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Mucinous Carcinoma of the Scrotum about a Case in Yaounde
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作者 Boris Amougou Fred Dikongue Dikongue +11 位作者 Divine Eyongeta Thierno Mamadou Oury Diallo David Douglas Banga Nkomo Demba Cisse Arlette Dongmo Alice Ghislaine Ndoumba Afouba Joseph Fondop Theodore Sala Beyeme Faustin Atemkeng Yaya Sow Abdoulaye Bobo Diallo Fru Angwafor 《Open Journal of Urology》 2023年第6期173-177,共5页
Aim: This paper aims to report the second case of mucinous carcinoma of the scrotum revealed by scrotal fistulas listed in the literature and highlight the difficulties in the search and difficulties encountered in th... Aim: This paper aims to report the second case of mucinous carcinoma of the scrotum revealed by scrotal fistulas listed in the literature and highlight the difficulties in the search and difficulties encountered in the management of urogenital cancers in developing countries. Case presentation: This was a 62-year-old patient who had consulted for fistulized lesions of the scrotum associated with urinary disorders. Physical examination found budding lesions in the scrotum from which mucus was leaking. The diagnostic assessment carried out consisted of a biopsy sample of the scrotal lesions, a blood analysis and medical imaging, which led to the diagnosis. The mutilating nature of the surgery proposed to the patient after multidisciplinary consultation meeting and the expensive cost of chemotherapy drugs constituted the limits of the patient’s therapeutic management. Conclusion: Mucinous carcinoma of the scrotum is rare and primary lesion should always be sought. The presence of budding lesions of the scrotum with discharge of mucus should suggest the diagnosis. 展开更多
关键词 Scrotal Cancer mucinous carcinoma Scrotal Fistulas
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Intraductal papillary mucinous carcinoma with atypical manifestations:Report of two cases 被引量:3
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作者 Seung Eun Lee Jin-Young Jang +1 位作者 Sung Hoon Yang Sun-Whe Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第10期1622-1625,共4页
Intraductal papillary mucinous neoplasms (IPMNs) are a well-characterized group of rnucin-producing cystic neoplasms of the clear malignant potential type. We report here two cases of intraductal papillary mucinous ... Intraductal papillary mucinous neoplasms (IPMNs) are a well-characterized group of rnucin-producing cystic neoplasms of the clear malignant potential type. We report here two cases of intraductal papillary mucinous carcinoma (IPMC) with atypical manifestations. In one case, we discussed a pseudomyxoma peritonei caused by a ruptured IPMC. In the other case we discussed the fistulization of IPMC into the stomach and duodenum. These two cases suggest that IPMN can either spontaneously rupture causing mucinous materials to spill into the free abdominal cavity or directly invade adjacent organs resulting in fistula development. 展开更多
关键词 Intraductal papillary mucinous neoplasm Intraductal papillary mucinous carcinoma Pseudomyxoma peritonei FISTULA
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Management about intravesical histological transformation of prostatic mucinous carcinoma after radical prostatectomy:A case report
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作者 Sheng-Jiang Bai Li Ma +2 位作者 Min Luo Hang Xu Lu Yang 《World Journal of Clinical Cases》 SCIE 2022年第14期4654-4660,共7页
BACKGROUND Prostatic mucinous carcinoma(MC)and prostatic signet ring cell carcinoma are two variants of prostate cancer.MC has a higher overall survival time among all variants,while signet ring cell carcinoma is asso... BACKGROUND Prostatic mucinous carcinoma(MC)and prostatic signet ring cell carcinoma are two variants of prostate cancer.MC has a higher overall survival time among all variants,while signet ring cell carcinoma is associated with lower survival time relative to other carcinomas.Only a small proportion of prostatic MC may contain signet ring cells.Over the last several decades there were only 12 patients that were documented in two studies.CASE SUMMARY We report on a 64-year-old man who was diagnosed with prostatic MC after he received a robotic-assisted laparoscopic radical prostatectomy in the West China Hospital.After robotic-assisted laparoscopic radical prostatectomy,the patient underwent three successive transurethral resections of bladder tumors.Pathological examination of the first transurethral resection of bladder tumors specimen indicated that the neoplasm was prostatic MC that had metastasized to the urinary bladder.The subsequent two transurethral resections of bladder tumors indicated the presence of prostatic mucinous carcinoma with signet ring cells.CONCLUSION This case report aimed to share the management experience,raise awareness,and highlight the importance of multidisciplinary cooperation of prostatic mucinous carcinoma with signet ring cells. 展开更多
关键词 Prostatic mucinous carcinoma Signet ring cells Bladder tumor Immunohistochemical analyses Therapy and management Case report
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Value of high-frequency ultrasonography with virtual touch tissue quantification in diagnosis of breast pure mucinous carcinomas
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作者 Jian Shi Guang Yang +1 位作者 Jialing Wu Wenlin Xu 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第8期445-448,共4页
Objective The aim of our study was to analyze the characters of breast pure mucinous carcinomas on highfrequency ultrasonography with virtual touch tissue quantification (VTQ).
关键词 BREAST pure mucinous carcinoma ULTRASONOGRAPHY virtual touch tissue quantification
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Primary mucinous carcinoma of the thyroid: case report and review of the literature
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作者 Neng-Liang Zhang Jian-Hua Wang +4 位作者 Wei Cheng Zheng-Jing Li Jie Tang Tao Wang Yi Chen 《Cancer Advances》 2022年第23期1-4,共4页
Primary mucinous carcinoma of the thyroid gland which is more difficult to diagnose than common thyroid cancer is an extremely rare disease.It is a malignant tumor that can secrete mucus.A 45-year-old Chinese man came... Primary mucinous carcinoma of the thyroid gland which is more difficult to diagnose than common thyroid cancer is an extremely rare disease.It is a malignant tumor that can secrete mucus.A 45-year-old Chinese man came to seek medical care because he found a lump in his right side.Tomography showed that there was a space-occupying lesion on the right thyroid gland which compressed the tracheal.After the operation of total thyroidectomy and lymph node dissection in the right central area,the pathological examination showed that tumor cells existed,showing a small nest-like and cribriform distribution characteristics.There were broad fibrous tissues,a large amount of mucus around the tumur cell that had no obvious amyloid deposition.The tumor cells were positive for thyroid transcription factor-1 and paired box gene-8,while they were focally positive for thyroglobulin.Considering the histological features and immunohistochemical profile and ruling out mucinous cancers originating from other organs.The patient was diagnosed with primary mucinous carcinoma of the thyroid gland.This patient is still alive at present.Prognosis of primary mucinous carcinoma of the thyroid gland is usually poor.The best way to improve the prognosis of these patients maybe to do surgery of complete tumor+lymph node resection as soon as possible. 展开更多
关键词 mucinous carcinoma thyroid cancer IMMUNOHISTOCHEMISTRY SURGERY
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Pure Mucinous Carcinoma of the Breast:a Clinicopathologic Analysis with 56 Patients 被引量:11
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作者 Li Peng Qiang Sun +3 位作者 Zhi-yong Liang Yi-dong Zhou Feng Mao Jing-hong Guan 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第2期115-118,共4页
Objective To assess recent trends and prognostic features in the treatment of pure mucinous carcinoma(PMC) of the breast.Methods Fifty-six patients diagnosed with PMC of the breast in our hospital from December 1982 t... Objective To assess recent trends and prognostic features in the treatment of pure mucinous carcinoma(PMC) of the breast.Methods Fifty-six patients diagnosed with PMC of the breast in our hospital from December 1982 to June 2008 were included.We evaluated the general information and tumor characteristics of the patients,examined the relationship between these factors and prognosis.Fisher's exact test was applied to analyze tumor characteristics.Results The mean age of the patients was 53.7 years.The majority of the patients presented with early stage disease.Tumor size was found not a significant prognostic factor in this study.Mean follow-up period was 39 months and no breast cancer-related deaths were identified in the patient cohort.Conclusions PMC of the breast has a favorable prognosis.Tumor size does not appear to significantly impact survival. 展开更多
关键词 breast cancer pure mucinous breast carcinoma lymph node status
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Rapid progression of colonic mucinous adenocarcinoma with immunosuppressive condition:A case report and review of literature
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作者 Youhei Koseki Kenya Kamimura +9 位作者 Yuto Tanaka Marina Ohkoshi-Yamada Qiliang Zhou Yoshifumi Matsumoto Takeshi Mizusawa Hiroki Sato Akira Sakamaki Hajime Umezu Junji Yokoyama Shuji Terai 《World Journal of Clinical Cases》 SCIE 2021年第30期9182-9191,共10页
BACKGROUND Colorectal mucinous adenocarcinoma is a rare subtype of colorectal cancer and is characterized by an abundance of mucin in the tumor.In addition,the colorectal mucinous adenocarcinoma often demonstrates poo... BACKGROUND Colorectal mucinous adenocarcinoma is a rare subtype of colorectal cancer and is characterized by an abundance of mucin in the tumor.In addition,the colorectal mucinous adenocarcinoma often demonstrates poor differentiation in the histology of tumor cells and poor prognosis compared with those with adenocarcinoma.Here,we present the case of a young woman with colonic mucinous adenocarcinoma showing significantly rapid progression within four months of immunosuppressant therapy for Henoch-Schonlein purpura.CASE SUMMARY Here we report a rare case of ascending colon mucinous adenocarcinoma with lymph node and liver metastases which developed and progressed rapidly within four months during the treatment of Henoch-Schonlein purpura using corticosteroids.The systemic screening examinations showed no tumors before the immunosuppressant therapy.Fortunately,the patient was successfully treated with chemotherapy.CONCLUSION While no direct evidence that the immunosuppressants accelerated the tumor development,the case presen-ta tion and review of the literature demonstrated that surveillance for malig-nancies before and during treatment with immunosuppressive agents is essential. 展开更多
关键词 Colorectal cancer mucinous carcinoma IMMUNOSUPPRESSANT CORTICOSTEROID Case report
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Prostate Mucinous Adenocarcinoma with Signet Ring Cells:a Case Report and Literature Review
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作者 Yi Wang Guang Sun +4 位作者 Jiangang Pan Jiwu Chang Shumin Zhang Tao Li Binghuang Ren 《Chinese Journal of Clinical Oncology》 CSCD 2006年第5期379-380,共2页
Prostate mucinous adenocarcinoma with signet ring cells (MC-SRC) is a rare morphologic variant of prostate cancer, with only 12 cases reported to date. Diagnosis of this carcinoma requires that at least 25% of the tum... Prostate mucinous adenocarcinoma with signet ring cells (MC-SRC) is a rare morphologic variant of prostate cancer, with only 12 cases reported to date. Diagnosis of this carcinoma requires that at least 25% of the tumor tissue should consist of an extracellular mucin pool. In this report, we present a case of prostate prostate mucinous adenocarcinoma with signet ring cells. 展开更多
关键词 prostatic cancer mucinous carcinoma signet ring cell.
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MicroRNA and histopathological characterization of pure mucinous breast carcinoma 被引量:5
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作者 Feng Zhou Shuai Li +2 位作者 Hui-Min Meng Li-Qiang Qi Lin Gu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2013年第1期22-27,共6页
Objective: Pure mucinous breast carcinoma (PMBC) is an uncommon histological type of breast cancer characterized by a large amount of mucin production. MicroRNA (miRNA) is a large class of small noncoding RNA of about... Objective: Pure mucinous breast carcinoma (PMBC) is an uncommon histological type of breast cancer characterized by a large amount of mucin production. MicroRNA (miRNA) is a large class of small noncoding RNA of about 22 nt involved in the regulation of various biological processes. This study aims to identify the miRNA expression profile in PMBC. Methods: MiRNA expression profiles in 11 PMBCs were analyzed by miRNA-microarray and real-time polymerase chain reaction (PCR). Thirty-one PMBCs and 27 invasive ductal carcinoma of no special types (IDC-NSTs) were assessed by immunohistochemistry using antibodies against ER, PR-progesterone receptor, HER2, Ki-67, Bcl-2, p53, PCNA, and CK5 and 6. Results: We analyzed the miRNA expression in 11 PMBCs and corresponding normal tissues using miRNA-microarray and real-time PCR, and found that miR-143 and miR-224-5p were significantly downregulated in mucinous carcinoma tissue. Compared with IDC-NSTs, PMBC showed a significantly higher ER positive rate, lower HER-2 positive rate, and lower cell proliferation rates. Conclusions: To our knowledge, this is the first study to demonstrate the miRNA expression profile of PMBC, and our findings may lead to further understanding of this type of breast cancer. 展开更多
关键词 Pure mucinous breast carcinoma MICRORNA real-time PCR
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Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma 被引量:3
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作者 Zhaode Bu Zhixue Zheng +5 位作者 Ziyu Li Xiaojiang Wu Lianhai Zhang Aiwen Wu Xianglong Zong Jiafu Ji 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第1期32-38,共7页
Objective: To analyze the differences in clinicopathologic characteristics and prognosis between mucinous gastric carcinoma (MGC) and signet-ring cell carcinoma (SRCC). Methods: Clinicopathologic and prognostic ... Objective: To analyze the differences in clinicopathologic characteristics and prognosis between mucinous gastric carcinoma (MGC) and signet-ring cell carcinoma (SRCC). Methods: Clinicopathologic and prognostic data of 1,637 patients with histologically confirmed MGC or SRCC who received surgical operations in the Department of Gastroenterological Surgery, Beijing Cancer Hospital between December 2004 and December 2009 were retrospectively collected and analyzed. The clinicopathological features were analyzed statistically using Z2 test. Survival was analyzed using the Kaplan- Meier method and multivariate analysis of Cox proportional hazards regression model (backward, stepwise). Results: A total of 181 patients with gastric cancer (74 MGC, 107 SRCC) were included. MGC, when compared with SRCC, was featured by senile patients, stage III and I~, upper third stomach, large tumor size, positive lymph node metastasis, and positive lymphatic vascular invasion (P〈0.05). The overall 5-year survival rate showed no difference between the two groups (48.8% vs. 44.8%, P〉0.05). However, the survival rate for MGC patients was significant lower than that for SRCC patients when compared among the age 〈60 years, negative distant metastasis, and tumor localized at upper third stomach (P〈0.05). Multivariate Cox proportional hazards models revealed that distant metastasis was a significant independent prognostic indicator in MGC group, and lymph node metastasis and distant metastasis was significant independent prognostic indicators in SRCC group. Conclusions: While compared with SRCC, MGC is associated with a more aggressive tumor biologic behavior. There is no statistically significant difference in distant metastasis, an independent prognostic indicator for both MGC and SRCC, which might be the reason for no significant difference of the overall survival rate between the patients with MGC and SRCC. 展开更多
关键词 mucinous gastric carcinoma signet-ring cell carcinoma CLINICOPATHOLOGY prognosis
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Renal mucinous tubular and spindle cell carcinoma: two cases report and review of the literature
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作者 Zhifeng Wei Zhengyu Zhang +2 位作者 Jingping Ge Jianping Gao Wenquan Zhou 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第11期672-675,共4页
We reported the clinical and pathologic features of two different types of renal mucinous tubular and spindle cell carcinoma (MTSCC). The first patient was incidentally discovered by health examination, with lower nuc... We reported the clinical and pathologic features of two different types of renal mucinous tubular and spindle cell carcinoma (MTSCC). The first patient was incidentally discovered by health examination, with lower nuclear grade, no part and distant metastasis. The second patient presented with persistence hyperpyrexia, part and distant metastasis, and high nuclear grade. Surgery were both performed successfully. The first patient had no recurrences and no distant metastases. The second patient died of multiple organ failure 3 months postoperatively. Although MTSCC is usually a low potential malignancy carcinoma, high malignancy may occur and lead to a fatal course. So it needs a proper management and prognostication. 展开更多
关键词 mucinous tubular and spindle cell carcinoma (MTSCC) KIDNEY
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Rental Mucinous Tubular and Spindle Cell Carcinoma:Case Report
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作者 Mosab Abdalla Ali Alzubier Abd Elmouniem Ali Elgasim Sami Mahjoub Taha 《Journal of Oncology Research》 2021年第1期28-30,共3页
Mucinous tubular and spindle cell carcinoma(MTSCC)of the kidney is an uncommon recently recognized renal cell carcinoma.We reported A 60 year's old man who presented with right flank pain,abdominal swelling and on... Mucinous tubular and spindle cell carcinoma(MTSCC)of the kidney is an uncommon recently recognized renal cell carcinoma.We reported A 60 year's old man who presented with right flank pain,abdominal swelling and one attack of hematuria.The intraoperative finding was a huge cystic swelling arising from the right kidney occupying almost all the abdominal cavity displacing the bowel to the left side of the abdomen.There was no ascites or evidences of metastasis.Right radical nephrectomy was done.Then the diagnosis of renal MTSCC was established.General condition of the patient was improved and one year prognosis was satisfactory.To our knowledge this is the first reported case of MTSCC in Sudan,and the outcome of treatment was satisfactory. 展开更多
关键词 mucinous tubular and spindle cell carcinoma Renal tumour SUDAN
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Invasive ductal carcinoma of the pancreas showing exophytic growth
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作者 Yuichi Sanada Kazuhiro Yoshida +2 位作者 Masaoki Itoh Riki Okita Morihito Okada 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2009年第1期97-102,共6页
BACKGROUND:Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic ... BACKGROUND:Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth. METHODS:A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic head.Preoperative computed tomography revealed a well-demarcated, primarily solid mass with a central low-density area. Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic duct.An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.Elevated serum carcinoembryonic antigen(CEA)levels and abnormal FDG positron emmission tomography accumulation suggested that the tumor had malignant potential requiring a pancreatoduodenectomy. RESULTS:The head of the pancreas contained a well- circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50%adenocarcinoma,with mucinous carci- noma in the center and anaplastic carcinoma at the periphery.The anaplastic carcinoma comprised pleo- morphic cells(PCs)and pleomorphic giant cells(PGCs). The PGCs phagocytozed mononuclear PCs and lymphocytes adjacent to the capsule without infiltrating the capsule itself.Immunohistochemistry revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin. CONCLUSION:Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs. 展开更多
关键词 pancreatic carcinoma anaplastic carcinoma mucinous carcinoma Mucin 1 carcinoembryonic antigen
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Mucinous colorectal adenocarcinoma:clinical pathology and treatment options 被引量:13
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作者 Cong Luo Shuyi Cen +1 位作者 Guojun Ding Wei Wu 《Cancer Communications》 SCIE 2019年第1期122-134,共13页
Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer(CRC)characterized by the pres-ence of abundant extracellular mucin which accounts for at least 50%of the tumor volume.Mucinous colorectal a... Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer(CRC)characterized by the pres-ence of abundant extracellular mucin which accounts for at least 50%of the tumor volume.Mucinous colorectal adenocarcinoma is found in 10%-20%of CRC patients and occurs more commonly in female and younger patients.Moreover,mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage.Based on its molecular context,mucinous colorectal adenocarcinoma is associated with the over-expression of mucin 2(MUC2)and mucin 5AC(MUC5AC)proteins.At the same time,it shows higher mutation rates in the fundamental genes of the RAS/MAPK and PI3K/Akt/mTOR pathways.Mucinous colorectal adenocarcinoma also shows higher rates of microsatellite instability(MSI)than non-mucinous colorectal adenocarcinoma which might correlate it with Lynch syndrome and the CpG island methylator phenotype.The prognosis of mucinous colorectal adenocarcinoma as to non-mucinous colorectal adenocarcinoma is debatable.Further,the impaired responses of mucinous colorectal adenocarcinoma to palliative or adjuvant chemotherapy warrant more studies to be performed for a specialized treatment for these patients.In this review,we discuss the molecular background and histopathol-ogy of mucinous colorectal adenocarcinoma,and provide an update on its prognosis and therapeutics from recent literatures. 展开更多
关键词 ADENOcarcinoma mucinous carcinoma Colorectal cancer MUC2 MUC5AC Microsatellite instability Lynch syndrome Targeted molecular therapy Hyperthermic intraperitoneal chemotherapy IMMUNOTHERAPY
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Clinical and CT imaging features of mucinous tubular and spindle cell carcinoma 被引量:11
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作者 Zhu Qingqiang Zhu Wenrong +1 位作者 Wang Zhongqiu Wu Jingtao 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第7期1278-1283,共6页
Background There are relatively few reports focusing on clinical and multi-slice CT (MSCT) imaging findings of mucinous tubular and spindle cell carcinoma (MTSCC).Our study aimed to characterize the clinical and M... Background There are relatively few reports focusing on clinical and multi-slice CT (MSCT) imaging findings of mucinous tubular and spindle cell carcinoma (MTSCC).Our study aimed to characterize the clinical and MSCT imaging features of MTSCC.Methods The imaging findings in 17 patients with MTSCC by MSCT were retrospectively studied.MSCT was undertaken to investigate tumor location,size,density,cystic or solid appearance,calcification,capsule sign,enhancement pattern,and retroperitoneal lymph node metastasis.Results Tumors (mean diameter,(3.9±1.7) cm) were solitary (17/17),solid (16/17) with cystic components (5/17),had no calcifications (14/17),had a poorly defined margin (14/17),were centered in the medulla (15/17),compressed the renal pelvis (7/17),and neither lymph node nor distant metastasis was found.The attenuation of MTSCC tumors was equal to that of the renal cortex or medulla on unenhanced CT (32.3±2.6,36.3±4.6,33.2±3.9,respectively,P >0.05),while tumor enhancement after administration of a contrast agent was lower than that of normal renal cortex and medulla during all phases (P <0.05).Conclusion MTSCC tends to be a solitary,isodense mass with poorly defined margin arising from the renal medulla with enhancement less than the cortex and medulla during all phases. 展开更多
关键词 mucinous tubular and spindle cell carcinoma computed tomography PATHOLOGY
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Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative 被引量:1
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作者 Jennifer L Leiting Jordan M Cloyd +21 位作者 Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel E Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2020年第7期756-767,共12页
BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal technique.AIM To evaluate the impact of HIP... BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal technique.AIM To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes.METHODS Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database.Post-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed HIPEC.RESULTS Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed HIPEC.There was no difference in re-operation or severe complications between the two groups.Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities.On multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire cohort.These findings remained consistent in the appendiceal and the colorectal subgroups.CONCLUSION In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term outcomes.HIPEC technique may be left to the discretion of the operating surgeon. 展开更多
关键词 mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional
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