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Treatment refractory mast cell leukemia with dominant gastrointestinal manifestation and concomitant skin symptoms:A case report
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作者 Maciej Tomasz Wysocki Maciej Gonciarz Bartosz Puła 《World Journal of Clinical Cases》 SCIE 2024年第20期4317-4324,共8页
BACKGROUND Mast cell leukemia(MCL),a subtype of systemic mastocytosis(SM),is an extremely rare clinical entity characterized by a very poor prognosis.Chemotherapy,tyrosine kinase inhibitors,and allogeneic hematopoieti... BACKGROUND Mast cell leukemia(MCL),a subtype of systemic mastocytosis(SM),is an extremely rare clinical entity characterized by a very poor prognosis.Chemotherapy,tyrosine kinase inhibitors,and allogeneic hematopoietic cell transplantation are the only treatment options,but they cannot provide the desired outcomes in most cases of MCL.However,other types of SM can be successfully treated.The disease has no specific manifestation,but gastroenterological symptoms are present in most cases.CASE SUMMARY The authors,hereby,report a case of a 46-year-old female patient diagnosed with MCL-the rarest subtype of SM.The patient presented to the gastroenterology clinic with multiple,various,and unspecific gastroenterological symptoms.Concomitance of skin lesions significantly contributed to a relatively prompt diagnosis.The serum tryptase level was extremely high and bone the marrow aspirate showed an infiltration of atypical mast cells.The disease was rapidly progressive and primary refractory to chemotherapy and the patient succumbed to the illness about a month after the initiation of treatment.CONCLUSION Despite its“hematological nature”,MCL,in most cases presents dominantly with unspecific gastroenterological symptoms.Thus,a high disease awareness among physicians other than hematologists is necessary to improve treatment outcomes.Serum tryptase level,due to its non-invasive nature and easy access,may serve as an initial step to estimate the probability of mastocytosis. 展开更多
关键词 mastOCYTOSIS Systemic mastocytosis mast cell leukemia TRYPTASE Case report
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Mast cell activation syndrome:An up-to-date review of literature
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作者 ÖnerÖzdemir Gökçe Kasımoğlu +2 位作者 Ayşegül Bak Hüseyin Sütlüoğlu Süreyya Savaşan 《World Journal of Clinical Pediatrics》 2024年第2期104-113,共10页
Mast cells are a subtype of white blood cells and are involved in the immune system.These cells contain many chemical substances called mediators,which are involved in the allergic response.The fact that mast cells pl... Mast cells are a subtype of white blood cells and are involved in the immune system.These cells contain many chemical substances called mediators,which are involved in the allergic response.The fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these cells.The diseases also caused by dysfunctions of mast cells have been examined in many circumstances.For instance,mast cell activation syndrome is known as an augmented number of cells due to decreased cell death,resulting in clinical symptoms affecting many systems.The main common symptoms include flushing,hypotension,urticaria,angioedema,headache,vomiting and diarrhea.Although the underlying mechanism is not yet clearly known,we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome. 展开更多
关键词 mast cell mast cell activation syndrome TRYPTASE HISTAMINE
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基于MasterCAM汽车异形支架数控加工工艺探析 被引量:1
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作者 隆丹宁 《模具工业》 2023年第1期56-59,68,共5页
根据汽车异形支架零件的形状和结构特点,利用三轴数控机床加工成本低和五轴数控机床加工精度高的优势合理制定加工工艺方案,结合零件结构特点设计夹具,确保异形支架的加工质量,为同类型零件加工方案的制定提供参考。
关键词 异形支架 五轴加工 数控加工工艺 mastERCAM
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Dynamic Analysis and Parametric Optimization of Telescopic Tubular Mast Applied on Solar Sail 被引量:1
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作者 Chenyang Ji Jinguo Liu +2 位作者 Chenchen Wu Pengyuan Zhao Keli Chen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第2期279-290,共12页
Large-scale solar sails can provide power to spacecraft for deep space exploration.A new type of telescopic tubular mast(TTM)driven by a bistable carbon fiber-reinforced polymer tube was designed in this study to solv... Large-scale solar sails can provide power to spacecraft for deep space exploration.A new type of telescopic tubular mast(TTM)driven by a bistable carbon fiber-reinforced polymer tube was designed in this study to solve the problem of contact between the sail membrane and the spacecraft under light pressure.Compared with the traditional TTM,it has a small size,light weight,high extension ratio,and simple structure.The anti-blossoming and self-unlocking structure of the proposed TTM was described.We aimed to simplify the TTM with a complex structure into a beam model with equal linear mass density,and the simulation results showed good consistency.The dynamic equation was derived based on the equivalent model,and the effects of different factors on the vibration characteristics of the TTM were analyzed.The performance parameters were optimized based on a multiobjective genetic algorithm,and prototype production and load experiments were conducted.The results show that the advantages of the new TTM can complete the deployment of large-scale solar sails,which is valuable for future deep space exploration. 展开更多
关键词 Telescopic tubular mast Solar sail Genetic algorithm Modal analysis OPTIMIZATION
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Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis by inhibiting mast cell degranulation
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作者 Lin Li Xiang-Yu Kong +6 位作者 Wu Chen Mei-Jiao Wang Zhi-Xing He Yun Zhang Cheng-Ping Wen Qiao Wang Lin Huang 《Traditional Medicine Research》 2023年第6期39-48,共10页
Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis ... Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis was used to evaluate the effect of GSZ in preventing arthritis and joint destruction.Immunohistochemical staining revealed the accumulation of histamine H4 receptor and tryptase alpha/beta-1 in the ankle joint of the model.Then,we explored the effect of GSZ serum on fibroblast-like synoviocytes using standard transwell invasion and migration assays.Real-time quantitative polymerase chain reaction and western blot were used to detect the expression of toll-like receptor 4(TLR4)/myeloid differentiationfactor 88(MyD88)/nuclear factor-κB p65(NF-κB p65).Results:The results showed that pre-rheumatoid arthritis treatment with GSZ could reduce inflammation and maintain cartilage structure in the collagen-induced arthritis model.Moreover,GSZ significantly blocked mast cell degranulation and inhibited the TLR4/MyD88/NF-κB p65 pathway.Since the combined activation of mast cells via TLR4 and immune complexes enhances inflammation in synovial tissue,we concluded that GSZ may block mast cell degranulation by inhibiting the TLR4/MyD88/NF-κB p65 pathway and thus influence rheumatoid arthritis onset.Conclusion:Taken together,our data suggested that GSZ may be a promising therapeutic decoction for the prophylactic treatment of rheumatoid arthritis. 展开更多
关键词 rheumatoid arthritis mast cells DEGRANULATION TLR4
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MAST D73C组合纸片法和PCR基因检测儿童碳青霉烯类耐药肠杆菌科细菌菌株中碳青霉烯酶的价值
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作者 黄校樑 李帼宁 +2 位作者 何杏欣 莫桂芳 许敏华 《中国医药科学》 2023年第3期146-149,共4页
目的探讨儿童碳青霉烯类耐药肠杆菌科细菌(CRE)菌株中碳青霉烯酶与其分型的检测方法和价值,本研究所用检测方法包括MAST D73C组合纸片法、聚合酶链式反应(PCR)基因检测法。方法MAST D73C组合纸片法与PCR基因检测结果显示,分离出CRE菌株... 目的探讨儿童碳青霉烯类耐药肠杆菌科细菌(CRE)菌株中碳青霉烯酶与其分型的检测方法和价值,本研究所用检测方法包括MAST D73C组合纸片法、聚合酶链式反应(PCR)基因检测法。方法MAST D73C组合纸片法与PCR基因检测结果显示,分离出CRE菌株碳青霉烯酶基因菌株数量为240株,所选菌株为2018年6月至2019年10月采集,针对MAST D73C在碳青霉烯酶中的检测灵敏度与特异度进行分析。结果PCR基因检测中,240株CRE菌株中检测到碳青霉烯酶基因菌株数量为233株,MAST D73C组合纸片MβL酶检出率达47.16%、OXA-48酶检出率达27.07%、KPC酶检出率达8.73%,无法解释其他17.03%细菌的抑菌圈结果。以PCR结果为金标准,以MAST D73C分别计算MβL酶及OXA-48酶的灵敏度和特异度,灵敏度>80%,特异度>95%。通过Youden指数与Kappa值可知,区分产MβL酶及OXA-48酶菌株均具有较好的一致性和真实性。KPC酶特异度达98.85%,灵敏度为32.14%,一致性及真实性均较差。通过MAST D73C组合纸片法总计检出CRE 39株,无法对所得结果进行准确解释,PCR检测结果确认CRE产KPC酶总计31株、产OXA-48酶CRE数量为8株。若B-A、C-A及D-A不足5 mm,E超过10 mm,对法罗培南耐药时可判定为产KPC酶,可使KPC酶检测灵敏度得到显著提高。结论儿童分离CRE菌株所检出的碳青霉烯酶类型包括NDM-1酶及OXA-232酶,MAST D73C组合纸片法可以简便、快速、准确地对碳青霉烯酶进行检测,还能够迅速分型,而且操作简单,值得应用。 展开更多
关键词 mast D73C 肠杆菌科细菌 碳青霉烯酶 检测方法 儿童
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MAST Quadrant通道下微创TLIF与开放TLIF两种术式治疗腰椎退行性疾病的效果比较 被引量:13
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作者 李永津 陈博来 林涌鹏 《广东医学》 CAS CSCD 北大核心 2012年第9期1287-1289,共3页
目的探讨MAST Quadrant通道下微创经椎间孔椎间融合术(mini-TLIF)治疗腰椎退行性疾病的临床疗效。方法将40例腰椎退行性疾病患者分成两组,mini-TLIF组20例在METRX Quadrant通道下行TLIF手术,open-TLIF组20例采用传统开放TLIF手术,随访(1... 目的探讨MAST Quadrant通道下微创经椎间孔椎间融合术(mini-TLIF)治疗腰椎退行性疾病的临床疗效。方法将40例腰椎退行性疾病患者分成两组,mini-TLIF组20例在METRX Quadrant通道下行TLIF手术,open-TLIF组20例采用传统开放TLIF手术,随访(13.77±1.52)个月,比较两组术前、术后2周以及末次随访的VAS和JOA评分。结果两组患者腰痛和下肢放射性麻痛等临床症状均有效缓解,在术后2周腰痛缓解程度(VAS)、生活质量改善(JOA)、手术时间、术中出血量、住院时间和术口长度等方面,mini-TLIF组均优于open-TLIF组(P<0.05)。结论 MAST Quadrant通道下mini-TLIF治疗腰椎退行性疾病具有损伤小、出血少、患者下床活动早、住院时间短、疼痛轻等优点。 展开更多
关键词 mast QUADRANT 微创TLIF 腰椎退行性疾病 临床短期效果
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基于MAST的智慧公交系统调度优化模型 被引量:7
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作者 陈坚 李武 +1 位作者 吴丹 徐誌蔓 《重庆交通大学学报(自然科学版)》 CAS 北大核心 2016年第5期140-145,共6页
为解决传统公交运行模式单一、乘客需求无法得到及时响应的问题,提出了基于MAST智慧公交的系统构架。在公交静态调度优化模型基础上,结合智慧公交可在一定范围内灵活变线、变站并及时满足乘客出行需求的特点,建立了智慧公交系统动态调... 为解决传统公交运行模式单一、乘客需求无法得到及时响应的问题,提出了基于MAST智慧公交的系统构架。在公交静态调度优化模型基础上,结合智慧公交可在一定范围内灵活变线、变站并及时满足乘客出行需求的特点,建立了智慧公交系统动态调度优化模型。以重庆市南岸区357路公交车为例,应用动态调度优化模型,计算智慧公交的相关运行参数。并将其与传统公交运行模式进行对比,结果表明:相同高峰时间段内,智慧公交的发班数目所需车辆数与传统公交相同,运送乘客总人数增长5.81%,平均每班载客率提高6.12%,经济利润增长2.86%。 展开更多
关键词 交通运输工程 公共交通 mast系统 动态调度模型
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Mast Quadrant可扩张通道微创系统与传统开放手术治疗LDH的疗效分析 被引量:6
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作者 杨佳宁 陈宾 +1 位作者 宋有鑫 赵丽丽 《重庆医学》 CAS 北大核心 2016年第4期527-529,共3页
目的探讨Mast Quadrant可扩张通道微创系统与传统后路开放手术治疗腰椎间盘突出症(LDH)的临床疗效及安全性。方法选择2011年1月至2013年1月该院脊柱外科收治的LDH患者57例,其中在Mast Quadrant通道下手术的患者26例(微创组),行传统后路... 目的探讨Mast Quadrant可扩张通道微创系统与传统后路开放手术治疗腰椎间盘突出症(LDH)的临床疗效及安全性。方法选择2011年1月至2013年1月该院脊柱外科收治的LDH患者57例,其中在Mast Quadrant通道下手术的患者26例(微创组),行传统后路开放手术患者31例(开放组)。比较两组患者的术中出血量、术后术区引流量及手术时间,以及术前、术后随访周期的日本骨科学会疗效评定标准(JOA)评分、视觉模拟评定(VAS)评分、功能障碍指数(ODI)评分,以评估两组患者的临床症状改善程度及手术疗效。结果 Mast Quadrant通道下微创手术治疗LDH对患者创伤显著小于开放手术,微创组的术中出血量、术后术区引流量及手术时间均明显少于开放组(P<0.01);与术前比较,两组患者术后3、6个月JOA评分、ODI评分、VAS评分明显改善,差异有统计学意义(P<0.01)。结论 Mast Quadrant通道下微创手术治疗LDH对患者创伤小,术后患者下腰痛发生率较低,可早期进行腰背肌功能锻炼,有利于术后早期康复。 展开更多
关键词 腰椎间盘突出症 手术治疗 外科手术 微创性 mast QUADRANT
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软件预测和MAST技术筛选mRNA反义核酸靶点的比较 被引量:4
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作者 毛建平 Zicai LIANG 毛秉智 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2004年第3期399-407,共9页
基因mRNA的结构靶点筛选是反义核酸药物研发的一个难题 .兔 (Oryctolaguscuniculus) β珠蛋白基因mRNA的结构靶位点通过运用MAST技术筛选获得 ,和计算机软件RNAstructure3 71模拟分析的位点进行了比较 ,也和寡核苷酸微阵列杂交技术筛选... 基因mRNA的结构靶点筛选是反义核酸药物研发的一个难题 .兔 (Oryctolaguscuniculus) β珠蛋白基因mRNA的结构靶位点通过运用MAST技术筛选获得 ,和计算机软件RNAstructure3 71模拟分析的位点进行了比较 ,也和寡核苷酸微阵列杂交技术筛选获得的靶点结果 (M .Natalie ,1 997)进行了比较 ,显示 :据MAST技术获得的兔 β珠蛋白基因 2个反义核酸结合靶位点 ,和用RNAstructure3 71软件给出的模拟分析的 2个靶位点相同 ,且它们与寡核苷酸微阵列杂交技术的结果完全一致 .运用MAST技术筛选获得绿色荧光蛋白 (GFP)mRNA有 4个结构靶位点 ,体外分析表明这 4个靶位点均有效 ,其中有 3个与RNAstructure3 71软件分析的靶点相同 ,但计算机模拟推荐的结构靶位点较多 ,而且随着基因长度增加确认靶位点的难度增大 ,获得的靶位点还需要实验验证 ,计算机软件模拟分析对实验筛选靶点、设计反义核酸有辅助价值 .MAST方法能筛选各种长度基因mRNA的全部可及位点和准确给定核苷酸的起止位置以供设计反义核酸 ,具有简单快捷的优点 ,将能为反义核酸设计起重要作用 . 展开更多
关键词 MRNA RNAstructure3.71 mast Β珠蛋白 GFP 可及位点 反义核酸
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HISTOCHEMICAL TECHNIQUES IDENTIFYING MAST CELLS IN PIG,CATTLE AND SHEEP 被引量:5
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作者 许乐仁 江萍 《Zoological Research》 CAS CSCD 1998年第1期1-10,共10页
Carnoy′s fluid and neutral buffered formalin(NBF)have been proved to be good fixatives for preservation of mast cells in pig,cattle and sheep except NBF blocked staining of most porcine mast cells,especially thos... Carnoy′s fluid and neutral buffered formalin(NBF)have been proved to be good fixatives for preservation of mast cells in pig,cattle and sheep except NBF blocked staining of most porcine mast cells,especially those located in intestinal mucosa(MMC)and in thymus medulla(TMMC). Both toluidine blue and Alcian blue were the excellent stains generally,but Alcian blue stained more porcine mast cells than did toluidine blue( P <0 01). Staining with toluidine blue of a wide pH range(from 0 1 to 7 0)showed that porcine mast cells were not very pH dependent,but the dye at pH 0 5 seemed to have the strongest affinity for all mast cells in pigs and it was also suitable for bovine and ovine mast cell staining. In the three species,unlike in rodents,the Alcian blue method did not distinguish between mast cells in the intestinal mucosa(MMC)and those in the connective tissue of the intestinal submucosa,tongue and skin(CTMC). Porcine CTMC,but not MMC,fluoresced strongly when stained with berberine sulphate or with a mixture of berberine sulphate and acridine orange. It suggested that porcine CTMC contained heparin proteoglycan. 展开更多
关键词 mast cell Histochemstry PIG CATTLE SHEEP
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酒依赖患者MAST评定结果分析及与疗效的相关性研究 被引量:3
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作者 原伟 卢怀云 +1 位作者 米国琳 唐济生 《精神医学杂志》 2007年第6期357-359,共3页
目的探讨酒依赖患者MAST的特点及与疗效的关系。方法68例酒依赖患者入组前给予MAST评定,然后随机给予纳曲酮或安慰剂治疗12周,每两周回访一次,随访时给予一般性心理治疗,根据患者和家属记录的每日饮酒状况记录表,判断患者戒酒疗效。结... 目的探讨酒依赖患者MAST的特点及与疗效的关系。方法68例酒依赖患者入组前给予MAST评定,然后随机给予纳曲酮或安慰剂治疗12周,每两周回访一次,随访时给予一般性心理治疗,根据患者和家属记录的每日饮酒状况记录表,判断患者戒酒疗效。结果两组酒依赖患者存在较严重的酒相关性问题,对酗酒危害婚姻家庭方面的认识与治疗效果存在影响。同时也对该量表在我国的应用提出了修改的建议。结论强化酗酒对婚姻家庭方面的影响,强化嗜酒者的家庭治疗有利于帮助酒依赖患者彻底戒酒,合并纳曲酮治疗效果更显著。 展开更多
关键词 酒依赖综合征 mast 纳曲酮
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血清mAST、CK-MB及肌钙蛋白T在新生儿窒息心脏损害中的变化 被引量:3
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作者 徐学卓 缪宇峰 陈海高 《广西医学》 CAS 2006年第12期1944-1945,共2页
关键词 新生儿窒息 肌钙蛋白T CK-MB 心脏损害 mast 血清 正常对照组 普通医院
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MAST3对胃癌细胞SGC-7901细胞增殖及迁移的作用 被引量:1
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作者 王磊 陈鹤 +1 位作者 张敏 王中新 《安徽医科大学学报》 CAS 北大核心 2020年第4期523-528,共6页
目的探讨MAST3对胃癌细胞SGC-7901的增殖及迁移作用。方法使用Western blot及qRT-PCR法检测MAST3在胃癌组织中的表达情况,进一步将MAST3-RNAi和pEx-3-MAST3转染到SGC-7901细胞中,分别使用qRT-PCR、Western blot检测CyclinD1、C-myc及MM... 目的探讨MAST3对胃癌细胞SGC-7901的增殖及迁移作用。方法使用Western blot及qRT-PCR法检测MAST3在胃癌组织中的表达情况,进一步将MAST3-RNAi和pEx-3-MAST3转染到SGC-7901细胞中,分别使用qRT-PCR、Western blot检测CyclinD1、C-myc及MMP-9、MMP-3的表达,观察MAST3对SGC-7901的增殖及迁移作用;通过流式细胞仪检测细胞周期。结果 Western blot结果显示,MAST3在胃癌组织中高于癌旁组织(P<0.01),且在TGF-β1刺激后表达也随之增加。使用MAST3-RNAi抑制MAST3表达后,CyclinD1和C-myc蛋白表达明显低于对照组(P<0.01),且S期和G2/M期细胞明显降低,同时MMP9和MMP3蛋白表达也明显低于对照组;使用pEx-3-MAST3过表达MAST3后,CyclinD1和C-myc蛋白表达明显高于对照组(P<0.01),且S期和G2/M期细胞升高,MMP-9和MMP-3蛋白表达也明显高于对照组。结论 MAST3能够调控胃癌细胞SGC-7901细胞的增殖及迁移能力。 展开更多
关键词 mast3 人胃癌SGC7901细胞 增殖 迁移
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联检血清CG、HA、mAST浓度在新生儿HIE的临床意义 被引量:1
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作者 黄卫良 周炯英 +1 位作者 吕卫华 何启志 《放射免疫学杂志》 CAS 2010年第5期516-517,共2页
文献报道,血清甘氨胆酸(CG)、透明质酸(HA)能较好地反映新生儿疾病的发展和预后,血清线粒体型天门冬氨酸氨基酸转移酶同工酶(mAST)可反映病脑的病情和预后,本文对35例新生儿缺氧缺血性脑病(HIE)检测了血清CG、HA、mAST浓度,旨... 文献报道,血清甘氨胆酸(CG)、透明质酸(HA)能较好地反映新生儿疾病的发展和预后,血清线粒体型天门冬氨酸氨基酸转移酶同工酶(mAST)可反映病脑的病情和预后,本文对35例新生儿缺氧缺血性脑病(HIE)检测了血清CG、HA、mAST浓度,旨在探讨三者联检对新生儿HIE的临床意义。 展开更多
关键词 新生儿HIE 血清CG 临床意义 mast 联检 HA 浓度 新生儿缺氧缺血性脑病
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Mast Quadrant通道辅助髓核摘除术治疗同侧邻近双节段腰椎间盘突出症 被引量:4
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作者 佘远时 沈军 +4 位作者 王烨峰 韦敏祥 成亮 陈广祥 邹天明 《中国骨科临床与基础研究杂志》 2013年第3期168-170,共3页
目的:探讨MastQuadrant通道辅助下髓核摘除术治疗邻近同侧双节段腰椎间盘突出症的临床效果。方法回顾性分析2008年1月至2012年12月南京医科大学附属苏州医院采用MastQuadrant通道辅助下微创髓核摘除术治疗的23例邻近同侧双节段腰椎间... 目的:探讨MastQuadrant通道辅助下髓核摘除术治疗邻近同侧双节段腰椎间盘突出症的临床效果。方法回顾性分析2008年1月至2012年12月南京医科大学附属苏州医院采用MastQuadrant通道辅助下微创髓核摘除术治疗的23例邻近同侧双节段腰椎间盘突出患者的临床资料,记录手术时间、术中出血量及术后并发症情况,应用视觉模拟量表(VAS)评分法和改良MacNab分级评定法对手术疗效进行评估。结果手术时间75~120min(平均95min),术中出血量120~200mL(平均155mL)。术中硬膜撕裂1例,处理后患者无明显临床症状;发生间隙错误1例。术后随访6~24个月(平均18.6个月)。术后3d和3个月,VAS评分分别为(3.9±0.3)分和(3.4±0.7)分,与术前的(8.4±0.3)分比较,差异有统计学意义(P<0.05)。改良MacNab疗效评定优17例、良4例、可2例,优良率为91%(21/23)。结论应用MastQuadrant通道辅助微创髓核摘除术治疗邻近同侧双节段腰椎间盘突出症出血量少,手术时间短,疗效可靠。 展开更多
关键词 腰椎 椎间盘移位 椎间盘切除术 mast QUADRANT通道
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Mast过敏原检测系统在阻塞性鼻病中的应用 被引量:1
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作者 杨媛媛 邹华 +1 位作者 刘翔 杨金珊 《中国中西医结合耳鼻咽喉科杂志》 2011年第3期156-158,175,共4页
目的探讨Mast过敏原检测系统应用于阻塞性鼻病中的意义,其检测出的特异性IgE(sIgE)、总IgE(tIgE)与血清学酶联免疫吸附方法检测的总IgE(tIgE)间的相关性。方法利用Mast系统对215例住院患者进行sIgE、tIgE的检测,并利用酶联免疫吸附方法... 目的探讨Mast过敏原检测系统应用于阻塞性鼻病中的意义,其检测出的特异性IgE(sIgE)、总IgE(tIgE)与血清学酶联免疫吸附方法检测的总IgE(tIgE)间的相关性。方法利用Mast系统对215例住院患者进行sIgE、tIgE的检测,并利用酶联免疫吸附方法对其中102例患者进行血清tIgE检测。结果 215例患者中,Mast系统测出的sIgE阳性率为43.3%,其中慢性鼻窦炎(伴或不伴鼻息肉)患者的sIgE阳性率为47.6%。Mast系统测出的sIgE升高的患者中,以粉尘螨(24.2%)、屋尘螨(20%)最多见。Mast系统测出的sIgE与酶联免疫吸附方法检测的tIgE关联系数r=0.29,Mast系统检测的tIgE与酶联免疫吸附方法检测的tIgE关联系数r=0.34,Mast系统检测的sIgE与Mast系统检测的tIgE关联系数r=0.22。结论 Mast过敏原检测系统可应用于阻塞性鼻病的过敏原检测;酶联免疫吸附方法总IgE检测可不作为常规的变应性鼻炎检测方法;对于慢性鼻窦炎(伴或不伴鼻息肉)患者应常规行Mast过敏原检测,并根据结果使用抗过敏药物;无法进行过敏原检测的医疗机构,可对就诊的无过敏症状的慢性鼻窦炎患者在进行过敏原检测之前酌情给予抗过敏药物冶疗。 展开更多
关键词 阻塞性鼻病 mast SIGE
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多车型MAST的调度优化及关键参数分析 被引量:2
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作者 王正武 赵振于 何煦 《交通科学与工程》 2018年第2期85-90,共6页
车辆容量对机动式辅助公交的发车间隔有重要影响。为研究多车型机动式辅助公交的调度优化问题,根据可逆距离对乘客类型的影响关系,构建不同类型乘客的出行费用函数。以公交公司不同车型运行成本和乘客出行成本之和最小为目标,以车辆容... 车辆容量对机动式辅助公交的发车间隔有重要影响。为研究多车型机动式辅助公交的调度优化问题,根据可逆距离对乘客类型的影响关系,构建不同类型乘客的出行费用函数。以公交公司不同车型运行成本和乘客出行成本之和最小为目标,以车辆容量和乘客时间窗等为约束,构建多车型MAST调度优化模型。基于遗传算法,设计了该模型的求解算法。结果分析表明:多车型机动式辅助功能总成本与需求水平相关。需求量较低时,多车型机动式辅助功能明显降低系统总成本;需求量较大时,多车型机动式辅助公交的总成本将高于常规公交的;并且该算法可确定在一定需求水平下使总成本最小的最大可逆距离。 展开更多
关键词 交通工程 mast 多车型 调度优化 遗传算法
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GEOMETRIC DESIGN OF DEPLOYABLE/RETRACTABLE MAST 被引量:1
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作者 杨玉龙 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2006年第4期250-256,共7页
To simplify the complicated design process of deployable/retractable structures, a new design process is developed. The process is divided into three phases: the concept design phase, the model phase and the optimiza... To simplify the complicated design process of deployable/retractable structures, a new design process is developed. The process is divided into three phases: the concept design phase, the model phase and the optimization phase. In each phase, different parameter targets have to be fulfilled. According to three phases, a deployable/retractable mast composed of four right triangle prism modules in the longitudinal direction is designed. It can be deployed and folded simultaneously by the linear movements of sleeve-joints. The deployable and retractable movement of the mast is analyzed and key joint forms are designed. Then bar diameters and joint forms are modified based on mast structural mechanics characteristics in the optimization phase. Finally a 1:1 scaled model mast is built to verify the design and the optimization. Analytical results show that the model mast has the advantages of simple locking mechanism, fewer types of joints and bars, so it can be easily manufactured. 展开更多
关键词 deployable/retractable mast geometric design design process OPTIMIZATION
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Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells 被引量:1
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作者 Selahittin ayan Duygu Dusmez Apa Erdem Akbay 《Asian Journal of Andrology》 SCIE CAS CSCD 2002年第4期291-294,共4页
Aim: To investigate the role of fexofenadine, a mast cell blocker, on semen quality in the treatment of infertile men. Methods: The study included 16 Turkish idiopathic infertile men with azoospermia or oligozoospermi... Aim: To investigate the role of fexofenadine, a mast cell blocker, on semen quality in the treatment of infertile men. Methods: The study included 16 Turkish idiopathic infertile men with azoospermia or oligozoospermia who underwent testicular biopsy to examine mast cells containing tryptase. In all patients, a complete medical history, clinical examination, semen analysis and serum hormone assay were carried out. The biopsy specimens were immunohistochemically stained with antihuman tryptase for mast cells. The number of total mast cells per seminiferous tubule was calculated and recorded as mast cell index. The patients were divided into two groups according to their mast cell index: the higher (≥1, n=9) and the lower (<1, n=7) index groups. Fexofenadine was administered orally at a dose of 180 mg/day for 4 to 9 months. Pre-and post-treatment semen parameters, including total motile sperm counts (TMC) were recorded and compared. Spontaneous pregnancies after the treatment were registered. Results: There was no statistically significant difference in TMC between the pre-treatment and post-treatment values in patients with higher and lower mast cell index (P≥0.05). In both groups, nobody had a significant response to the treatment and there was no spontaneous pregnancy after the treatment. Conclusion: Although testicular dysfunction is closely associated with increased number of testicular mast cells, fexofenadine, a mast cell blocker, appears not having any benefit in the treatment of Turkish infertile men with a significant increase in testicular mast cells. (Asian J Androl 2002 Dec; 4: 291-294) 展开更多
关键词 male infertility testicular biopsy mast cells mast cell blocker FEXOFENADINE semen quality
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