This article is the result of a research carried out in a private hospital of Belo Horizonte, Brazil. The patient care model of the Mastology Department includes an interdisciplinary staff that aims for the comprehens...This article is the result of a research carried out in a private hospital of Belo Horizonte, Brazil. The patient care model of the Mastology Department includes an interdisciplinary staff that aims for the comprehensive treatment of these surgical patients. The research is based on clinical approach, under the framework of Analytical Psychology. Feminine archetypal images are symbolically represented by the Main Goddesses of the Olympus. It is natural for one of these expressions to prevail throughout a woman’s life, or even in specific moments of her life, but it is important to recognize that all of them are part of the feminine soul. We can, therefore, define and understand the Goddesses from Greek Mythology symbolically as being representative of the various feminine psychogenic forces that are projected. In reality, they are internal images that can be used to help know and understand personal issues and changes that are necessary in a woman’s life, enabling personal growth and the possibility to identify herself with the more authentic elements of her being. In this work experience, the feminine force showed itself to be a force of creation, of expression and of overcoming.展开更多
This systematic literature review examines the impact of breast cancer treatment experiences, with a focus on mastectomy, on the psychosocial well-being of women. While previous studies have shown that mastectomy is a...This systematic literature review examines the impact of breast cancer treatment experiences, with a focus on mastectomy, on the psychosocial well-being of women. While previous studies have shown that mastectomy is associated with negative psychological outcomes such as anxiety, depression, and a loss of femininity, a new body of literature suggests that it can also be a catalyst for post-traumatic growth and personal transformation. The article argues that mastectomy experiences can initiate an individuation process that leads to a more empowered sense of self and a higher quality of life. The review identified 25 studies that employed qualitative methods and analyzed data from interviews, focus groups, and surveys. The article discusses the application of Jung’s individuation theory to categorize the experiences of women with breast cancer and links breast cancer diagnosis and treatment to the death-experience stage of the theory. The content highlights the importance of movement, contemplation, and spirituality in the healing process, and how they can help women connect with their bodies and develop a new sense of identity. Additionally, the content discusses the role of spirituality in enhancing growth and healing among indigenous native women patients with breast cancer. Overall, this article provides insights into how breast cancer treatment experiences can shape women’s identity, enhance resilience, and provide opportunities for personal growth and transformation.展开更多
Demian:The Story of Emil Sinclair’s Youth is one of Hesse’s most representative works,which tells the story of the protagonist Sinclair’s arduous journey to find his inner self.Greatly influenced by C.G.Jung,a famo...Demian:The Story of Emil Sinclair’s Youth is one of Hesse’s most representative works,which tells the story of the protagonist Sinclair’s arduous journey to find his inner self.Greatly influenced by C.G.Jung,a famous 20th century psychologist and the founder of archetypal approaches,Hesse integrated the knowledge and experience gained from psychoanalysis into his literary creations.Based on archetypal approaches such as shadow and anima,this paper will analyze the protagonist Sinclair’s individuation,or self-growth in other words,so as to prove that people can find more ways to get out of spiritual dilemma for themselves in modern times,and also realize the unity of self-worth and social value.展开更多
This paper tries to interpreter Passing on the basis of Jungian archetypes. First this paper gives a brief introduction to Jung`s concept of individuation, then it analyses the archetypes: shadow, anima/animus, and pe...This paper tries to interpreter Passing on the basis of Jungian archetypes. First this paper gives a brief introduction to Jung`s concept of individuation, then it analyses the archetypes: shadow, anima/animus, and persona of the individual respectively so that it shows that the individual has been through the process of individuation and finds her real self at last.展开更多
Dear Editor,Reproductive healthcare and autonomy are integral to overall health,well-being,and human fundamental rights[1].However,for individuals with disabilities,access to reproductive healthcare and their autonomy...Dear Editor,Reproductive healthcare and autonomy are integral to overall health,well-being,and human fundamental rights[1].However,for individuals with disabilities,access to reproductive healthcare and their autonomy is significantly jeopardized due to a combination of parameters[1].Disabled people have to deal with a wide range of social barriers while they decide to access healthcare facilities for reproductive health[2,3].展开更多
BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequen...BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequently influenced by the patient's nutritional status and the quality of nursing care provided.AIM To examine the comprehensive impact of personalized nutritional support and nursing strategies on the postoperative rehabilitation of patients with liver cancer.METHODS In this study,a retrospective comparative analysis was conducted involving 60 post-operative liver cancer patients.The subjects were selected as subjects and divided into two groups based on differing nursing interventions,with each group comprising 30 patients.The control group received standard nutritional support and care,whereas the experimental group received individualized nutritional support and nursing strategies.The study aimed to evaluate the impact of individualized nutrition by comparing the rehabilitation indices,nutritional status,quality of life(QoL),and complication rates between the two groups.RESULTS The results showed that the recovery index of the experimental group was significantly better than that of the control group 2 weeks after surgery,and the average liver function recovery index of the experimental group was 85.significantly higher than that of the control group(73.67±7.19).In terms of nutritional status,the serum albumin level and body weight stabilization rate of the experimental group were also significantly higher than those of the control group,which were 42.33±2.4 g/L and 93.3%,respectively,compared with 36.01±3.85 g/L and 76.7%of the control group.In addition,the average QoL score of the experimental group was 84.66±3.7 points,which was significantly higher than that of the control group(70.92±4.28 points).At the psychological level,the average anxiety score of the experimental group was 1.17±0.29,and the average depression score was 1.47±0.4,which were significantly lower than the 2.26±0.42 and 2.57±0.45 of the control group.This showed that patients in the experimental group were better relieved of anxiety and depression under the individualized nutrition support and nursing strategy.More importantly,the complication rate in the experimental group was only 10%,much lower than the 33.3%in the control group.CONCLUSION Personalized nutritional support and tailored nursing strategies significantly enhance the postoperative rehabilitation of liver cancer patients.Consequently,it is recommended to implement and advocate for these individualized approaches to improve both the recovery outcomes and QoL for these patients.展开更多
The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Sat...The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 Her.The primary and secondary times of minima were extracted from al the data,and,by collecting the literature,a new ephemeris was computed for each system.Linear fits for the O-C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) method.Light curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC approach.The systems were found to be contact binary stars based on the fillout factor and mass ratio.V1023 Her showed the O’Connell effect and a cold starspot on the secondary component was required for the light curve solution.The absolute parameters of the system were estimated based on an empirical relationship between orbital period and mass.We presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the fit.The positions of the systems were also depicted on the M–L,M–R,q–L_(ratio),and M_(tot)–J_(0)diagrams in the logarithmic scales.展开更多
BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindicatio...BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver resection.Up to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after resection.AIM To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to surgery.METHODS In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after chemotherapy.Various parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were measured.The parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node status.The reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation coefficient.RESULTS Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of 0.873.Furthermore,parameters from SEM showed substantial repeatability.CONCLUSION The developed nomogram,incorporating the pre-treatment DDC and the short axis of the largest lymph node,can be used to predict the presence of hepatic LNM in CRLM patients undergoing chemotherapy before surgery.This nomogram was proven to be more valuable,exhibiting superior diagnostic performance compared to quantitative parameters derived from multiple b values of DWI.The nomogram can serve as a preoperative assessment tool for determining the status of hepatic lymph nodes and aiding in the decision-making process for surgical treatment in CRLM patients.展开更多
We propose a multi-source radio frequency interference(RFI)mitigation method based on a reference antenna array to address the challenge of RFI from multiple directions in radio observation equipment.It introduces a s...We propose a multi-source radio frequency interference(RFI)mitigation method based on a reference antenna array to address the challenge of RFI from multiple directions in radio observation equipment.It introduces a sampling point correction technique using a multi-channel parallel cross-correlation computation method,enhancing the effectiveness of frequency domain adaptive RFI fast mitigation algorithms.The design implements an RFI component detection method based on cross-correlation coefficient thresholds to effectively reduce new interference frequency components introduced by the reference antenna array.Simulated RFI signals and baseband signals of pulsar J0332+5434 observed by the Nanshan 26 m Radio Telescope(NSRT)were used to test the algorithm proposed in this paper.Simulation results demonstrate that the simulated radio telescope signals after RFI mitigation closely match the original pulsar data in profile and phase,confirming the effectiveness of the proposed method.展开更多
The marine green algae genus Chaetomorpha is a common source of“green tide”and is widespread on coasts around the world.In this study,based on invasive Chaetomorpha valida collected from the Shandong Peninsula,the m...The marine green algae genus Chaetomorpha is a common source of“green tide”and is widespread on coasts around the world.In this study,based on invasive Chaetomorpha valida collected from the Shandong Peninsula,the morphogenesis and reproductive characteristics of two strains that are morphologically different from each other,were observed using experimental biology methods.The main results are as follows:(1)significant difference in the size of reproductive cells produced by Strains 1 and 2;(2)gametes produced by Strain 2 are isogamous and same gametangial during the binding process of gametes,whereas those of Strain 1 are isogamous but hetero-cystic;(3)progeny from Strain 1 has rhizoidal holdfast,whereas that of Strain 2 has discoid holdfast;(4)gametophytic“branching”was found in Strain 1.These results could validate the high phenotypic plasticity of macroalgae and offered an interpretation of habitat adaptation.Furthermore,this study innovatively provided fundamental research on the selection of macroalgal traits and explored competitive strategies for the dominant survival of macroalgae from a new perspective.展开更多
Dear Editor,This letter deals with the robustness problem of gait recognition method against maximum number of clothing conditions.By selecting four kinds of time-varying silhouette features,gait dynamics underlying d...Dear Editor,This letter deals with the robustness problem of gait recognition method against maximum number of clothing conditions.By selecting four kinds of time-varying silhouette features,gait dynamics underlying different individuals’gait features is effectively modeled by radial basis function(RBF)neural networks through deterministic learning.This kind of dynamics information has little sensitivity to the variance between gait patterns under different clothing conditions.In order to eliminate the effect of clothing differences,the training patterns under different clothing conditions further constitute a uniform training dataset,containing all kinds of gait dynamics under different clothing conditions.A rapid recognition scheme is presented on published gait databases.Extensive experiments demonstrate the efficacy of the proposed method.展开更多
Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypert...Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and meta-analysis.Methods:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were included.Results:Thirteen studies were included.Selexipag led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good effects.When treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage group.This finding is important for guiding individualized treatments.展开更多
We report a new high-sensitivity HⅠmapping observation of the NGC 5055 galaxy group over an area of 1°.5×0°.75 with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).Our observation revea...We report a new high-sensitivity HⅠmapping observation of the NGC 5055 galaxy group over an area of 1°.5×0°.75 with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).Our observation reveals that the warped HⅠdisk of NGC 5055 is more extended than what was previously observed by WSRT,out to239(61.7 kpc).The total HⅠmass of NGC 5055 is determined to be~1.1×10^(10)M_Θ.We identified three HⅠclouds with HⅠmasses of the order of~10^(7)M_Θat the southeastern edge of the HⅠdisk,as well as a candidate high-velocity cloud with an HⅠmass of(1.2±0.5)×10^(6)M_Θto the north of NGC 5055.The HⅠcontent of UGCA337 is robustly detected for the first time by the FAST observations.It has a narrow HⅠlinewidth of W_(50)=17.4±3.8 km s^(-1)with a total HⅠmass of(3.5±0.3)×10^(6)M_Θ.Comparing the gas content and g-r color of UGCA 337 with typical low-mass dwarf galaxies,UGCA 337 appears relatively gas-poor despite its blue color.This suggests that UGCA 337 may have undergone gas stripping in the past.We also analyzed the possible origin of the diffuse HⅠclouds located at the outskirts of NGC 5055,and speculate that they might be the remnant features of a merger event in the past.展开更多
In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this...In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.展开更多
Generalized Additive Models(GAMs)are widely employed in ecological research,serving as a powerful tool for ecologists to explore complex nonlinear relationships between a response variable and predictors.Nevertheless,...Generalized Additive Models(GAMs)are widely employed in ecological research,serving as a powerful tool for ecologists to explore complex nonlinear relationships between a response variable and predictors.Nevertheless,evaluating the relative importance of predictors with concurvity(analogous to collinearity)on response variables in GAMs remains a challenge.To address this challenge,we developed an R package named gam.hp.gam.hp calculates individual R^(2) values for predictors,based on the concept of'average shared variance',a method previously introduced for multiple regression and canonical analyses.Through these individual R^(2)s,which add up to the overall R^(2),researchers can evaluate the relative importance of each predictor within GAMs.We illustrate the utility of the gam.hp package by evaluating the relative importance of emission sources and meteorological factors in explaining ozone concentration variability in air quality data from London,UK.We believe that the gam.hp package will improve the interpretation of results obtained from GAMs.展开更多
The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is commo...The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is common to set up a one-to-one correspondence between the nodes of a multi-layer network,ignoring the more complex situations in reality.In the present work,we explore this situation by setting up a partially coupled model of a two-layer network and investigating the impact of asymptomatic infected individuals on epidemics.We propose a self-discovery mechanism for asymptomatic infected individuals,taking into account situations such as nucleic acid testing in the community and individuals performing self-antigen testing during the epidemic.Considering these factors together,through the microscopic Markov chain approach(MMCA)and extensive Monte Carlo(MC)numerical simulations,we find that the greater the coupling between the networks,the more information dissemination is facilitated.In order to control the epidemics,more asymptomatic infected individuals should be made aware of their infection.Massive adoption of nucleic acid testing and individual adoption of antigenic self-testing can help to contain epidemic outbreaks.Meanwhile,the epidemic threshold of the proposed model is derived,and then miscellaneous factors affecting the epidemic threshold are also discussed.Current results are conducive to devising the prevention and control policies of pandemics.展开更多
Objective Our study aimed to conduct genomic characterization of Salmonella strains carrying the blaNDM-1 gene in the intestinal tract of healthy individuals.The objectives were to underscore the importance of genomic...Objective Our study aimed to conduct genomic characterization of Salmonella strains carrying the blaNDM-1 gene in the intestinal tract of healthy individuals.The objectives were to underscore the importance of genomic surveillance for drug resistance in both commensal and pathogenic bacteria among healthy populations,and to establish protocols for regulating drug resistance plasmids based on the completion of a comprehensive map of drug resistance plasmid genomes.Methods We performed antimicrobial susceptibility testing and employed second-and third-generation sequencing techniques to analyze Salmonella strains harboring the blaNDM-1 gene,to surveil drug-resistant bacteria in the intestines of healthy subjects.Sequence comparison was conducted using both core-and pan-genome approaches.Concurrently,conjugation experiments were carried out to assess the efficiency of plasmid transfer.Results We isolated a carbapenem-resistant Salmonella enterica serovar Typhimurium strain from a healthy food worker in China.This strain harbored an IncHI2/IncHI2A plasmid carrying blaNDM-1 along with multiple antibiotic resistance genes(ARGs).Our findings highlight the potential for asymptomatic carriers to facilitate the transmission of ARGs.Pan-genomic analysis revealed that blaNDM-1-positive plasmids could traverse bacterial species barriers,facilitating cross-host transmission.Conclusion This study marks the first detection of blaNDM-1 in Salmonella strains isolated from healthy individuals.We underscore the risk associated with the transmission of conjugative hybrid plasmids carrying blaNDM-1,which have the potential to be harbored and transmitted among healthy individuals.Enhanced surveillance of drug-resistant pathogens and plasmids in the intestinal microbiota of healthy individuals could provide insights into the risk of ARG transmission and pathways for population-wide dissemination via ARG transfer factors.展开更多
We report the detection of type-B quasi-periodic oscillation(QPO)of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst.A type-B QPO was observed for the first two days and it dis...We report the detection of type-B quasi-periodic oscillation(QPO)of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst.A type-B QPO was observed for the first two days and it disappeared as flux increased,but again appeared at∼7.70 Hz when flux was dramatically decreased.The source was found in the soft intermediate state during these observations.We further studied the energy dependence of the QPO.We found that QPO was observed only for a higher energy range implying that the origin of QPO is possibly due to the corona emitting higher energy photons by the inverse Compton process.The variation of spectral parameters can be explained with the disk truncation model.The fractional rms was found to be monotonically increased with energy.The phase lag spectrum followed the“U-shaped”curve.The rms and phase lag spectrum are modeled and explained with the single-component Comptonization model vkompthdk.展开更多
The double neutron star PSR J1846-0513 is discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)in Commensal Radio Astronomy FAST Survey.The pulsar is revealed to be harbored in an eccentric orb...The double neutron star PSR J1846-0513 is discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)in Commensal Radio Astronomy FAST Survey.The pulsar is revealed to be harbored in an eccentric orbit with e=0.208 and an orbital period of 0.613 day.The total mass of the system is constrained to b2.6287(35)M_(⊙),with a mass upper limit of 1.3455 M_(⊙)for the pulsar and a mass lower limit of 1.2845 M_(⊙)for th companion star.To reproduce its evolution history,we perform a 1D model for the formation of PSR J1846-0513whose progenitor is assumed to be neutron star—helium(He)star system via MESA code.Since the larg eccentricity is widely believed to originate from an asymmetric supernova explosion,we also investigate th dynamical effects of the supernova explosion.Our simulated results show that the progenitor of PSR J1846-0513could be a binary system consisting of a He star of 3.3-4.0 M_(⊙)and a neutron star in a circular orbit with an initia period of~0.5 day.展开更多
We report a gradual brighteningγ-ray source,4FGL J1718.5+4237,in 0.1-500.0 GeV,which may be associated with a blazar NVSS J171822+423948 with a redshift of~2.7.We analyzed 15.25 yr ofγ-ray data recorded by the Large...We report a gradual brighteningγ-ray source,4FGL J1718.5+4237,in 0.1-500.0 GeV,which may be associated with a blazar NVSS J171822+423948 with a redshift of~2.7.We analyzed 15.25 yr ofγ-ray data recorded by the Large Area Telescope on board the Fermi Gamma-ray Space Telescope and detected significantγ-ray emissions in the direction of the blazar with a test statistic(TS)of~135.Based on timing analysis using a 1 yr time bin,we have observed a gradual brightening inγ-ray emissions from the target.In our analysis,we categorize them into two states:Quiet(TS~0)and Loud(TS~226)states,with the distinction occurring in 2016 August(MJD57602.69).From the Quiet state to the brightest period(the last data point),theγ-ray flux in 0.1-500.0 GeV increased by more than 12-fold from<0.2×10^(-8)photons cm^(-1)s^(-1)to 2.6×10^(-8)photons cm^(-1)s^(-1).Additionally,we studied the spectral properties in detail for the Loud state and the overall data.While no significant variation was detected,both exhibited a spectral indexΓof~2.6.The origin of the brighteningγ-ray emissions from the target is not yet clear.Future long-term multi-wavelength observations and studies will provide insight into the astrophysical mechanisms of the target.展开更多
文摘This article is the result of a research carried out in a private hospital of Belo Horizonte, Brazil. The patient care model of the Mastology Department includes an interdisciplinary staff that aims for the comprehensive treatment of these surgical patients. The research is based on clinical approach, under the framework of Analytical Psychology. Feminine archetypal images are symbolically represented by the Main Goddesses of the Olympus. It is natural for one of these expressions to prevail throughout a woman’s life, or even in specific moments of her life, but it is important to recognize that all of them are part of the feminine soul. We can, therefore, define and understand the Goddesses from Greek Mythology symbolically as being representative of the various feminine psychogenic forces that are projected. In reality, they are internal images that can be used to help know and understand personal issues and changes that are necessary in a woman’s life, enabling personal growth and the possibility to identify herself with the more authentic elements of her being. In this work experience, the feminine force showed itself to be a force of creation, of expression and of overcoming.
文摘This systematic literature review examines the impact of breast cancer treatment experiences, with a focus on mastectomy, on the psychosocial well-being of women. While previous studies have shown that mastectomy is associated with negative psychological outcomes such as anxiety, depression, and a loss of femininity, a new body of literature suggests that it can also be a catalyst for post-traumatic growth and personal transformation. The article argues that mastectomy experiences can initiate an individuation process that leads to a more empowered sense of self and a higher quality of life. The review identified 25 studies that employed qualitative methods and analyzed data from interviews, focus groups, and surveys. The article discusses the application of Jung’s individuation theory to categorize the experiences of women with breast cancer and links breast cancer diagnosis and treatment to the death-experience stage of the theory. The content highlights the importance of movement, contemplation, and spirituality in the healing process, and how they can help women connect with their bodies and develop a new sense of identity. Additionally, the content discusses the role of spirituality in enhancing growth and healing among indigenous native women patients with breast cancer. Overall, this article provides insights into how breast cancer treatment experiences can shape women’s identity, enhance resilience, and provide opportunities for personal growth and transformation.
文摘Demian:The Story of Emil Sinclair’s Youth is one of Hesse’s most representative works,which tells the story of the protagonist Sinclair’s arduous journey to find his inner self.Greatly influenced by C.G.Jung,a famous 20th century psychologist and the founder of archetypal approaches,Hesse integrated the knowledge and experience gained from psychoanalysis into his literary creations.Based on archetypal approaches such as shadow and anima,this paper will analyze the protagonist Sinclair’s individuation,or self-growth in other words,so as to prove that people can find more ways to get out of spiritual dilemma for themselves in modern times,and also realize the unity of self-worth and social value.
文摘This paper tries to interpreter Passing on the basis of Jungian archetypes. First this paper gives a brief introduction to Jung`s concept of individuation, then it analyses the archetypes: shadow, anima/animus, and persona of the individual respectively so that it shows that the individual has been through the process of individuation and finds her real self at last.
文摘Dear Editor,Reproductive healthcare and autonomy are integral to overall health,well-being,and human fundamental rights[1].However,for individuals with disabilities,access to reproductive healthcare and their autonomy is significantly jeopardized due to a combination of parameters[1].Disabled people have to deal with a wide range of social barriers while they decide to access healthcare facilities for reproductive health[2,3].
文摘BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequently influenced by the patient's nutritional status and the quality of nursing care provided.AIM To examine the comprehensive impact of personalized nutritional support and nursing strategies on the postoperative rehabilitation of patients with liver cancer.METHODS In this study,a retrospective comparative analysis was conducted involving 60 post-operative liver cancer patients.The subjects were selected as subjects and divided into two groups based on differing nursing interventions,with each group comprising 30 patients.The control group received standard nutritional support and care,whereas the experimental group received individualized nutritional support and nursing strategies.The study aimed to evaluate the impact of individualized nutrition by comparing the rehabilitation indices,nutritional status,quality of life(QoL),and complication rates between the two groups.RESULTS The results showed that the recovery index of the experimental group was significantly better than that of the control group 2 weeks after surgery,and the average liver function recovery index of the experimental group was 85.significantly higher than that of the control group(73.67±7.19).In terms of nutritional status,the serum albumin level and body weight stabilization rate of the experimental group were also significantly higher than those of the control group,which were 42.33±2.4 g/L and 93.3%,respectively,compared with 36.01±3.85 g/L and 76.7%of the control group.In addition,the average QoL score of the experimental group was 84.66±3.7 points,which was significantly higher than that of the control group(70.92±4.28 points).At the psychological level,the average anxiety score of the experimental group was 1.17±0.29,and the average depression score was 1.47±0.4,which were significantly lower than the 2.26±0.42 and 2.57±0.45 of the control group.This showed that patients in the experimental group were better relieved of anxiety and depression under the individualized nutrition support and nursing strategy.More importantly,the complication rate in the experimental group was only 10%,much lower than the 33.3%in the control group.CONCLUSION Personalized nutritional support and tailored nursing strategies significantly enhance the postoperative rehabilitation of liver cancer patients.Consequently,it is recommended to implement and advocate for these individualized approaches to improve both the recovery outcomes and QoL for these patients.
文摘The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is presented.We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 Her.The primary and secondary times of minima were extracted from al the data,and,by collecting the literature,a new ephemeris was computed for each system.Linear fits for the O-C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) method.Light curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC approach.The systems were found to be contact binary stars based on the fillout factor and mass ratio.V1023 Her showed the O’Connell effect and a cold starspot on the secondary component was required for the light curve solution.The absolute parameters of the system were estimated based on an empirical relationship between orbital period and mass.We presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the fit.The positions of the systems were also depicted on the M–L,M–R,q–L_(ratio),and M_(tot)–J_(0)diagrams in the logarithmic scales.
基金Supported by Beijing Hospitals Authority Youth Program,No.QML20231103Beijing Hospitals Authority Ascent Plan,No.DFL20191103National Key R&D Program of China,No.2023YFC3402805.
文摘BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver resection.Up to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after resection.AIM To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to surgery.METHODS In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after chemotherapy.Various parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were measured.The parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node status.The reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation coefficient.RESULTS Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of 0.873.Furthermore,parameters from SEM showed substantial repeatability.CONCLUSION The developed nomogram,incorporating the pre-treatment DDC and the short axis of the largest lymph node,can be used to predict the presence of hepatic LNM in CRLM patients undergoing chemotherapy before surgery.This nomogram was proven to be more valuable,exhibiting superior diagnostic performance compared to quantitative parameters derived from multiple b values of DWI.The nomogram can serve as a preoperative assessment tool for determining the status of hepatic lymph nodes and aiding in the decision-making process for surgical treatment in CRLM patients.
基金supported by the National Key R&D Program of China Nos.2021YFC2203502 and 2022YFF0711502the National Natural Science Foundation of China(NSFC,grant Nos.12173077,12073067)+4 种基金the Tianshan Talent Project of Xinjiang Uygur Autonomous Region(2022TSYCCX0095 and2023TSYCCX0112)the Scientific Instrument Developing Project of the Chinese Academy of Sciences,grant No.PTYQ2022YZZD01China National Astronomical Data Center(NADC)the Operation,Maintenance and Upgrading Fund for Astronomical Telescopes and Facility Instruments,budgeted from the Ministry of Finance of China(MOF)and administrated by the Chinese Academy of Sciences(CAS)Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01A360)。
文摘We propose a multi-source radio frequency interference(RFI)mitigation method based on a reference antenna array to address the challenge of RFI from multiple directions in radio observation equipment.It introduces a sampling point correction technique using a multi-channel parallel cross-correlation computation method,enhancing the effectiveness of frequency domain adaptive RFI fast mitigation algorithms.The design implements an RFI component detection method based on cross-correlation coefficient thresholds to effectively reduce new interference frequency components introduced by the reference antenna array.Simulated RFI signals and baseband signals of pulsar J0332+5434 observed by the Nanshan 26 m Radio Telescope(NSRT)were used to test the algorithm proposed in this paper.Simulation results demonstrate that the simulated radio telescope signals after RFI mitigation closely match the original pulsar data in profile and phase,confirming the effectiveness of the proposed method.
基金Supported by the National Natural Science Foundation of China(Nos.32270219,31970216)。
文摘The marine green algae genus Chaetomorpha is a common source of“green tide”and is widespread on coasts around the world.In this study,based on invasive Chaetomorpha valida collected from the Shandong Peninsula,the morphogenesis and reproductive characteristics of two strains that are morphologically different from each other,were observed using experimental biology methods.The main results are as follows:(1)significant difference in the size of reproductive cells produced by Strains 1 and 2;(2)gametes produced by Strain 2 are isogamous and same gametangial during the binding process of gametes,whereas those of Strain 1 are isogamous but hetero-cystic;(3)progeny from Strain 1 has rhizoidal holdfast,whereas that of Strain 2 has discoid holdfast;(4)gametophytic“branching”was found in Strain 1.These results could validate the high phenotypic plasticity of macroalgae and offered an interpretation of habitat adaptation.Furthermore,this study innovatively provided fundamental research on the selection of macroalgal traits and explored competitive strategies for the dominant survival of macroalgae from a new perspective.
基金supported by the National Natural Science Foundation of China(T2341019,61803133)the Guangzhou Basic and Applied Basic Research Project(202201010346,2023A04J0347)the Guangdong Basic and Applied Basic Research Foundation(2021A1515012635,2023A1515011245).
文摘Dear Editor,This letter deals with the robustness problem of gait recognition method against maximum number of clothing conditions.By selecting four kinds of time-varying silhouette features,gait dynamics underlying different individuals’gait features is effectively modeled by radial basis function(RBF)neural networks through deterministic learning.This kind of dynamics information has little sensitivity to the variance between gait patterns under different clothing conditions.In order to eliminate the effect of clothing differences,the training patterns under different clothing conditions further constitute a uniform training dataset,containing all kinds of gait dynamics under different clothing conditions.A rapid recognition scheme is presented on published gait databases.Extensive experiments demonstrate the efficacy of the proposed method.
基金Program of the National Natural Science Foundation of China,Grant/Award Number:81700045,81870042 and 82200065The Department Development Fund of Shanghai Pulmonary Hospital,Grant/Award Number:201906-0314+2 种基金The Program of Shanghai Pulmonary Hospital,Grant/Award Number:FKLY20011The Three-year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR4021Young Talent Program of Shanghai Municipal Health Commission,Grant/Award Number:2022YQ070。
文摘Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and meta-analysis.Methods:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were included.Results:Thirteen studies were included.Selexipag led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good effects.When treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage group.This finding is important for guiding individualized treatments.
基金supported by the National Key R&D Program of China(2022YFA1602901)the National Natural Science Foundation of China(NSFC,grant No.12373001)supported by the Open Project Program of the Key Laboratory of FAST,NAOC,Chinese Academy of Sciences。
文摘We report a new high-sensitivity HⅠmapping observation of the NGC 5055 galaxy group over an area of 1°.5×0°.75 with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).Our observation reveals that the warped HⅠdisk of NGC 5055 is more extended than what was previously observed by WSRT,out to239(61.7 kpc).The total HⅠmass of NGC 5055 is determined to be~1.1×10^(10)M_Θ.We identified three HⅠclouds with HⅠmasses of the order of~10^(7)M_Θat the southeastern edge of the HⅠdisk,as well as a candidate high-velocity cloud with an HⅠmass of(1.2±0.5)×10^(6)M_Θto the north of NGC 5055.The HⅠcontent of UGCA337 is robustly detected for the first time by the FAST observations.It has a narrow HⅠlinewidth of W_(50)=17.4±3.8 km s^(-1)with a total HⅠmass of(3.5±0.3)×10^(6)M_Θ.Comparing the gas content and g-r color of UGCA 337 with typical low-mass dwarf galaxies,UGCA 337 appears relatively gas-poor despite its blue color.This suggests that UGCA 337 may have undergone gas stripping in the past.We also analyzed the possible origin of the diffuse HⅠclouds located at the outskirts of NGC 5055,and speculate that they might be the remnant features of a merger event in the past.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.72031009 and 61473338)。
文摘In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.
基金supported by the National Natural Science Foundation of China (32271551)National Key Research and Development Program of China (2023YFF0805803)the Metasequoia funding of Nanjing Forestry University。
文摘Generalized Additive Models(GAMs)are widely employed in ecological research,serving as a powerful tool for ecologists to explore complex nonlinear relationships between a response variable and predictors.Nevertheless,evaluating the relative importance of predictors with concurvity(analogous to collinearity)on response variables in GAMs remains a challenge.To address this challenge,we developed an R package named gam.hp.gam.hp calculates individual R^(2) values for predictors,based on the concept of'average shared variance',a method previously introduced for multiple regression and canonical analyses.Through these individual R^(2)s,which add up to the overall R^(2),researchers can evaluate the relative importance of each predictor within GAMs.We illustrate the utility of the gam.hp package by evaluating the relative importance of emission sources and meteorological factors in explaining ozone concentration variability in air quality data from London,UK.We believe that the gam.hp package will improve the interpretation of results obtained from GAMs.
基金supported by the National Natural Science Foundation of China(Grant No.62173247).
文摘The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is common to set up a one-to-one correspondence between the nodes of a multi-layer network,ignoring the more complex situations in reality.In the present work,we explore this situation by setting up a partially coupled model of a two-layer network and investigating the impact of asymptomatic infected individuals on epidemics.We propose a self-discovery mechanism for asymptomatic infected individuals,taking into account situations such as nucleic acid testing in the community and individuals performing self-antigen testing during the epidemic.Considering these factors together,through the microscopic Markov chain approach(MMCA)and extensive Monte Carlo(MC)numerical simulations,we find that the greater the coupling between the networks,the more information dissemination is facilitated.In order to control the epidemics,more asymptomatic infected individuals should be made aware of their infection.Massive adoption of nucleic acid testing and individual adoption of antigenic self-testing can help to contain epidemic outbreaks.Meanwhile,the epidemic threshold of the proposed model is derived,and then miscellaneous factors affecting the epidemic threshold are also discussed.Current results are conducive to devising the prevention and control policies of pandemics.
基金supported by the National Key Research and Development Program of China(2022YFC2303900)the major projects of the National Natural Science Foundation of China(22193064)the Science Foundation(2022SKLID303)of the State Key Laboratory of Infectious Disease Prevention and Control,China。
文摘Objective Our study aimed to conduct genomic characterization of Salmonella strains carrying the blaNDM-1 gene in the intestinal tract of healthy individuals.The objectives were to underscore the importance of genomic surveillance for drug resistance in both commensal and pathogenic bacteria among healthy populations,and to establish protocols for regulating drug resistance plasmids based on the completion of a comprehensive map of drug resistance plasmid genomes.Methods We performed antimicrobial susceptibility testing and employed second-and third-generation sequencing techniques to analyze Salmonella strains harboring the blaNDM-1 gene,to surveil drug-resistant bacteria in the intestines of healthy subjects.Sequence comparison was conducted using both core-and pan-genome approaches.Concurrently,conjugation experiments were carried out to assess the efficiency of plasmid transfer.Results We isolated a carbapenem-resistant Salmonella enterica serovar Typhimurium strain from a healthy food worker in China.This strain harbored an IncHI2/IncHI2A plasmid carrying blaNDM-1 along with multiple antibiotic resistance genes(ARGs).Our findings highlight the potential for asymptomatic carriers to facilitate the transmission of ARGs.Pan-genomic analysis revealed that blaNDM-1-positive plasmids could traverse bacterial species barriers,facilitating cross-host transmission.Conclusion This study marks the first detection of blaNDM-1 in Salmonella strains isolated from healthy individuals.We underscore the risk associated with the transmission of conjugative hybrid plasmids carrying blaNDM-1,which have the potential to be harbored and transmitted among healthy individuals.Enhanced surveillance of drug-resistant pathogens and plasmids in the intestinal microbiota of healthy individuals could provide insights into the risk of ARG transmission and pathways for population-wide dissemination via ARG transfer factors.
文摘We report the detection of type-B quasi-periodic oscillation(QPO)of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst.A type-B QPO was observed for the first two days and it disappeared as flux increased,but again appeared at∼7.70 Hz when flux was dramatically decreased.The source was found in the soft intermediate state during these observations.We further studied the energy dependence of the QPO.We found that QPO was observed only for a higher energy range implying that the origin of QPO is possibly due to the corona emitting higher energy photons by the inverse Compton process.The variation of spectral parameters can be explained with the disk truncation model.The fractional rms was found to be monotonically increased with energy.The phase lag spectrum followed the“U-shaped”curve.The rms and phase lag spectrum are modeled and explained with the single-component Comptonization model vkompthdk.
基金supported by the National Natural Science Foundation of China(under grant Nos.12373044,12273014,12203051,12403035,12393811,12288102,and 12041304)the Natural Science Foundation of Shandong Province(under grant Nos.ZR2023MA050,and ZR2021MA013)+4 种基金the China Postdoctoral Science Foundation(under grant Nos.2024M751375 and 2024T170393)the Postdoctoral Fellowship Program of CPSF(under grant No.GZB20240307)the Jiangsu Funding Program for Excellent Postdoctoral Talent(under grant No.2024ZB705)the Tianshan Talent Program of Xinjiang Uygur autonomous region(under grant No.2023TSYCTD0013)the CAS“Light of West China”Program(under grant No.2018-XBQNXZ-B-022)。
文摘The double neutron star PSR J1846-0513 is discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)in Commensal Radio Astronomy FAST Survey.The pulsar is revealed to be harbored in an eccentric orbit with e=0.208 and an orbital period of 0.613 day.The total mass of the system is constrained to b2.6287(35)M_(⊙),with a mass upper limit of 1.3455 M_(⊙)for the pulsar and a mass lower limit of 1.2845 M_(⊙)for th companion star.To reproduce its evolution history,we perform a 1D model for the formation of PSR J1846-0513whose progenitor is assumed to be neutron star—helium(He)star system via MESA code.Since the larg eccentricity is widely believed to originate from an asymmetric supernova explosion,we also investigate th dynamical effects of the supernova explosion.Our simulated results show that the progenitor of PSR J1846-0513could be a binary system consisting of a He star of 3.3-4.0 M_(⊙)and a neutron star in a circular orbit with an initia period of~0.5 day.
基金supported in part by the National Natural Science Foundation of China(NSFC,grant Nos.12233006 and 12163006)the Basic Research Program of Yunnan Province No.202201AT070137+1 种基金the joint foundation of Department of Science and Technology of Yunnan Province and Yunnan University No.202201BF070001-020support by the Xingdian Talent Support Plan—Youth Project。
文摘We report a gradual brighteningγ-ray source,4FGL J1718.5+4237,in 0.1-500.0 GeV,which may be associated with a blazar NVSS J171822+423948 with a redshift of~2.7.We analyzed 15.25 yr ofγ-ray data recorded by the Large Area Telescope on board the Fermi Gamma-ray Space Telescope and detected significantγ-ray emissions in the direction of the blazar with a test statistic(TS)of~135.Based on timing analysis using a 1 yr time bin,we have observed a gradual brightening inγ-ray emissions from the target.In our analysis,we categorize them into two states:Quiet(TS~0)and Loud(TS~226)states,with the distinction occurring in 2016 August(MJD57602.69).From the Quiet state to the brightest period(the last data point),theγ-ray flux in 0.1-500.0 GeV increased by more than 12-fold from<0.2×10^(-8)photons cm^(-1)s^(-1)to 2.6×10^(-8)photons cm^(-1)s^(-1).Additionally,we studied the spectral properties in detail for the Loud state and the overall data.While no significant variation was detected,both exhibited a spectral indexΓof~2.6.The origin of the brighteningγ-ray emissions from the target is not yet clear.Future long-term multi-wavelength observations and studies will provide insight into the astrophysical mechanisms of the target.