BACKGROUND Pelvic floor dysfunction(PFD)is related to muscle fiber tearing during childbirth,negatively impacting postpartum quality of life of parturient.Appropriate and effective intervention is necessary to promote...BACKGROUND Pelvic floor dysfunction(PFD)is related to muscle fiber tearing during childbirth,negatively impacting postpartum quality of life of parturient.Appropriate and effective intervention is necessary to promote PFD recovery.AIM To analyze the use of hydrogen peroxide and silver ion disinfection for vaginal electrodes in conjunction with comprehensive rehabilitation therapy for postpartum women with PFD.METHODS A total of 59 women with PFD who were admitted to the hospital from May 2019 to July 2022 were divided into two groups:Control group(n=27)received comprehensive rehabilitation therapy and observation group(n=32)received intervention with pelvic floor biostimulation feedback instrument in addition to comprehensive rehabilitation therapy.The vaginal electrodes were disinfected with hydrogen peroxide and silver ion before treatment.Intervention for both groups was started 6 weeks postpartum,and rehabilitation lasted for 3 months.Pelvic floor muscle voltage,pelvic floor muscle strength,vaginal muscle voltage,vaginal muscle tone,pelvic floor function,quality of life,and incidence of postpartum PFD were compared between the two groups.RESULTS Before comprehensive rehabilitation treatment,basic data and pelvic floor function were not significantly different between the two groups.After treatment,the observation group showed significant improvements in the maximum voltage and average voltage of pelvic floor muscles,contraction time of type I and type II fibers,pelvic floor muscle strength,vaginal muscle tone,vaginal muscle voltage,and quality of life(GQOLI-74 reports),compared with the control group.The observation group had lower scores on the pelvic floor distress inventory(PFDI-20)and a lower incidence of postpartum PFD,indicating the effectiveness of the pelvic floor biostimulation feedback instrument in promoting the recovery of maternal pelvic floor function.CONCLUSION The combination of the pelvic floor biostimulation feedback instrument and comprehensive rehabilitation nursing can improve pelvic floor muscle strength,promote the recovery of vaginal muscle tone,and improve pelvic floor function and quality of life.The use of hydrogen peroxide and silver ion disinfectant demonstrated favorable antibacterial efficacy and is worthy of clinical application.展开更多
Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,t...Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.展开更多
Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric...Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems.These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications.The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver nanoparticles.Using Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis conditions.UV-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric acid.This highlights the increased stability that tartaric acid provides in AgNP ssssynthesis.Particle size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 nm.The second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 mV.In contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 mV.The more negative zeta potential of AgNP-tartaric acid indicates its increased stability.Evaluation of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against E.coli and B.subtilis bacteria compared with AgNPs-PVP.In summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.展开更多
Green synthesis of silver nanoparticles (AgNPs) using aqueous extracts of orange and lemon peels, as a reducing agent, and silver nitrate salts as a source of silver ions is a promising field of research due to the ve...Green synthesis of silver nanoparticles (AgNPs) using aqueous extracts of orange and lemon peels, as a reducing agent, and silver nitrate salts as a source of silver ions is a promising field of research due to the versatility of biomedical applications of metal nanoparticles. In this paper, AgNPs were synthetized at different reaction parameters such as the type and concentration of the extracts, metal salt concentration, temperature, speed stirring, and pH. The antibacterial properties of the obtained silver nanoparticles against E. coli, as well as the physical and chemical characteristics of the synthesized silver nanoparticles, were investigated. UV-Vis spectroscopy was used to confirm the formation of AgNPs. In addition to green biogenic synthesis, chemical synthesis of silver nanoparticles was also carried out. The optimal temperature for extraction was 65˚C, while for the synthesis of AgNPs was 35˚C. The synthesis is carried out in an acidic environment (pH = 4.7 orange and pH = 3.8 lemon), neutral (pH = 7) and alkaline (pH = 10), then for different concentrations of silver nitrate solution (0.5 mM - 1 mM), optimal time duration of the reaction was 60 min and optimal stirring speed rotation was 250 rpm on the magnetic stirrer. The physical properties of the synthesized silver nanoparticles (conductivity, density and refractive index) were also studied, and the passage of laser light through the obtained solution and distilled water was compared. Positive inhibitory effect on the growth of new Escherichia coli colonies have shown AgNPs synthesized at a basic pH value and at a 0.1 mM AgNO<sub>3</sub> using orange or lemon peel extract, while for a 0.5 mM AgNO<sub>3 </sub>using lemon peel extract.展开更多
BACKGROUND Pressure ulcer(PU)are prevalent among critically ill trauma patients,posing substantial risks.Bundled care strategies and silver nanoparticle dressings offer potential solutions,yet their combined effective...BACKGROUND Pressure ulcer(PU)are prevalent among critically ill trauma patients,posing substantial risks.Bundled care strategies and silver nanoparticle dressings offer potential solutions,yet their combined effectiveness and impact on patient satisfaction remain insufficiently investigated.AIM To assess the impact of bundled care along with silver nanoparticle dressing on PUs management and family satisfaction in critically ill trauma patients.METHODS A total of 98 critically ill trauma patients with PUs in intensive care unit(ICU)were included in this study.Patients were randomly assigned to either the control group(conventional care with silver nanoparticle dressing,n=49)or the intervention group(bundled care with silver nanoparticle dressing,n=49).The PU Scale for Healing(PUSH)tool was used to monitor changes in status of pressure injuries over time.Assessments were conducted at various time points:Baseline(day 0)and subsequent assessments on day 3,day 6,day 9,and day 12.Family satisfaction was assessed using the Family Satisfaction ICU 24 ques-tionnaire.RESULTS No significant differences in baseline characteristics were observed between the two groups.In the intervention group,there were significant reductions in total PUSH scores over the assessment period.Specifically,surface area,exudate,and tissue type parameters all showed significant improvements compared to the control group.Family satisfaction with care and decision-making was notably higher in the intervention group.Overall family satisfaction was significantly better in the intervention group.CONCLUSION Bundled care in combination with silver nanoparticle dressings effectively alleviated PUs and enhances family satisfaction in critically ill trauma patients.This approach holds promise for improving PUs management in the ICU,benefiting both patients and their families.展开更多
China is striving to build an elderly-friendly society,with comfortable living facilities,convenient transportation,and accessible leisure services.THE Chinese path to modernization entails the modernization of a huge...China is striving to build an elderly-friendly society,with comfortable living facilities,convenient transportation,and accessible leisure services.THE Chinese path to modernization entails the modernization of a huge population.Part of this,as was declared at the 20th National Congress of the Communist Party of China(CPC),means China will pursue a proactive national strategy in response to population aging,and develop elderly care programs and services.To actively respond to population aging,there is more to care than just the physical health of the elderly.Their needs are multi-level and diverse.To some extent,it’s fair to say that a society’s happiness is largely dependent on whether or not the elderly are happy.The silver economy,which meets the needs of the elderly for a better life,therefore has enormous development potentials.展开更多
Developing the silver economy is not only a requirement for enhancing services for the elderly,but also an important part of achieving China's high-quality development.CHINA’s latest Central Economic Work Confere...Developing the silver economy is not only a requirement for enhancing services for the elderly,but also an important part of achieving China's high-quality development.CHINA’s latest Central Economic Work Conference held in December 2023 emphasized the need to accelerate the improvement of a childbearing supportive policy system and develop the silver economy.As a result of the rapidly aging population in China,the silver economy has risen to an unprecedented height in China’s development strategy.From concept to action,the silver economy has become a significant part of China’s active response to such national issues as population aging,boosting domestic demands,and achieving high-quality development.展开更多
The government work report delivered at the second session of the 14th National People’s Congress(NPC)in Beijing on March 5 stated that“a further push will be made to develop the silver economy.”Before this,on Janu...The government work report delivered at the second session of the 14th National People’s Congress(NPC)in Beijing on March 5 stated that“a further push will be made to develop the silver economy.”Before this,on January 15,the State Council issued Opinions on Developing the Silver Economy to Enhance the Well-being of the Elderly.The first in China dedicated to supporting the“silver economy,”the document outlines goals and measures for the development of the sector.So what can be done to seize the new opportunities emerging alongside the growing aging population to advance high-quality economic development?展开更多
Silver nanoparticles are versatile nanomaterials that have found numerous applications in various fields.The use of plant extract for the synthesis of silver is a green and sustainable approach.Clerodendron phlomoides...Silver nanoparticles are versatile nanomaterials that have found numerous applications in various fields.The use of plant extract for the synthesis of silver is a green and sustainable approach.Clerodendron phlomoides leaves extract has been found to contain various phytochemicals,such as phenols,flavonoids,tannins,and alkaloids,which possess reducing and stabilizing properties that can aid the production of silver particles.In this paper,morphological and topographical analyses were performed on silver nanoparticles.The biosynthesized silver nanoparticles showed antimicrobial potential against wound pathogens.SEM and TEM micrographs revealed that the particles were sphere and nanosized,which makes them suitable for various biomedical applications.展开更多
Silver nanoparticles(Ag NPs)are an effective antibacterial agent,but their application in food packaging is limited due to their easy agglomeration and oxidation.In this study,antibacterial microcapsules were fabricat...Silver nanoparticles(Ag NPs)are an effective antibacterial agent,but their application in food packaging is limited due to their easy agglomeration and oxidation.In this study,antibacterial microcapsules were fabricated using Ginkgo biloba essential oil(GBEO)as core material and chitosan and type B gelatin biopolymer as capsule mate-rials.These antibacterial microcapsules were then modified with green-synthesized Ag NPs,blended into the bio-polymer polylactic acid(PLA),and finally formed as films.Physicochemical properties and antibacterial activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were evaluated.Results showed that the prepared antibacterial PLA films exhibited excellent antibacterial activity against foodborne pathogens.Its TVC exceeded the limit value of 7 log CFU/g at 7 days compared with the 5 days of pure PLA films.Therefore,these films can extend the shelf life of grass carp fillets by 2–3 days under refrigeration.展开更多
Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(...Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics.展开更多
China has widely distributed silver deposits,and is rich in silver resources.Although silver deposits are mainly associated with Pb-Zn deposits,a number of independent silver deposits have also been discovered in rece...China has widely distributed silver deposits,and is rich in silver resources.Although silver deposits are mainly associated with Pb-Zn deposits,a number of independent silver deposits have also been discovered in recent years.Silver deposits include different types,such as submarine volcanism and continental volcanism related type,intrusion related type,and sedimentary related type.This study summarized the metallogenic regularity of China's silver deposits systematically based mainly on the data from 490 silver deposits.It is shown that submarine volcanic sedimentary type,continental volcanic or sub-volcanic type,skarn type,hydrothermal type(including vein type and stratabound type),sedimentary metamorphic type,sedimentary type and regolith type should be regarded as the most important prediction types of silver deposit.A total of 32 silver mineralization belts and 111 silver concentration areas have been delineated.The map of "Spatial distribution of silver mineralization belts in China" and other series of maps finished in this study may provide a theoretical basis for the evaluation and prognosis of silver resources potential in China.展开更多
The poly(epoxy-N-methylaniline)conductive organic carrier was used as the bonding phase of the low-temperature conductive silver paste.Then,this was mixed with different proportions of silver powder to prepare the low...The poly(epoxy-N-methylaniline)conductive organic carrier was used as the bonding phase of the low-temperature conductive silver paste.Then,this was mixed with different proportions of silver powder to prepare the low-temperature conductive silver paste.Afterwards,the effect of the conductive organic carrier on the properties of the low-temperature conductive silver paste was determined by IR,DMA and SEM.The results revealed that the prepared conductive paste has good conductivity,film-forming performance,printing performance,low-temperature curing performance,and anti-aging performance.When the mass percentage of the bonding phase/conductive phase was 40/60,the lowest volume resistivity of the conductive silver paste was 4.9×10^(−6)Ω⋅cm,and the conductivity was the best.展开更多
目的:对1例产前B超提示骨骼系统发育异常,疑似宫内生长受限的胎儿进行基因检测及生物信息学分析以明确其致病原因。方法:采集胎儿羊水及父母外周血,提取基因组DNA,利用高通量测序平台进行家系全外显子组测序(whole exome sequencing,WES...目的:对1例产前B超提示骨骼系统发育异常,疑似宫内生长受限的胎儿进行基因检测及生物信息学分析以明确其致病原因。方法:采集胎儿羊水及父母外周血,提取基因组DNA,利用高通量测序平台进行家系全外显子组测序(whole exome sequencing,WES)及拷贝数变异测序(copy number variation sequencing,CNV-seq)技术检测,可疑结果经Sanger测序进行验证。结果:胎儿高迁移率族蛋白A2(high mobility group protein AT-Hook-2,HMGA2)基因存在c.223C>T(p.R75W)新发变异,导致氨基酸改变为p.R75W(p.Arg75Trp),为错义突变。根据美国医学遗传学与基因组学学会(American College of Medical Genetics and Genomics,ACMG)指南评级,该变异判定为可能致病性(likely pathogenic):PS2+PM2_Supporting+PP3+PS4_Supporting。根据其临床表型,该胎儿被确诊为常染色体显性遗传的Silver-Russell综合征5型(Silver-Russell syndrome 5,SRS5)。Sanger测序确证了其变异的真实性。结论:HMGA2基因的c.223C>T(p.R75W)杂合致病性变异可能是SRS5的遗传学致病原因,扩充了该基因的变异谱,同时为该胎儿的产前遗传咨询和后续的干预措施提供了理论依据。展开更多
The introduction of bifunctional groups into low-cost adsorbents for selective adsorption of Ag(I) through synergistic effect will have a profound impact on the recovery of precious metals. Organo silica nanosheets(or...The introduction of bifunctional groups into low-cost adsorbents for selective adsorption of Ag(I) through synergistic effect will have a profound impact on the recovery of precious metals. Organo silica nanosheets(organo-Si NSs) functionalized by series of azole derivatives(2-mercaptoimidazole(MI), 2-mercaptobenzimidazole(MBT) and 1H-1,2,4-triazole-3-thiol(MTT)), are fabricated and employed for selective removal of Ag(I). The structures of the organo-Si NSs are investigated using several characterization methods. The results of batch adsorption experiments display that the maximum adsorption amounts are 70.3, 103.2 and 139.5 mg·g^(-1) on MI-Si NSs, MBI-Si NSs and MTT-Si NSs for Ag(I) ions, and reach rapid equilibrium within 10–30 min. The adsorption processes are chemisorption and fit pseudo-second-order kinetic model and Langmuir adsorption isotherm model. Notably, MTT-Si NSs is greatly selective for Ag(I) in multicomponent system, and the distribution coefficient value of Ag(I) ions reaches 2331.26 ml·g^(-1). The reusability of organo-Si NSs is verified by four cycles of regeneration tests with 0.1 mol·L^(-1) HNO_(3) as the eluent. A combination of experimental, structural along with theoretical analysis is conducted to proclaim the structure-adsorptivity relationship:(i) The adsorption mechanisms are attributed to complexation.(ii) The amino group and sulfhydryl group of MTT-Si NSs as well as MBISi NSs may have synergistic impacts on Ag(I) capture.(iii) The differences in adsorption behavior and selectivity of the three organo-Si NSs are mainly related to the form of function groups, charge density and steric hindrance of adsorbent. This work not only sheds light on the promise of functionalized organo-Si NSs for the rapid and selective removal/enrichment of Ag(I) ions in complex water systems,but also provides new insights for designing cost-effective Si NSs-based adsorbents.展开更多
Objective:To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles(neem-Ag NPs)against Biomphalaria alexandrina,the snail intermediate host for Schistosoma mansoni,and their c...Objective:To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles(neem-Ag NPs)against Biomphalaria alexandrina,the snail intermediate host for Schistosoma mansoni,and their cercaricidal potential.Methods:Methanol extracts from neem fruits were used for green synthesis of neem-Ag NPs.The neem-Ag NPs were characterized using UV-visible absorption spectra,dynamic laser light scattering technique,and transmission electron microscopy.The potential molluscicidal effect against adult and juvenile Biomphalaria alexandrina and the effect of the sub-lethal concentration on hatching of snail eggs and Schistosoma mansoni cercariae were evaluated.Results:The surface plasmon resonance of neem-Ag NPs showed a sharp absorption peak atλ_(max)=518 nm together with multiple peaks.The hydrodynamic diameter was(77.15±34.53)nm,the polydispersity index(0.338±0.000)and the zeta-potential-14.07 mV.Moreover,transmission electron microscopy showed that the average size of the nanoparticles was(27±2)nm.Agglomeration was evident and a light-colored capping layer could be seen coating the nanoparticles.Juvenile snails(LC_(50):0.83 ppm)were more susceptible to neem-Ag NPs than adults(LC_(50):1.07 ppm).In addition,neem-Ag NPs and neem at LC_(50)concentrations inhibited the egg-hatching of snails and showed cercaricidal activity in a time-dependent manner.Conclusions:Neem-Ag NPs have lethal activities against Biomphalaria alexandrina snails and their eggs,as well as Schistosoma mansoni cercariae.Hence,neem-Ag NPs could be a potential agent to control schistosomiasis.展开更多
Silver nanoclusters(AgNCs)are a new type of nanomaterials with similar properties to molecules and unique applications.The applications of AgNCs can be significantly expanded by combining them with different matrix ma...Silver nanoclusters(AgNCs)are a new type of nanomaterials with similar properties to molecules and unique applications.The applications of AgNCs can be significantly expanded by combining them with different matrix materials to obtain AgNC composites.Using irradiation techniques,we developed a simple two-step method for preparing silver nanocluster composites.First,polyacrylic acid(PAA)chains were grafted onto the surface of a PE film as templates(PE-g-PAA).Subsequently,silver ions were reduced in situ on the surface of the template material to obtain the AgNC composites(AgNCs@PE-g-PAA).The degree of AgNC loading on the composite film was easily controlled by adjusting the reaction conditions.The loaded AgNCs were anchored to the carboxyl groups of the PAA and wrapped in the graft chain.The particle size of the AgNCs was only 4.38±0.85 nm,with a very uniform particle size distribution.The AgNCs@PE-g-PAA exhibited fluorescence characteristics derived from the AgNCs.The fluorescence of the AgNCs@PE-g-PAA was easily quenched by Cr^(3+)ions.The composite can be used as a fluorescence test paper to realize visual detection of Cr^(3+).展开更多
A silver microelectrode with a diameter of 30μm in an aqueous K_(2)SO_(4) electrolyte was irradiated with 55 fs and 213 fs laser pulses.This caused the emission of electrons which transiently charged the electrochemi...A silver microelectrode with a diameter of 30μm in an aqueous K_(2)SO_(4) electrolyte was irradiated with 55 fs and 213 fs laser pulses.This caused the emission of electrons which transiently charged the electrochemical double layer.The two applied pulse durations were significantly shorter than the electron-phonon relaxation time.The laser pulse durations had negligible impact on the emitted charge,which is incompatible with multiphoton emission.On the other hand,the ob-served dependence of emitted charge on laser fluence and electrode potential supports the thermionic emission mechanism.展开更多
文摘BACKGROUND Pelvic floor dysfunction(PFD)is related to muscle fiber tearing during childbirth,negatively impacting postpartum quality of life of parturient.Appropriate and effective intervention is necessary to promote PFD recovery.AIM To analyze the use of hydrogen peroxide and silver ion disinfection for vaginal electrodes in conjunction with comprehensive rehabilitation therapy for postpartum women with PFD.METHODS A total of 59 women with PFD who were admitted to the hospital from May 2019 to July 2022 were divided into two groups:Control group(n=27)received comprehensive rehabilitation therapy and observation group(n=32)received intervention with pelvic floor biostimulation feedback instrument in addition to comprehensive rehabilitation therapy.The vaginal electrodes were disinfected with hydrogen peroxide and silver ion before treatment.Intervention for both groups was started 6 weeks postpartum,and rehabilitation lasted for 3 months.Pelvic floor muscle voltage,pelvic floor muscle strength,vaginal muscle voltage,vaginal muscle tone,pelvic floor function,quality of life,and incidence of postpartum PFD were compared between the two groups.RESULTS Before comprehensive rehabilitation treatment,basic data and pelvic floor function were not significantly different between the two groups.After treatment,the observation group showed significant improvements in the maximum voltage and average voltage of pelvic floor muscles,contraction time of type I and type II fibers,pelvic floor muscle strength,vaginal muscle tone,vaginal muscle voltage,and quality of life(GQOLI-74 reports),compared with the control group.The observation group had lower scores on the pelvic floor distress inventory(PFDI-20)and a lower incidence of postpartum PFD,indicating the effectiveness of the pelvic floor biostimulation feedback instrument in promoting the recovery of maternal pelvic floor function.CONCLUSION The combination of the pelvic floor biostimulation feedback instrument and comprehensive rehabilitation nursing can improve pelvic floor muscle strength,promote the recovery of vaginal muscle tone,and improve pelvic floor function and quality of life.The use of hydrogen peroxide and silver ion disinfectant demonstrated favorable antibacterial efficacy and is worthy of clinical application.
基金supported by the China Scholarship Council (CSC) (No.202206020149)the Academic Excellence Foundation of BUAA for PhD Students,the Funding Project of Science and Technology on Reliability and Environmental Engineering Laboratory (No.6142004210106).
文摘Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.
基金funded by the Directorate of Research and Community Service (DRPM,Direktorat Riset dan Pengabdian Kepada Masyarakat)ITS through the ITS Research Local Grant (No:1665/PKS/ITS/2023).
文摘Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems.These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications.The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver nanoparticles.Using Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis conditions.UV-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric acid.This highlights the increased stability that tartaric acid provides in AgNP ssssynthesis.Particle size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 nm.The second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 mV.In contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 mV.The more negative zeta potential of AgNP-tartaric acid indicates its increased stability.Evaluation of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against E.coli and B.subtilis bacteria compared with AgNPs-PVP.In summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.
文摘Green synthesis of silver nanoparticles (AgNPs) using aqueous extracts of orange and lemon peels, as a reducing agent, and silver nitrate salts as a source of silver ions is a promising field of research due to the versatility of biomedical applications of metal nanoparticles. In this paper, AgNPs were synthetized at different reaction parameters such as the type and concentration of the extracts, metal salt concentration, temperature, speed stirring, and pH. The antibacterial properties of the obtained silver nanoparticles against E. coli, as well as the physical and chemical characteristics of the synthesized silver nanoparticles, were investigated. UV-Vis spectroscopy was used to confirm the formation of AgNPs. In addition to green biogenic synthesis, chemical synthesis of silver nanoparticles was also carried out. The optimal temperature for extraction was 65˚C, while for the synthesis of AgNPs was 35˚C. The synthesis is carried out in an acidic environment (pH = 4.7 orange and pH = 3.8 lemon), neutral (pH = 7) and alkaline (pH = 10), then for different concentrations of silver nitrate solution (0.5 mM - 1 mM), optimal time duration of the reaction was 60 min and optimal stirring speed rotation was 250 rpm on the magnetic stirrer. The physical properties of the synthesized silver nanoparticles (conductivity, density and refractive index) were also studied, and the passage of laser light through the obtained solution and distilled water was compared. Positive inhibitory effect on the growth of new Escherichia coli colonies have shown AgNPs synthesized at a basic pH value and at a 0.1 mM AgNO<sub>3</sub> using orange or lemon peel extract, while for a 0.5 mM AgNO<sub>3 </sub>using lemon peel extract.
文摘BACKGROUND Pressure ulcer(PU)are prevalent among critically ill trauma patients,posing substantial risks.Bundled care strategies and silver nanoparticle dressings offer potential solutions,yet their combined effectiveness and impact on patient satisfaction remain insufficiently investigated.AIM To assess the impact of bundled care along with silver nanoparticle dressing on PUs management and family satisfaction in critically ill trauma patients.METHODS A total of 98 critically ill trauma patients with PUs in intensive care unit(ICU)were included in this study.Patients were randomly assigned to either the control group(conventional care with silver nanoparticle dressing,n=49)or the intervention group(bundled care with silver nanoparticle dressing,n=49).The PU Scale for Healing(PUSH)tool was used to monitor changes in status of pressure injuries over time.Assessments were conducted at various time points:Baseline(day 0)and subsequent assessments on day 3,day 6,day 9,and day 12.Family satisfaction was assessed using the Family Satisfaction ICU 24 ques-tionnaire.RESULTS No significant differences in baseline characteristics were observed between the two groups.In the intervention group,there were significant reductions in total PUSH scores over the assessment period.Specifically,surface area,exudate,and tissue type parameters all showed significant improvements compared to the control group.Family satisfaction with care and decision-making was notably higher in the intervention group.Overall family satisfaction was significantly better in the intervention group.CONCLUSION Bundled care in combination with silver nanoparticle dressings effectively alleviated PUs and enhances family satisfaction in critically ill trauma patients.This approach holds promise for improving PUs management in the ICU,benefiting both patients and their families.
文摘China is striving to build an elderly-friendly society,with comfortable living facilities,convenient transportation,and accessible leisure services.THE Chinese path to modernization entails the modernization of a huge population.Part of this,as was declared at the 20th National Congress of the Communist Party of China(CPC),means China will pursue a proactive national strategy in response to population aging,and develop elderly care programs and services.To actively respond to population aging,there is more to care than just the physical health of the elderly.Their needs are multi-level and diverse.To some extent,it’s fair to say that a society’s happiness is largely dependent on whether or not the elderly are happy.The silver economy,which meets the needs of the elderly for a better life,therefore has enormous development potentials.
文摘Developing the silver economy is not only a requirement for enhancing services for the elderly,but also an important part of achieving China's high-quality development.CHINA’s latest Central Economic Work Conference held in December 2023 emphasized the need to accelerate the improvement of a childbearing supportive policy system and develop the silver economy.As a result of the rapidly aging population in China,the silver economy has risen to an unprecedented height in China’s development strategy.From concept to action,the silver economy has become a significant part of China’s active response to such national issues as population aging,boosting domestic demands,and achieving high-quality development.
文摘The government work report delivered at the second session of the 14th National People’s Congress(NPC)in Beijing on March 5 stated that“a further push will be made to develop the silver economy.”Before this,on January 15,the State Council issued Opinions on Developing the Silver Economy to Enhance the Well-being of the Elderly.The first in China dedicated to supporting the“silver economy,”the document outlines goals and measures for the development of the sector.So what can be done to seize the new opportunities emerging alongside the growing aging population to advance high-quality economic development?
文摘Silver nanoparticles are versatile nanomaterials that have found numerous applications in various fields.The use of plant extract for the synthesis of silver is a green and sustainable approach.Clerodendron phlomoides leaves extract has been found to contain various phytochemicals,such as phenols,flavonoids,tannins,and alkaloids,which possess reducing and stabilizing properties that can aid the production of silver particles.In this paper,morphological and topographical analyses were performed on silver nanoparticles.The biosynthesized silver nanoparticles showed antimicrobial potential against wound pathogens.SEM and TEM micrographs revealed that the particles were sphere and nanosized,which makes them suitable for various biomedical applications.
基金supported by the National Key R&D Program of China(Grant No.2020YFD0900905).
文摘Silver nanoparticles(Ag NPs)are an effective antibacterial agent,but their application in food packaging is limited due to their easy agglomeration and oxidation.In this study,antibacterial microcapsules were fabricated using Ginkgo biloba essential oil(GBEO)as core material and chitosan and type B gelatin biopolymer as capsule mate-rials.These antibacterial microcapsules were then modified with green-synthesized Ag NPs,blended into the bio-polymer polylactic acid(PLA),and finally formed as films.Physicochemical properties and antibacterial activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were evaluated.Results showed that the prepared antibacterial PLA films exhibited excellent antibacterial activity against foodborne pathogens.Its TVC exceeded the limit value of 7 log CFU/g at 7 days compared with the 5 days of pure PLA films.Therefore,these films can extend the shelf life of grass carp fillets by 2–3 days under refrigeration.
基金supports from the National Natural Science Foundation of China (Grant No. 52175300)Fundamental Research Funds for the Central Universities (2022FRFK060008)+2 种基金Heilongjiang Touyan Innovation Team Program (HITTY-20190013)Shenzhen Fundamental Research Programs (JCYJ20200925160843002)Start-up fund of SUSTech (Y01256114)
文摘Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics.
基金funded by the Chinese Geological Survey(Grant no.12120114039601,1212011121037,1212011220369)
文摘China has widely distributed silver deposits,and is rich in silver resources.Although silver deposits are mainly associated with Pb-Zn deposits,a number of independent silver deposits have also been discovered in recent years.Silver deposits include different types,such as submarine volcanism and continental volcanism related type,intrusion related type,and sedimentary related type.This study summarized the metallogenic regularity of China's silver deposits systematically based mainly on the data from 490 silver deposits.It is shown that submarine volcanic sedimentary type,continental volcanic or sub-volcanic type,skarn type,hydrothermal type(including vein type and stratabound type),sedimentary metamorphic type,sedimentary type and regolith type should be regarded as the most important prediction types of silver deposit.A total of 32 silver mineralization belts and 111 silver concentration areas have been delineated.The map of "Spatial distribution of silver mineralization belts in China" and other series of maps finished in this study may provide a theoretical basis for the evaluation and prognosis of silver resources potential in China.
基金fund for this work was provided by the“Research on Key Technologies of Photosensitive Conductive Silver Paste Based on Domestic Circuit Protection Micro Chip Components”(Project No.BE2020008 and Supporting Author:Chen P).
文摘The poly(epoxy-N-methylaniline)conductive organic carrier was used as the bonding phase of the low-temperature conductive silver paste.Then,this was mixed with different proportions of silver powder to prepare the low-temperature conductive silver paste.Afterwards,the effect of the conductive organic carrier on the properties of the low-temperature conductive silver paste was determined by IR,DMA and SEM.The results revealed that the prepared conductive paste has good conductivity,film-forming performance,printing performance,low-temperature curing performance,and anti-aging performance.When the mass percentage of the bonding phase/conductive phase was 40/60,the lowest volume resistivity of the conductive silver paste was 4.9×10^(−6)Ω⋅cm,and the conductivity was the best.
文摘目的:对1例产前B超提示骨骼系统发育异常,疑似宫内生长受限的胎儿进行基因检测及生物信息学分析以明确其致病原因。方法:采集胎儿羊水及父母外周血,提取基因组DNA,利用高通量测序平台进行家系全外显子组测序(whole exome sequencing,WES)及拷贝数变异测序(copy number variation sequencing,CNV-seq)技术检测,可疑结果经Sanger测序进行验证。结果:胎儿高迁移率族蛋白A2(high mobility group protein AT-Hook-2,HMGA2)基因存在c.223C>T(p.R75W)新发变异,导致氨基酸改变为p.R75W(p.Arg75Trp),为错义突变。根据美国医学遗传学与基因组学学会(American College of Medical Genetics and Genomics,ACMG)指南评级,该变异判定为可能致病性(likely pathogenic):PS2+PM2_Supporting+PP3+PS4_Supporting。根据其临床表型,该胎儿被确诊为常染色体显性遗传的Silver-Russell综合征5型(Silver-Russell syndrome 5,SRS5)。Sanger测序确证了其变异的真实性。结论:HMGA2基因的c.223C>T(p.R75W)杂合致病性变异可能是SRS5的遗传学致病原因,扩充了该基因的变异谱,同时为该胎儿的产前遗传咨询和后续的干预措施提供了理论依据。
基金the National Natural Science Foundation of China (21776306)。
文摘The introduction of bifunctional groups into low-cost adsorbents for selective adsorption of Ag(I) through synergistic effect will have a profound impact on the recovery of precious metals. Organo silica nanosheets(organo-Si NSs) functionalized by series of azole derivatives(2-mercaptoimidazole(MI), 2-mercaptobenzimidazole(MBT) and 1H-1,2,4-triazole-3-thiol(MTT)), are fabricated and employed for selective removal of Ag(I). The structures of the organo-Si NSs are investigated using several characterization methods. The results of batch adsorption experiments display that the maximum adsorption amounts are 70.3, 103.2 and 139.5 mg·g^(-1) on MI-Si NSs, MBI-Si NSs and MTT-Si NSs for Ag(I) ions, and reach rapid equilibrium within 10–30 min. The adsorption processes are chemisorption and fit pseudo-second-order kinetic model and Langmuir adsorption isotherm model. Notably, MTT-Si NSs is greatly selective for Ag(I) in multicomponent system, and the distribution coefficient value of Ag(I) ions reaches 2331.26 ml·g^(-1). The reusability of organo-Si NSs is verified by four cycles of regeneration tests with 0.1 mol·L^(-1) HNO_(3) as the eluent. A combination of experimental, structural along with theoretical analysis is conducted to proclaim the structure-adsorptivity relationship:(i) The adsorption mechanisms are attributed to complexation.(ii) The amino group and sulfhydryl group of MTT-Si NSs as well as MBISi NSs may have synergistic impacts on Ag(I) capture.(iii) The differences in adsorption behavior and selectivity of the three organo-Si NSs are mainly related to the form of function groups, charge density and steric hindrance of adsorbent. This work not only sheds light on the promise of functionalized organo-Si NSs for the rapid and selective removal/enrichment of Ag(I) ions in complex water systems,but also provides new insights for designing cost-effective Si NSs-based adsorbents.
文摘Objective:To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles(neem-Ag NPs)against Biomphalaria alexandrina,the snail intermediate host for Schistosoma mansoni,and their cercaricidal potential.Methods:Methanol extracts from neem fruits were used for green synthesis of neem-Ag NPs.The neem-Ag NPs were characterized using UV-visible absorption spectra,dynamic laser light scattering technique,and transmission electron microscopy.The potential molluscicidal effect against adult and juvenile Biomphalaria alexandrina and the effect of the sub-lethal concentration on hatching of snail eggs and Schistosoma mansoni cercariae were evaluated.Results:The surface plasmon resonance of neem-Ag NPs showed a sharp absorption peak atλ_(max)=518 nm together with multiple peaks.The hydrodynamic diameter was(77.15±34.53)nm,the polydispersity index(0.338±0.000)and the zeta-potential-14.07 mV.Moreover,transmission electron microscopy showed that the average size of the nanoparticles was(27±2)nm.Agglomeration was evident and a light-colored capping layer could be seen coating the nanoparticles.Juvenile snails(LC_(50):0.83 ppm)were more susceptible to neem-Ag NPs than adults(LC_(50):1.07 ppm).In addition,neem-Ag NPs and neem at LC_(50)concentrations inhibited the egg-hatching of snails and showed cercaricidal activity in a time-dependent manner.Conclusions:Neem-Ag NPs have lethal activities against Biomphalaria alexandrina snails and their eggs,as well as Schistosoma mansoni cercariae.Hence,neem-Ag NPs could be a potential agent to control schistosomiasis.
基金supported by the Gansu Natural Science Foundation (Nos.20JR10RA778 and 20JR10RA777)。
文摘Silver nanoclusters(AgNCs)are a new type of nanomaterials with similar properties to molecules and unique applications.The applications of AgNCs can be significantly expanded by combining them with different matrix materials to obtain AgNC composites.Using irradiation techniques,we developed a simple two-step method for preparing silver nanocluster composites.First,polyacrylic acid(PAA)chains were grafted onto the surface of a PE film as templates(PE-g-PAA).Subsequently,silver ions were reduced in situ on the surface of the template material to obtain the AgNC composites(AgNCs@PE-g-PAA).The degree of AgNC loading on the composite film was easily controlled by adjusting the reaction conditions.The loaded AgNCs were anchored to the carboxyl groups of the PAA and wrapped in the graft chain.The particle size of the AgNCs was only 4.38±0.85 nm,with a very uniform particle size distribution.The AgNCs@PE-g-PAA exhibited fluorescence characteristics derived from the AgNCs.The fluorescence of the AgNCs@PE-g-PAA was easily quenched by Cr^(3+)ions.The composite can be used as a fluorescence test paper to realize visual detection of Cr^(3+).
文摘A silver microelectrode with a diameter of 30μm in an aqueous K_(2)SO_(4) electrolyte was irradiated with 55 fs and 213 fs laser pulses.This caused the emission of electrons which transiently charged the electrochemical double layer.The two applied pulse durations were significantly shorter than the electron-phonon relaxation time.The laser pulse durations had negligible impact on the emitted charge,which is incompatible with multiphoton emission.On the other hand,the ob-served dependence of emitted charge on laser fluence and electrode potential supports the thermionic emission mechanism.