Some of the progress made in our laboratories in collaboration with industry in research and development work on high performance oxide-nonoxide composites for metallurgical applications has been reviewed. （1） SiAlO...Some of the progress made in our laboratories in collaboration with industry in research and development work on high performance oxide-nonoxide composites for metallurgical applications has been reviewed. （1） SiAlON bonded corundum composites for blast furnace usage have been produced by reduction-nitridation sinte-ring at high temperature, using bauxite instead of alu-mina in the matrix. （2） Low carbon Al2O3 - SiAlON slide plate materials successfully used in high quality steel continuous casting have been developed in which most or all of the graphite in Al2O3 - C brick is replaced by bauxite-based β-SiAlON. （3） A1/Si metal bonded A12 03 - C material characterized by low carbon content, low firing temperature and in-situ formation of carbides and nitrides at high temperature during service are found to possess very high hot strength and very good thermal shock resistance and have also been successfully used as slide plates in ladles and tundishes for high quality steel casting.展开更多
Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum th...Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.展开更多
In 1981,Nanyang Technological Institute was established in Singapore to train engineers and accountants to keep up with the fast-growing economy of the country.In 1991,the institute was upgraded to Nanyang Technologic...In 1981,Nanyang Technological Institute was established in Singapore to train engineers and accountants to keep up with the fast-growing economy of the country.In 1991,the institute was upgraded to Nanyang Technological University(NTU).NTU holds the rank for world's top young university for six consecutive years according to the Quacquarelli Symonds(QS)world university ranking.Virtual Reality(VR)research began in NTU in the late 1990s.NTU's colleges,schools,institutes,and centers have contributed toward the excellence of VR research.This article briefly describes the VR research directions and activities in NTU.展开更多
The full name of CISRI is Central Iron&Steel Research Institute under the Ministry of Metallurgical Industry in China.It is the largest institute of metallurgical process research in China(the word"large"...The full name of CISRI is Central Iron&Steel Research Institute under the Ministry of Metallurgical Industry in China.It is the largest institute of metallurgical process research in China(the word"large"here refers to various fields,large personnel and many research projects).It includes ironmaking,steel-making,cold and hot processing of steel,metallic product,ferroalloy,refractory,automatic metallurgy control,design展开更多
Broadband Wireless Access (BWA) has become one of the major evolution trends in the fields of broadband access and mobile communications. However,some difficulties emerged during the application and industrialization ...Broadband Wireless Access (BWA) has become one of the major evolution trends in the fields of broadband access and mobile communications. However,some difficulties emerged during the application and industrialization of the BWA system,which calls for typical service models,key technology innovations and backbone support from broadband Internet. This article introduces a Broadband Wireless Multimedia (BWM) access system. It aims to build a new-type "triple play" BWA network by integrating terrestrial digital TV system and the BWA system,and by taking broadband Internet as its core network platform. A primary research shows that the new BWA system is an effective solution to the existing difficulties of BWA system. Moreover,it is quite competitive in service provision,service coverage,frequency planning,terminal power consumption and cost for network construction.展开更多
Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Method...Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.展开更多
Tsinghua-TOYO Research and Development Center of Magnesium and Aluminum Alloys Processing Technology was officially established between Tsinghua University and TOYO Machinery & Metal Co. on Feb. 26, 2002, which is...Tsinghua-TOYO Research and Development Center of Magnesium and Aluminum Alloys Processing Technology was officially established between Tsinghua University and TOYO Machinery & Metal Co. on Feb. 26, 2002, which is a non-independent legal research organization located in Department of Mechanical Engineering of Tsinghua University. The center was equipped with one set of 650t automatic magnesium and aluminum alloys diecasting machine and necessary accessories including the melting furnaces for magnesium alloys and aluminum alloys, an accurate magnesium pump to transfer the magnesium alloys to the shot sleeve of the die casting machine, a die temperature controller, and data logging systems for cavity pressure and die temperature distributions, etc. The center is aimed to the research and development of magnesium and aluminum die casting process and their related technologies, and the main research contents include:展开更多
The Institute for Agricultural Research,Samaru,has the national mandate for genetic improvement and development of production technologies for cotton,maize,sorghum,cowpea,groundnut,
Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy ...Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.展开更多
Pharmaceutical technology is an indispensable and important link in drug research and development,which plays a key role in drug research and development quality.In the background of science and technology development...Pharmaceutical technology is an indispensable and important link in drug research and development,which plays a key role in drug research and development quality.In the background of science and technology development,pharmaceutical technology has been greatly developed,but also to promote the quality of drug research and development,to provide more guarantee for people’s health.In the new era,how to achieve pharmaceutical technology innovation,so as to further improve the quality of drug research and development,is an important research topic in the current related industries.This paper mainly revolves around quality of pharmaceutical technology development of a series of exploration,in the traditional drug development based on a better control of drug quality,the future of smart pharmaceutical green pharmaceutical development direction,aims to further enhance the pharmaceutical technology,promote the quality of research and development to promote the comprehensive,promote the steady development of the pharmaceutical industry as a whole.展开更多
There are many access ends and information asymmetry in the management of offshore platform production facility personnel information. In the actual business, the problem is decomposed and a multi-layer logical archit...There are many access ends and information asymmetry in the management of offshore platform production facility personnel information. In the actual business, the problem is decomposed and a multi-layer logical architecture is selected to design and develop the POB plan management module applicable to offshore platform facilities. The main functions of this module include task management, facility management, area management, sea-going unit management, plan management, report management, authority control, and comprehensive query. It can efficiently solve on-site business problems and improve the efficiency of POB plan management for various professionals on land and at sea. In actual use, the module can well assist in completing POB plan management tasks and improve work efficiency.展开更多
In comparison with copper processing industrial leader Furukawa Electric Co., Ltd., Chinese copper processing industry faces many shortcomings and difficulties including but not limited to outdated equipment and techn...In comparison with copper processing industrial leader Furukawa Electric Co., Ltd., Chinese copper processing industry faces many shortcomings and difficulties including but not limited to outdated equipment and technologies, low degree of specialization, and unstable product quality. The review of Furukawa Electric’s development milestones reveals that Chinese copper processing industry has reached a stage in which it must rely on technological research and development (R & D) to promote sustainable productivity. Chinese copper processing firms have to invest in R & D to promote sustainable technological innovations and to improve the precisions of business practice in order to ensure the firms’ improvement.展开更多
As far as Chinese herbal medicine resources are concerned,China is one of the countries with the richest biodiversity in the world.As for the future development direction of Chinese skin care products,the development ...As far as Chinese herbal medicine resources are concerned,China is one of the countries with the richest biodiversity in the world.As for the future development direction of Chinese skin care products,the development of special Chinese herbal skin care products is an important issue.The technical route for the research and development(R&D)of Chinese herbal-medicine skin care products should focus on“combining ancient and modern,combining Chinese and Western”,that is to say combining the ancient knowledge and wisdom with modern science and technology,and combining Chinese traditional therapy with western pharmacology.This article will elaborate the five stages of developing innovative Chinese herbal skin care products:pondering and thinking stage;extraction and purification stage;experimental evaluation stage;quality index establishment stage;product development stage.The key points of these five stages can provide a reference for the cosmetics R&D personnel.This project will be beneficial to the development of Chinese herbal-medicine skin care products and the formulation of an overall effective development strategy,which is helpful to actively respond to new challenges and continuously improve product competitiveness,so as to vigorously build a world-renowned high-end cosmetic brand in China,and strive to cultivate a world-class cosmetics talent team.展开更多
Objective To help investors assess and control the costs of new drug development and reduce the risks of new drug development projects.Methods Cost analysis and financial forecasting were carried out with the integrat...Objective To help investors assess and control the costs of new drug development and reduce the risks of new drug development projects.Methods Cost analysis and financial forecasting were carried out with the integrated approach of earned value management.According to the principle of earned value management deviation analysis,the basic process of the new drug research and development project was combined with the hypothesis method from the research of Tufts Drug Development Research Center.Results and Conclusion If the project progress check was carried out in the clinical trial,the project costs were found overspent,the efficiency was low,the project progress was faster,and the resource investment was ahead.It is recommended that the adjustment should be made to reduce the input of resources,and increase the efficient key personnel to take the place of some less efficient staff.展开更多
The Single European Sky Air Traffic management(ATM)Research(SESAR)project is the technological pillar of the European Commission’s Single European Sky Initiative to modernize ATM.Here,we describe the process of estab...The Single European Sky Air Traffic management(ATM)Research(SESAR)project is the technological pillar of the European Commission’s Single European Sky Initiative to modernize ATM.Here,we describe the process of establishing SESAR and the main parts of the project:the research and development(R&D)part,which is led by the SESAR Joint Undertaking;the deployment part,which is managed by the SESAR Deployment Manager;and the European ATM Master Plan,which collects and lays out both the R&D and deployment needs.The latest European ATM Master Plan was adopted just prior to the current pandemic.The huge loss in air traffic due to the pandemic,and the speed of the recovery of the aviation industry will require reprioritization,but the main elements that have been established-particularly those in support of the environment-remain valid.展开更多
文摘Some of the progress made in our laboratories in collaboration with industry in research and development work on high performance oxide-nonoxide composites for metallurgical applications has been reviewed. （1） SiAlON bonded corundum composites for blast furnace usage have been produced by reduction-nitridation sinte-ring at high temperature, using bauxite instead of alu-mina in the matrix. （2） Low carbon Al2O3 - SiAlON slide plate materials successfully used in high quality steel continuous casting have been developed in which most or all of the graphite in Al2O3 - C brick is replaced by bauxite-based β-SiAlON. （3） A1/Si metal bonded A12 03 - C material characterized by low carbon content, low firing temperature and in-situ formation of carbides and nitrides at high temperature during service are found to possess very high hot strength and very good thermal shock resistance and have also been successfully used as slide plates in ladles and tundishes for high quality steel casting.
文摘Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.
文摘In 1981,Nanyang Technological Institute was established in Singapore to train engineers and accountants to keep up with the fast-growing economy of the country.In 1991,the institute was upgraded to Nanyang Technological University(NTU).NTU holds the rank for world's top young university for six consecutive years according to the Quacquarelli Symonds(QS)world university ranking.Virtual Reality(VR)research began in NTU in the late 1990s.NTU's colleges,schools,institutes,and centers have contributed toward the excellence of VR research.This article briefly describes the VR research directions and activities in NTU.
文摘The full name of CISRI is Central Iron&Steel Research Institute under the Ministry of Metallurgical Industry in China.It is the largest institute of metallurgical process research in China(the word"large"here refers to various fields,large personnel and many research projects).It includes ironmaking,steel-making,cold and hot processing of steel,metallic product,ferroalloy,refractory,automatic metallurgy control,design
文摘Broadband Wireless Access (BWA) has become one of the major evolution trends in the fields of broadband access and mobile communications. However,some difficulties emerged during the application and industrialization of the BWA system,which calls for typical service models,key technology innovations and backbone support from broadband Internet. This article introduces a Broadband Wireless Multimedia (BWM) access system. It aims to build a new-type "triple play" BWA network by integrating terrestrial digital TV system and the BWA system,and by taking broadband Internet as its core network platform. A primary research shows that the new BWA system is an effective solution to the existing difficulties of BWA system. Moreover,it is quite competitive in service provision,service coverage,frequency planning,terminal power consumption and cost for network construction.
文摘Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.
文摘Tsinghua-TOYO Research and Development Center of Magnesium and Aluminum Alloys Processing Technology was officially established between Tsinghua University and TOYO Machinery & Metal Co. on Feb. 26, 2002, which is a non-independent legal research organization located in Department of Mechanical Engineering of Tsinghua University. The center was equipped with one set of 650t automatic magnesium and aluminum alloys diecasting machine and necessary accessories including the melting furnaces for magnesium alloys and aluminum alloys, an accurate magnesium pump to transfer the magnesium alloys to the shot sleeve of the die casting machine, a die temperature controller, and data logging systems for cavity pressure and die temperature distributions, etc. The center is aimed to the research and development of magnesium and aluminum die casting process and their related technologies, and the main research contents include:
文摘The Institute for Agricultural Research,Samaru,has the national mandate for genetic improvement and development of production technologies for cotton,maize,sorghum,cowpea,groundnut,
文摘Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.
文摘Pharmaceutical technology is an indispensable and important link in drug research and development,which plays a key role in drug research and development quality.In the background of science and technology development,pharmaceutical technology has been greatly developed,but also to promote the quality of drug research and development,to provide more guarantee for people’s health.In the new era,how to achieve pharmaceutical technology innovation,so as to further improve the quality of drug research and development,is an important research topic in the current related industries.This paper mainly revolves around quality of pharmaceutical technology development of a series of exploration,in the traditional drug development based on a better control of drug quality,the future of smart pharmaceutical green pharmaceutical development direction,aims to further enhance the pharmaceutical technology,promote the quality of research and development to promote the comprehensive,promote the steady development of the pharmaceutical industry as a whole.
文摘There are many access ends and information asymmetry in the management of offshore platform production facility personnel information. In the actual business, the problem is decomposed and a multi-layer logical architecture is selected to design and develop the POB plan management module applicable to offshore platform facilities. The main functions of this module include task management, facility management, area management, sea-going unit management, plan management, report management, authority control, and comprehensive query. It can efficiently solve on-site business problems and improve the efficiency of POB plan management for various professionals on land and at sea. In actual use, the module can well assist in completing POB plan management tasks and improve work efficiency.
文摘In comparison with copper processing industrial leader Furukawa Electric Co., Ltd., Chinese copper processing industry faces many shortcomings and difficulties including but not limited to outdated equipment and technologies, low degree of specialization, and unstable product quality. The review of Furukawa Electric’s development milestones reveals that Chinese copper processing industry has reached a stage in which it must rely on technological research and development (R & D) to promote sustainable productivity. Chinese copper processing firms have to invest in R & D to promote sustainable technological innovations and to improve the precisions of business practice in order to ensure the firms’ improvement.
文摘As far as Chinese herbal medicine resources are concerned,China is one of the countries with the richest biodiversity in the world.As for the future development direction of Chinese skin care products,the development of special Chinese herbal skin care products is an important issue.The technical route for the research and development(R&D)of Chinese herbal-medicine skin care products should focus on“combining ancient and modern,combining Chinese and Western”,that is to say combining the ancient knowledge and wisdom with modern science and technology,and combining Chinese traditional therapy with western pharmacology.This article will elaborate the five stages of developing innovative Chinese herbal skin care products:pondering and thinking stage;extraction and purification stage;experimental evaluation stage;quality index establishment stage;product development stage.The key points of these five stages can provide a reference for the cosmetics R&D personnel.This project will be beneficial to the development of Chinese herbal-medicine skin care products and the formulation of an overall effective development strategy,which is helpful to actively respond to new challenges and continuously improve product competitiveness,so as to vigorously build a world-renowned high-end cosmetic brand in China,and strive to cultivate a world-class cosmetics talent team.
文摘Objective To help investors assess and control the costs of new drug development and reduce the risks of new drug development projects.Methods Cost analysis and financial forecasting were carried out with the integrated approach of earned value management.According to the principle of earned value management deviation analysis,the basic process of the new drug research and development project was combined with the hypothesis method from the research of Tufts Drug Development Research Center.Results and Conclusion If the project progress check was carried out in the clinical trial,the project costs were found overspent,the efficiency was low,the project progress was faster,and the resource investment was ahead.It is recommended that the adjustment should be made to reduce the input of resources,and increase the efficient key personnel to take the place of some less efficient staff.
文摘The Single European Sky Air Traffic management(ATM)Research(SESAR)project is the technological pillar of the European Commission’s Single European Sky Initiative to modernize ATM.Here,we describe the process of establishing SESAR and the main parts of the project:the research and development(R&D)part,which is led by the SESAR Joint Undertaking;the deployment part,which is managed by the SESAR Deployment Manager;and the European ATM Master Plan,which collects and lays out both the R&D and deployment needs.The latest European ATM Master Plan was adopted just prior to the current pandemic.The huge loss in air traffic due to the pandemic,and the speed of the recovery of the aviation industry will require reprioritization,but the main elements that have been established-particularly those in support of the environment-remain valid.
