and the deltamethod are used to obtain the approximate confidence intervals for any unknown parametric function of the suggestedmodel.In the Bayesian paradigm,the same traditional inferential approaches are used to estimate all unknown subjects.Markov-Chain with Monte-Carlo steps are considered to approximate all Bayes’findings.Extensive numerical comparisons are presented to examine the performance of the proposed methodologies using various criteria of accuracy.Further,using several optimality criteria,the optimumprogressive censoring design is suggested.To highlight how the proposed estimators can be used in practice and to verify the flexibility of the proposed model,we analyze the failure times of twenty mechanical components of a diesel engine.
基金supported by the Technology Project of State Grid Jiangsu Electric Power Co.,Ltd.,China (J2022160,Research on Key Technologies of Distributed Power Dispatching Control for Resilience Improvement of Distribution Networks).
文摘To improve the resilience of a distribution system against extreme weather,a fuel-based distributed generator(DG)allocation model is proposed in this study.In this model,the DGs are placed at the planning stage.When an extreme event occurs,the controllable generators form temporary microgrids(MGs)to restore the load maximally.Simultaneously,a demand response program(DRP)mitigates the imbalance between the power supply and demand during extreme events.To cope with the fault uncertainty,a robust optimization(RO)method is applied to reduce the long-term investment and short-term operation costs.The optimization is formulated as a tri-level defenderattacker-defender(DAD)framework.At the first level,decision-makers work out the DG allocation scheme;at the second level,the attacker finds the optimal attack strategy with maximum damage;and at the third level,restoration measures,namely distribution network reconfiguration(DNR)and demand response are performed.The problem is solved by the nested column and constraint generation(NC&CG)method and the model is validated using an IEEE 33-node system.Case studies validate the effectiveness and superiority of the proposed model according to the enhanced resilience and reduced cost.
文摘For a set S of real numbers, we introduce the concept of S-almost automorphic functions valued in a Banach space. It generalizes in particular the space of Z-almost automorphic functions. Considering the space of S-almost automorphic functions, we give sufficient conditions of the existence and uniqueness of almost automorphic solutions of a differential equation with a piecewise constant argument of generalized type. This is done using the Banach fixed point theorem.
文摘The magnetic flux in a permanent magnet transverse flux generator(PMTFG) is three-dimensional(3D), therefore, its efficacy is evaluated using 3D magnetic field analysis. Although the 3D finite-element method(FEM) is highly accurate and reliable for machine simulation, it requires a long computation time, which is crucial when it is to be used in an iterative optimization process. Therefore, an alternative to 3DFEM is required as a rapid and accurate analytical technique. This paper presents an analytical model for PMTFG analysis using winding function method. To obtain the air gap MMF distribution, the excitation magneto-motive force(MMF) and the turn function are determined based on certain assumptions. The magnetizing inductance, flux density, and back-electro-magnetomotive force of the winding are then determined. To assess the accuracy of the proposed method, the analytically calculated parameters of the generator are compared to those obtained by a 3D-FEM. The presented method requires significantly shorter computation time than the 3D-FEM with comparable accuracy.
文摘Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers are renowned for their good mechanical properties,abundance,and short cycle growth.As beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic foundation.Three different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the thickness.The elastic properties of the composite are determined with the law of mixture.Employing Hamilton’s principle,the governing equations of motion are obtained.The generalized differential quadrature method(GDQM)is then applied to the equations to obtain the results.The achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam change.Furthermore,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber distribution.Eventually,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.
文摘Tool condition monitoring(TCM)is a key technology for intelligent manufacturing.The objective is to monitor the tool operation status and detect tool breakage so that the tool can be changed in time to avoid significant damage to workpieces and reduce manufacturing costs.Recently,an innovative TCM approach based on sensor data modelling and model frequency analysis has been proposed.Different from traditional signal feature-based monitoring,the data from sensors are utilized to build a dynamic process model.Then,the nonlinear output frequency response functions,a concept which extends the linear system frequency response function to the nonlinear case,over the frequency range of the tooth passing frequency of the machining process are extracted to reveal tool health conditions.In order to extend the novel sensor data modelling and model frequency analysis to unsupervised condition monitoring of cutting tools,in the present study,a multivariate control chart is proposed for TCM based on the frequency domain properties of machining processes derived from the innovative sensor data modelling and model frequency analysis.The feature dimension is reduced by principal component analysis first.Then the moving average strategy is exploited to generate monitoring variables and overcome the effects of noises.The milling experiments of titanium alloys are conducted to verify the effectiveness of the proposed approach in detecting excessive flank wear of solid carbide end mills.The results demonstrate the advantages of the new approach over conventional TCM techniques and its potential in industrial applications.
文摘BACKGROUND Kidney function loss or renal insufficiency indicated by elevated creatinine levels and/or an estimated glomerular filtration rate(eGFR)<60 mL/minute/1.73 m²at presentation in patients with primary focal segmental glomerulosclerosis(FSGS)is commonly seen as a poor prognostic marker for kidney survival.However,a pre>vious study from our center suggested this may be due to hemodynamic factors.AIM To observe the clinical and biochemical parameters,treatment response,kidney survival,and overall outcomes of adult patients with primary FSGS presenting with kidney function insufficiency.METHODS This retrospective observational study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from January 1995 to December 2017.During this period,401 biopsy-proven primary FSGS patients were identified,of which 98(24.4%)presented with kidney function loss or renal insufficiency defined as eGFR<60 mL/minute/1.73 m²at presentation and were studied in detail.RESULTS Among the 98 patients with renal function loss on presentation,the mean age was 30.9 years±13.6 years with a male-to-female ratio of 2.5:1.The mean serum creatinine level was 2.2 mg/dL±1.3 mg/dL and mean eGFR 37.1 mL/minute/1.73 m2±12.8 mL/minute/1.73 m2.The mean 24-hour urinary protein excretion was 5.9 g/day±4.0 g/day,and the mean serum albumin was 2.1 g/dL±1.0 g/dL(median:1.5 g/dL).The mean systolic blood pressure(BP)was 132.7 mmHg±19.8 mmHg,and the mean diastolic BP was 87.4 mmHg±12.7 mmHg.Steroid treatment was given to 81(82.6%)of 98 patients for an average duration of 19.9 weeks±14.4 weeks,with a mean total steroid dose of 4.4 g±1.5 g.Treatment response showed that 20(24.6%)patients achieved complete remission,9(11.1%)achieved partial remission,and 52(64.1%)did not respond.The baseline eGFR was significantly lower in the non-responsive group(P=0.006).The distribution of FSGS variants was also significantly different among steroid-responsive and non-responsive groups(P=0.012).CONCLUSION Renal function loss in FSGS patients at presentation does not necessarily indicate irreversible kidney function loss and a significant number of patients respond to appropriate treatment of the underlying disease.
基金The National Natural Science Foundation of China(No.50323008,31070517)Scientific Research Foundation of Guangxi Education Department(No.201203YB097)
文摘Finite dement formulations are used to simulate the evolution of the elastoplastic response of functionally graded cemented carbides (FGCC) due to thermal loading. The geometry of specimens is an axisymmetric solid cylinder with a two-dimensional gradient. The elastoplastic constitutive relationship is developed by constraint factors. Numerical results show that compressive stresses occur in the surface zone and tensile stresses in the cobalt rich zone when the temperature drops from the initial stress-free temperature of 800 to 0℃. The maximum value of the surface compressive stress is 254 MPa and the maximum value of the tensile stress is 252 MPa in the cobalt rich zones. When the cobalt concentration difference in the specimens is equal to or greater than 0.3, there is pronounced plastic flow in cobalt rich zone. When the temperature heats up from 0 to 800 ℃, the total plastic strain reaches 0.001 4. Plastic flow has a significant effect on the reduction of thermal stress concentration.