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Laser Light Scattering Study on Aggregation of Cellulose Diacetate in Acetone 被引量:1
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作者 Ding-hai Xie Xu-hua Li +1 位作者 Xi-ling Fang Chun-feng Ma 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第3期256-258,共3页
We have investigated the properties of cellulose diacetate in solution by using laser light scattering. The cellulose diacetate molecules can form micelles and micellar clusters in acetone besides the individual chain... We have investigated the properties of cellulose diacetate in solution by using laser light scattering. The cellulose diacetate molecules can form micelles and micellar clusters in acetone besides the individual chains. As the concentration increases, the average hydrodynamic radius (Rh) linearly increases, whereas the ratio of gyration radius to hydrodynamic radins 〈Rg〉/〈Rh〉 linearly decreases. It indicates that the micelles associate and form micellar clusters due to the intermolecular interactions. 展开更多
关键词 Cellulose diacetate laser light scattering Multi-aggregation form structure
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Variable Temperature Laser Light Scattering Microscopy (VTLLSM) Studies on 10-100 μm Size High Purity Gold and Commercial Grade Zinc Grains
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作者 P. Sita Rama Rao P. B. V. Prasad P. B. Shashikanth 《Materials Sciences and Applications》 2010年第6期329-335,共7页
The VTLLS microscopy studies were made on high purity gold and commercial grade zinc grains in a temperature range of 30-230?C. Differential area ω and surface activity Sa were estimated from photomicrographs. The ω... The VTLLS microscopy studies were made on high purity gold and commercial grade zinc grains in a temperature range of 30-230?C. Differential area ω and surface activity Sa were estimated from photomicrographs. The ω vs dT/dt (rate of heating) curve was seen to differ from those of silver and titanium. The nature of curve between normalized ω and dT/dt was seen to be non-exponential. The characteristic relation between sectorized differential area ωsec and mean temperature was examined. The present study further establishes the simplicity and versatility of the VTLLS technique, in studying the defect-sub-structure of metal particles such as Au and Zn in presence of an imposed temperature gradient in a reasonable way. As such an attempt was made to connect the ω and defect-sub-structure related parameters. 展开更多
关键词 Variable Temperature laser light scatterING MICROSCOPY Au and Zn Grains DEFECTS
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LIGHT-SCATTERING STUDY OF POLYELECTROLYTE HOLLOW CAPSULES
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作者 张拥军 徐坚 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2004年第2期111-115,共5页
Silver halide (AgX) microcrystal was used as template to synthesize hollow polyelectrolyte capsules. These hollow capsules were characterized by laser light scattering (LLS) used to measure the size of the capsules in... Silver halide (AgX) microcrystal was used as template to synthesize hollow polyelectrolyte capsules. These hollow capsules were characterized by laser light scattering (LLS) used to measure the size of the capsules in solution. The ratio of hydrodynamic radius (R h ) from dynamic LLS to the radius of gyration (Rg) from static LLS is almost unity, revealing that the entities are hollow in solution. The results suggest that the LLS method can be regarded as a good complement to the confocal laser scanning microscopy (CLSM) method for the characterization of small hollow capsules, and it possesses the advantage of not needing fluorescence labeling. 展开更多
关键词 Layer-by-layer (LbL) self-assembly Hollow capsule Silver halide laser light scattering
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Measurement of the Average Molecular Weight of Cotton Cellulose Crosslinked by a Polycarboxylic Acid at Different pH Using Multiple Angle Light Scattering Photometer in a DMAc/LiCl Solvent System
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作者 毛志平 YANG Charles Q 《Journal of Donghua University(English Edition)》 EI CAS 2003年第4期5-7,共3页
Durable press finishing of cotton fabrics with polycarboxylic acid increases fabric wrinkle-resistance at the expense of its mechanical strength. Severe tensile strength loss is the major disadvantage for wrinkle resi... Durable press finishing of cotton fabrics with polycarboxylic acid increases fabric wrinkle-resistance at the expense of its mechanical strength. Severe tensile strength loss is the major disadvantage for wrinkle resistant cotton fabrics.Tensile strength loss of cotton fabric crosslinked by a polycarboxylic acid can be attributed to depolymerization and crosslink of cellulose molecules. Measurement of the molecular weight of cotton fabric before and after crosslinked by polycarboxylic acids can offer a possibility of direct understanding of the depolymerization. In this research, amultiple angle laser light scattering photometer was used todetermine the absolute molecular weight of cotton fabric treated with BTCA at different pH and then hydrolyzed with 0. 5 M NaOH solution at 50℃ for 144 h. The results indicate that average molecular weights of cotton fabric treated with polycarboxylic acids at different pH are almost the same. 展开更多
关键词 cotton cellulose DEPOLYMERIZATION laser light scattering photometer molecular weight
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LIGHT SCATTERING PROPERTY OF HUMAN BLOOD AT THE WAVELENGTH OF 810NM
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作者 Jian Zhong Duan Xinmin +1 位作者 Wang Sigang Long Kaiping(Department of Physics,The Fourth Military Medical UniversityXi’an, 710032, China)The optical properties of blood play an important role in diagnose and laser treatment. Weprovide an empirical formul estimat 《Chinese Journal of Biomedical Engineering(English Edition)》 1995年第4期165-165,共1页
LIGHTSCATTERINGPROPERTYOFHUMANBLOODATTHEWAVELENGTHOF810NMLIGHTSCATTERINGPROPERTYOFHUMANBLOODATTHEWAVELENGTHO... LIGHTSCATTERINGPROPERTYOFHUMANBLOODATTHEWAVELENGTHOF810NMLIGHTSCATTERINGPROPERTYOFHUMANBLOODATTHEWAVELENGTHOF810NMJianZhong;D... 展开更多
关键词 light scatterING BLOOD laser
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碱性蛋白酶酶解蛋白制备活性肽的质控研究
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作者 李娟 樊丽 +3 位作者 郭玉杰 周娇娇 张明晶 李春红 《现代农业科技》 2024年第18期141-146,共6页
以胶原蛋白和大豆分离蛋白为主要研究对象,应用体积排阻色谱(SEC)结合多角度激光光散射(MALLS)及示差折光(RI)联用技术对碱性蛋白酶酶解蛋白制备肽段的过程进行了详细分析。在酶解过程中,不同来源的胶原蛋白(牛、鸡)和大豆分离蛋白在分... 以胶原蛋白和大豆分离蛋白为主要研究对象,应用体积排阻色谱(SEC)结合多角度激光光散射(MALLS)及示差折光(RI)联用技术对碱性蛋白酶酶解蛋白制备肽段的过程进行了详细分析。在酶解过程中,不同来源的胶原蛋白(牛、鸡)和大豆分离蛋白在分子量分布、体系的分散度及粒径变化规律上表现出了典型的差异。结果表明,牛胶原蛋白在酶解开始时就迅速被降解产生了大量小分子肽段,鸡胶原蛋白相对于牛胶原蛋白在相同的酶解条件下更难产生小分子肽段,大豆分离蛋白随着酶的加入则是表现出了先聚集再降解的特性。SEC-MALLS技术可以有效把控蛋白酶解的过程以及体系中肽段分子量分布,该技术可以为活性肽产品的开发及品质检测提供依据。 展开更多
关键词 胶原蛋白 大豆分离蛋白 酶解 碱性蛋白酶 体积排阻色谱 多角度激光光散射 肽段 分子量分布
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Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media 被引量:1
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作者 Petr Ermolinskiy Matvey Maksimov +3 位作者 Andrei Lugovtsov Alexey Muravyov Irina Tikhomirova Alexander Priezzhev 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第5期23-31,共9页
Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signali... Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signaling molecule in the bloodstream.The purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells(RBCs)in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in vitro.Microrheological properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,respectively.The study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100,and 200M,while EDTA-stabilized blood showed slightly decreased aggregation and unchanged deformation.With washed RBCs in dextran solution,the addition of sodium nitroprusside(in the concentrations of 100,and 200M)resulted in decreased aggregation and increased deformation.These-ndings aid in our understanding of nitric oxide's effect on RBC microrheological properties. 展开更多
关键词 Sodium nitroprusside nitric oxide red blood cells RBC aggregation diffuse light scattering laser diffractometer
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变压器油中微水的激光散射测量技术
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作者 袁田 卫卓 +3 位作者 胡坤芳 伍罡 应斯 蔡胜伟 《高电压技术》 EI CAS CSCD 北大核心 2024年第8期3607-3615,共9页
变压器油中微水是影响绝缘性能的重要因素,为了克服现有检测方法稳定性差、主观性强、使用条件严苛等不足,通过数字图像量化波长为650 nm的激光在油中形成的散射光柱灰度,结合米氏散射和瑞利散射理论特征,利用光强衰减、区间灰度像素统... 变压器油中微水是影响绝缘性能的重要因素,为了克服现有检测方法稳定性差、主观性强、使用条件严苛等不足,通过数字图像量化波长为650 nm的激光在油中形成的散射光柱灰度,结合米氏散射和瑞利散射理论特征,利用光强衰减、区间灰度像素统计等手段对比了变压器油的温度、颗粒度和微水含量(水分质量分数)等数据。研究发现:散射光强与微水颗粒的尺寸之间的关系为主导关系,但会受到油温度、颗粒度的干扰;油中温度升高会促使微水含量≤10×10^(−6)的微水颗粒合并为主导,而当微水含量(水分质量分数)>10×10^(−6)时,微水颗粒分解和合并逐渐达到平衡;油微水与光柱呈现明显的指数关系,通过调节数字图像灰度的敏感度,增加像素统计量匹配不同区间微水,可以降低数值波动,并给出了颗粒度和温度线性校准的实例。研究结果表明,所提方法能够实现变压器油中微水含量的测量,可用于油浸式变压器的油中微水检测。 展开更多
关键词 变压器油 微水 激光 光散射 灰度 颗粒度
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激光散射法测定右美托咪定的粒度分布
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作者 王迪 杨剑 《食品与药品》 CAS 2024年第2期I0005-I0008,共4页
目的建立检测右美托咪定原料药粒度分布的方法。方法使用激光粒度分析仪,采用干法检测右美托咪定原料药的粒径。经优化,折射率设为1.56,漏斗池高度设为1.5 mm,遮光度设为3.0%~4.0%,分散气体的压力设为0.8 bar,进样速度设为50%,样品测量... 目的建立检测右美托咪定原料药粒度分布的方法。方法使用激光粒度分析仪,采用干法检测右美托咪定原料药的粒径。经优化,折射率设为1.56,漏斗池高度设为1.5 mm,遮光度设为3.0%~4.0%,分散气体的压力设为0.8 bar,进样速度设为50%,样品测量时间设为18 s。结果在优化条件下,粒径分布结果的RSD值小于2.0%,数据与电子显微镜扫描结果相似。结论方法操作简单,重现性较好、准确度较高,可用于右美托咪定原料药的粒度测定。 展开更多
关键词 激光散射法 右美托咪定 粒度
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考虑高斯能量分布的复杂表面航天器激光雷达散射特性分析
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作者 程勋龙 康国华 +3 位作者 邱钰桓 武俊峰 吴佳奇 尹一蓁 《上海航天(中英文)》 CSCD 2024年第1期57-65,共9页
针对复杂表面航天器在激光雷达照射下散射特性模拟不准的问题,通过表面建模和激光特性修正进行了解决。该方法首先通过高斯能量分布法对激光光束模型进行修正;然后基于有限元的思想,针对航天器复杂表面非光滑、非连续以及多材质等特性,... 针对复杂表面航天器在激光雷达照射下散射特性模拟不准的问题,通过表面建模和激光特性修正进行了解决。该方法首先通过高斯能量分布法对激光光束模型进行修正;然后基于有限元的思想,针对航天器复杂表面非光滑、非连续以及多材质等特性,利用改进Z-buffer的消隐算法解决了复杂航天器表面建模问题;最后建立了面向激光雷达的复杂表面航天器激光雷达散射截面的计算方法。仿真分析表明:航天器不同姿态下的激光雷达散射截面精度提升了14 58%,为后续面向激光雷达的隐身设计奠定了基础。 展开更多
关键词 激光隐身 激光散射特性 激光雷达(Lidar)建模 Z缓冲技术 高斯能量分布
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Improved uniformity of deposited metallic layer on hybrid micro/nano-structured Si substrates fabricated by two-step laser ablation for SERS application
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作者 LI Long-fan ZHOU Rui +2 位作者 CUI Jing-qin YAN Huang-ping WANG Zhen-zhong 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第10期3312-3322,共11页
Surface-enhanced Raman scattering(SERS) has been widely used as an effective technique for lowconcentration molecules detections in the past decades. This work proposes a rapid and accessible process to fabricate SERS... Surface-enhanced Raman scattering(SERS) has been widely used as an effective technique for lowconcentration molecules detections in the past decades. This work proposes a rapid and accessible process to fabricate SERS-active substrates with high uniformity and controllability based on two-step laser ablation. Laser beams directly ablate the surface of Si, concurrently creating microstructures and ejecting molten materials caused by the thermal effect that nucleate in ambient air. The nuclei grow into nanoparticles and deposit over the surface. These nanoparticles,together with microstructures, improve the light collection efficiency of the SERS-active substrates. Especially after Au thin film deposition, these nanoparticles can provide nanogaps as hotspots for SERS. By orthogonal experiment design,laser processing parameters for better performances are determined. Compared with substrates fabricated by single 1064 nm master oscillator power amplifier(MOPA) laser ablation, substrates ablated by the primary 1064 nm MOPA laser and secondary UV pulsed laser show more uniform nanoparticles’ deposition over the surface. The optimized largearea substrate has a SERS detection limit of 10^(-8)mol/L for 4-aminothiophenol(4-ATP), indicating the potential realworld applications for trace detection. 展开更多
关键词 laser ablation surface-enhanced Raman scattering(SERS) light trapping effect orthogonal experiment design
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高精度激光定位散斑机理分析及抑制
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作者 徐晶 王钎潮 +2 位作者 任正玮 付飞蚺 方明 《光学精密工程》 EI CAS CSCD 北大核心 2023年第13期1900-1908,共9页
为有效解决高精度视觉定位测量系统中激光随机散斑导致的光斑质心定位精度降低问题,对散斑机理及抑制方法进行研究。从激光光斑的成像过程分析了激光随机散斑出现的原因,并推导出空间中任意一点总波扰表达式。建立了成像介质吸光性、粗... 为有效解决高精度视觉定位测量系统中激光随机散斑导致的光斑质心定位精度降低问题,对散斑机理及抑制方法进行研究。从激光光斑的成像过程分析了激光随机散斑出现的原因,并推导出空间中任意一点总波扰表达式。建立了成像介质吸光性、粗糙度和表面出射光信噪比与随机散斑强度的关系模型,得出增加成像介质粗糙度和吸光性来提高出射光信噪比,进而降低随机散斑强度的结论。通过改变成像介质的物理特性进行对比实验,获得光斑质心位置稳定性随成像介质物理特性变化的趋势,验证了关系模型的正确性。实验结果表明,当激光功率为50 mW时,选取吸光性强、粗糙度与厚度适中的成像介质作为成像靶面,激光光斑质心的提取精度稳定在0.04个pixel之内,实现了对激光散斑的抑制,提高了光斑质心的定位精度。 展开更多
关键词 激光光斑 动态散斑 光的散射 分子运动论 微表面模型
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激光散射法测定布洛芬混悬液粒度的研究
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作者 章娟 丁怡 赖俊敏 《中国处方药》 2023年第11期34-37,共4页
目的 建立激光散射法测定布洛芬混悬液中布洛芬的粒度及粒度分布的方法。方法 使用Malvern Mastersizer 2000激光粒度分析仪,Hydro 2000SM进样器;背景及样品的扫描时间为15 s,搅拌速率为850 r/min;分散剂为水,以辅料溶液为背景测试样品... 目的 建立激光散射法测定布洛芬混悬液中布洛芬的粒度及粒度分布的方法。方法 使用Malvern Mastersizer 2000激光粒度分析仪,Hydro 2000SM进样器;背景及样品的扫描时间为15 s,搅拌速率为850 r/min;分散剂为水,以辅料溶液为背景测试样品溶液;颗粒折射率为1.400~1.500;颗粒的吸收率为0.001;遮光度为5%~20%。结果 激光散射法可以测定布洛芬混悬液的粒度及其分布,由体积平均粒径D(4,3)可以直观地表征不同批号的布洛芬混悬液中布洛芬颗粒的大小差异,由d(0.1)、d(0.5)、d(0.9)数值表示其粒度分布的特征。方法学考察结果和样品测定结果的d(0.1)、d(0.5)和d(0.9)的RSD均小于8%。结论 本方法适合布洛芬混悬液中布洛芬药物的粒度及粒度分布的测定。 展开更多
关键词 激光散射法 粒度分析 布洛芬混悬液 混悬剂 湿法测定
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亚微米液体颗粒计数器的关键技术研究及应用
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作者 梁凤飞 孙吉勇 +2 位作者 陈建 沈玮栋 吴晨炜 《中国仪器仪表》 2023年第2期63-66,共4页
亚微米液体颗粒计数器是一种应用于半导体、电子等领域进行超纯水、超净液体的颗粒污染程度检测的主要仪器。基于光散射原理,采用半导体激光器作为光源,以雪崩光电二极管作为光电转换元件,以比较器实现颗粒物粒径的甄别,以计数芯片实现... 亚微米液体颗粒计数器是一种应用于半导体、电子等领域进行超纯水、超净液体的颗粒污染程度检测的主要仪器。基于光散射原理,采用半导体激光器作为光源,以雪崩光电二极管作为光电转换元件,以比较器实现颗粒物粒径的甄别,以计数芯片实现单个粒径颗粒的统计,以嵌入式芯片实现不同粒径颗粒的统计,开发了一种可实现检测液体中0.2μm粒径的不溶性颗粒计数器,并通过测试纯水、光刻胶等溶剂与进口检测仪器相比误差<1%,达到替代进口的目的,实现高端颗粒计数仪器的国产化。 展开更多
关键词 亚微米液体颗粒计数器 光散射 半导体激光器 雪崩光电二极管
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基于激光诱导荧光光谱的酸奶乳酸菌数快速检测
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作者 马劭瑾 李永玉 +1 位作者 彭彦昆 王绮 《江苏大学学报(自然科学版)》 CAS 北大核心 2023年第5期540-546,共7页
以市售搅拌型酸奶为研究对象,利用自行搭建的激光诱导荧光(LIF)采集系统,获取不同乳酸菌数酸奶样品的荧光光谱,探讨酸奶中各种荧光物质的荧光峰强度随乳酸菌数变化的响应关系,结合光散射校正算法建立了酸奶中乳酸菌数定量预测模型.结果... 以市售搅拌型酸奶为研究对象,利用自行搭建的激光诱导荧光(LIF)采集系统,获取不同乳酸菌数酸奶样品的荧光光谱,探讨酸奶中各种荧光物质的荧光峰强度随乳酸菌数变化的响应关系,结合光散射校正算法建立了酸奶中乳酸菌数定量预测模型.结果显示,不同乳酸菌数酸奶样品均在435、485和520 nm附近出现了荧光特征峰,且均随乳酸菌数的变化呈现规律性变化.利用4种光散射校正方法对酸奶原始荧光光谱进行了校正,其中,OPLEC+SR光散射校正算法能够有效消除与波长相关的基线漂移的影响,所建立的PLSR预测模型结果最优,其校正集、验证集相关系数R_(c)、R_(p)分别为0.9654和0.9533,均方根误差C_(RMSE)、P_(RMSE)分别为0.1525 logCFU/mL和0.2362 logCFU/mL.为验证模型的稳定性与可靠性,利用未参与建模的8个酸奶样品对最优模型进行外部验证,实测值与预测值线性拟合后的相关系数R可达到0.9510,拟合残差模为0.8606,说明所建预测模型可以实现酸奶中乳酸菌数的实时监测. 展开更多
关键词 酸奶 乳酸菌数 激光诱导荧光光谱 光散射校正 无损检测
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激光散射测定甲苯磺酸拉帕替尼粒度方法的建立和验证 被引量:2
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作者 刘亚方 张治云 +3 位作者 郭新艳 王静 王帆 杨琪 《食品与药品》 CAS 2023年第2期119-122,共4页
目的 建立激光散射法测定甲苯磺酸拉帕替尼原料药的粒度分布。方法 采用Malvern Mastersizer 2000型激光粒度分析仪及Hydro 2000MU型湿法进样器,样品采用2%十二烷基硫酸钠分散,样品折射率1.5,样品吸收率1,遮光比8%~20%,超声50 s,循环速... 目的 建立激光散射法测定甲苯磺酸拉帕替尼原料药的粒度分布。方法 采用Malvern Mastersizer 2000型激光粒度分析仪及Hydro 2000MU型湿法进样器,样品采用2%十二烷基硫酸钠分散,样品折射率1.5,样品吸收率1,遮光比8%~20%,超声50 s,循环速度2000 r/min,样品测量5次。结果 d(0.5)值的RSD均小于3%,d(0.1)和d(0.9)值的RSD均小于5%。结论 本法可准确测定甲苯磺酸拉帕替尼原料药的粒度。 展开更多
关键词 甲苯磺酸拉帕替尼 激光散射法 粒度
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R12 hydrate formation kinetics based on laser light scattering technique 被引量:5
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作者 孙长宇 陈光进 郭天民 《Science China Chemistry》 SCIE EI CAS 2003年第5期487-494,共8页
A circulating flow system consisting of a transparent U-bend flow loop, a mixing tank and a laser granulometer was set up for studying the kinetics hydrate formation and the pressure is up to 4 MPa. Refrigerant CCl2F2... A circulating flow system consisting of a transparent U-bend flow loop, a mixing tank and a laser granulometer was set up for studying the kinetics hydrate formation and the pressure is up to 4 MPa. Refrigerant CCl2F2 (R12) hydrate formation experiments were performed using laser light scattering method at 277.1 K and pressures of 0.24 and 0.32 MPa. The liquid flow rates were in the range of 300—1400 L/h. The size distribution and density of R12 hydrate particles in pure water were measured using a laser granulometer. Experimental results show that the size of hydrate particles increases sharply at the initial stage and approaches gradually to a stable size. The hydrate particle concentration in the aqueous phase increases with pressure and circulating liquid flow rate. Based on the material balance, the mathematical model among gas consumption, average hydrate particle size and shading ratio has been established. The calculated results using the mathematical model accord well with the experimental gas consumption data. 展开更多
关键词 hydrate kinetics flow loop laser light scattering R12 model.
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Microscope laser light scattering spectroscopy and its applications to non-invasive in situ real time measurements on single intact cells 被引量:3
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作者 HUANG YaoxiongInstitute of Biomedical Engineering, Ji’nan University, Guangzhou 510632, China 《Chinese Science Bulletin》 SCIE EI CAS 2000年第22期2084-2088,共5页
The principle of the technique of microscope laser light scattering spectroscopy, its development and applications to the studies on single intact cells, including our work on non-invasive in situ real time measuremen... The principle of the technique of microscope laser light scattering spectroscopy, its development and applications to the studies on single intact cells, including our work on non-invasive in situ real time measurements on single intact erythrocyte simultaneously at the levels of cellular, sub-cellular and intracellular molecules, are introduced. 展开更多
关键词 MICROSCOPE laser light scattering SINGLE INTACT cell NON-INVASIVE in SITU measurement.
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分布式光纤测温在海底管道泄漏监测中的应用 被引量:2
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作者 李志强 《石化技术》 CAS 2023年第4期10-12,共3页
海底管道泄漏成为近几年常常发生的热点现象,严重影响了海域的生态环境和人民的切身利益,做好海底管道泄漏监测是确保海底管道安全运行的关键。近年来研究出的新技术——分布式光纤测温系统,具有抗电磁干扰、检测距离长、电绝缘、耐腐... 海底管道泄漏成为近几年常常发生的热点现象,严重影响了海域的生态环境和人民的切身利益,做好海底管道泄漏监测是确保海底管道安全运行的关键。近年来研究出的新技术——分布式光纤测温系统,具有抗电磁干扰、检测距离长、电绝缘、耐腐蚀、使用成本低、操作简单等优点。通过详细阐述分布式光纤测温系统监测管道泄漏的使用原理,并将其应用到具体的案例中,以此来提高应用的实际性,增强分布式光纤测温系统在海底管道泄漏监测中的应用推广。 展开更多
关键词 分布式光纤测温系统 激光光源 管道泄漏 监测 拉曼散射
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激光散射法测定双氢青蒿素原料药的粒度 被引量:1
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作者 李昊 赵煊 +1 位作者 汤宇 马立波 《中国药物评价》 2023年第2期142-146,共5页
目的:建立激光散射法测定双氢青蒿素原料药的粒度大小和分布。方法:样品采用吐温80水溶液分散后强力振摇2 min,再超声90 s制成样品混悬液。然后采用Malvern Mastersizer 3000型激光粒度分析仪进行测试,进样模式为湿法,样品折射率1.520,... 目的:建立激光散射法测定双氢青蒿素原料药的粒度大小和分布。方法:样品采用吐温80水溶液分散后强力振摇2 min,再超声90 s制成样品混悬液。然后采用Malvern Mastersizer 3000型激光粒度分析仪进行测试,进样模式为湿法,样品折射率1.520,样品吸收率0.1,分散剂折射率1.330,遮光度10%~25%,搅拌速度1 500 r·min-1,样品测量3次,样品测量时间和背景测量时间均为10.0 s。结果:方法验证结果:重复性RSD(n=6):d(0.5)为6.4%,d(0.1)为9.5%,d(0.9)为9.8%;中间精密度RSD(n=12):d(0.5)为8.0%,d(0.1)为15.3%,d(0.9)为11.6%;耐用性:不同搅拌速度(±10%)和测量时间(±2 s)得到的结果,d(0.5)的RSD均小于4%,d(0.1)的RSD均小于3%,d(0.9)的RSD均小于7%;溶液稳定性:样品混悬液和样品池混悬液在室温下放置1 h内得到的结果,d(0.5)的RSD均小于3%,d(0.1)的RSD均小于4%,d(0.9)的RSD均小于4%,方法验证结果均符合USP<429>的规定。3批样品的测定结果中,d(0.5)的RSD均小于3%,d(0.1)和d(0.9)的RSD均小于5%,结果准确。结论:本方法操作简便、结果准确、精密度好,可用于有效控制双氢青蒿素原料药的粒度。 展开更多
关键词 双氢青蒿素 激光散射法 粒度 方法验证 USP<429>
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