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Effectiveness of Chromated Copper Arsenate against Deteriorating Agents of Eucalyptus Poles and Posts in Four Eco-Regions in Kenya
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作者 Miriam Gathogo Evanson Omuse George Muthike 《Open Journal of Forestry》 2024年第3期281-296,共16页
Previous studies done elsewhere have shown that Eucalyptus poles treated with chromated copper arsenate (CCA) can last over 30 years. Kenya is exceptional because in some eco-regions, the Eucalyptus poles’ life span ... Previous studies done elsewhere have shown that Eucalyptus poles treated with chromated copper arsenate (CCA) can last over 30 years. Kenya is exceptional because in some eco-regions, the Eucalyptus poles’ life span has greatly reduced to 5 years. The current study was designed to evaluate wood deteriorating agents of CCA-treated Eucalyptus poles and variability in four eco-regions of Kenya, namely, dryland, coastal, highland and humid lake. A total of 360 Eucalyptus pole samples were used for this experiment. Three CCA treatments were used to treat transmission poles at 20 kg/cm3 fencing posts samples at 6 kg/cm3, and a control group. Results indicated that termites and wood-decay fungi attacks caused wood deterioration in the four eco-regions. The proportion of power transmission pole degradation by wood deteriorating agents varied across eco-regions, between treatments and control and between time after treatments. Dryland eco-regions had the highest termite-related degradation (41.82%) while wood-decay fungi attack was highest in the highland eco-regions (9.20%). Samples treated with 6 kg/cm3 recorded the lowest level of wood deterioration, manifested by minimal superficial termite and wood-decay fungi attack. Samples treated with 20 kg/cm3 were characterized by moderate termite and wood-decay fungi attacks observed around the heartwood region, unlike sapwood. This study concluded that the deterioration of Eucalyptus CCA-treated poles is a question of climatic variability and hence, to increase the poles’ lifespan, CCA treatment should be tailored according to the characteristics of the ecoregion of use. Further investigations will inform the diversity of termites and decay-fungi across different eco-regions. 展开更多
关键词 Wood Deteriorating Agents CCA Transmission poles Wood-Decay Fungi
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LMI Approach to Robust H_∞/H_2 Controller Design with Regional Poles Constraint of a Pump-Motor System 被引量:1
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作者 郭初生 王向周 王渝 《Journal of Beijing Institute of Technology》 EI CAS 2006年第1期57-61,共5页
The time domain guideposts requirements of a pump-motor system is transfered into a series of constraints which express the robust performance upper bound and regional poles limits of the closed loop system. Then the ... The time domain guideposts requirements of a pump-motor system is transfered into a series of constraints which express the robust performance upper bound and regional poles limits of the closed loop system. Then the servo system control problem is transferred into the problem of robust performance optimizing under regional poles constrains described by linear matrix inequality (LMI). These LMIs are easy to solve through the Matlab LMI-toolbox. Simulations indicate that the controller has excellent dynamic, static and disturbance rejection performance, and the control system is robust and has perfect H2 performance to the bounded external torque disturbance. 展开更多
关键词 linear matrix inequality (LMI) H∞/H2 robust control regional poles placement pump-motor system servo system
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Research on Combined Hot Extrusion Forming Process of Alternator Poles 被引量:1
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作者 Cheng Yang Shengdun Zhao 《Journal of Materials Science and Chemical Engineering》 2013年第5期16-22,共7页
Based on the structure analysis of alternator poles, two closed die forging steps in one heat forming process of alternator poles were put forward, as well as the forming die system. Firstly, a thicker bottom base of ... Based on the structure analysis of alternator poles, two closed die forging steps in one heat forming process of alternator poles were put forward, as well as the forming die system. Firstly, a thicker bottom base of alternator poles was per-formed by radial forging, then the middle boss and pole claw were forming on the bottom base by backward extrusion. A 3-D coupled thermo-mechanical finite element model was created. The billet deformation, metal flow and forming load were obtained. The results showed that a filling well forging without overlap defects could be obtained by this process, and that?the forming load at the first step increased slowly, but the load increased sharply at the second step when the middle boss was filling completely by the former process. An improved process was put forward, which changed the flow mode in the second forging step, it can considerably reduce the final forging load. 展开更多
关键词 Radial FORGING BACKWARD EXTRUSION ALTERNATOR poles CLOSED Die FORGING
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GFRP Poles for Traffic Signs and Signal Poles: A Case Study in Saudi Arabia
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作者 Waseem Ahmad Khatri Muhammed Al Mehthel +1 位作者 Mirza M. Baig Tariq Al Baker 《Open Journal of Civil Engineering》 CAS 2022年第4期476-491,共16页
GFRP poles have been widely used as lighting poles but their use as traffic signs and signal poles is still under development. This paper highlights the literature review and case study of using GFRP poles for traffic... GFRP poles have been widely used as lighting poles but their use as traffic signs and signal poles is still under development. This paper highlights the literature review and case study of using GFRP poles for traffic signs and signal poles in the Eastern Province of Saudi Arabia. The case study details the design of poles, construction, maintenance and their performance. Traffic sign poles were manufactured using filament winding and signal poles using pultrusion process. AASHTO Standard “Specifications for Structural Supports for Highway Signs, Luminaires and Traffic Signals” and ANSI 136.2. were used as materials specification and design for the pole. There is a need to develop dedicated design and construction guidelines to standardize the construction process. Further study about the crash resistance of GFRP poles at different speeds needs to be explored. In addition, the paper presents a high level comparison between the different materials like weight, safety, environmental degradation, strength, service life, durability in an aggressive environment, carbon footprint and economics. 展开更多
关键词 Glass Fiber Reinforced Plastics (GFRP) poles FOUNDATIONS Filament Winding PULTRUSION
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POLES DISTRIBUTION OF THE BLOOD FLOW IN THE UMBILICAL ARTERY
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《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第4期69-70,共2页
关键词 WANG poles DISTRIBUTION OF THE BLOOD FLOW IN THE UMBILICAL ARTERY
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Adobe Telephone Wire Poles in Tibet
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作者 TUBDAIN 《China's Tibet》 1999年第6期14-14,共1页
关键词 Adobe Telephone Wire poles in Tibet
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Research on the Casting-forging Precision Forming Process of Alternator Poles 被引量:6
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作者 CHEN Hui-qin, WANG Quan-cong, GUO Hui-guang (Material Science and Engineering Department, Taiyuan Heavy Machinery Institute, Taiyuan 030024, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期4-5,共2页
The casting-forging combined technique and the closed die forging without flash-less are both new developed material working methods. The former can not only decrease forming operations of forgings, but also increase ... The casting-forging combined technique and the closed die forging without flash-less are both new developed material working methods. The former can not only decrease forming operations of forgings, but also increase the material utilization ratio. Therefore, it is applied to produce more complex forgings. The latter is required for forging precise parts without burrs. The alternator pole is a complex forging, which was usually produced by hot forging, upsetting-extrusion or upsetting-extrusion and bending processes. During these processes, not only the forming force is higher, but the material of burrs accounts for 30 percent or so of total required material. And burrs are difficult to remove in the sequential machining process. In accordance with defects exiting in current manufacturing of alternator poles by upsetting-extruding process, such as more material demand, higher forming force and difficulty of next machining, a casting-forging precision process of alternator poles was developed and investigated in this paper. In the process, the pole was formed by two operations. One is the pre-forming operation by casting. The other is the final forming operation by the closed precision forging process. This can not only shorten processes, decrease material and power demand, but also increase precision of forgings. First, the casting blocker was designed considering the casting process and the forging ratio and the mode of deformation. Then the die structure for closed precision forging was designed, and the closing device for forging dies with spring assemblies in order to provide the necessary closing force was also designed. Finally the forming processes was investigated by test and numerical simulation method to optimum process parameters and die structure design parameters. The result can provide basis for applying the process to manufacture poles in practice. 展开更多
关键词 alternator pole casting-forging precision forming process
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AN INEQUALITY ON THE ZEROS AND POLES OF VECTOR VALUED MEROMORPHIC FUNCTIONS 被引量:1
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作者 吴昭君 《Acta Mathematica Scientia》 SCIE CSCD 2014年第2期380-386,共7页
The author proves that if f : C → C^n is a transcendental vector valued mero-morphic function of finite order and assume, This result extends the related results for meromorphic function by Singh and Kulkarni.
关键词 Characteristic function vector valued meromorphic function ZERO POLE
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Collecting Traffic Video Data Using Portable Poles: Survey, Proposal, and Analysis 被引量:2
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作者 Morten B. Jensen Chris H. Bahnsen +2 位作者 Harry S. Lahrmann Tanja K. O. Madsen Thomas B. Moeslund 《Journal of Transportation Technologies》 2018年第4期376-400,共25页
Several initiatives have been launched to help prevention of traffic accidents and near-accidents across the European Union. To aid the overall goal of reducing deaths and injuries related to traffic, one must underst... Several initiatives have been launched to help prevention of traffic accidents and near-accidents across the European Union. To aid the overall goal of reducing deaths and injuries related to traffic, one must understand the causation of the traffic accidents in order to prevent them. Rather than deploying a person to physically monitor a location, the task is eased by camera equipment installed in existing infrastructure, e.g. poles, and buildings, etc. In rural areas there is however a very limited infrastructure available which complicates the data acquisition. But even if there is infrastructure available in either the rural area or the urban area, this might not serve as an ideal position to capture video data from. In this work, we survey and provide an overview of available and relevant portable poles setups with respect to capturing data in both urban areas and rural areas. The conclusion of the survey shows a lack of a mobile, lightweight, compact, and easy deployable portable pole. We therefore design and develop a new portable pole meeting these requirements. The new proposed portable pole can be deployed by 2 persons in 2 hours in both rural areas as well as urban areas due to its compactness. The deployment and usage of the new portable pole is a complimentary tool, which may improve the camera capturing angle in case existing infrastructure is insufficient. This ultimately improves the traffic monitoring opportunities. Further, the survey of selected portable poles provides an excellent overview and can aid multiple applications within road traffic. 展开更多
关键词 Road TRAFFIC Video ANALYSIS Camera MOUNTING Pole PORTABLE
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Torque Calculation of Five-Phase Synchronous Reluctance Motors With Shifted-Asymmetrical-Salient-Poles Under Saturation Condition 被引量:2
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作者 Qian Chen Xuping Shi +1 位作者 Gaohong Xu Wenxiang Zhao 《CES Transactions on Electrical Machines and Systems》 CSCD 2020年第2期105-113,共9页
In traditional analytical method(AM),the magnetic saturation is always ignored to simplify the calculation process.However,synchronous reluctance motors(SynRMs)often operate around saturation point to achieve higher t... In traditional analytical method(AM),the magnetic saturation is always ignored to simplify the calculation process.However,synchronous reluctance motors(SynRMs)often operate around saturation point to achieve higher torque density.Therefore,a new AM is proposed,in which the saturation of stator iron has been considered.The key of the proposed method includes a saturation factor,and an iterative method is adopted to compute the saturation factor in the SynRM by increasing the air-gap length.Especially,the proposed AM can be applied to a SynRM even with shifted-asymmetrical-salient-poles.In the process of AM,the expression of stator magnetomotive force(MMF)is built firstly.Additionally,the air-gap density including slotting effect and salient-poles is calculated.Then,the rotor MMF under saturation of the stator iron is obtained.Therefore,the precision of the instantaneous torque can be improved significantly.Eventually,by the verification of finite elements method(FEM)and experiments,the torque performance of SynRMs with shifted asymmetrical rotor can be predicted accurately by the proposed AM. 展开更多
关键词 Synchronous reluctance motors TORQUE shifted asymmetrical salient pole analytical method saturation.
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A Dynamic Model for a Single Helicopter in the Low Airspace with Telegraph Poles and Electrical Wire
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作者 唐铁桥 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第12期1149-1154,共6页
In this paper, we propose a dynamic model for a single helicopter in the low airspace with telegraph poles and electrical wire. The numerical results show that the proposed model can qualitatively describe the helicop... In this paper, we propose a dynamic model for a single helicopter in the low airspace with telegraph poles and electrical wire. The numerical results show that the proposed model can qualitatively describe the helicopter's velocity, safe distances, and safe sphere when it runs across the obstacle consisting of telegraph poles and electricaJ wire. 展开更多
关键词 HELICOPTER telegraph pole electrical wire safe distance dynamic model
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Reducing Greenhouse Gas Emissions through Improving the Life Span of Wooden Power Electric Poles of Eucalyptus saligna
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作者 Joseph Voufo Zakari Yaou +3 位作者 Florent Biyeme Rolland Djomi Richard Dadji Metangmo Théodore Tchotang 《Modern Mechanical Engineering》 2022年第1期1-26,共26页
The present work deals with reducing greenhouse gas emissions through improving the life span of wooden power electric poles of Eucalyptus saligna. Indeed, in Sub-Saharan African countries, Cameroon in particular, mos... The present work deals with reducing greenhouse gas emissions through improving the life span of wooden power electric poles of Eucalyptus saligna. Indeed, in Sub-Saharan African countries, Cameroon in particular, most of the power line networks are made of wooden supports and according to the Cameroon energy distribution company, wooden poles represent 32% of the causes of death linked to the state of the network. The company’s 2019 annual report indicates that 40,000 wooden poles were in critical condition and should be replaced. A significant number of mechanical failures affecting these supports have been observed. For example, on the HVA/LV power line “D17 Nko- abang” in Yaoundé in Cameroon, less than three years old, 10 (ten) cases of poles falling and/or breaking, due to their mechanical loading, were observed over a period of fewer than nine months, causing an average service stoppage for more than 11 hours and affecting an average of 3280 customers. These incidents lead to questions about how the supports are dimensioned and what load capacities they are designed to support. The aim of this work is, therefore, to suggest a method of dimensioning wooden poles hence reducing green- house gas emissions due to the deforestation by reducing the number of woo- den poles at risk to be replaced on Cameroon’s electricity distribution network. And more specifically, to reduce the number of mechanical failures affecting the wooden supports observed by analyzing the current wooden supports with their loads and to make proposals for improving the actual dimensioning me- thods. From the study carried out, it appears that 449 out of 845 supports, i.e., 53% needed to be replaced or monitored because they support the nominal forces ranging from 85% to 150% of their admissible limit and proposals have been made to improve their dimensioning. 展开更多
关键词 Electrical Power Line Dimensioning Wooden Pole Efforts on Pole Pole’s Height Method of Loading Overload Coefficients
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Planar matrices and arrays of Feynman diagrams:poles for higher k
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作者 Alfredo Guevara Yong Zhang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2024年第4期1-13,共13页
Planar arrays of tree diagrams were introduced as a generalization of Feynman diagrams that enable the computation of biadjoint amplitudes m_(n)(^(k))for k>2.In this follow-up work,we investigate the poles of m_(n)... Planar arrays of tree diagrams were introduced as a generalization of Feynman diagrams that enable the computation of biadjoint amplitudes m_(n)(^(k))for k>2.In this follow-up work,we investigate the poles of m_(n)(^(k))from the perspective of such arrays.For general k,we characterize the underlying polytope as a Flag Complex and propose a computation of the amplitude-based solely on the knowledge of the poles,whose number is drastically less than the number of the full arrays.As an example,we first provide all the poles for the cases(k,n)=(3,7),(3,8),(3,9),(3,10),(4,8)and(4,9)in terms of their planar arrays of degenerate Feynman diagrams.We then implement simple compatibility criteria together with an addition operation between arrays and recover the full collections/arrays for such cases.Along the way,we implement hard and soft kinematical limits,which provide a map between the poles in kinematic space and their combinatoric arrays.We use the operation to give a proof of a previously conjectured combinatorial duality for arrays in(k,n)and(n-k,n).We also outline the relation to boundary maps of the hypersimplex Δ_(k,n) and rays in the tropical Grassmannian Tr(k,n). 展开更多
关键词 Feynman diagrams biadjoint amplitudes poles
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具有POLE致病性突变子宫内膜癌的临床病理及分子特征分析
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作者 蔡宇梦 周杨 +4 位作者 汪昊 庞钧译 吴焕文 师晓华 梁智勇 《诊断病理学杂志》 2024年第4期282-286,322,共6页
目的探讨具有POLE致病性突变子宫内膜癌(EC)的临床病理及分子特征。方法选取179例EC患者,根据POLE基因突变、错配修复(MMR)蛋白表达及p53表达/TP53突变进行分子分型,分析POLE mut型EC的临床病理及分子特征。结果POLE mut20例,MMRd 48例,... 目的探讨具有POLE致病性突变子宫内膜癌(EC)的临床病理及分子特征。方法选取179例EC患者,根据POLE基因突变、错配修复(MMR)蛋白表达及p53表达/TP53突变进行分子分型,分析POLE mut型EC的临床病理及分子特征。结果POLE mut20例,MMRd 48例,NSMP 90例,p53 abn 21例。POLE mut EC多为FIGOⅠ期(17/20),中-低分化子宫内膜样癌(EEC)(13/20)、局限于内膜/浅肌层(17/20)、肿瘤浸润性淋巴细胞(TILs)显著(17/20)、无/局灶(LVSI)(18/20)、无淋巴结转移(19/20)。4个亚组间临床病理特征的差异均有统计学意义(P<0.05)。POLE mut型预后最好,具有多重分类特征的病例预后更接近POLE mut型。结论POLE mut EC提示着较高的组织学分级,较早的临床分期及较好的预后;POLE mut可继发dMMR/MSI-H表型及p53/TP53异常,应归类为POLE mut型。 展开更多
关键词 子宫内膜癌 分子分型 POLE 错配修复缺陷 TP53
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Surface energy budget diagnosis reveals possible mechanism for the different warming rate among Earth’s three poles in recent decades 被引量:18
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作者 Kailun Gao Anmin Duan +1 位作者 Deliang Chen Guoxiong Wu 《Science Bulletin》 SCIE EI CAS CSCD 2019年第16期1140-1143,共4页
With the introduction of the‘‘Third Pole'[1],the Arctic,Antarctic,and Tibetan Plateau(TP)can be collectively referred to as the‘‘three poles of the Earth'.The cryosphere is an important component of the cl... With the introduction of the‘‘Third Pole'[1],the Arctic,Antarctic,and Tibetan Plateau(TP)can be collectively referred to as the‘‘three poles of the Earth'.The cryosphere is an important component of the climate system because of its effect on Earth’s surface albedo and its role in reducing the amount of heat exchanged between the atmosphere and ocean or land(2)As the dominant parts of the cryosphere,the Arctic,Antarctic,and TP are pivotal and sensitive areas of global climate change.Global warming will weaken the inherent stability of the cryosphere,such as its ice shelves,glaciers and permafrost[3,4]. 展开更多
关键词 energy budget WARMING Earth’s three poles
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Co-varying temperatures at 200 hPa over the Earth’s three poles 被引量:1
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作者 Keyan FANG Peng ZHANG +1 位作者 Jingming CHEN Deliang CHEN 《Science China Earth Sciences》 SCIE EI CSCD 2021年第2期340-350,共11页
The Earth’s three poles,the North Pole,South Pole,and Third Pole(i.e.,the Tibetan Plateau and its surroundings),hold the largest amount of fresh water on Earth as glaciers,sea ice,and snow.They are sensitive to clima... The Earth’s three poles,the North Pole,South Pole,and Third Pole(i.e.,the Tibetan Plateau and its surroundings),hold the largest amount of fresh water on Earth as glaciers,sea ice,and snow.They are sensitive to climate change.However,the linkages between climate variations of the three poles,particularly between the South Pole and Third Pole,remain largely unknown.The temperatures at 200 hPa over the three poles are the highest in the summer and are less affected by surface conditions,which could reflect large-scale dynamic linkages.Temperatures at 200 hPa peak the three poles during their respective hemispheric summer and exhibit in-phase variations on interdecadal timescales(10–100 years).The 200 hPa temperatures over the North Pole and South Pole were significantly correlated with the Brewer-Dobson circulation(BDC),which transports stratospheric ozone poleward,heating the air at 200 hPa.Tropopause warming over the Third Pole was found to enhance the poleward BDC,particularly to the South Pole,linking the Third Pole’s climate to the other two poles.Additionally,the Interdecadal Pacific Oscillation(IPO)also exhibits links with the 200 hPa temperatures of the three poles. 展开更多
关键词 Three poles Tibetan Plateau Brewer-Dobson circulation Interdecadal Pacific Oscillation Climate teleconnection
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Five-phase Synchronous Reluctance Machines Equipped with a Novel Type of Fractional Slot Winding
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作者 S.M.Taghavi Araghi A.Kiyoumarsi B.Mirzaeian Dehkordi 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第3期264-273,共10页
Multi-phase machines are so attractive for electrical machine designers because of their valuable advantages such as high reliability and fault tolerant ability.Meanwhile,fractional slot concentrated windings(FSCW)are... Multi-phase machines are so attractive for electrical machine designers because of their valuable advantages such as high reliability and fault tolerant ability.Meanwhile,fractional slot concentrated windings(FSCW)are well known because of short end winding length,simple structure,field weakening sufficiency,fault tolerant capability and higher slot fill factor.The five-phase machines equipped with FSCW,are very good candidates for the purpose of designing motors for high reliable applications,like electric cars,major transporting buses,high speed trains and massive trucks.But,in comparison to the general distributed windings,the FSCWs contain high magnetomotive force(MMF)space harmonic contents,which cause unwanted effects on the machine ability,such as localized iron saturation and core losses.This manuscript introduces several new five-phase fractional slot winding layouts,by the means of slot shifting concept in order to design the new types of synchronous reluctance motors(SynRels).In order to examine the proposed winding’s performances,three sample machines are designed as case studies,and analytical study and finite element analysis(FEA)is used for validation. 展开更多
关键词 Finite element analysis Five-phase machine Fractional slot concentrated winding(FSCW) Machine slot/pole combination MMF harmonics Synchronous reluctance machine Winding factor
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Progress of International Meridian Circle Program
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作者 WANG Chi BLANC Michel +13 位作者 ZHANG Shunrong DENARDINI Clezio Marcos LIU William SHEN Xuhui WU Jian XU Jiyao LI Hui ZHANG Qinghe REN Liwen ZHU Yajun LI Guozhu DING Zonghua LIU Zhengkuan YANG Fang 《空间科学学报》 CAS CSCD 北大核心 2024年第4期741-745,共5页
In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the I... In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to Earth.Additionally,it monitors various disturbances generated within the Earth system that impact geospace.Over the past two years,significant progress has been made on the IMCP.In particular,the second phase of construction for the China-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active construction.The 2024 IMCP joint observation campaign was successfully conducted.To facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by Chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil. 展开更多
关键词 Chinese Meridian Project(CMP) International Meridian Circle Program(IMCP) China-Brazil Joint Laboratory for Space Weather North Pole and Southeast Asia networks
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Fibrillarin redistributes to the spindle poles and partially colocalizes with NuMA during mitosis
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作者 Yan Guo Chaoliang Wei +2 位作者 Jinsong Hu Mingxiao Ding Jianguo Chen 《Chinese Science Bulletin》 SCIE EI CAS 2002年第23期1995-1998,2027-2028,共6页
Fibrillann, a major protein in the nucleolus. is known to redistribute during mitosis from the nucleolus to the cytosol, and is related to the dynamics of post-mitotic reassembly of the nucleolus. To better understand... Fibrillann, a major protein in the nucleolus. is known to redistribute during mitosis from the nucleolus to the cytosol, and is related to the dynamics of post-mitotic reassembly of the nucleolus. To better understand the dynamic behavior and the relationship with other cytoplasmic structures, we have now expressed fibrillarin-pDsRedl fusion protein in HeLa cells. The results showed that a part of fibrillarin was associated with mitotic spindle poles in the mitotic cells. Nocodazole-induced microtubule depolymeri-zation resulted in fibrillarin redistribution throughout the cytoplasm, and removal of nocodazole resulted in relocaliza-tion of fibrillarin at the polar region during the mitotic spindles reassembly. In a mitotic cell free system, fibrillarin was found in the center of taxol-induced microtubule asters. Moreover, fibrillarin was found to colocalize with the nuclear mitotic apparatus protein (NuMA) at the poles of mitotic cells. Therefore, it is postulated that the polar redistribution of 展开更多
关键词 FIBRILLARIN MITOTIC spindle poles CENTROSOME NuMA.
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子宫内膜癌分子分型的研究进展
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作者 赵伟 《医学理论与实践》 2024年第20期3451-3453,3456,共4页
子宫内膜癌是女性生殖系统常见的恶性肿瘤,临床工作根据形态学特点及激素依赖性将其分为两个亚型,即激素依赖型和非激素依赖型。2013年癌症基因组图谱网络根据不同的分子特征将子宫内膜癌分为4个分子亚型,即POLE突变型、微卫星不稳定型... 子宫内膜癌是女性生殖系统常见的恶性肿瘤,临床工作根据形态学特点及激素依赖性将其分为两个亚型,即激素依赖型和非激素依赖型。2013年癌症基因组图谱网络根据不同的分子特征将子宫内膜癌分为4个分子亚型,即POLE突变型、微卫星不稳定型、低拷贝数变异型、高拷贝数变异型。但该分组方法需要基因组测序,成本昂贵、操作复杂,不适合广泛的临床应用。因此,在这个分子分型的基础上MC Alpine团队在2015年对该方法进行改良,提出子宫内膜癌的主动分子风险分类器,并在2018年确定分类器的最终验证步骤。这个主动分子风险分类器已被广泛应用。 展开更多
关键词 子宫内膜癌 分子分型 POLE突变型 微卫星不稳定型 高拷贝数变异型 低拷贝数变异型
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