Late effects of the treatment of childhood cancer

Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.

Effects of cell wall property on compressive performance of aluminum foams

The effects of cell wall property on the compressive performance of high porosity, closed-cell aluminum foams prepared by gas injection method were investigated. The research was conducted both experimentally and numerically. Foam specimens prepared from conditioned melt were tested under uniaxial compressive loading condition. The cell wall microstructure and fracture were observed through optical microscope（OM） and scanning electron microscope（SEM）, which indicates that the cell wall property is impaired by the defects in cell walls and oxide films on the cell wall surface. Subsequently, finite element（FE） models based on three-dimensional thin shell Kelvin tetrakaidecahedron were developed based on the mechanical properties of the raw material and solid material that are determined by using experimental measurements. The simulation results show that the plateau stress of the nominal stress-strain curve exhibits a linear relationship with the yield strength of the cell wall material. The simulation plateau stress is higher than the experimental data, partly owing to the substitution of solid material for cell wall material in the process of the establishment of FE models.

Side Wall Effects on the Hydrodynamics of a Floating Body by ImageGreen Function Based on TEBEM

A novel numerical model based on the image Green function and first-order Taylor expansion boundary element method(TEBEM), which can improve the accuracy of the hydrodynamic simulation for the non-smooth body, was developed to calculate the side wall effects on first-order motion responses and second-order drift loads upon offshore structures in the wave tank. This model was confirmed by comparing it to the results from experiments on hydrodynamic coefficients, namely the first-order motion response and second-order drift load upon a hemisphere, prolate spheroid, and box-shaped barge in the wave tank. Then,the hydrodynamics of the KVLCC2 model were also calculated in two wave tanks with different widths. It was concluded that this model can predict the hydrodynamics for offshore structures effectively, and the side wall has a significant impact on the firstorder quantities and second-order drift loads, which satisfied the resonant rule.

Flow behavior in microchannel made of different materials with wall slip velocity and electro-viscous effects

In a microfluidic system, flow slip velocity on a solid wall can be the same order of magnitude as the average velocity in a microchannel. The flow-electricity interaction in a complex microfluidic system subjected to joint action of wall slip and electro-viscous effect is an important topic. This paper presents an analytic solution of pressuredriven liquid flow velocity and flow-induced electric field in a two-dimensional microchannel made of different materials with wall slip and electro-viscous effects. The Poisson- Boltzmann equation and the Navier-Stokes equation are solved for the analytic solutions. The analytic solutions agree well with the numerical solutions. It was found that the wall slip amplifies the fow-induced electric field and enhances the electro-viscous effect on flow. Thus the electro-viscous effect can be significant in a relatively wide microchannel with relatively large kh, the ratio of channel width to thickness of electric double layer, in comparison with the channel without wall slip.

Effects of hanging wall and footwall on demand of structural input energy during the 2008 Wenchuan earthquake

Systematic differences in the duration and frequency content of ground motions from the hanging wall and footwall during the 2008 Wenchuan earthquake are investigated,focusing on the influence of these differences on structural input energy based on the elastic and inelastic energy responses of structures.A comparison of the input energy spectra between the hanging wall and the footwall reveal that the structural input energy on the hanging wall is not amplified due to the short duration and low peak ground velocity to acceleration ratio（V/A）.However,the larger demand of structural input energy on the footwall in the range of medium and long periods is observed and the demand increases up to 50% relative to the average level of structural input energy for rupture distances larger than 30 km.The importance of considering the footwall effect on structural input energy when comparing ground motions in the range of medium and long periods is recognized.

Effects of the hanging wall and footwall on peak acceleration during the Jiji (Chi-Chi), Taiwan Province, earthquake

The M=7.6 Jiji (Chi-Chi) earthquake, Taiwan Province, on September 21, 1999 (local time) is a thrust fault style earthquake. The empirical attenuation relations of the horizontal and vertical peak ground accelerations (PGA) for the Jiji (Chi-Chi) earthquake are developed by regression method. By examining the residuals from the Jiji (Chi-Chi) earthquake-specific peak acceleration attenuation relations, it is found that there are systematic differences between PGA on the hanging-wall and footwall. The recorded peak accelerations are higher on the hanging-wall and lower on the footwall. The clear asymmetry of PGA distribution to the surface rupture trace can also be seen from the PGA contour map. These evidences indicate that the PGA attenuates faster on the hanging-wall than on the footwall. In the study of near-source strong motion, seismic hazard assessment, scenario earthquake and seismic disaster prediction, the style-of-faulting must be considered in order that the attenuation model can reflect the characteristic of ground motion in various seismic environmental regions.

THERMAL EFFECTS OF BUILDING′S EXTERNAL SURFACES IN CITY——Characteristics of Heat Flux into and out of External Wall Surfaces

This study examined the thermal effects of building′s external wall surfaces, using observational data of spatial-temporal distribution of surface temperature, air temperature, and heat flux into and out of external surface. Results indicate that external wall surface temperature and nearby air temperature vary with the change of orientation, height and season. In general, the external wall surface temperature is lower near the ground, and is higher near the roof, than nearby air temperature. But north wall surface temperature is mostly lower than nearby air temperature at the same height; south wall surface temperature during the daytime in December, and west wall surface temperature all day in August, is respectively higher than nearby air temperature. The heat fluxes into and out of external wall surfaces show the differences that exist in the various orientations, heights and seasons. In December, south wall surface at the lower sites emits heat and north wall surface at the higher sites absorbs heat. In April, all external wall surfaces, emit heat near the ground and absorb heat near the roof. In August, west wall surface all day emits heat, and other wall surfaces just show the commensurate behavior with that in April.

Effects of a liquid lithium curtain as the first wall in a fusion reactor plasma

This paper explores the effect of a liquid lithium curtain on fusion reactor plasma, such curtain is utilized as the first wall for the engineering outline design of the Fusion Experimental Breeder （FEB-E）. The relationships between the surface temperature of a liquid lithium curtain and the effective plasma charge, fuel dilution and fusion power production have been derived. Results indicate that under normal operation, the evaporation of liquid lithium does not seriously affect the effective plasma charge, but effects on fuel dilution and fusion power are more sensitive. As an example, it has investigated the relationships between the liquid lithium curtain flow velocity and the rise of surface temperature based on operation scenario II of the FEB-E design with reversed shear configuration and high power density. Results show that even if the liquid lithium curtain flow velocity is as low as 0.5 m/s, the effects of evaporation from the liquid lithium curtain on plasma are negligible. In the present design, the sputtering of liquid lithium curtain and the particle removal effects of the divertor are not yet considered in detail. Further studies are in progress, and in this work implication of lithium erosion and divertor physics on fusion reactor operation are discussed.

Doping effects of manganese on the catalytic performance and structure of NiMgO catalysts for controllabe synthesis of multi-walled carbon nanotubes

Doping effects of manganese （Mn） on catalytic performance and structure evolution of NiMgO catalysts for synthesis of multi-walled carbon nanotubes （MWCNTs） from methane were investigated for the first time. Addition of Mn in NiMgO catalyst can greatly improve the MWCNTs yield. Mno.2NiMgO catalyst among the tested ones gives the highest MWCNTs yield as 2244%, which is two times higher than that of the catalyst without Mn. The structure evolution, reduction behaviors and surface chemical properties of MnNiMgO catalysts with various Mn contents were studied in detail. It was found that the stable solid solution of NiMgO2 formed in NiMgO catalyst was disturbed by the addition of Mn. Instead, another solid solution of MnMg608 is formed. More amount of Ni can be reduced and dispersed on the catalyst surface to be acted as active sites. Importantly, the changes of Ni content on the surface are correlated with the Ni particle size and the outer diameter of MWCNTs, suggesting the controllable synthesis of MWCNTs over MnNiMgO catalysts.

Higher mode effects in hinged wall with BRBsin base-frame structures using distributed parameter models

To investigate the effect of higher modes on the displacement and inner forces in HWBB(hinged wall with buckling-restrained braces in base)-frame structure,distributed parameter models for both the HWBB-hinged frame structure and the HWBB-MRF(moment resisting frame)structure are built.The hinged wall is simplified as a flexural beam.BRBs(bucking-restrained braces)are simplified to a rotational spring.MRF is simplified to a shear beam.Vibration equations of distributed parameter models are derived.Natural periods,natural modes of vibration,inner forces and displacements of the distributed parameter models are derived based on the vibration equations using numerical methods.The effect of the relative stiffness ratio and the rotational stiffness ratio on the higher mode effects is investigated.For elastic structures,the global displacement and shear in MRF are predominantly controlled by the first mode,while the shear and bending moment in the wall are significantly affected by higher mode effects.The effect of the yielding of BRB on the inner forces distribution in the HWBB-hinged frame is investigated.The results indicate that the first mode will no longer contribute to the inner forces and the contribution from higher modes to inner forces increases after the BRBs yield.Displacement is not sensitive to higher mode effects and it is controlled by the first mode after the BRBs yield.Parameter analysis demonstrates that the displacement amplitudes are reduced with the increase in the flexural stiffness of the wall before the flexural stiffness reaches a certain value.The first three periods decrease with the increase in the rotational stiffness.With the increase in the rotational stiffness ratio,the contribution from the first mode decreases while contributions from both the second mode and third mode increase.

Energy conserving effects of dividing wall column

The energy-conserving performance of dividing wall column(DWC) is discussed in this paper. The heat transfer through the dividing wall is considered and the results are compared with that of common heat insulation dividing wall column(HIDWC). Based on the thermodynamic analysis of heat transfer dividing wall column(HTDWC) and HIDWC, both computer simulation and experiments are employed to analyze the energyconserving situation. Mixtures of n-hexane, n-heptane and n-octane are chosen as the example for separation.The results show that the energy consumption of HTDWC is 50.3% less than that of conventional distillation column, while it is 46.4% less than that of HIDWC. It indicates that DWC is efficient on separating threecomponent mixtures and HTDWC can save more energy than HIDWC. Thus it is necessary to consider the heat transfer while applying DWC to industry.

Cu-doping induced ferromagnetic insulating behavior and domain wall pinning effects in LaMnO_3

A systematic study on the structural, magnetic, and electrical transport properties was performed for the LaMnlxCUxO3 system. A single phase of orthorhornbic perovskite structure was formed for x = 0.05-0.40. A striking paramagnetic-ferromagnetic transition and a considerable magnetoresistance effect were observed at the ferromagnetic ordering temperature Tc, but no insulator-metal transition induced by Cu-doping was observed. Below Tc, a visible unexpected drop was observed in the ac susceptibility and zero-field-cooled dc magnetization for the dilute doped samples with x≤0.10, which was proven to be associated with domain wall pinning effects by milling the bulk material into single domain particles. It is validated that there is no exchange interaction between Cu and Mn, and double exchange interactions between Mn^3＋ and Mn^4＋ are induced by Cu-doping in the anti-ferromagnetic LaMnO3 matrix, whereas the severe distortion and disorder caused by occupied-dopant prohibits charge carriers from hopping.

Nonmonotonic effects of perpendicular magnetic anisotropy on current-driven vortex wall motions in magnetic nanostripes

In a magnetic nanostripe, the effects of perpendicular magnetic anisotropy（PMA） on the current-driven horizontal motion of vortex wall along the stripe and the vertical motion of the vortex core are studied by micromagnetic simulations.The results show that the horizontal and vertical motion can generally be monotonously enhanced by PMA. However, when the current is small, a nonmonotonic phenomenon for the horizontal motion is found. Namely, the velocity of the horizontal motion firstly decreases and then increases with the increase of the PMA. We find that the reason for this is that the PMA can firstly increase and then decrease the confining force induced by the confining potential energy. In addition, the PMA always enhances the driving force induced by the current.

Combined effects of local curvature and elasticity of an isothermal wall for jet impingement cooling under magnetic field effects

The aim of this study is to examine the effects of local curvature and elastic wall effects of an isothermal hot wall for the purpose of jet impingement cooling performance.Finite element method was used with ALE.Different important parametric effects such as Re number(between 100 and 700),Ha number(between 0 and 20),elasticity(between 104 and 109),curvature of the surface(elliptic,radius ratio between 1 and 0.25) and nanoparticle volume fraction(between 0 and 0.05) on the cooling performance were investigated numerically.The results showed that the average Nu number enhances for higher Hartmann number,higher values of elastic modulus of partly flexible wall and higher nanoparticle volume fraction.When the magnetic field is imposed at the highest strength,there is an increase of3.85% in the average Nu for the curved elastic wall whereas it is 89.22% for the hot part above it,which is due to the vortex suppression effects.Nanoparticle inclusion in the base fluid improves the heat transfer rate by about 27.6% in the absence of magnetic field whereas it is 20.5% under the effects of magnetic field at Ha=20.Curvature effects become important for higher Re numbers and at Re=700,there is 14.11% variation in the average Nu between the cases with the lowest and highest radius ratio.The elastic wall effects on the heat transfer are reduced with the increased curvature of the bottom wall.

Effects of Magnetic Shear on the Resistive Wall Mode Instability in a Cylindrical Model

The linear evolution of a resistive wall mode(RWM)with magnetic shears was analytically studied in a cylindrical geometry.The incompressible magnetohydrodynamic(MHD)equations were solved by the Fourier analysis method,and various equilibrium magnetic fields were considered.The shear in the magnetic field had an unstable effect on the linear evolution of the RWM.The linear growth rate increased obviously with increase of the magnetic shear rate for higher magnetic shears.Slow plasma rotation could stabilize the RWM with low magnetic shears,but the plasma rotation could not stabilize the RWM with high magnetic shears.The stabilizing effects of the wall conductivity on the RWM are more efficient for lager magnetic shear.

Closed-form solution to thin-walled box girders considering effects of shear deformation and shear lag

Considering three longitudinal displacement functions and uniform axial displacement functions for shear lag effect and uniform axial deformation of thin-walled box girder with varying depths,a simple and efficient method with high precision to analyze the shear lag effect of thin-walled box girders was proposed.The governing differential equations and boundary conditions of the box girder under lateral loading were derived based on the energy-variational method,and closed-form solutions to stress and deflection corresponding to lateral loading were obtained.Analysis and calculations were carried out with respect to a trapezoidal box girder under concentrated loading or uniform loading and a rectangular box girder under concentrated loading.The analytical results were compared with numerical solutions derived according to the high order finite strip element method and the experimental results.The investigation shows that the closed-form solution is in good agreement with the numerical solutions derived according to the high order finite strip method and the experimental results,and has good stability.Because of the shear lag effect,the stress in cross-section centroid is no longer zero,thus it is not reasonable enough to assume that the strain in cross-section centroid is zero without considering uniform axial deformation.

Effects of Elasticity on Wall Shear Stress in Patient-Specific Aneurysm of Cerebral Artery

The behavior of wall shear stress (WSS) was previously reported in a deformable aneurysm model using fluid-structure interactions. However, these findings have not been validated. In the present study, we examined the effect of elasticity (i.e., deformation) on wall shear stress inside a cerebral aneurysm at the apex of a bifurcation using particle image velocimetry in vitro. The flow model simulated a human patient-specific aneurysm at the apex of the bifurcation of the middle cerebral artery. Flow characteristics by wall elasticity were examined for both elastic and non-deformable aneurysm models with pulsatile blood flow. The absolute temporally- and spatially-averaged WSS along the bleb wall was smaller in the elastic model than that in the non-deformable model. This small WSS may be related to attenuation of the WSS. Further, the WSS gradient had a finite value near the stagnation point of the aneurysm dome. Finally, the WSS gradient near the stagnation point was slightly smaller in the elastic model than that in the non-deformable model. These data suggest that elasticity of the aneurysm wall can affect the progression and rupture of aneurysms via hemodynamic stress.

Effects of Wall Emissivity on Aerodynamic Heating in Scramjets

The effects of the wall emissivity on aerodynamic heating in a scramjet are analyzed.The supersonic turbulent combustion flow including radiation is solved in the framework of a decoupled strategy where the flow field is determined first and the radiation field next.In particular,a finite difference method is used for solving the flow while a DOM(iscrete ordinates method)approach combined with a WSGGM(weighted sum of gray gases)model is implemented for radiative transfer.Supersonic nonreactive turbulent channel flows are examined for a DLR hydrogen fueled scramjet changing parametrically the wall emissivity.The results indicate that the wall radiative heating rises greatly with increasing the wall emissivity.As the wall emissivity rises,the radiative source and total absorption increase,while the incident radiation decreases apparently.Notably,although the radiative heating can reach a significant level,its contribution to the total aerodynamic heating is relatively limited.

Geometric effects resulting from the asymmetry of dipping fault:Hanging wall/ footwall effects

Root-mean-square distance Drms with characteristic of weighted-average is introduced in this article firstly. Drms can be used to capture the general proximity of a site to a dipping fault plane comparing with the rupture distance Drup and the seismogenic distance Dseis. Then, using Drup, Dseis and Drms, the hanging wall/footwall effects on the peak ground acceleration (PGA) during the 1999 Chi-Chi earthquake are evaluated by regression analysis. The logarithm residual shows that the PGA on hanging wall is much greater than that on footwall at the same Drup or Dseis when the Drup or Dseis is used as site-to-source distance measure. In contrast, there is no significant difference between the PGA on hanging wall and that on footwall at the same Drms when Drms is used. This result confirms that the hanging wall/footwall effect is mainly a geometric effect caused by the asymmetry of dipping fault. Therefore, the hanging wall/footwall effect on the near-fault ground motions can be ignored in the future attenuation analysis if the root-mean-square distance Drms is used as the site-to-source distance measure.

Fluid flow driven along microchannel by its upper stretching wall with electrokinetic effects

We develop a mathematical model to describe the flow in a microchannel driven by the upper stretching wall of the channel in the presence of electrokinetic effects. In this model, we avoid imposing any unphysical boundary condition, for instance, the zero electrostatic potential in the middle of the channel. Using the similarity transformation, we employ the homotopy analysis method （HAM） to get the analytical solution of the model. In our approach, the unknown pressure constant and the integral constant related to the electric potential are solved spontaneously by using the proper boundary conditions on the channel walls, which makes our model consistent with the commonly accepted models in the field of fluid mechanics. It is expected that our model can offer a general and proper way to study the flow phenomena in microchannels.