Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy

Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and is not fully understood.Intracellular calcium dynamics have been implicated in temporal lobe epilepsy.However,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice.In this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process.We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes.In particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures.Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠepisodes.In addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced.Intriguingly,it was possible to rescue the altered intracellular calcium dynamics.Via simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were improved.Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades.Furthermore,the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy,thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.

2D DOA Estimation of Coherent Signals with a Separated Linear Acoustic Vector-Sensor Array

In this paper, a two-dimensional(2D) DOA estimation algorithm of coherent signals with a separated linear acoustic vector-sensor(AVS) array consisting of two sparse AVS arrays is proposed. Firstly,the partitioned spatial smoothing(PSS) technique is used to construct a block covariance matrix, so as to decorrelate the coherency of signals. Then a signal subspace can be obtained by singular value decomposition(SVD) of the covariance matrix. Using the signal subspace, two extended signal subspaces are constructed to compensate aperture loss caused by PSS.The elevation angles can be estimated by estimation of signal parameter via rotational invariance techniques(ESPRIT) algorithm. At last, the estimated elevation angles can be used to estimate automatically paired azimuth angles. Compared with some other ESPRIT algorithms, the proposed algorithm shows higher estimation accuracy, which can be proved through the simulation results.

Automatic modulation recognition of radiation source signals based on two-dimensional data matrix and improved residual neural network

Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.

Adversarial attacks and defenses for digital communication signals identification

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management systems.AI has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and industry.However,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial attacks.Adversarial examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong results.Therefore,the security of AI models for the digital communication signals identification is the premise of its efficient and credible applications.In this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial principle.Next we present more detailed adversarial indicators to evaluate attack and defense behavior.Finally,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

Impact of correlated private signals on continuous-time insider trading

A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establish three lemmas:normal corre-lation,equivalent pricing and equivalent profit,which can guarantee to turn our model into a model with insider knowing full information.Then we investigate the impact of the two correlated signals on the market equilibrium consisting of optimal insider trading strategy and semi-strong pricing rule.It shows that in the equilibrium,(1)the market depth is constant over time;(2)if the two noisy signals are not linerly correlated,then all private information of the insider is incorporated into prices in the end while the whole information on the asset value can not incorporated into prices in the end;(3)if the two noisy signals are linear correlated such that the insider can infer the whole information of the asset value,then our model turns into a model with insider knowing full information;(4)if the two noisy signals are the same then the total ex ant profit of the insider is increasing with the noise decreasing,while down to O as the noise going up to infinity;(5)if the two noisy signals are not linear correlated then with one noisy signal fixed,the total ex ante profit of the insider is single-peaked with a unique minimum with respect to the other noisy signal value,and furthermore as the noisy value going to O it gets its maximum,the profit in the case that the real value is observed.

Identification of Early Warning Signals of Infectious Diseases in Hospitals by Integrating Clinical Treatment and Disease Prevention

The global incidence of infectious diseases has increased in recent years,posing a significant threat to human health.Hospitals typically serve as frontline institutions for detecting infectious diseases.However,accurately identifying warning signals of infectious diseases in a timely manner,especially emerging infectious diseases,can be challenging.Consequently,there is a pressing need to integrate treatment and disease prevention data to conduct comprehensive analyses aimed at preventing and controlling infectious diseases within hospitals.This paper examines the role of medical data in the early identification of infectious diseases,explores early warning technologies for infectious disease recognition,and assesses monitoring and early warning mechanisms for infectious diseases.We propose that hospitals adopt novel multidimensional early warning technologies to mine and analyze medical data from various systems,in compliance with national strategies to integrate clinical treatment and disease prevention.Furthermore,hospitals should establish institution-specific,clinical-based early warning models for infectious diseases to actively monitor early signals and enhance preparedness for infectious disease prevention and control.

HQNN-SFOP:Hybrid Quantum Neural Networks with Signal Feature Overlay Projection for Drone Detection Using Radar Return Signals-A Simulation

With the wide application of drone technology,there is an increasing demand for the detection of radar return signals from drones.Existing detection methods mainly rely on time-frequency domain feature extraction and classical machine learning algorithms for image recognition.This method suffers from the problem of large dimensionality of image features,which leads to large input data size and noise affecting learning.Therefore,this paper proposes to extract signal time-domain statistical features for radar return signals from drones and reduce the feature dimension from 512×4 to 16 dimensions.However,the downscaled feature data makes the accuracy of traditional machine learning algorithms decrease,so we propose a new hybrid quantum neural network with signal feature overlay projection(HQNN-SFOP),which reduces the dimensionality of the signal by extracting the statistical features in the time domain of the signal,introduces the signal feature overlay projection to enhance the expression ability of quantum computation on the signal features,and introduces the quantum circuits to improve the neural network’s ability to obtain the inline relationship of features,thus improving the accuracy and migration generalization ability of drone detection.In order to validate the effectiveness of the proposed method,we experimented with the method using the MM model that combines the real parameters of five commercial drones and random drones parameters to generate data to simulate a realistic environment.The results show that the method based on statistical features in the time domain of the signal is able to extract features at smaller scales and obtain higher accuracy on a dataset with an SNR of 10 dB.On the time-domain feature data set,HQNNSFOP obtains the highest accuracy compared to other conventional methods.In addition,HQNN-SFOP has good migration generalization ability on five commercial drones and random drones data at different SNR conditions.Our method verifies the feasibility and effectiveness of signal detection methods based on quantum computation and experimentally demonstrates that the advantages of quantum computation for information processing are still valid in the field of signal processing,it provides a highly efficient method for the drone detection using radar return signals.

MAPOD Analysis in Eddy Current Testing of Flaws Considering Multiple Response Signals and Multiple Flaw Parameters

The reliability of the eddy current testing (ECT) in flaw detection is quantitatively evaluated by theprobability of detection (POD). Precise and efficient modeling of POD gives direction for the implement of ECTon sites to avoid false or missing flaw detection. Traditional POD analysis focuses on single uncertain factor orsingle response signal with limited credibility in engineering. This paper considers multiple response signals andmultiple flaw parameters to perform POD. The flaw length, the flaw depth, the coil impedance, and the magneticflux density are comprehensively studied under various lift-off distances. A finite element model (FEM) of ECT isestablished and verified with experiments to obtain sufficient simulation data for discrete POD modeling. Thecontinuous POD function is then fitted based on the discrete values to show the superiority of integrating multiplefactors. A comparison with conventional POD analysis further demonstrates the higher reliability of ECT flawdetection considering multiple flaw parameters and multiple response signals, especially for small flaws.

Automatic Extraction of Medical Latent Variables from ECG Signals Utilizing a Mutual Information-Based Technique and Capsular Neural Networks for Arrhythmia Detection

From a medical perspective,the 12 leads of the heart in an electrocardiogram(ECG)signal have functional dependencies with each other.Therefore,all these leads report different aspects of an arrhythmia.Their differences lie in the level of highlighting and displaying information about that arrhythmia.For example,although all leads show traces of atrial excitation,this function is more evident in lead II than in any other lead.In this article,a new model was proposed using ECG functional and structural dependencies between heart leads.In the prescreening stage,the ECG signals are segmented from the QRS point so that further analyzes can be performed on these segments in a more detailed manner.The mutual information indices were used to assess the relationship between leads.In order to calculate mutual information,the correlation between the 12 ECG leads has been calculated.The output of this step is a matrix containing all mutual information.Furthermore,to calculate the structural information of ECG signals,a capsule neural network was implemented to aid physicians in the automatic classification of cardiac arrhythmias.The architecture of this capsule neural network has been modified to perform the classification task.In the experimental results section,the proposed model was used to classify arrhythmias in ECG signals from the Chapman dataset.Numerical evaluations showed that this model has a precision of 97.02%,recall of 96.13%,F1-score of 96.57%and accuracy of 97.38%,indicating acceptable performance compared to other state-of-the-art methods.The proposed method shows an average accuracy of 2%superiority over similar works.

THE STABLE RECONSTRUCTION OF STRONGLY-DECAYING BLOCK SPARSE SIGNALS

In this paper,we reconstruct strongly-decaying block sparse signals by the block generalized orthogonal matching pursuit(BgOMP)algorithm in the l2-bounded noise case.Under some restraints on the minimum magnitude of the nonzero elements of the strongly-decaying block sparse signal,if the sensing matrix satisfies the the block restricted isometry property(block-RIP),then arbitrary strongly-decaying block sparse signals can be accurately and steadily reconstructed by the BgOMP algorithm in iterations.Furthermore,we conjecture that this condition is sharp.

Application of the CatBoost Model for Stirred Reactor State Monitoring Based on Vibration Signals

Stirred reactors are key equipment in production,and unpredictable failures will result in significant economic losses and safety issues.Therefore,it is necessary to monitor its health state.To achieve this goal,in this study,five states of the stirred reactor were firstly preset:normal,shaft bending,blade eccentricity,bearing wear,and bolt looseness.Vibration signals along x,y and z axes were collected and analyzed in both the time domain and frequency domain.Secondly,93 statistical features were extracted and evaluated by ReliefF,Maximal Information Coefficient(MIC)and XGBoost.The above evaluation results were then fused by D-S evidence theory to extract the final 16 features that are most relevant to the state of the stirred reactor.Finally,the CatBoost algorithm was introduced to establish the stirred reactor health monitoring model.The validation results showed that the model achieves 100%accuracy in detecting the fault/normal state of the stirred reactor and 98%accuracy in diagnosing the type of fault.

N-th root slant stack for enhancing weak seismic signals

Seismic imaging of complicated underground structures with severe surface undulation(i.e.,double complex areas)is challenging owing to the difficulty of collecting the very weak reflected signal.Enhancing the weak signal is difficult even with state-of-the-art multi-domain and multidimensional prestack denoising techniques.This paper presents a time–space dip analysis of offset vector tile(OVT)domain data based on theτ-p transform.The proposed N-th root slant stack method enhances the signal in a three-dimensionalτ-p domain by establishing a zero-offset time-dip seismic attribute trace and calculating the coherence values of a given data sub-volume(i.e.,inline,crossline,time),which are then used to recalculate the data.After sorting,the new data provide a solid foundation for obtaining the optimal N value of the N-th root slant stack,which is used to enhance a weak signal.The proposed method was applied to denoising low signal-to-noise ratio(SNR)data from Western China.The optimal N value was determined for improving the SNR in deep strata,and the weak seismic signal was enhanced.The results showed that the proposed method effectively suppressed noise in low-SNR data.

Subtraction of liposome signals in cryo-EM structural determination of protein-liposome complexes

Reconstituting membrane proteins in liposomes and determining their structure is a common method for determining membrane protein structures using single-particle cryo-electron microscopy(cryo-EM).However,the strong signal of liposomes under cryo-EM imaging conditions often interferes with the structural determination of the embedded membrane proteins.Here,we propose a liposome signal subtraction method based on single-particle two-dimensional(2D)classification average images,aimed at enhancing the reconstruction resolution of membrane proteins.We analyzed the signal distribution characteristics of liposomes and proteins within the 2D classification average images of protein–liposome complexes in the frequency domain.Based on this analysis,we designed a method to subtract the liposome signals from the original particle images.After the subtraction,the accuracy of single-particle three-dimensional(3D)alignment was improved,enhancing the resolution of the final 3D reconstruction.We demonstrated this method using a PIEZO1-proteoliposome dataset by improving the resolution of the PIEZO1 protein.

Comprehensive Analysis of Gender Classification Accuracy across Varied Geographic Regions through the Application of Deep Learning Algorithms to Speech Signals

This article presents an exhaustive comparative investigation into the accuracy of gender identification across diverse geographical regions,employing a deep learning classification algorithm for speech signal analysis.In this study,speech samples are categorized for both training and testing purposes based on their geographical origin.Category 1 comprises speech samples from speakers outside of India,whereas Category 2 comprises live-recorded speech samples from Indian speakers.Testing speech samples are likewise classified into four distinct sets,taking into consideration both geographical origin and the language spoken by the speakers.Significantly,the results indicate a noticeable difference in gender identification accuracy among speakers from different geographical areas.Indian speakers,utilizing 52 Hindi and 26 English phonemes in their speech,demonstrate a notably higher gender identification accuracy of 85.75%compared to those speakers who predominantly use 26 English phonemes in their conversations when the system is trained using speech samples from Indian speakers.The gender identification accuracy of the proposed model reaches 83.20%when the system is trained using speech samples from speakers outside of India.In the analysis of speech signals,Mel Frequency Cepstral Coefficients(MFCCs)serve as relevant features for the speech data.The deep learning classification algorithm utilized in this research is based on a Bidirectional Long Short-Term Memory(BiLSTM)architecture within a Recurrent Neural Network(RNN)model.

Open World Recognition of Communication Jamming Signals

To improve the recognition ability of communication jamming signals,Siamese Neural Network-based Open World Recognition(SNNOWR)is proposed.The algorithm can recognize known jamming classes,detect new(unknown)jamming classes,and unsupervised cluseter new classes.The network of SNN-OWR is trained supervised with paired input data consisting of two samples from a known dataset.On the one hand,the network is required to have the ability to distinguish whether two samples are from the same class.On the other hand,the latent distribution of known class is forced to approach their own unique Gaussian distribution,which is prepared for the subsequent open set testing.During the test,the unknown class detection process based on Gaussian probability density function threshold is designed,and an unsupervised clustering algorithm of the unknown jamming is realized by using the prior knowledge of known classes.The simulation results show that when the jamming-to-noise ratio is more than 0d B,the accuracy of SNN-OWR algorithm for known jamming classes recognition,unknown jamming detection and unsupervised clustering of unknown jamming is about 95%.This indicates that the SNN-OWR algorithm can make the effect of the recognition of unknown jamming be almost the same as that of known jamming.

Detection of healthy and pathological heartbeat dynamics in ECG signals using multivariate recurrence networks with multiple scale factors

The electrocardiogram(ECG)is one of the physiological signals applied in medical clinics to determine health status.The physiological complexity of the cardiac system is related to age,disease,etc.For the investigation of the effects of age and cardiovascular disease on the cardiac system,we then construct multivariate recurrence networks with multiple scale factors from multivariate time series.We propose a new concept of cross-clustering coefficient entropy to construct a weighted network,and calculate the average weighted path length and the graph energy of the weighted network to quantitatively probe the topological properties.The obtained results suggest that these two network measures show distinct changes between different subjects.This is because,with aging or cardiovascular disease,a reduction in the conductivity or structural changes in the myocardium of the heart contributes to a reduction in the complexity of the cardiac system.Consequently,the complexity of the cardiac system is reduced.After that,the support vector machine(SVM)classifier is adopted to evaluate the performance of the proposed approach.Accuracy of 94.1%and 95.58%between healthy and myocardial infarction is achieved on two datasets.Therefore,this method can be adopted for the development of a noninvasive and low-cost clinical prognostic system to identify heart-related diseases and detect hidden state changes in the cardiac system.

Multi-View & Transfer Learning for Epilepsy Recognition Based on EEG Signals

Epilepsy is a central nervous system disorder in which brain activity becomes abnormal.Electroencephalogram(EEG)signals,as recordings of brain activity,have been widely used for epilepsy recognition.To study epilep-tic EEG signals and develop artificial intelligence(AI)-assist recognition,a multi-view transfer learning(MVTL-LSR)algorithm based on least squares regression is proposed in this study.Compared with most existing multi-view transfer learning algorithms,MVTL-LSR has two merits:(1)Since traditional transfer learning algorithms leverage knowledge from different sources,which poses a significant risk to data privacy.Therefore,we develop a knowledge transfer mechanism that can protect the security of source domain data while guaranteeing performance.(2)When utilizing multi-view data,we embed view weighting and manifold regularization into the transfer framework to measure the views’strengths and weaknesses and improve generalization ability.In the experimental studies,12 different simulated multi-view&transfer scenarios are constructed from epileptic EEG signals licensed and provided by the Uni-versity of Bonn,Germany.Extensive experimental results show that MVTL-LSR outperforms baselines.The source code will be available on https://github.com/didid5/MVTL-LSR.

Feature Selection with Deep Belief Network for Epileptic Seizure Detection on EEG Signals

The term Epilepsy refers to a most commonly occurring brain disorder after a migraine.Early identification of incoming seizures significantly impacts the lives of people with Epilepsy.Automated detection of epileptic seizures(ES)has dramatically improved the life quality of the patients.Recent Electroencephalogram(EEG)related seizure detection mechanisms encountered several difficulties in real-time.The EEGs are the non-stationary signal,and seizure patternswould changewith patients and recording sessions.Further,EEG data were disposed to wide noise varieties that adversely moved the recognition accuracy of ESs.Artificial intelligence(AI)methods in the domain of ES analysis use traditional deep learning(DL),and machine learning(ML)approaches.This article introduces an Oppositional Aquila Optimizer-based Feature Selection with Deep Belief Network for Epileptic Seizure Detection(OAOFS-DBNECD)technique using EEG signals.The primary aim of the presented OAOFS-DBNECD system is to categorize and classify the presence of ESs.The suggested OAOFS-DBNECD technique transforms the EEG signals into.csv format at the initial stage.Next,the OAOFS technique selects an optimal subset of features using the preprocessed data.For seizure classification,the presented OAOFS-DBNECD technique applies Artificial Ecosystem Optimizer(AEO)with a deep belief network(DBN)model.An extensive range of simulations was performed on the benchmark dataset to ensure the enhanced performance of the presented OAOFS-DBNECD algorithm.The comparison study shows the significant outcomes of the OAOFS-DBNECD approach over other methodologies.In addition,the result of the suggested approach has been evaluated using the CHB-MIT database,and the findings demonstrate accuracy of 97.81%.These findings confirmed the best seizure categorization accuracy on the EEG data considered.

Optimal Sparse Autoencoder Based Sleep Stage Classification Using Biomedical Signals

The recently developed machine learning(ML)models have the ability to obtain high detection rate using biomedical signals.Therefore,this article develops an Optimal Sparse Autoencoder based Sleep Stage Classification Model on Electroencephalography(EEG)Biomedical Signals,named OSAE-SSCEEG technique.The major intention of the OSAE-SSCEEG technique is tofind the sleep stage disorders using the EEG biomedical signals.The OSAE-SSCEEG technique primarily undergoes preprocessing using min-max data normalization approach.Moreover,the classification of sleep stages takes place using the Sparse Autoencoder with Smoothed Regularization(SAE-SR)with softmax(SM)approach.Finally,the parameter optimization of the SAE-SR technique is carried out by the use of Coyote Optimization Algorithm(COA)and it leads to boosted classification efficiency.In order to ensure the enhanced performance of the OSAE-SSCEEG technique,a wide ranging simulation analysis is performed and the obtained results demonstrate the betterment of the OSAE-SSCEEG tech-nique over the recent methods.

Contrastive Clustering for Unsupervised Recognition of Interference Signals

Interference signals recognition plays an important role in anti-jamming communication.With the development of deep learning,many supervised interference signals recognition algorithms based on deep learning have emerged recently and show better performance than traditional recognition algorithms.However,there is no unsupervised interference signals recognition algorithm at present.In this paper,an unsupervised interference signals recognition method called double phases and double dimensions contrastive clustering(DDCC)is proposed.Specifically,in the first phase,four data augmentation strategies for interference signals are used in data-augmentation-based(DA-based)contrastive learning.In the second phase,the original dataset’s k-nearest neighbor set(KNNset)is designed in double dimensions contrastive learning.In addition,a dynamic entropy parameter strategy is proposed.The simulation experiments of 9 types of interference signals show that random cropping is the best one of the four data augmentation strategies;the feature dimensional contrastive learning in the second phase can improve the clustering purity;the dynamic entropy parameter strategy can improve the stability of DDCC effectively.The unsupervised interference signals recognition results of DDCC and five other deep clustering algorithms show that the clustering performance of DDCC is superior to other algorithms.In particular,the clustering purity of our method is above 92%,SCAN’s is 81%,and the other three methods’are below 71%when jammingnoise-ratio(JNR)is−5 dB.In addition,our method is close to the supervised learning algorithm.