Effectiveness of Chuzhi Shengfa Tablets Combined with Ketoconazole Shampoo and Chuzhi Shengfa Tablets Combined with 5%Minoxidil Foam in the Treatment of Male Androgenetic Alopecia

Objective:To investigate the clinical efficacy and safety of Chuzhi Shengfa Tablets combined with ketoconazole shampoo and Chuzhi Shengfa Tablets combined with 5%minoxidil foam in the treatment of male androgenetic alopecia.Methods:From July 2022 to July 2023,120 male patients with androgenetic alopecia were selected from our Department of Dermatology and randomly divided into Control Group 1,Control Group 2,Observation Group 1,and Observation Group 2,with 30 patients in each group.Control Group 1 was treated with ketoconazole shampoo,Control Group 2 with 5%minoxidil foam,Observation Group 1 with ketoconazole shampoo combined with Chuzhi Shengfa Tablets,and Observation Group 2 with 5%minoxidil foam combined with Chuzhi Shengfa Tablets.Hair density,hair diameter,scalp oil secretion(using oil secretion scoring),and adverse reactions were compared before and after treatment across the four groups.Results:After treatment,hair density and hair diameter significantly increased in all four groups compared to before treatment,while scalp oil secretion scores significantly decreased(P<0.05).The improvements in Observation Groups 1 and 2 were significantly better than those in Control Groups 1 and 2(P<0.05).No significant differences in the incidence of adverse reactions were observed among the four groups(P>0.05).Conclusion:Chuzhi Shengfa Tablets combined with ketoconazole shampoo and Chuzhi Shengfa Tablets combined with 5%minoxidil foam are both effective and safe for treating male androgenetic alopecia.These combinations can significantly improve hair growth and are worthy of clinical promotion.

New Thai herbal shampoos as pediculicides for killing head louse, Pediculus humanus capitis De Geer(Phthiraptera)

Objective: To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum(C.formosum) + eucalyptus essential oil(EO), C. formosum + citrus EO, Solanum trilobatum+ eucalyptus EO, Solanum trilobatum + citrus EO, Moringa oleifera + eucalyptus EO and Moringa oleifera + citrus EO] for killing all stages of Pediculus humanus capitis(Phthiraptera).Methods: A filter paper contact method was applied with three concentrations(0.05, 0.10 and 0.20 mL/cm^2) of each Thai herbal shampoo as well as permethrin pediculicide(positive control) and drinking water(negative control) against eggs, nymphs and adults of Pediculus humanus capitis. Mortality rates of the eggs were recorded after 7 days of incubation while those of nymphs and adults were recorded after 5 minutes of contact. Results: All herbal shampoos at the high concentration were highly effective against nymphs and adults, but not effective against the eggs. C. formosum + eucalyptus EO and C. formosum + citrus EO shampoos at all concentrations exhibited the highest efficacy against nymphs and adults with100% mortality rate at 5 min and LC_(50) values of 0.004 and 0.005 mL/cm^2, respectively. All formulation of Solanum trilobatum and Moringa oleifera shampoos added with eucalyptus EO showed mortality rates against nymphs at 92.0%-100.0% and 76.0%-100.0% and against adults at 84.0%-100.0% and 20.0%-32.0%, respectively. Permethrin pediculicide was not effective against the eggs, but showed 68.0%-92.0% and 28.0%-60.0% mortality rates against nymphs and adults. Conclusions: These results indicate that C. formosum + eucalyptus EO shampoo can be used as an effective nymphicide and adulticide against Pediculus humanus capitis.

A Case of Serratia marcescens Conjunctivitis in a Young Male after Exposure to Contaminated Shampoo in a Fitness Club

The contamination of shampoo with bacteria is not very common but can happen and can be a potential cause of conjunctivitis. This case report describes a 24-year-old male who developed conjunctivitis after using a Serratia marcescens contaminated shampoo in a fitness club. The patient had redness, swelling, and discharge in both eyes. Cultures of the shampoo and eye swabs were positive for S. marcescens with indistinguishable DNA fingerprints. The patient was treated with an eye drop antibiotic and his symptoms resolved within a week. This case highlights the possibility of exposure in places where shampoos containers are refilled or shared. The avoidance of refilling them and using replaceable cartridges, single-sealed refill bags, or bringing personal shampoo is highly recommended to prevent such incidents.

Patimas Shampoo

Patimas shampoos are three in one——Shampoo,tonic and moisturizer. The shampoo contains the essence ofnatural flowers and Chinese traditionalmedicinal herbs,and are matched with naturalcomposition for stopping itches,removingdandruff and stimulating blood circulation.

Study on the Performance of Sodium Methyl Cocoyl Taurate and Its Application in the Shampoo

The effects of pH and water hardness on the foaming properties of sodium methyl cocoyl taurate and its performance in combination with zwitterionic surfactants were investigated.The irritation of sodium methyl cocoyl taurate and its application in a shampoo formula were also studied.According to the result of experiment,sodium methyl cocoyl taurate had a wide pH stability range and good resistance to hard water,and it showed good synergistic thickening effect with betaine surfactants,especially when mixed with acyl hydroxysulfo betaine;The skin cholesterol dissolution test and red blood cell hemolysis test showed that its irritation was very low.Sodium methyl cocoyl taurate was applied to the transparent shampoo formula,and the sulfate-free transparent shampoo thus prepared had good stability and low eye irritation.It was both mild and non-irritating to skin.

香波——Shampoo

香波是专为洗发用的化妆品,它是一种以表面活性剂制成的液体、固体或粉状制品,使用时能从头发及头皮上去除油污和皮屑,而对头发、头皮和人身健康无不良影响。 香波不单是一种洗涤剂,它还有良好的化妆效果,使头发光亮、美观和顺服。 香波最早是以肥皂或肥皂混合物制成,但目前大多数产品多采用合成洗涤剂,合成洗涤剂使香波产品的质量提高一大步。

洗发水瓶盖注射成型模流分析及工艺优化

以一种洗发水瓶盖注射成型模具为研究对象,利用模流分析软件对该塑件开展了成型窗口分析、充填分析、冷却分析、翘曲分析,模拟了洗发水瓶盖注射成型的注射、保压、冷却、开模等过程,对可能会产生的体积收缩、气孔、缩痕及翘曲变形进行了预测,同时简化了冷却回路结构以便更易加工,针对翘曲变形的影响因素进行了探索研究。结果表明:影响翘曲变形的原因比较复杂,而收缩不均对塑件整体翘曲变形的影响最大。最佳工艺组合为:模具表面温度为80℃、熔体温度为180℃、注射时间为0.3696s、保压时间为30s、保压压力13.42MPa。

高效去屑剂二硫化硒的应用研究

二硫化硒是一种非常优秀的去屑剂,本文通过控制质量,对产品配方设计及生产工艺进行优化研究,解决了二硫化硒在配方中变色及聚沉的应用难题。通过对马拉色菌的杀菌及抑菌实验、安全测试及人体功效测试实验,证实配方添加1%的二硫化硒具有优异的去屑、止痒和控油功效,说明二硫化硒具有良好的应用前景。

洗发水表面活性剂对头皮的影响及其内在机制的研究进展

头皮的屏障功能需要正常的皮脂分泌和平衡的微生态共同维持。表面活性剂作为洗发水的核心成分,在提供清洁作用时,会与角质层(SC)蛋白质和脂质相互作用,并且对头皮微生态产生影响,从而破坏头皮屏障。此外,表面活性剂的使用可能会造成头皮瘙痒、刺痛、发红、炎症等刺激反应。值得注意的是,不同种类的表面活性剂对脂质的去除可能具有选择性。阴离子表面活性剂处理会去除胆固醇、游离脂肪酸和角鲨烯,但不影响神经酰胺和甘油三酯的含量,而阳离子表面活性剂却可以显著减少甘油三酯和神经酰胺的含量。脂质组学与微生物组学策略的结合将有助于进一步研究表面活性剂对头皮脂质和微生物的影响,从而指导不同表面活性剂在不同头皮类型中的使用,为研发具有针对性、低刺激性、高功效性的洗发水提供依据。

红外光谱结合贝叶斯判别对洗发用品的分类研究

建立一种基于红外光谱的快速无损地检验洗发用品的分析方法。利用傅里叶红外光谱对60个常见的洗发用品样品进行检验,分别采用Savitzky-Golay(S-G)平滑、快速傅里叶变换(FFT)、降噪等方法对光谱数据进行预处理,并结合主成分分析法对光谱数据进行降维处理。同时建立多层感知器神经网络和贝叶斯判别分析两种分类模型,对光谱数据进行分析验证。多层感知器神经网络对原始数据、经过S-G平滑、FFT、降噪后的分类准确率分别为86.67%、88.33%、80%、90%,贝叶斯判别的分类准确率为83.33%、85%、83.33%、95%。结果显示,降噪处理效果较佳,贝叶斯判别具有更高的准确率。该方法重现性好、样品用量少、无损样品,可为洗发用品类物证鉴定提供科学依据。

阳离子调理剂组合在蓬松洗发水中的应用

针对两种阳离子调理剂组合在蓬松洗发水配方中的性能进行研究,结果证实,聚季铵盐-11与瓜儿胶羟丙基三甲基氯化铵的调理聚合物组合(0.1%/0.2%固含量),其配方具有良好的泡沫性质、合适的絮凝特征、容易冲洗干净的性能以及较低的致痒率,在整个洗发阶段顺滑,干发后蓬松,适合用于开发控油蓬松型洗发水。

洗发护发类化妆品的国际法规动态和技术要点研究

本研究通过分析洗发护发类化妆品的国际法规动态和技术监管研究现状,为洗发护发类化妆品的精细化管理提供思路。通过文献调查和数据统计分析,对洗发护发类产品的国际监管动态和法规进行梳理,并分析讨论了洗发护发类产品的原料使用、限值规定、生产工艺、理化检验和功效测试等相关技术要点。不同国家的监管动态反映了防腐剂原料在洗发护发类化妆品中的风险性,对生产企业的产品质量管理和化妆品检测工作具有参考价值;此外技术相关要点的研究总结能够促进洗发护发类化妆品技术和监管体系的完善和优化。分析结果显示,洗发护发类化妆品市场规模日渐扩大,产品功能日趋丰富,未来对其的精细化和科学化管理将是我国化妆品监管的重要趋势,除对原料中的风险成分进行监管外,还应进一步加强对其原料配比、生产流程和功效评价的监管体系研究,完善洗发护发类化妆品体系的总体监管机制。

洗发液瓶盖倒装式多板点浇口模具设计

基于三板模设计了洗发液瓶盖的倒装式点浇口多瓣式模具,模具解决了瓶盖外表面不留浇口痕迹的浇注系统设计难点,也解决了被动式脱螺纹容易导致塑件成型螺纹损伤的问题。首先,将模腔在模具中按倒装方式布置,使点浇口可以设置开设在瓶盖内部。其次,固定内螺纹型芯不动,利用液压马达驱动的旋转动力驱动型芯镶件转动,带动瓶盖在内螺纹型芯上转动,从而主动脱模,并同步依靠瓶盖外沿推板辅助推动将瓶盖从旋转的型芯镶件上推出而完全脱模。瓶盖通过模具的4次机械开模,达到自动脱模的目的,动作可靠,生产效率较高,能将单模瓶盖生产能力提高到40万件/月的能力。所设计的脱螺纹方法新颖实用,模具多次开模顺序控制件简单可靠,将三板模模具结构进行衍生创新,设计为多板式点浇口模具,满足塑件成型要求。

高效液相色谱法同时测定洗发水中10种防腐剂的含量

建立高效液相色谱法(HPLC)同时测定洗发水中苯酚等10种防腐剂含量的方法。样品经甲醇提取后,使用Capcellpak C_(18) MGⅢ柱(250 mm×4.6 mm×5μm)色谱柱,以乙腈、甲醇、0.02 mol/L乙酸铵溶液为流动相,梯度洗脱。采用二极管阵列检测器在280 nm波长下同时测定洗发水中10种防腐剂。通过试验探究,在质量浓度5~100μg/mL,10种防腐剂质量浓度与峰面积呈良好的线性关系(r~2≥0.998);检出限(LOD)为0.4~2.2μg/g,定量限(LOQ)为1.2~7.3μg/g,样品平均加标回收率为85.2%~107.4%,相对标准偏差(RSD)为0.7%~4.8%(n=6)。结果表明该方法操作简单,灵敏度高,结果准确,重复性好,可用于洗发水中多种防腐剂的同时测定。

一款中药复方防脱抑菌洗发剂的安全性及功效评价

目的:评价含有中药复方提取物的一款防脱抑菌洗发剂的安全性及功效。方法:以丹参、黄芩、人参、侧柏叶、姜根五种中药提取物为原料,制备一款防脱抑菌洗发产品,按照相关标准和方法进行感官、理化、卫生指标评价;采用急性眼刺激试验、急性皮肤刺激试验、人体皮肤斑贴试验对洗发剂进行安全性评价;通过马拉色菌抑菌性能测试、产品使用前后脱发计数、整体毛发密度视觉评估和受试者自评,考察洗发剂的抑菌防脱功效。结果:研制的洗发剂感官、理化、卫生各项指标均符合国家标准;产品通过安全性评价,未发生不良反应;对马拉色菌的抑菌率大于50%;产品使用前后防脱效果差异有统计学意义,且100%的受试者整体认同该产品。结论:该洗发产品性能优良,对人体安全无刺激,抑菌及防脱效果显著,具有良好的市场应用前景。

超高效液相色谱-串联质谱法测定洗发水中14种防脱育发类药物的含量

提出了超高效液相色谱-串联质谱法测定洗发水中西咪替丁、米诺地尔、美拉酮宁、香草酸甲酯、酮康唑、比马前列素、非那雄胺、塞替匹仑、尼鲁米特、氟罗地尔、螺内酯、氟他胺、拉坦前列素、度他雄胺等14种防脱育发类药物含量的方法。样品经水溶解、乙腈提取后,用氨基固相萃取柱净化。以Waters Accquity UPLC BEH C18色谱柱为固定相,以乙腈-含0.1%(体积分数)甲酸的2 mmol·L^(-1)乙酸铵溶液为流动相体系进行梯度洗脱;分离后的14种目标物经电喷雾离子源正、负离子模式扫描,多反应监测模式检测。结果表明:14种目标物的质量浓度在1.0~50.0μg·L^(-1)内与对应的峰面积呈线性关系,检出限(3S/N)为0.05~3.0μg·kg^(-1);对空白样品进行3个浓度水平的加标回收试验,回收率为83.6%~99.0%,测定值的相对标准偏差(n=6)为5.6%~15%;方法用于10个洗发水样品分析,一个样品中检出米诺地尔、西咪替丁、塞替匹仑、酮康唑、尼鲁米特、氟罗地尔,另一个样品中检出美拉酮宁,检出量为0.4~47.8μg·kg^(-1)。

温和表面活性剂对染后头发色素洗脱能力的影响探究

主要介绍超声法用于模拟实际生活中染烫头发的多次清洗过程,并用此方法验证多种阴离子表面活性剂、两性表面活性剂和非离子表面活性剂对漂染后发束的色素洗脱能力的影响。结果表明,对漂染后发束的色素洗脱能力测试排序为:阴离子表面活性剂>两性表面活性剂>非离子表面活性剂,这与表面活性剂的温和性排序基本一致。其中在阴离子表面活性剂中,传统的硫酸盐表面活性剂对色素的洗脱能力较一些温和的表面活性剂强,如椰油酰羟乙磺酸酯钠、椰油酰甲基牛磺酸牛磺酸钠、甲基椰油酰基牛磺酸钠等。基于筛选结果开发了一款对染后头发色素洗脱能力较小的香波,其具有与一些宣称护色的市售样品相当的护色功效。

芒果生物合成纳米银化妆品及抗菌性能研究

采用芒果生物合成制备纳米银悬浮液,并加入洗发香波中,配制出纳米银化妆品,并探究纳米银化妆品的pH值、发泡与稳泡性能和抗菌性能。结果表明,当纳米银悬浮液的添加量为0.5%时,洗发香波水溶液的pH值下降,更加接近人类油脂外表面皮肤的自然pH值;洗发香波的泡沫稳定指数和发泡力均较好;洗发香波能有效的抑制细菌与霉菌。纳米银悬浮液能有效地降低化妆品微生物污染,增强化妆品安全性,保证化妆品的质量。

一款修护洗发水的功效评价研究

制备一款洗发水,并评价其修护效果。通过仪器检测样品使用前后的毛鳞片状态、头发的梳理性能和光泽度,实验结果表明,此款洗发水对毛鳞片修复、干梳理性和光泽度的改善效果比较明显。33名受试者进行洗发水使用测评,在使用的0 d、14 d和28 d分别用Dermalab Hydration Probe、VapoMeter对头皮水分、TEWL进行测试,结果表明可增加头皮水分含量、减少经皮水分丢失量、增强皮肤屏障,说明该洗发水具有良好的修护功效。

二硫化硒洗发水的去屑止痒性能研究

为了研究二硫化硒原料在洗发水中的去屑止痒性能,采用体外抑菌方法测定样品对糠秕马拉色菌、白念珠菌代表真菌的抑菌效果,采用人体试用测试方法对受试者连续使用二硫化硒洗发水28 d后进行去屑止痒评价。结果表明,糠秕马拉色菌和白念珠菌抑菌环直径均>7 mm,93.3%的受试者感到头屑症状明显减轻或消失,二硫化硒添加量为1%的洗发水具有抑菌和去屑止痒作用。