(+) 8-O-Cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) and its analogues have been synthesized in nine steps from alpha-D-glucoheptonic-gamma-lactone. Pharmacological tests showed that most of the compounds possesse...(+) 8-O-Cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) and its analogues have been synthesized in nine steps from alpha-D-glucoheptonic-gamma-lactone. Pharmacological tests showed that most of the compounds possessed antitumor activities toward tumor cell in vitro.展开更多
A circuit system of on\|chip BP(Back\|Propagation) learning neural network with programmable neurons has been designed,which comprises a feedforward network,a n error back\|propagation network and a weight updating ci...A circuit system of on\|chip BP(Back\|Propagation) learning neural network with programmable neurons has been designed,which comprises a feedforward network,a n error back\|propagation network and a weight updating circuit.It has the merit s of simplicity,programmability,speediness,low power\|consumption and high densi ty.A novel neuron circuit with programmable parameters has been proposed.It gene rates not only the sigmoidal function but also its derivative.HSPICE simulations are done to a neuron circuit with level 47 transistor models as a standard 1 2 μm CMOS process.The results show that both functions are matched with their res pective ideal functions very well.The non\|linear partition problem is used to v erify the operation of the network.The simulation result shows the superior perf ormance of this BP neural network with on\|chip learning.展开更多
为了综合反映马铃薯（Solanum tuberosum）的遗传图信息，本试验中我们用已开发的PBA（P450 based analogue，即P450基因模型）标记以及不同的DNA标记来构成了遗传图。供试材料为二倍体马铃薯的F1群体，用各种DNA标记共计401个来检测了...为了综合反映马铃薯（Solanum tuberosum）的遗传图信息，本试验中我们用已开发的PBA（P450 based analogue，即P450基因模型）标记以及不同的DNA标记来构成了遗传图。供试材料为二倍体马铃薯的F1群体，用各种DNA标记共计401个来检测了双亲间的多态性；这401个标记分别为111个SSR，33个RFLP，87个RFLP-SIS，45个CAPS，94个RAPD，15个PBA，9个AFLP，3个RGL以及4个ISSR。结果在这401个标记中有127个标记（172个基因位点）显示出了亲本间的多态性，展开更多
目的通过对山西省乙型肝炎病毒（hepatitis B virus，HBV）P区基因测序的研究，探讨HBV基因变异位点及基因分型的分布规律。方法采集61例HBV患者血清标本，采用双脱氧末端终止法对待检标本P区进行基因序列检测，用Chromas 2．23软件对...目的通过对山西省乙型肝炎病毒（hepatitis B virus，HBV）P区基因测序的研究，探讨HBV基因变异位点及基因分型的分布规律。方法采集61例HBV患者血清标本，采用双脱氧末端终止法对待检标本P区进行基因序列检测，用Chromas 2．23软件对测序结果进行分析，通过在NCBI网站进行序列比对，并进行基因分型。结果53例受检患者均检测出P区的碱基以及氨基酸序列图，其中，有28例（52．8％）发生突变，突变位点分别有rt204、rt180、rt236、rt173、rt181、n214、rt250、rt213、rt184、rt237；各突变的位点中，以rt204和rt180位点的突变比例最高，分别占67．9％和53．5％。2例为B基因型，阳性率为3．8％，其余51例均为C基因型，阳性率为96.2％。结论山西省地区HBV分布以C基因型多见；发生变异的HBV病毒株中，10个变异位点均有涉及，但是仍以rt204位点突变为主，伴随其他位点突变，提示rt204位点可能存在顺式作用元件，在HBVDNA基因转录、翻译中起到调控作用。展开更多
文摘(+) 8-O-Cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) and its analogues have been synthesized in nine steps from alpha-D-glucoheptonic-gamma-lactone. Pharmacological tests showed that most of the compounds possessed antitumor activities toward tumor cell in vitro.
基金Project Supported by National N atural Science Foundation of China!( U nder Grant No.696360 30 )
文摘A circuit system of on\|chip BP(Back\|Propagation) learning neural network with programmable neurons has been designed,which comprises a feedforward network,a n error back\|propagation network and a weight updating circuit.It has the merit s of simplicity,programmability,speediness,low power\|consumption and high densi ty.A novel neuron circuit with programmable parameters has been proposed.It gene rates not only the sigmoidal function but also its derivative.HSPICE simulations are done to a neuron circuit with level 47 transistor models as a standard 1 2 μm CMOS process.The results show that both functions are matched with their res pective ideal functions very well.The non\|linear partition problem is used to v erify the operation of the network.The simulation result shows the superior perf ormance of this BP neural network with on\|chip learning.
文摘为了综合反映马铃薯（Solanum tuberosum）的遗传图信息，本试验中我们用已开发的PBA（P450 based analogue，即P450基因模型）标记以及不同的DNA标记来构成了遗传图。供试材料为二倍体马铃薯的F1群体，用各种DNA标记共计401个来检测了双亲间的多态性；这401个标记分别为111个SSR，33个RFLP，87个RFLP-SIS，45个CAPS，94个RAPD，15个PBA，9个AFLP，3个RGL以及4个ISSR。结果在这401个标记中有127个标记（172个基因位点）显示出了亲本间的多态性，
文摘目的通过对山西省乙型肝炎病毒（hepatitis B virus，HBV）P区基因测序的研究，探讨HBV基因变异位点及基因分型的分布规律。方法采集61例HBV患者血清标本，采用双脱氧末端终止法对待检标本P区进行基因序列检测，用Chromas 2．23软件对测序结果进行分析，通过在NCBI网站进行序列比对，并进行基因分型。结果53例受检患者均检测出P区的碱基以及氨基酸序列图，其中，有28例（52．8％）发生突变，突变位点分别有rt204、rt180、rt236、rt173、rt181、n214、rt250、rt213、rt184、rt237；各突变的位点中，以rt204和rt180位点的突变比例最高，分别占67．9％和53．5％。2例为B基因型，阳性率为3．8％，其余51例均为C基因型，阳性率为96.2％。结论山西省地区HBV分布以C基因型多见；发生变异的HBV病毒株中，10个变异位点均有涉及，但是仍以rt204位点突变为主，伴随其他位点突变，提示rt204位点可能存在顺式作用元件，在HBVDNA基因转录、翻译中起到调控作用。
