A STUDY OF THE RELATIONSHIP BETWEEN URINARY KALLIKREIN AND HYPERTENSION IN CHILDREN

hour urinary kallikrein excreation was measured(by fluorometry)in 300 children aged 10￣ 15 in Hanzhong. By comparison and retrospective study,the results showed:(1)in children with higher blood pressure(HBP)and positive family history of hypertension (FH+ ),the urinary kallikrein excreation was significantly lower than that in controls(P< 0.01).(2) the 12-hour urinary kallikrein excreation was negatively correlated with the SBP and DBP in the following up 3 times.(3)6-year retrospective review of blood pressure evolution showed that the blood pressure increased degree(△SBP) in children with lower urinary kallikrein excreation was much greater than that in those with higher one(P<0.01),and the percentiles or systolic blood pressure(△SBP)for children with lower urinary kallikrein mostly kept rising or kept up higher percentiles during the period. It is indicated that low urinary kallokrein may be a genetic marker to identify the children who are in danger or developing essential hypertension in future.

Meta-analysis of the clinical efficacy and safety of Urinary Kallidinogenase in the treatment of acute cerebral infarction

Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase's treatment of acute cerebral infarction.The time limit was set up until September 2019.At the same time,the references and grey literature in the literature were manually screened.Two independent researchers were screened,evaluated and extracted according to inclusion and exclusion criteria.Meta-analysis was carried out by RevMan 5.3 software.Results:A total of 17 randomized controlled trials involving 2,066 patients,including 1,033 in the experimental group,and 1,033 in the control group.meta-analysis results showed that compared with the conventional treatment,Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction[OR=3.26,95%CI(2.56,4.16),P<0.00001];the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group.Urinary Kallidinogenase group activity of daily living scale was better than the control group[OR=21.33,95%CI(6.64,36.01),P=0.004];a total of 7 articles reported adverse reactions,including 19 cases in the trial group and 21 cases in the control group,the main adverse reactions were blood pressure drop,other symptoms were chest tightness,facial redness,dizziness fever,nausea and vomiting,arrhythmia,and no other serious adverse reactions.It can recover itself.Conclusion:the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction,and is safe.However,the quality of the study is limited.