The beginning of failure of a (ZrO2-7%Y2O3)/(Ni-22%Co-17%Cr-12.5%Al-0.6%Y) duplex andgraded coating systems on lnconel 617 and IN738LC in burner rig tests has been characterized.The test conditions are 40 s heating up...The beginning of failure of a (ZrO2-7%Y2O3)/(Ni-22%Co-17%Cr-12.5%Al-0.6%Y) duplex andgraded coating systems on lnconel 617 and IN738LC in burner rig tests has been characterized.The test conditions are 40 s heating up to 75O℃ substrate temperature followed by 80 s aircooling. Failure is considered at the appearance of the first bright spot during heating period.Stresses due to thermal expansion mismatch strains on cooling are the probable cause of life-limiting in this conditions of testing.展开更多
Background:This study aimed to clarify the effects of a Graded Brisk Walking Test(GBWT)program on blood pressure(BP)control in elderly patients with essential hypertension and to determine its appropriate degree of in...Background:This study aimed to clarify the effects of a Graded Brisk Walking Test(GBWT)program on blood pressure(BP)control in elderly patients with essential hypertension and to determine its appropriate degree of intensity for elderly people.Methods:In total,421 out of 620 participants were randomly sampled from a community health center in Shanghai,China.Among them,200 and 221 patients were assigned to the intervened and control groups,respectively.They were all treated with the GBWT program for 8 weeks,16 weeks,and 24 weeks.Results:Based on ANOVA,there was no significant time main effect,condition main effect,or time by condition interaction both in heart rate and body mass index indicators(P>0.05).There were significant condition main effects,time by condition interaction,or time main effects in blood pressure(F=21.875,33.457,65.342,respectively;All P<0.05).After the intervention,significant differences in systolic blood pressure(SBP)and diastolic blood pressure(DBP)values were also observed in the two groups(P<0.05);the average values of the baseline and second phases of the intervention group were significantly lower than those of the control group(P<0.05).Significant differences in blood pressure values after the first two phases were also observed when compared with those before the intervention.Similarly,a significant difference in the first phase and second phase was also found between the BP group and intervention group.However,after the third phase(24 weeks,high-intensity exercise),no significant differences existed both in SBP and DBP groups compared with those before the intervention(P=0.07).Conclusion:GBWT is an effective exercise prescription to mitigate the essential hypertension in elderly Chinese patients,and the intensity,walking distance,and target number of steps can be adjusted according to the age of the patients.展开更多
In this paper, an experimental and analytical study of two half-scale steel X-braced flames with equal nominal shear strength under cyclic loading is described. In these tests, all members except the braces are simila...In this paper, an experimental and analytical study of two half-scale steel X-braced flames with equal nominal shear strength under cyclic loading is described. In these tests, all members except the braces are similar. The braces are made of various steel grades to monitor the effects of seismic excitation. Internal stiffeners are employed to limit the local buckling and increase the fracture life of the steel bracing. A heavy central core is introduced at the intersection of the braces to decrease their effective length. Recent seismic specifications are considered in the design of the X-braced frame members to verify their efficiency. The failure modes of the X-braced frames are also illustrated. It is observed that the energy dissipation capacity, ultimate load capacity and ductility of the system increase considerably by using lower grade steel and proposed detailing. Analytical modeling of the specimens using nonlinear finite element software supports the experimental findings.展开更多
Regarding the freezing damage of high-grade highway subgrade in seasonally frozen area,the thesis explores the effect on the dynamic behavior of subgrade soil under freeze–thaw cycles and draws the change law of para...Regarding the freezing damage of high-grade highway subgrade in seasonally frozen area,the thesis explores the effect on the dynamic behavior of subgrade soil under freeze–thaw cycles and draws the change law of parameters(including dynamic strength,dynamic cohesion,and internal friction angle;and dynamic elastic modulus)of high-grade highway-subgrade soil with the number of freeze–thaw cycles.It aims to provide the reference for operation and maintenance of a high-grade highway.Conclusions:(1)Dynamic strength tends to decline evidently after freeze–thaw cycles,with 60%~70%decline after three cycles,and remains stable after five to seven cycles.(2)With the number of freeze–thaw cycles increasing,the internal friction angle fluctuates within a certain range without an obvious change law,only presenting the tendency of dropping off.The dynamic cohesion declines obviously,about 20%~40%after seven freeze–thaw cycles,and then tends to be stable.(3)With the number of freeze-thaw cycles increasing,the dynamic elastic modulus and maximum dynamic elastic modulus are inclined to decrease distinctly.After five freeze–thaw cycles,the former declines 30%~40%and then remains stable.Meanwhile,the latter falls 20%~40%.展开更多
It is quite necessary for teachers of English to know the basic knowledge and techniques about how to design good English testpapers. To meet this necessity, this paper first tells of the basic principles and requirem...It is quite necessary for teachers of English to know the basic knowledge and techniques about how to design good English testpapers. To meet this necessity, this paper first tells of the basic principles and requirements of designing English test papers, then the procedures,and, at last, the characters of some test questions and the techniques when designing them.展开更多
目的探讨I D H突变和1p/19q共缺失型少突胶质细胞瘤的临床病理特征及预后相关影响因素。方法收集54例IDH突变和1p/19q共缺失型少突胶质细胞瘤病例,分析其临床病理特点,包括年龄、组织学分级和肿瘤部位等因素对无进展生存期和总生存期的...目的探讨I D H突变和1p/19q共缺失型少突胶质细胞瘤的临床病理特征及预后相关影响因素。方法收集54例IDH突变和1p/19q共缺失型少突胶质细胞瘤病例,分析其临床病理特点,包括年龄、组织学分级和肿瘤部位等因素对无进展生存期和总生存期的影响。结果 54例患者中,肿瘤发生于1个脑叶者46例,发生于2个脑叶以上者8例。肿瘤组织学WHO分级2级12例,3级42例。FISH检测显示54例均为1p/19q共缺失;免疫组织化学检测显示Olig2均为弥漫强阳性;GFAP均为阳性;p53有6例强阳性;48例患者ATRX未缺失;Ki-67增殖指数5%~60%。Sanger测序显示54例均发生IDH基因突变(40例为IDH1突变,14例为IDH2突变),33例发生TERT启动子突变。16例在治疗过程中发生复发及转移。单因素分析显示,手术后复发转移间隔时间超过2年可以延长患者无进展生存和总生存期。54例患者平均无进展生存期33.5个月,平均总生存期40.7个月。结论 IDH突变和1p/19q共缺失型少突胶质细胞瘤术后联合精准放化疗降低了进展风险,手术后复发转移间隔时间与该型患者预后相关。展开更多
文摘The beginning of failure of a (ZrO2-7%Y2O3)/(Ni-22%Co-17%Cr-12.5%Al-0.6%Y) duplex andgraded coating systems on lnconel 617 and IN738LC in burner rig tests has been characterized.The test conditions are 40 s heating up to 75O℃ substrate temperature followed by 80 s aircooling. Failure is considered at the appearance of the first bright spot during heating period.Stresses due to thermal expansion mismatch strains on cooling are the probable cause of life-limiting in this conditions of testing.
基金the Shanghai University of Medicine&Health Sciences’Institutional Review Board for the Protection of Human Subjects(No.2018-pdwjw-01-372424198012222511).
文摘Background:This study aimed to clarify the effects of a Graded Brisk Walking Test(GBWT)program on blood pressure(BP)control in elderly patients with essential hypertension and to determine its appropriate degree of intensity for elderly people.Methods:In total,421 out of 620 participants were randomly sampled from a community health center in Shanghai,China.Among them,200 and 221 patients were assigned to the intervened and control groups,respectively.They were all treated with the GBWT program for 8 weeks,16 weeks,and 24 weeks.Results:Based on ANOVA,there was no significant time main effect,condition main effect,or time by condition interaction both in heart rate and body mass index indicators(P>0.05).There were significant condition main effects,time by condition interaction,or time main effects in blood pressure(F=21.875,33.457,65.342,respectively;All P<0.05).After the intervention,significant differences in systolic blood pressure(SBP)and diastolic blood pressure(DBP)values were also observed in the two groups(P<0.05);the average values of the baseline and second phases of the intervention group were significantly lower than those of the control group(P<0.05).Significant differences in blood pressure values after the first two phases were also observed when compared with those before the intervention.Similarly,a significant difference in the first phase and second phase was also found between the BP group and intervention group.However,after the third phase(24 weeks,high-intensity exercise),no significant differences existed both in SBP and DBP groups compared with those before the intervention(P=0.07).Conclusion:GBWT is an effective exercise prescription to mitigate the essential hypertension in elderly Chinese patients,and the intensity,walking distance,and target number of steps can be adjusted according to the age of the patients.
文摘In this paper, an experimental and analytical study of two half-scale steel X-braced flames with equal nominal shear strength under cyclic loading is described. In these tests, all members except the braces are similar. The braces are made of various steel grades to monitor the effects of seismic excitation. Internal stiffeners are employed to limit the local buckling and increase the fracture life of the steel bracing. A heavy central core is introduced at the intersection of the braces to decrease their effective length. Recent seismic specifications are considered in the design of the X-braced frame members to verify their efficiency. The failure modes of the X-braced frames are also illustrated. It is observed that the energy dissipation capacity, ultimate load capacity and ductility of the system increase considerably by using lower grade steel and proposed detailing. Analytical modeling of the specimens using nonlinear finite element software supports the experimental findings.
基金funded by the National Natural Science Foundation of China (No. 51378057)
文摘Regarding the freezing damage of high-grade highway subgrade in seasonally frozen area,the thesis explores the effect on the dynamic behavior of subgrade soil under freeze–thaw cycles and draws the change law of parameters(including dynamic strength,dynamic cohesion,and internal friction angle;and dynamic elastic modulus)of high-grade highway-subgrade soil with the number of freeze–thaw cycles.It aims to provide the reference for operation and maintenance of a high-grade highway.Conclusions:(1)Dynamic strength tends to decline evidently after freeze–thaw cycles,with 60%~70%decline after three cycles,and remains stable after five to seven cycles.(2)With the number of freeze–thaw cycles increasing,the internal friction angle fluctuates within a certain range without an obvious change law,only presenting the tendency of dropping off.The dynamic cohesion declines obviously,about 20%~40%after seven freeze–thaw cycles,and then tends to be stable.(3)With the number of freeze-thaw cycles increasing,the dynamic elastic modulus and maximum dynamic elastic modulus are inclined to decrease distinctly.After five freeze–thaw cycles,the former declines 30%~40%and then remains stable.Meanwhile,the latter falls 20%~40%.
文摘It is quite necessary for teachers of English to know the basic knowledge and techniques about how to design good English testpapers. To meet this necessity, this paper first tells of the basic principles and requirements of designing English test papers, then the procedures,and, at last, the characters of some test questions and the techniques when designing them.
文摘目的探讨I D H突变和1p/19q共缺失型少突胶质细胞瘤的临床病理特征及预后相关影响因素。方法收集54例IDH突变和1p/19q共缺失型少突胶质细胞瘤病例,分析其临床病理特点,包括年龄、组织学分级和肿瘤部位等因素对无进展生存期和总生存期的影响。结果 54例患者中,肿瘤发生于1个脑叶者46例,发生于2个脑叶以上者8例。肿瘤组织学WHO分级2级12例,3级42例。FISH检测显示54例均为1p/19q共缺失;免疫组织化学检测显示Olig2均为弥漫强阳性;GFAP均为阳性;p53有6例强阳性;48例患者ATRX未缺失;Ki-67增殖指数5%~60%。Sanger测序显示54例均发生IDH基因突变(40例为IDH1突变,14例为IDH2突变),33例发生TERT启动子突变。16例在治疗过程中发生复发及转移。单因素分析显示,手术后复发转移间隔时间超过2年可以延长患者无进展生存和总生存期。54例患者平均无进展生存期33.5个月,平均总生存期40.7个月。结论 IDH突变和1p/19q共缺失型少突胶质细胞瘤术后联合精准放化疗降低了进展风险,手术后复发转移间隔时间与该型患者预后相关。
