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Preparation and Characterization for Bispecific Antibodies of Anti-CD3×Anti-Idiotype to BCellLym phocytic Leukem ia
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作者 SHEN Guanxin , ZHANG Yue , ZHU Huifen , YANG Jing , WANG Xiaolin Department of Immunology, School of Basic Medical Sciences, Tongji Medical University, Wuhan 430030 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第3期166-169,共4页
Bispecific antibodies (BsAbs) of anti CD3×anti idiotype (Id) to B cell lymphocytic leukemia (CLL) were prepared by chemical conjugation and direct hybridization technique of hybridoma and hybridoma without scr... Bispecific antibodies (BsAbs) of anti CD3×anti idiotype (Id) to B cell lymphocytic leukemia (CLL) were prepared by chemical conjugation and direct hybridization technique of hybridoma and hybridoma without screening markers. The specificity of BsAbs from culture supernatants or ascites was assayed by indirect ELISA and indirect immunoflurescence (IF). The results showed that BsAbs could specifically react with homologous serum IgM from patients with B CLL and cells carrying CD3 marker respectively. Cell combination test and LDH assay demonstrated that BsAb significantly increased the conjugate formation between lymphocyte activated kill (LAK) cells and Daudi cells, and enhanced the cytotoxic activity of LAK cells against Daudi cells. 展开更多
关键词 B chronic lymphocytic leukemia bispecific antibody quadruma chemical conjugation
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