Is yawning a tool for wakefulness or for sleep?

Numerous theories as to why we yawn have been advanced, but yawning appears to be a complex phenomenon that is difficult to study. The physiology of yawning with its sharp chest inhalation, along with its contagious nature, can be explained by an arousal theory, that is, yawning promotes vigilance and alertness within a group that overrides a drive to sleep. Other theories of yawning, such as brain thermoregulation, are not necessarily excluded by the arousal theory but may be the results of yawning rather than its cause.

Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice

Cerebellar malfunction can lead to sleep disturbance such as excessive daytime sleepiness,suggesting that the cerebellum may be involved in regulating sleep and/or wakefulness.However,understanding the features of cerebellar regulation in sleep and wakefulness states requires a detailed characterization of neuronal activity within this area.By performing multiple-unit recordings in mice,we showed that Purkinje cells(PCs)in the cerebellar cortex exhibited increased firing activity prior to the transition from sleep to wakefulness.Notably,the increased PC activity resulted from the inputs of lowfrequency non-PC units in the cerebellar cortex.Moreover,the increased PC activity was accompanied by decreased activity in neurons of the deep cerebellar nuclei at the nonrapid eye-movement sleep-wakefulness transition.Our results provide in vivo electrophysiological evidence that the cerebellum has the potential to actively regulate the sleep-wakefulness transition.

Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus

The parabrachial nucleus(PBN)integrates interoceptive and exteroceptive information to control various behavioral and physiological processes including breathing,emotion,and sleep/wake regulation through the neural circuits that connect to the forebrain and the brainstem.However,the precise identity and function of distinct PBN subpopulations are still largely unknown.Here,we leveraged molecular characterization,retrograde tracing,optogenetics,chemogenetics,and electrocortical recording approaches to identify a small subpopulation of neurotensin-expressing neurons in the PBN that largely project to the emotional control regions in the forebrain,rather than the medulla.Their activation induces freezing and anxiety-like behaviors,which in turn result in tachypnea.In addition,optogenetic and chemogenetic manipulations of these neurons revealed their function in promoting wakefulness and maintaining sleep architecture.We propose that these neurons comprise a PBN subpopulation with specific gene expression,connectivity,and function,which play essential roles in behavioral and physiological regulation.

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in mammals.Studies on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between neurons.Astrocytes,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic function.Recent research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel signaling.This summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical states.These findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and responsiveness.Targeting astrocytic signaling pathways shows promise for treating sleep disorders and arousal dysregulation.More research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

A nonlinear wake model of a wind turbine considering the yaw wake steering

Duo to fluctuations in atmospheric turbulence and yaw control strategies,wind turbines are often in a yaw state.To predict the far wake velocity field of wind turbines quickly and accurately,a wake velocity model was derived based on the method of momentum conservation considering the wake steering of the wind turbine under yaw conditions.To consider the shear effect of the vertical incoming wind direction,a two-dimensional Gaussian distribution function was introduced to model the velocity loss at different axial positions in the far wake region based on the assumption of nonlinear wake expansion.This work also developed a“prediction-correction”method to solve the wake velocity field,and the accuracy of the model results was verified in wake experiments on the Garrad Hassan wind turbine.Moreover,a 33-kW two-blade horizontal axis wind turbine was simulated using this method,and the results were compared with the classical wake model under the same parameters and the computational fluid dynamics(CFD)simulation results.The results show that the nonlinear wake model well reflected the influence of incoming flow shear and yaw wake steering in the wake velocity field.Finally,computation of the wake flow for the Horns Rev offshore wind farm with 80 wind turbines showed an error within 8%compared to the experimental values.The established wake model is less computationally intensive than other methods,has a faster calculation speed,and can be used for engineering calculations of the wake velocity in the far wakefield of wind turbines.

Coupling of RANS and BEM Solvers for Simulation of Propeller Behind the Hull in Full Appended Model

To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this paper,a coupled BEM(Boundary Element Method)/RANS(Renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion test.The motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational time.An unsteady boundary element method which is also known as panel method is chosen to estimate the propeller forces.Propeller wakes are treated using a time marching wake alignment method.Also,a RANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the RANS code.Based on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller RPM in every time step.Verification of the solver is carried out using the towing tank test report of a 50 m oceanography research vessel.Wake factor and trust deduction coefficient are estimated numerically.Also,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field.

水下航行体湍流数值模拟方法研究进展综述

In this paper,we present an overview of numerical simulation methods for the flow around typical underwater vehicles at high Reynolds numbers,which highlights the dominant flow structures in different regions of interest.This overview covers the forebody,midbody,stern,wake region,and appendages and summarizes flow phenomena,including laminar-to-turbulent transition,turbulent boundary layers,flow under the influence of curvatures,wake interactions,and all associated complex vortex structures.Furthermore,the current issues and challenges of capturing these flow structures are addressed.This overview provides a deep insight into the use of numerical simulation methods,including the Reynolds-averaged Navier–Stokes(RANS)method,large eddy simulation(LES)method,and the hybrid RANS/LES method,and evaluates their applicability in capturing detailed flow features.

Coupled Cross-Flow/in-Line Vortex-Induced Vibration Responses of a Catenary-Type Riser Subjected to Uniform Flows

A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)directions.By using the vector form intrinsic finite element method,the CTR was discretized into a finite number of spatial particles whose motions satisfy Newton’s second law.The Van der Pol oscillator was used to simulate the effect of vortex shedding.The coupling equations of structural vibration and wake oscillator were solved using an explicit central differential algorithm.The numerical model was verified with the published results.The VIV characteristics of the CTR subjected to uniform flows,including displacement,frequency,standing wave,traveling wave,motion trajectory,and energy transfer,were studied comprehensively.The numerical results revealed that the multimode property occurs in the CF-and IL-direction VIV responses of the CTR.An increase in the flow velocity has slight effects on the maximum VIV displacement.Due to structural nonlin-earity,the double-frequency relationship in the CF and IL directions is rarely captured.Therefore,the vibration trajectories display the shape of an inclined elliptical orbit.Moreover,the negative energy region is inconspicuous under the excitation of the uniform flow.

A grouping strategy for reinforcement learning-based collective yawcontrol of wind farms

Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical applications.In this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind farms.To reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake interaction.Meanwhile,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single agent.Optimized results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.

Boulder-induced form roughness and skin shear stresses in a gravel-bed stream

Boulder spacing in mountain rivers and near-wake flow zones within the boulder array is very useful for fish habitat and growth of aquatic organisms.The present study aims to investigate how the boulder array and spacing influence the near-bed flow structures in a gravel-bed stream.Boulders are staggered over a gravel-bed stream with three different inter-boulder spacing namely(a)large(b)medium and(c)small spacing.An acoustic Doppler velocimeter was used for flow measurements in a rectangular channel and the results were compared with those acquired from numerical simulation.The time-averaged velocity profiles at the near-wake flow zones of boulders experience maximum flow retardation which is an outcome of the boulder-induced form roughness.The ratio of velocity differences associated to form and skin roughness and its positive magnitude reveals the dominance of form roughness closest to the boulders.Form roughness computed is 1.75 to 2 times higher than the skin roughness at the near-wake flow region.In particular,the collective immobile boulders placed at different inter-boulder spacings developed high and low bed shear stresses closest to the boulders.The low bed shear stresses characterised by a secondary peak developed at the trough location of the boulders is attributed to the skin shear stress.Further,the spatial averaging of time-averaged flow quantities gives additional impetus to present an improved illustration of fluid shear stresses.The formation of form-induced shear stress is estimated to be 17%to 23%of doubleaveraged Reynolds shear stress and partially compensates for the damping of time-averaged Reynolds shear stress in the interfacial sub-layer.The quadrant analysis of spatial velocity fluctuations depicts that the form-induced shear stresses are dominant in the interfacial sub-layer and have no significance above the gravel-bed surface.

A call for enhanced data-driven insights into wind energy flow physics

With the increased availability of experimental measurements aiming at probing wind resources and wind turbine operations,machine learning(ML)models are poised to advance our understanding of the physics underpinning the interaction between the atmospheric boundary layer and wind turbine arrays,the generated wakes and their interactions,and wind energy harvesting.However,the majority of the existing ML models for predicting wind turbine wakes merely recreate Computational fluid dynamics(CFD)simulated data with analogous accuracy but reduced computational costs,thus providing surrogate models rather than enhanced data-enabled physics insights.Although ML-based surrogate models are useful to overcome current limitations associated with the high computational costs of CFD models,using ML to unveil processes from experimental data or enhance modeling capabilities is deemed a potential research direction to pursue.In this letter,we discuss recent achievements in the realm of ML modeling of wind turbine wakes and operations,along with new promising research strategies.

Assessment of scale interactions associated with wake meandering using bispectral analysis methodologies

Large atmospheric boundary layer fluctuations and smaller turbine-scale vorticity dynamics are separately hypothesized to initiate the wind turbine wake meandering phenomenon,a coherent,dynamic,turbine-scale oscillation of the far wake.Triadic interactions,the mechanism of energy transfers between scales,manifest as triples of wavenumbers or frequencies and can be characterized through bispectral analyses.The bispectrum,which correlates the two frequencies to their sum,is calculated by two recently developed multi-dimensional modal decomposition methods:scale-specific energy transfer method and bispectral mode decomposition.Large-eddy simulation of a utility-scale wind turbine in an atmospheric boundary layer with a broad range of large length-scales is used to acquire instantaneous velocity snapshots.The bispectrum from both methods identifies prominent upwind and wake meandering interactions that create a broad range of energy scales including the wake meandering scale.The coherent kinetic energy associated with the interactions shows strong correlation between upwind scales and wake meandering.

Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic

Common psychiatric disorders(CPDs)and depression contribute significantly to the global epidemic of type 2 diabetes(T2D).We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs,promotes the establishment of emotional eating,activation of the reward system,onset of overweight and obesity and,ultimately the increased risk of developing T2D.The plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexonebupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction,but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug addiction.We hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.

Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex

Orexins, produced in the lateral hypothalamus, are important neuropeptides that participate in the sleep/wake cycle, and their expres- sion coincides with the projection area of the vagus nerve in the brain. Vagus nerve stimulation has been shown to decrease the amounts of daytime sleep and rapid eye movement in epilepsy patients with traumatic brain injury. In the present study, we investigated whether vagus nerve stimulation promotes wakefulness and affects orexin expression. A rat model of traumatic brain injury was established using the free fall drop method. In the stimulated group, rats with traumatic brain injury received vagus nerve stimulation （frequency, 30 Hz, current, 1.0 mA; pulse width, 0.5 ms; total stimulation time, 15 minutes）. In the antagonist group, rats with traumatic brain injury were intracerebroventricularly injected with the orexin receptor type 1 （OXIR） antagonist SB334867 and received vagus nerve stimulation. Changes in consciousness were observed after stimulation in each group. Enzyme-linked immunosorbent assay, western blot assay and immunohistochemistry were used to assess the levels of orexin-A and OX1R expression in the prefrontal cortex. In the stimulated group, consciousness was substantially improved, orexin-A protein expression gradually increased within 24 hours after injury and OX1R expres- sion reached a peak at 12 hours, compared with rats subjected to traumatic brain injury only. In the antagonist group, the wake-promoting effect of vagus nerve stimulation was diminished, and orexin-A and OX1R expression were decreased, compared with that of the stim- ulated group. Taken together, our findings suggest that vagus nerve stimulation promotes the recovery of consciousness in comatose rats after traumatic brain injury. The upregulation of orexin-A and OXIR expression in the prefrontal cortex might be involved in the wake-promoting effects of vagus nerve stimulation.

Measuring consciousness in coma and related states

Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Severe acquired brain injuries resulting in a disorder of con-sciousness(DOC) provide a model from which insights into consciousness can be drawn. A number of recent studies highlight the difficulty in making a diagnosis in patients with DOC based only on behavioral assessments. Here we aim to provide an overview of how neuroimaging techniques can help assess patients with DOC. Such techniques are expected to facilitate a more accurate understanding of brain function in states of unconsciousness and to improve the evaluation of thepatient's cognitive abilities by providing both diagnostic and prognostic indicators.

地震作用下海底悬跨管道水动力计算模型

在不同方向的地震动输入下海底悬跨管道的动力响应存在差别.基于Wake模型,提出了三维地震输入下的海底悬跨管道的水动力模型,并推导了有限元控制方程.建立有限元离散模型模拟模型试验工况,进行了正弦波和El Centro模拟地震波输入下海底悬跨管道的动力分析.通过数值计算和模型试验的结果比较可以看出,考虑地震动输入方向影响的Wake模型能够应用于海底悬跨管道的地震响应分析,其计算结果与试验结果符合得较好.

ENHANCED UNSTEADY AND NONLINEAR ROTOR WAKE MODEL FOR REAL-TIME FLIG HT SIMULATION

WT5 'BZThis paper presents an unsteady and nonlinear wake model based on th e widely used Peters He finite state dynamic wake model with improvements. The swirl component in the tip trace plane (TTP) can be predicted, nonlinear items are added into the linear theory, and the old small angle assumption use d in matrix prediction is removed. All of these enha ncements are aimed at the low speed flight phase and formulations for the induce d velocity field just in the TTP frame are derived. The corresponding FORTRAN pr ogram is tested and optimized for the real time applications on PCs.

轿车尾流移测试验研究

轿车的尾流结构与其空气阻力、升力与安全性有密切联系 ,为进一步研究轿车尾流结构及验证尾流场数值模拟结果的精确性提供依据 ,需通过试验得到较为全面地反映尾流结构的定量信息。为此 ,进行了红旗CA774轿车 1 10模型的七孔探针尾流移测试验 。

AN IMPROVED MODEL OF CURVED VORTEX ELEMENT FOR ROTOR WAKE ANALYSIS

This paper describes an improved model of curved vortex element on the circular arc (CVEC) for rotor wake analysis.As the key of the paper,two approximate formulas are derived by the series of limited terms to replace the Legendre incomplete elliptical integrals from the Biot-Savart integration,and the analytical solution of the induced velocity for the CVEC is obtained, which is more efficient in the complex rotor free wake calculation. Furthermore,the approximate formulas with the chosen factors are selected to avoid sigularity and give finite result of the induced velocity on the Vortex line,and an equivalent viscous vortex core radius might be evaluated.As examples, the induced velocity calculations on the vortex ring and two turns of a skew vortex helix are performed, and the comparisons between the circular-arc vortex element and the conventional straightline vortex element (SLVE) are given.It is shown that this curved vortex element model is advantageous over the SLVE model and is suitable for the rotor wake analysis.

Modifi cation of sleep architecture in an animal model of experimental cirrhosis

AIM： To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCh administration. METHODS： Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were im- planted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological confirmation of cirrhosis was performed after 11 wk. RESULTS： The results showed a progressive decrease in total wake time that reached statistical significance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep （SWS）Ⅱ and rapid eye movement sleep （REM sleep） in most of the 11 wk. SWS I showed no significant variations. During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION： These data suggest that hepatic failure produced by CCh administration is capable of modifying the sleep pattern even after only a few doses.