Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chron...Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.展开更多
Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure w...Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure who were treated in the People's Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA I-II group and NYHA III-IV group according to cardiac function classification;healthy subjects who received physical examination during the same period were selected as the control group. The levels of Ang-2, neurohumor indexes and myocardial remodeling indexes in serum were determined. Results: Serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA I-II group and NYHA III-IV group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group;serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA III-IV group were significantly higher than those of NYHA I-II group whereas TIMP4 level was significantly lower than that of NYHA I-II group. Serum NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels in chronic heart failure patients with high Ang-2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion:The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.展开更多
Objective: To explore the effect of tibolone as well as Estradiol and Drospirenone replacement therapy on the neurohumoral indexes and immune function in perimenopausal women. Methods: A total of 180 perimenopausal wo...Objective: To explore the effect of tibolone as well as Estradiol and Drospirenone replacement therapy on the neurohumoral indexes and immune function in perimenopausal women. Methods: A total of 180 perimenopausal women who were treated in our hospital between December 2014 and December 2016 were collected and divided into the tibolone group (n=90) as well as Estradiol and Drospirenone group (n=90) by random number table, they received tibolone as well as Estradiol and Drospirenone replacement therapy respectively, and both therapies lasted for 6 months. The differences in serum levels of neurohumoral indexes and immune function indexes were compared between the two groups. Results:Before treatment, differences in serum levels of neurohumoral indexes and immune function indexes were not statistically significant between the two groups. After 6 months of treatment, serum E2, IL-4 and IL-13 levels of both groups of patients were significantly higher than those before treatment while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those before treatment, and serum E2, IL-4 and IL-13 levels of observation group were significantly higher than those of control group while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those of control group. Conclusion: Both tibolone and Estradiol and Drospirenone can be used in the treatment of women with perimenopausal syndrome, but tibolone is more effective in optimizing hormone levels and equalizing immune function.展开更多
目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究...目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究组(n=107)及对照组(n=106)。对照组选用传统手术联合枸橼酸氢钾钠治疗,研究组则选用经筋微创痛风石切除术联合枸橼酸氢钾钠治疗。对比两组疗效,疼痛程度及关节功能,肾功能指标水平,神经体液因子水平。结果:研究组治疗总有效率高于对照组(97.19%vs 86.79%,P<0.05)。术后两组视觉模拟评分法(visual analogue scale,VAS)评分均低于术前,而美国特种外科医院(Hospital for Special Surgery,HSS)评分均高于术前;且研究组VAS评分低于对照组,而HSS评分高于对照组(均P<0.05)。术后两组各项肾功能指标水平均低于术前,且研究组低于对照组(均P<0.05)。术后两组各项神经体液因子水平均高于术前,但研究组低于对照组(均P<0.05)。结论:经筋微创痛风石切除术联合枸橼酸氢钾钠治疗巨大痛风石的效果较佳,可有效改善患者疼痛程度、关节功能、肾功能及神经体液因子水平。展开更多
基金supported by the grant from the Ministry of Science and Higher Education of the Russian Federation(agreement 075-15-2020-800)。
文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.
文摘Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure who were treated in the People's Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA I-II group and NYHA III-IV group according to cardiac function classification;healthy subjects who received physical examination during the same period were selected as the control group. The levels of Ang-2, neurohumor indexes and myocardial remodeling indexes in serum were determined. Results: Serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA I-II group and NYHA III-IV group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group;serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA III-IV group were significantly higher than those of NYHA I-II group whereas TIMP4 level was significantly lower than that of NYHA I-II group. Serum NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels in chronic heart failure patients with high Ang-2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion:The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.
文摘Objective: To explore the effect of tibolone as well as Estradiol and Drospirenone replacement therapy on the neurohumoral indexes and immune function in perimenopausal women. Methods: A total of 180 perimenopausal women who were treated in our hospital between December 2014 and December 2016 were collected and divided into the tibolone group (n=90) as well as Estradiol and Drospirenone group (n=90) by random number table, they received tibolone as well as Estradiol and Drospirenone replacement therapy respectively, and both therapies lasted for 6 months. The differences in serum levels of neurohumoral indexes and immune function indexes were compared between the two groups. Results:Before treatment, differences in serum levels of neurohumoral indexes and immune function indexes were not statistically significant between the two groups. After 6 months of treatment, serum E2, IL-4 and IL-13 levels of both groups of patients were significantly higher than those before treatment while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those before treatment, and serum E2, IL-4 and IL-13 levels of observation group were significantly higher than those of control group while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those of control group. Conclusion: Both tibolone and Estradiol and Drospirenone can be used in the treatment of women with perimenopausal syndrome, but tibolone is more effective in optimizing hormone levels and equalizing immune function.
文摘目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究组(n=107)及对照组(n=106)。对照组选用传统手术联合枸橼酸氢钾钠治疗,研究组则选用经筋微创痛风石切除术联合枸橼酸氢钾钠治疗。对比两组疗效,疼痛程度及关节功能,肾功能指标水平,神经体液因子水平。结果:研究组治疗总有效率高于对照组(97.19%vs 86.79%,P<0.05)。术后两组视觉模拟评分法(visual analogue scale,VAS)评分均低于术前,而美国特种外科医院(Hospital for Special Surgery,HSS)评分均高于术前;且研究组VAS评分低于对照组,而HSS评分高于对照组(均P<0.05)。术后两组各项肾功能指标水平均低于术前,且研究组低于对照组(均P<0.05)。术后两组各项神经体液因子水平均高于术前,但研究组低于对照组(均P<0.05)。结论:经筋微创痛风石切除术联合枸橼酸氢钾钠治疗巨大痛风石的效果较佳,可有效改善患者疼痛程度、关节功能、肾功能及神经体液因子水平。
