Consumption of soybean,soy foods,soy isoflavones and breast cancer incidence:Differences between Chinese women and women in Western countries and possible mechanisms

Breast cancer is one of the most lethal diseases world-wide.However,there is a large difference in breast cancer incidence among Caucasian,Hispanic,African and Asian(e.g.Chinese)women with Caucasian women being the highest and Asian women being the lowest.It has been suggested that the dietary factors may account for approximately 50%of the breast cancer.One of such dietary components which are typical to Asian but not Caucasian diet is soy foods.A number of epidemiological studies have suggested that increasing soy consumption could be related to the decreased risk of occurrence and/or mortality of breast cancer.In this review,we first described briefly different types of soy products and their nutritional functions and consumption.Then,we described briefly soybean isoflavones,i.e.genistein(GEN),daidzein,glycitein,and presented several lines of evidence to demonstrate the possible association of soy flavone food consumption with incidence and prognosis of breast cancer;finally,we summarized several possible molecular mechanisms,including the effects of GEN as an agonist of ER,epigenetic and genome-wide effects,activation of peroxisome proliferator-activated receptors,induction of apoptosis and stimulation of autophagy,involved in the chemo-preventive effects of GEN on breast cancer.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved.

Soy food consumption in relation to breast cancer modified by menopause status

It has been found that lifestyle and diet are associated with the development of cancers.The mortality of breast cancer in Wuhan city is increasing,according to the statistics of recent years.This case control study was aimed to provide data for alimentary therapeutics for breast carcinomas.It included a case group(n 5196)and an age frequency-matched control group(n 5202).A validated food frequency questionnaire was used to obtain information on usual food consumption.The results indicate that intake of soy foods more than 5 times per week was associated with a decreased risk of breast cancer,especially in premenopausal women.The adjusted OR was 0.294[95%CI was(0.158–0.546),P 50.000].Our results indicate that alimentary therapeutics for breast cancer can be adjusted by status of menopause.