L-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of L-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, L-arginine (L), Dichlorvos (D), and L-arginine + Dichlorvos (L + D). Dichlorvos was administered to the D group, L-arginine (100 mg/kg) to the L group, and both L-arginine and dichlorvos to the L + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, L-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with L-arginine supplementation, indicating protection against cardiotoxicity. Moreover, L-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, L-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that L-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poisoning.

Extended Kantorovich method for local stresses in composite laminates upon polynomial stress functions

The extended Kantorovich method is employed to study the local stress concentrations at the vicinity of free edges in symmetrically layered composite laminates subjected to uniaxial tensile load upon polynomial stress functions. The stress fields are initially assumed by means of the Lekhnitskii stress functions under the plane strain state. Applying the principle of complementary virtual work,the coupled ordinary differential equations are obtained in which the solutions can be obtained by solving a generalized eigenvalue problem. Then an iterative procedure is established to achieve convergent stress distributions. It should be noted that the stress function based extended Kantorovich method can satisfy both the traction-free and free edge stress boundary conditions during the iterative processes. The stress components near the free edges and in the interior regions are calculated and compared with those obtained results by finite element method（FEM）. The convergent stresses have good agreements with those results obtained by three dimensional（3D） FEM. For generality, various layup configurations are considered for the numerical analysis. The results show that the proposed polynomial stress function based extended Kantorovich method is accurate and efficient in predicting the local stresses in composite laminates and computationally much more efficient than the 3D FEM.

Investigation of the effect of military stress on the prevalence of functional bowel disorders

AIM: To investigate the morbidity of functional bowel disorders (FBD) under military stress conditions in order to lay foundations for the prevention and treatment of this disease. METHODS: Four hundred and fifty-seven soldiers who were assigned to specified services and 471 soldiers who were assigned to routine services were enrolled using cluster sampling, with the latter as a control group. They were surveyed using the Rome Ⅲ FBD standard questionnaire. The FBD symptom question-naire included FBD-related symptoms, severity, dura- tion or attack time, and accompanying symptoms. RESULTS: The morbidity of the military stress group (14.6%) was significantly higher than in the control group (9.98%) ( 2 = 4.585, P < 0.05). The incidence of smoking, abdominal pain and acid regurgitation ( 2 = 4.761, P < 0.05) as well as the ZUNG anxiety/depression scores ( 2 = 7.982, P < 0.01) were also sig- nificantly higher in the military stress group compared with the control group. ZUNG anxiety ( 2 = 11.523, P < 0.01) and depression ( 2 = 5.149, P < 0.05) scores were higher in the FBD group compared with the non-FBD group. The differences in the ZUNG self-rated anxiety and depression scales between the 2 groups were statistically significant ( 2 = 14.482, P < 0.01 and 2 = 6.176, P < 0.05). CONCLUSION: The morbidity of FBD was higher under military stress conditions.

Thermoelastic stresses in a uniformly heated functionally graded isotropic hollow cylinder

The axisymmetric thermoelastic problem of a uniformly heated, functionally graded isotropic hollow cylinder is considered. An analytical form of solution is proposed, For the case when the Young's modulus and thermal expansion coefficient have a power-law dependence on the radial coordinate, explicit exact solution is obtained. For the degenerated ease, i.e. when the cylinder is homogeneous and isotropie, no stresses will occur provided it is subjected to a uniform temperature. Numerical results are finally given and some important inclusions are obtained.

THE IMPROVEMENT OF THE GENERAL EXPRESSION FOR THE STRESS FUNCTION φ OF THE TWO-DIMENSIONAL PROBLEM

In this paper, it is pointed that the general expression for the stress function of the plane problem in polar coordinates is incomplete. The problems of the curved bar with an arbitrary distributive load at the boundries can't he solved by this stress function. For this reason, we suggest two new stress functions and put them into the general expression. Then, the problems of the curved bar applied with an arbitrary distributive load at r=a,b boundaries can be solved. This is a new stress function including geometric boundary constants.

Analysis of the Realization and Functions of Stress

In the field of phonology,the suprasegmental features has now won wide attention.Suprasegmental features or prosodic features are those aspects of speech that involve more than one sound segment.The principal suprasegmental feachures are syllable,stress,tone and intonation.This paper is going to focus on the feature of stress.It will cover the definition,categories,realization and functions of stress in detail.

DERIVATION OF SOME SPECIAL STRESS FUNCTION FROM BELTRAMI-SCHAEFER STRESS FUNCTION

Using liellrami-Schaefer stress funtion in the theory of elasticity in this paper, we derive the stress functions of torsion, plane problem, axisymmetric deformation in solid of revolution and torsion on solid of revolution.

Stress Field Analyses of Functionally Gradient Ceramic Tool by FEM

The cutting properties of the functionally gradient ceramic cutting tools relate closely to the gradient distribution. A cutting model of the functionally gradient ceramic tool is firstly designed in the present paper. The optimum of gradient distribution is obtained by way of the FEM analyses.

Stress analysis of functionally graded rotating discs: analytical and numerical solutions

This study deals with stress analysis of annular rotating discs made of functionally graded materials（FGMs）.Elasticity modulus and density of the discs are assumed to vary radially according to a power law function,but the material is of constant Poisson＇s ratio.A gradient parameter n is chosen between 0 and 1.0.When n = 0,the disc becomes a homogeneous isotropic material.Tangential and radial stress distributions and displacements on the disc are investigated for various gradient parameters n by means of the diverse elasticity modulus and density by using analytical and numerical solutions.Finally,a homogenous tangential stress distribution and the lowest radial stresses along the radius of a rotating disc are approximately obtained for the gradient parameter n = 1.0 compared with the homogeneous,isotropic case n = 0.This means that a disc made of FGMs has the capability of higher angular rotations compared with the homogeneous isotropic disc.

Effect of hydrostatic stress on yield function and plastic constitutive relations

A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and strong in generality. In order to reveal its availability, a comparison is made between the results obtained with it and the experimental results of grey cast iron has be done, both seem to be in good agreement. At the same time, taking the yield function obtained here as a potential function, a new associative plastic constitutive equation taking effect of hydrostatic stress into account is built, and the plastic volume change ratio of plastic deformation is given.

Green's function for T-stress of semi-infinite plane crack

Green’s function for the T-stress near a crack tip is addressed with an analytic function method for a semi-infinite crack lying in an elastical, isotropic, and infinite plate. The cracked plate is loaded by a single inclined concentrated force at an interior point. The complex potentials are obtained based on a superposition principle, which provide the solutions to the plane problems of elasticity. The regular parts of the potentials are extracted in an asymptotic analysis. Based on the regular parts, Green’s function for the T-stress is obtained in a straightforward manner. Furthermore, Green’s functions are derived for a pair of symmetrically and anti-symmetrically concentrated forces by the superimposing method. Then, Green’s function is used to predict the domain-switch-induced T-stress in a ferroelectric double cantilever beam （DCB） test. The T-stress induced by the electromechanical loading is used to judge the stable and unstable crack growth behaviors observed in the test. The prediction results generally agree with the experimental data.

SCATTERING OF HARMONIC ANTI-PLANE SHEAR STRESS WAVES BY A CRACK IN FUNCTIONALLY GRADED PIEZOELECTRIC/PIEZOMAGNETIC MATERIALS

In this paper, the dynamic behavior of a permeable crack in functionally graded piezoelectric/piezomagnetic materials is investigated. To make the analysis tractable, it is assumed that the material properties vary exponentially with the coordinate parallel to the crack. By using the Fourier transform, the problem can be solved with the help of a pair of dual integral equations in which the unknown is the jump of displacements across the crack surfaces. These equations are solved to obtain the relations between the electric filed, the magnetic flux field and the dynamic stress field near the crack tips using the Schmidt method. Numerical examples are provided to show the effect of the functionally graded parameter and the circular frequency of the incident waves upon the stress, the electric displacement and the magnetic flux intensity factors of the crack.

SEMI-WEIGHT FUNCTION METHOD ON COMPUTATION OF STRESS INTENSITY FACTORS IN DISSIMILAR MATERIALS

Semi_weight function method is developed to solve the plane problem of two bonded dissimilar materials containing a crack along the bond. From equilibrium equation, stress and strain relationship, conditions of continuity across interface and free crack surface, the stress and displacement fields were obtained. The eigenvalue of these fields is lambda. Semi_weight functions were obtained as virtual displacement and stress fields with eigenvalue?_lambda. Integral expression of fracture parameters, K Ⅰ and K Ⅱ, were obtained from reciprocal work theorem with semi_weight functions and approximate displacement and stress values on any integral path around crack tip. The calculation results of applications show that the semi_weight function method is a simple, convenient and high precision calculation method.

Positively Worded Subscale Score of the Perceived Stress Scale Is Associated with Cognitive Domain Function

Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive domain function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive domains (language: r = -0.15, p < 0.001;episodic memory: r = -0.16, p < 0.001;frontal-executive: r = -0.21, p <0.001) while the negatively worded subscale of the PSS (PSS-NW) was not significantly associated with any cognitive domain. In linear regression analyses adjusted for age, white race, gender, years of education, and depressive symptoms, the PSS-PW remained significantly associated with each of the cognitive domains. The PSS-NW was not associated with any cognitive domains in any model. The PSS-14 was significantly associated with language and episodic memory, but not the frontal-executive domain. Conclusion: Worse PSS-PW scores are associated with reduced cognitive function in the executive, memory, and language domains in nondemented older adults. The PSS-PW subscale correlated better with cognitive function than the overall PSS-14. Future research should evaluate the temporality of the association and if stress reduction therapies improve cognitive performance.

Weight Function Method for Stress Intensity Factor of Internal Surface Semi-elliptical Crack in Elliptical Holes

The hatches for inspecting are usually designed with elliptical holes in airplane structures, so computation of the stress intensity factor of three dimensional crack at elliptical holes is pivotal for damage tolerance analysis of these structures. In this paper, weight function is derived for a two dimensional through cracks at elliptical holes by applying a compounding method. Stress intensity factor formulas for an internal surface semi-elliptical crack in elliptical holes are obtained wing the three dimensional weight function method. Stress intensity factors for an internal surface semi-elliptical crack in elliptical holes under remote tension are computed. At the same time, research on how radius of curvature for elliptical holes affect stress intensity factors was conducted. Stress intensity factors decrease when radius of curvature increases. Some results and conclusions which are of practical value are given.

SCATTERING OF THE HARMONIC STRESS WAVE BY CRACKS IN FUNCTIONALLY GRADED PIEZOELECTRIC MATERIALS

The present paper considers the scattering of the time harmonic stress wave by a single crack and two collinear cracks in functionally graded piezoelectric material （FGPM）. It is assumed that the properties of the FGPM vary continuously as an exponential function. By using the Fourier transform and defining the jumps of displacements and electric potential components across the crack surface as the unknown functions, two pairs of dual integral equations are derived. To solve the dual integral equations, the jumps of the displacement and electric potential components across the crack surface are expanded in a series of Jacobi polynomials. Numerical examples are provided to show the influences of material properties on the dynamic stress and the electric displacement intensity factors.

Transfer Function Relating Compressive Pressure to Interfacial Stress Sensor for Biomedical Applications

To help comfort for an amputee, it is important to understand the load distribution between the residual limb and the prosthetic socket for a prosthetic socket system. An interfacial stress sensor was presented which was capable of measuring compressive pressure and shear stress simultaneously. A mathematical model was built and an experiment was conducted to obtain the transfer function of interfacial stress sensor to compressive pressure. The results show that the sensor is capable of measuring a range of 30-217 kPa compressive pressure with a relative error of 32.15% in lower range and 6.22% in upper range.

葡萄MYB转录因子基因VvMYB30的克隆及其耐盐性分析

MYB转录因子在响应各类非生物胁迫中发挥着重要作用。本研究以‘阳光玫瑰’葡萄为材料,鉴定了1个盐胁迫响应MYB转录因子基因VvMYB30,并对其特性及功能进行研究。该基因cDNA全长为984 bp,编码327个氨基酸。生物信息学分析发现,VvMYB30含有1个保守的R2R3蛋白结构域,与甜橙CsMYB30转录因子的同源性最高,相似度为64.75%,归属于SubgroupⅠ亚类。亚细胞定位及转录激活分析表明,VvMYB30定位于细胞核,且具有转录激活活性。qRT-PCR结果表明,VvMYB30受盐胁迫诱导,处理24 h表达量达到最高,为对照的6.86倍。将VvMYB30基因转化拟南芥,盐胁迫下VvMYB30转基因拟南芥种子萌发率和幼苗的成活率均显著高于野生型,表明过表达VvMYB30可增强转基因拟南芥的耐盐性。

Evaluation of strongly singular domain integrals for internal stresses in functionally graded materials analyses using RIBEM

An accurate evaluation of strongly singular domain integral appearing in the stress representation formula is a crucial problem in the stress analysis of functionally graded materials using boundary element method.To solve this problem,a singularity separation technique is presented in the paper to split the singular integral into regular and singular parts by subtracting and adding a singular term.The singular domain integral is transformed into a boundary integral using the radial integration method.Analytical expressions of the radial integrals are obtained for two commonly used shear moduli varying with spatial coordinates.The regular domain integral,after expressing the displacements in terms of the radial basis functions,is also transformed to the boundary using the radial integration method.Finally,a boundary element method without internal cells is established for computing the stresses at internal nodes of the functionally graded materials with varying shear modulus.