Fast prototype and rapid construction of three-dimensional and multi-scaled pitcher for controlled drainage by systematic biomimicry

Biomimetic materials that use natural wisdom to solve practical problems are developing rapidly.The trend for systematic biomimicry is towards in-situ characterization of naturalcreatures with high spatial resolutions.Furthermore,rapid reconstruction of digital twin models with the same complex features as the prototype is indispensable.However,it faces bottlenecks and limits in fast characterization and fabrication,precise parameter optimization,geometricdeviations control,and quality prediction.To solve these challenges,here,we demonstrate astate-of-the-art method taking advantage of micro-computed tomography and three-dimensional printing for the fast characterization of the pitcher plant Nepenthes x ventrata and fabrication of its biomimetic model to obtain a superior drainage controller with multiscale structures withprecise surface morphology optimization and geometric deviation control.Thefilm-rupture-based drainage dynamic and mechanisms are characterized by x-ray and high-speed videography,which determines the crucial structures for unique directionaldrainage.Then the optimized artificial pitchers are further developed into sustained drainage devices with novel applications,such as detection,reaction,and smoke control.

Biologically Inspired Self-assembling Synthesis of Bone-like Nano-hydroxyapatite/PLGA-(PEG-ASP)_n Composite: A New Biomimetic Bone Tissue Engineering Scaffold Material

A new biomimetic bone tissue engineering scaffold material, nano-HAI PLGA-（ PEG-Asp ）n composite, was synthesized by a biologically inspired self-assembling approach. A novel biodegradable PLGA- （ PEG-Asp ）n copolymer with pendant amine functional groups and enhanced hydrophilicity woo synthesized by bulk ring-opening copolymerization by DL-lactide（ DLLA） and glycolide（ GA ） with Aspartic acid （ Asp ）-Polyethylene glycol（PEG） alt-prepolymer. A Three-dimensional, porous scaffold of the PLGA-（ PEG- Asp）n copolymer was fabricated by a solvent casting , particulate leaching process. The scaffold woo then incubated in modified simulated body fluid （naSBF）. Growth of HA nanocrystals on the inner pore surfaces of the porous scaffold is confirmed by calcium ion binding analyses, SEM , mass increooe meoourements and quantification of phosphate content within scaffolds. SEM analysis demonstrated the nucleation and growth of a continuous bonelike, low crystalline carbonated HA nanocrystals on the inner pore surfaces of the PLGA- （ PEG-Asp ）n scaffolds. The amount of calcium binding, total mass and the mass of phosphate on experimental PLGA- （ PEG-Asp ） n scaffolds at different incubation times in mSBF was significantly greater than that of control PLGA scaffolds. This nano-HA/ PLGA-（ PEG- Asp ）n composite stunts some features of natural bone both in main composition and hierarchical microstrueture. The Asp- PEG alt-prepolymer modified PleA copolymer provide a controllable high surface density and distribution of anionic functional groups which would enhance nucleation and growth of bonelike mineral following exposure to mSBF. This biomimetic treatment provides a simple method for surface functionalization and sabsequent mineral nucleation and self-oosembling on bodegradable polymer scaffolds for tissue engineering.

3D printing biomimeticmaterials and structures for biomedical applications

Over millions of years of evolution,nature has created organisms with overwhelming performances due to their unique materials and structures,providing us with valuable inspirations for the development of next-generation biomedical devices.As a promising new technology,3D printing enables the fabrication of multiscale,multi-material,and multi-functional threedimensional(3D)biomimetic materials and structures with high precision and great flexibility.The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies.In this paper,the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed.Various kinds of biomedical applications,including implants,lab-on-chip,medicine,microvascular network,and artificial organs and tissues,were respectively discussed.The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated,and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted.

Arg-Gly-Asp(RGD)Modified Biomimetic Polymeric Materials

The new generation of biomaterials focuses on the design of biomimetic polymeric materials that are capable of eliciting specific cellular responses and directing new tissue formation. Since Arg-Gly-Asp （RGD） sequences have been found to promote cell adhesion in 1984, numerous polymers have been functionalized with RGD peptides for tissue engineering applications. This review gave the advance in RGD modified biomimetic polymeric materials,focusing on the mechanism of RGD, the surface and bulk modification of polymer with RGD peptides and the evaluation in vitro and in vivo of the modified biomimetic materials.

A Biomimetic Model of Fiber-reinforced Composite Materials

In thjs paper. bamboo fiber has been. on micro scale. investigated as a helical. multi-layered hollow cylinder, the stiffness featu res of bamboo bast fiber were compared with those of a multifilament yarn in traditional fiber-reinforced composite materials, Moreover. a biomimetic model of the reinforce ment of fiber-reinforced composite materials was proposed by imitating the fine structure of bamboo bast fiber. The results show that the comprehensive stiffness properties of the cornplicated fine struc ture of bamboo fiber is superior over those of traditional fiber-reinforced composites.

A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting

Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.

Inorganic ionic polymerization:From biomineralization to materials manufacturing

Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent properties.The intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic materials.The methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and compositions.However,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization strategy.Recently,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization process.Based on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic materials.Moreover,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials science.The inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials.

基于蝶翅三级微纳米结构的定制光子工程辐射制冷纺织品

People could potentially mitigate heat discomfort when outdoors by combining passive radiative cooling(PRC)strategies with personal thermal management techniques.However,most current PRC materials lack wearing comfort and durability.In this study,a microarray technique is applied to fabricate the tailoring photonic-engineered textiles with intriguing PRC capability and appealing wearability.The developed radiative cooling textiles(RCTs)demonstrate appropriate air-moisture permeability,structural stability,and extended spectroscopic response with high sunlight reflectivity(91.7%)and robust heat emissivity(95.8%)through the atmospheric transparent spectral window(ATSW).In a hot outdoor cooling test,a skin simulator covered by the RCTs displays a temperature drop of approximately 4.4℃at noon compared with cotton textiles.The evolution of our mimetic structures may provide new insights into the generation of wearable,thermal-wet comfortable,and robust textiles for exploring PRC techniques in personal thermal management applications.

Ultra-warm artificial aerogel fibers:a biomimetic material based on polar bear hair

Aerogels are widely recognized as the premier thermal insulation materials due to their high porosity and exception-ally low thermal conductivity^([1,2]).Regrettably,their wide-spread application in thermal insulation textiles is signific-antly limited by their fragility and poor processability.Al-though many aerogel fibers made with silica^([3]),graphene^([4,5]),carbon nanotube^([6]),titanium oxide^([7]),and cellulose^([8])have been prepared through various methods.

Ectopic Bone Formation in vivo Induced by a Novel Synthetic Peptide Derived from BMP-2 Using Porous Collagen Scaffolds

To investigate the osteoinductive and ectopicly osteogenic effects of a novel peptide P24 derived from bone morphogenetic protein 2 （BMP2）, biodegradable collagen scaffolds （CS） were used to load BMP-2-derived peptide solutions with different concentrations （0.4 mg peptide/CS, 0.1 mg peptide/CS and pure CS, respectively）, and the implants were implanted into muscular pockets on the back of Wistar rats. Radiographs and histological analysis were performed to evaluate the ectopic bone effects. Active ectopic bone formation was seen in both groups containing the peptide at different concentration （0.4 mg and 0.1 mg）, whereas no bone formation and only fibrous tissue was seen in the pure CS group. The new bone formation induced by the peptide P24 displayed a dose-dependent and time-dependent efficiency. The new bone formation in the 0.4 mg peptide/CS group significantly increased than that of the 0.1 mg peptide/CS group. This novel BMP-2-derived peptide had excellent osteoinductive and ectopicly osteogenic properties which were similar to those of BMP2.

Surface Modification of Biomimetic PLGA-(ASP-PEG) Matrix with RGD-Containing Peptide:a New Non-Viral Vector for Gene Transfer and Tissue Engineering

RGD-containing peptide （ K16-GRGDSPC） , characterized as non-viral gene vectors, was fabricated to modify the surface of PLGA-[ASP- PEG] matrix, which offered the foundation for gene transfer with porous matrix of gene activated later. Peptide was synthesized and matrix was executed into chips A, B and chip C. Chip C was regarded as control. Chips A and B were reacted with cross-linker. Then chip A was reacted with peptide. MS and HPLC were ased to detect the .14W and purity of peptide. Sulphur, existing on the surface of biomaterials, was detected by XPS. The purity of un-reacted peptide in residual solution was detected by a spectrophotometer. HPLC shows that the peptide purity was 94%- 95% , and MS shows that the MW was 2 741. 3307. XPS reveals that the binding energy of sulphur was 164 eV and the ratio of carbon to sulphur （C/S） was 99. 746 ：0. 1014 in reacted chip A. The binding energy of sulphur in reacted chip B was 164 eV and 162 eV, C/ S was 99.574：0.4255, aM there was no sulphur in chip C. Peptide was manufactured and linked to the surface of biomimetic and 3-D matrix, which offered the possibilities for gene transfer and tissue engineering with this new kind of non-viral gene vector.

Cocoon Silk-Derived, Hierarchically Porous Carbon as Anode for Highly Robust Potassium-Ion Hybrid Capacitors

Potassium-ion hybrid capacitors(KIHCs) have attracted increasing research interest because of the virtues of potassium-ion batteries and supercapacitors.The development of KIHCs is subject to the investigation of applicable K+storage materials which are able to accommodate the relatively large size and high activity of potassium.Here,we report a cocoon silk chemistry strategy to synthesize a hierarchically porous nitrogen-doped carbon(SHPNC).The as-prepared SHPNC with high surface area and rich N-doping not only offers highly efficient channels for the fast transport of electrons and K ions during cycling,but also provides sufficient void space to relieve volume expansion of electrode and improves its stability.Therefore,KIHCs with SHPNC anode and activated carbon cathode afford high energy of 135 Wh kg-1(calculated based on the total mass of anode and cathode),long lifespan,and ultrafast charge/slow discharge performance.This study defines that the KIHCs show great application prospect in the field of high-performance energy storage devices.

TGF-beta 1 Gene-Activated Matrices Regulated the Osteogenic Differentiation of BMSCs

Poly （lactic acid/glycolic acid/asparagic acid-co-polyethylene glycol）（PLGA-[ASP-PEG]） scaffold materials were linked with a novel nonviral vector （K）16GRGDSPC through cross linker Sulfo- LC-SPDP to construct a new type of nonviral gene transfer system. Eukaryotic expressing vector containing transforming growth factor beta 1 （pcDNA3-TGFβ1） was encapsulated by the system. Bone marrow stromal cells （BMSCs） obtained from rabbit were cultured on PLGA-[ASP-PEG] modified by （K）16GRGDSPC and TGF-β1 gene and PLGA-[ASP-PEG] modified by （K）16GRGDSPC and empty vector pcDNA3 as control. The expressions of osteogenic makers of the BMSCs cultured on the TGF-β1 gene-activated scaffold materials were found significantly higher than those of the control group （P〈0.05）. A brand-new way was provided for regulating seed cells to directionally differentiate into osteoblasts for bone defect restoration in bone tissue engineering.

Biomimetic design of highly flexible metal oxide nanofibrous membranes with exceptional mechanical performance for superior phosphopeptide enrichment

Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches,but still a significant challenge in materials design.To this end,we firstly constructed highly flexible ZrTiO_(4) nanofibrous membranes(NFMs)with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination technique.Then,to further increase the enrichment capacity of the phosphopeptide,the biomimetic TiO_(2)@ZrTiO_(4) NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO_(4) NFMs through growing unfurling TiO_(2) nanosheets onto the ZrTiO_(4) nanofibers.Importantly,remarkable flexibility and mechanical stability enable the resulting TiO_(2)@ZrTiO_(4) NFMs excellent practicability,while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer cells.Specifically,6770 phosphopeptides can be enriched by TiO_(2)@ZrTiO_(4) NFMs(2205 corresponding phosphoproteins can be identified),and the value is much higher than that of ZrTiO_(4) NFMs(6399 phosphopeptides and 2132 identified phosphoproteins)and commercial high-performance TiO_(2) particles(4525 phosphopeptides and 1811 identified phosphoproteins).These results demonstrate the super ability of TiO_(2)@ZrTiO_(4) NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.

Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding

Biological structural materials,despite consisting of limited kinds of compounds,display multifunctionalities due to their complex hierarchical architectures.While some biomimetic strategies have been applied in artificial materials to enhance their mechanical stability,the simultaneous optimization of other functions along with the mechanical properties via biomimetic designs has not been thoroughly investigated.Herein,iron oxide/carbon nanotube(CNT)-based artificial nacre with both improved mechanical and electromagnetic interference(EMI)shielding performance is fabricated via the mineralization of Fe_(3)O_(4)onto a CNTincorporated matrix.The micro-and nano-structures of the artificial nacre are similar to those of natural nacre,which in turn improves its mechanical properties.The alternating electromagnetic wave-reflective CNT layers and the wave-absorptive iron oxide layers can improve the multiple reflections of the waves on the surfaces of the reflection layers,which then allows sufficient interactions between the waves and the absorption layers.Consequently,compared with the reflection-dependent EMI-shielding of the non-structured material,the artificial nacre exhibits strong absorption-dependent shielding behavior even with a very low content of wave-absorptive phase.Owing to the high mechanical stability,the shielding effectiveness of the artificial nacre that deeply cut by a blade is still maintained at approximately 70%−96%depending on the incident wave frequency.The present work provides a new way for designing structural materials with concurrently enhanced mechanical and functional properties,and a path to combine structural design and intrinsic properties of specific materials via a biomimetic strategy.

Biomimetic Material Simulating Solar Spectrum Reflection Characteristics of Yellow Leaf

To counter the threat of hyperspectral detection, it is necessary to develop biomimetic materials to simulate the solar spectral re- flection characteristics of plant leaf accurately. Two kinds ofmembranaceous yellow biomimetic materials were prepared by dispersing the particles of chrome titanium yellow and iron oxide yellow as fillers in polyvinyl alcohol films respectively. Reflectance and transmittance of the biomimetic materials were measured, and absorption and scattering coefficients of the biomimetic materials were inverted with a four-flux model. Results indicate that the biomimetic material adopting chrome titanium yellow particles can simulate the solar spectrum reflection characteristics of yellow leaf because of the similar absorption and scattering characteristics. The biomimetic material adopting iron oxide yellow particles cannot simulate the spectrum reflection characteristics of yellow leaf near the wavelength of 900 nm due to the characteristic absorption of the iron oxide. When the volume fraction of the chrome titanium yellow particles is lower than 2.12%, the absorption and scattering coefficients both increase approximately linearly with the volume fraction, indicating that the particles can scatter radiation independently. Therefore, the reflectance of the biomimetic material can be regulated through linearly changing of the volume fraction of the chrome titanium yellow particles.

Advanced engineering and biomimetic materials for bone repair and regeneration

Over the past decade, there has been tremendous progress in developing advanced biomaterials for tissue repair and regeneration. This article reviews the frontiers of this field from two closely related areas, new engineering materials for bone substitution and biomimetic mineralization for bone-like nanocomposites. Rather than providing an exhaustive overview of the literature, we focus on several representative directions. We also discuss likely future trends in these areas, including synthetic biology-enabled biomaterials design and multifunctional implant materials for bone repair and regeneration.

Biopolymers and Biomimetic Materials in Medical and Electronic-Related Applications for Environment-Health-Development Nexus:Systematic Review

Biocomposites as bio-inspired materials are produced from renewable resources that are organic and ecofriendly alternative materials.To improve the lifestyle of human beings as well as enhancing the environmental indices,functional bio-materials are now implemented in various promising industries.This work has systematically discussed and highlighted the implementations and trends of functional bionic materials in high tech industries,which are necessary for developing modern societies.Various medical,electronic,food and pharmaceutical applications have been considered.Bio-inspired materials are used to develop more sustainable possibilities to increase environmental conservation while maintaining customer satisfaction.Biopolymers were found employed in several sectors for various functional bio-products including organic thin-film transistors,organic phototransistor,emitting diodes,photodiodes,photovoltaic solar cells,hybrid dental resins,sustainable pharmaceuticals,and food packaging.They are used to create sustainable bio-products for energy storage and harvesting,bone regeneration,nerve damage repair,drug applications and various other industrial subcategories.

Biomimetic Preparation of Alumina Hierarchical Papillary Microrough Structure for Hydrophobic Improvement and Its Abrasion Resistance Finite Element Analysis

The surface of lotus leaves has a hierarchical micro–nano-rough structure.We determined that the papillary structure also possesses hierarchical features on the microscale.We used alumina particles as rough structure building units to construct a Hierarchical Papillary microrough Structure(HPS)on a ceramic surface.The effects of the spatial distribution of HPS on the abrasion resistance and mechanical stability of hydrophobic coatings were investigated.Furthermore,for each HPS,the falling sand abrasion process was analyzed using finite element fluid mechanics analysis.A denser or more two-dimensional HPS implied that more area was impacted by the falling sand and that the abrasion amount and rate were higher.This is contrary to the common belief that when there are more wear-resistant substances on the surface,the abrasion resistance is better;thus,abrasion resistance does not necessarily depend entirely on the concentration of wear-resistant substances on the surface,but it is also influenced by the abrasion mode and the spatial distribution structure of the wear-resistant substances.The 3D stacked HPS(3D-HPS)with excellent abrasion resistance and rich pore structure considerably enhanced the mechanical stability of the hydrophobic coatings.These findings provide novel insights and a theoretical basis for designing spatial structures on high abrasion-resistant superhydrophobic ceramic surfaces.