Since recombinant human endostatin (rh-endostatin;Endostar) has been listed 5 years,clinicians have combined it with chemotherapy for the treatment of lung cancers and other malignant tumors,and proved its effect and ...Since recombinant human endostatin (rh-endostatin;Endostar) has been listed 5 years,clinicians have combined it with chemotherapy for the treatment of lung cancers and other malignant tumors,and proved its effect and safety.A number of scholars have explored the application of Endostar alone or in combination with chemotherapy for treatment of malignant serous effusion,finding its high efficiency and low toxicity;and that hydrops controlling is stronger,and that it can significantly improve patients' quality of life.It is worthy of conducting prospective,randomized and multi-center clinical studies and basic researches to clarify the mechanism.展开更多
Objective:To study the effect of exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.Methods:236 cases of patients who were diagnosed as serous eff...Objective:To study the effect of exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.Methods:236 cases of patients who were diagnosed as serous effusion during inpatient in our hospital from January of 2015 to January of 2017 were selected as research objects.According to biopsy and pathological examinations,the diagnostic results were cleared that there were 136 cases of patients with benign serous effusion(benign group)and 100 cases of patients with malignant serous effusion(malignant group).Two groups of patients were both given exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations for tumor markers to analyze the effect of exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.Results:The levels of tumor markers CEA,CA125,CA15-3 and CA19-9 in the benign group were all lower than those in the malignant group,and the difference was of statistical significance(p<0.05).In addition,exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations showed a higher sensitivity,specificity and accuracy than any of the above examinations alone,and the difference was of statistical significance(p<0.05).Conclusions:Exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations can effectively improve the diagnostic accuracy of malignant serous effusion and is worthy of being spread clinically.展开更多
基金Supported by a grant of Key Medical Issue of Nanjing Military Region (No.2007-012007-06)
文摘Since recombinant human endostatin (rh-endostatin;Endostar) has been listed 5 years,clinicians have combined it with chemotherapy for the treatment of lung cancers and other malignant tumors,and proved its effect and safety.A number of scholars have explored the application of Endostar alone or in combination with chemotherapy for treatment of malignant serous effusion,finding its high efficiency and low toxicity;and that hydrops controlling is stronger,and that it can significantly improve patients' quality of life.It is worthy of conducting prospective,randomized and multi-center clinical studies and basic researches to clarify the mechanism.
文摘Objective:To study the effect of exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.Methods:236 cases of patients who were diagnosed as serous effusion during inpatient in our hospital from January of 2015 to January of 2017 were selected as research objects.According to biopsy and pathological examinations,the diagnostic results were cleared that there were 136 cases of patients with benign serous effusion(benign group)and 100 cases of patients with malignant serous effusion(malignant group).Two groups of patients were both given exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations for tumor markers to analyze the effect of exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.Results:The levels of tumor markers CEA,CA125,CA15-3 and CA19-9 in the benign group were all lower than those in the malignant group,and the difference was of statistical significance(p<0.05).In addition,exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations showed a higher sensitivity,specificity and accuracy than any of the above examinations alone,and the difference was of statistical significance(p<0.05).Conclusions:Exfoliative cytology combined with CEA,CA125,CA15-3 and CA19-9 examinations can effectively improve the diagnostic accuracy of malignant serous effusion and is worthy of being spread clinically.
