●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features ...●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS.However,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special characteristics.The associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular toxoplasmosis.The related retinal injury is laser photocoagulation,surgery,and trauma.Although primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and complications.Notably,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with corticosteroids.The possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s membrane.The MEWDS-related features in secondary MEWDS are still evanescent under most circumstances.Its prognosis and treatment depend on the severity of complications.Current studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal insults.More pathogenic studies should be conducted in the future.Accurate diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.展开更多
Dear Editor,Multiple evanescent white dot syndrome （MEWDS） was first described in 1984 as a rare, acute, unilateral,multifocal retinochoroidal disorder, typically affecting young myopic women. Previous studies with ...Dear Editor,Multiple evanescent white dot syndrome （MEWDS） was first described in 1984 as a rare, acute, unilateral,multifocal retinochoroidal disorder, typically affecting young myopic women. Previous studies with fluorescein angiography （FA） and electrophysiology suggested that MEWDS to be a disease in the retinal pigment epithelium （RPE） or outer retina, while recent studies with spectral- domain optical coherence tomography （SD-OCT） suggested it may be an outer retinal disease due to observation of hyperreflective material in outer retina and subtle disruptionsof the ellipsoid zone without RPE disruption.展开更多
To report the case of a patient who presented with idiopathic choroidal neovascularization(CNV)as the first sign of multiple evanescent white dot syndrome(MEWDS).A 25-year-old woman presented with recent onset of decr...To report the case of a patient who presented with idiopathic choroidal neovascularization(CNV)as the first sign of multiple evanescent white dot syndrome(MEWDS).A 25-year-old woman presented with recent onset of decreased vision and metamorphopsia in the right eye.The results of fundoscopic examination,fluorescein angiography,and optical coherence tomography(OCT) were compatible with a diagnosis of idiopathic CNV,which was treated with one intravitreal injection of bevacizumab.Five years later,the patient returned complaining of photopsia and decreased vision in the same eye.The fundoscopic examination showed typical signs of MEWDS.After 3 months,recurrence of CNV was observed in the same eye.In conclusion,idiopathic CNV might be the only manifestation of a subclinical occurrence of MEWDS.In this case,it was followed by a recurrence of MEWDS and subsequent reactivation of CNV.展开更多
Purpose: To study the clinicopathological change on "Multiple Evanescent White-dot Syndrome (MEWDS)"through fundus angiogrphy analyses.Methods:Examing the case with fluorescein angiography (FFA) and indocyan...Purpose: To study the clinicopathological change on "Multiple Evanescent White-dot Syndrome (MEWDS)"through fundus angiogrphy analyses.Methods:Examing the case with fluorescein angiography (FFA) and indocyanine green angiography(ICGA), visual field and following up for 15 months.Results :There exist multiple white dots in the fundus photo and angiography. The changes on ICGA maintain longer than fundus photo and FFA. Papille may be edematous and macula could present with special hypofluorescent flecks.Conclusions:MEWDS has specific angiographic features. Its pathological changes involve deep retinal pigment epithelium(RPE) as well as choroidal capillaries. The prognosis of the visual acuity for MEWDS is very good.展开更多
Hybrid white micro-pillar structure light emitting diodes(LEDs)have been manufacture utilizing blue micro-LEDs arrays integrated with 580 nm CIS((CuInS2-ZnS)/ZnS)core/shell quantum dots.The fabricated hybrid white mic...Hybrid white micro-pillar structure light emitting diodes(LEDs)have been manufacture utilizing blue micro-LEDs arrays integrated with 580 nm CIS((CuInS2-ZnS)/ZnS)core/shell quantum dots.The fabricated hybrid white micro-LEDs have good electrical properties,which are manifested in relatively low turn-on voltage and reverse leakage current.High-quality hybrid white light emission has been demonstrated by the hybrid white micro-LEDs after a systemic optimization,in which the corresponding color coordinates are calculated to be(0.3303,0.3501)and the calculated color temperature is 5596 K.This result indicates an effective way to achieve high-performance white LEDs and shows great promise in a large range of applications in the future including micro-displays,bioinstrumentation and visible light communication.展开更多
A bright white quantum dot light-emitting device （white-QLED） with 4-[4-（1-phenyl-lH-benzo[d]imidazol-2- yl）phenyl]-2- [3-（tri-phenylen-2-yl）phen-3-yl]quinazoline deposited on a thin film of mixed green/red-QDs ...A bright white quantum dot light-emitting device （white-QLED） with 4-[4-（1-phenyl-lH-benzo[d]imidazol-2- yl）phenyl]-2- [3-（tri-phenylen-2-yl）phen-3-yl]quinazoline deposited on a thin film of mixed green/red-QDs as a bilayer emitter is fabricated. The optimized white-QLED exhibits a turn-on voltage of 3.2 V and a maximum brightness of 3660 cd/m2 @8 V with the Commission Internationale de l＇Eclairage （CIE） chromaticity in the region of white light. The ultra-thin layer of QDs is proved to be critical for the white light generation in the devices. Excitation mechanism in the white-QLEDs is investigated by the detailed analyses of electroluminescence （EL） spectral and the fluorescence lifetime of QDs. The results show that charge injection is a dominant mechanism of excitation in the white-QLED.展开更多
We make a rigorous exploration of the profiles of a few diagonal and off-diagonal components of linear (αxx, αyy, αxy andαyx), first nonlinear (βxxx, βyyy, βxyy andβyxx), and second nonlinear (γxxxx, γyyyy, ...We make a rigorous exploration of the profiles of a few diagonal and off-diagonal components of linear (αxx, αyy, αxy andαyx), first nonlinear (βxxx, βyyy, βxyy andβyxx), and second nonlinear (γxxxx, γyyyy, γxxyyandγyyxx) polarizabilities of quantum dots under the influence of external pulsed field. Simultaneous presence of additive white noise has also been considered. The quantum dot contains dopant described by a Gaussian potential. The numbers of pulse and the dopant location have been found to fabricate the said profiles jointly. The β components display greater complexity in their profiles in comparison with the α and γ counterparts. The presence of noise prominently enhances the influence of dopant coordinate on the polarizability profiles, particularly for α and γ components. However, for β components, the said influence becomes quite evident both in the presence and absence of additive noise. The study reveals some means of achieving stable, enhanced, and often maximized output of noise-driven linear and nonlinear polarizabilities.展开更多
Optoelectronic applications require the development of new fluorescent and efficient luminescent materials, free of toxicity, low in cost, and easy to produce. In this way the synthesis of zinc-oxide (ZnO) quantum dot...Optoelectronic applications require the development of new fluorescent and efficient luminescent materials, free of toxicity, low in cost, and easy to produce. In this way the synthesis of zinc-oxide (ZnO) quantum dots (QDs) has recently received special attention due to their good optical, electrical and chemical properties with low production costs and blue light emission. In this work ZnO QDs were successfully doped with europium in order to obtain a tunable emission luminescence from blue emission of ZnO to red emission of europium as a function of wavelength excitation. Results show an efficient blue to red tuning when the excitation wavelength was changed from 317 nm to 395 nm, respectively. This opens the possibility of having new optical devices to produce different color emission using the same material.展开更多
A rebuilt vector pCANTAB 5 EE was obtained by inserting a 34 bp double-stranded oligonucleotide which contained a EcoRV recognition sequence into pCANTAB 5 E. White spot syndrome virus （WSSV） genome DNA was fragment...A rebuilt vector pCANTAB 5 EE was obtained by inserting a 34 bp double-stranded oligonucleotide which contained a EcoRV recognition sequence into pCANTAB 5 E. White spot syndrome virus （WSSV） genome DNA was fragmented by sonication to isolate fragments mainly in the range of 0.8 ～2.0 kb, then the fragments were blunt-ended with T4 DNA polymerase and cloned into the EcoRV site of pCANTAB 5 EE. The primary recombinant clone of the library was 3.0 × 10^5.Colony PCR of random selected recombinants showed that the size of the inserts was 0.12 ～ 1.77 kb. After the whole library recombinant phages infected Escherichia coli HB2151 cells, the extracellular and periplasmic extracts were dropped on PVDF membranes to perform dot blot, using polyclonal mouse anti-VP24 serum,anti-WSV026 serum,anti-WSV063 serum,anti-WSV069 serum,anti-WSV112 serum, anti WSV238 serum,anti-WSV303 serum and anti-VP26 serum as the primary antibody, respectively. The results showed that the display library could express the viral proteins.展开更多
研究了6世代线生产的A产品边角白点不良问题。首先针对不良进行实物分析,然后利用Minitab软件的二元逻辑回归方法进行了数据分析,最后通过不同的工艺试验条件对不良进行改善。实验结果表明:不良区域封框胶被金属走线遮挡,遮挡比例是边...研究了6世代线生产的A产品边角白点不良问题。首先针对不良进行实物分析,然后利用Minitab软件的二元逻辑回归方法进行了数据分析,最后通过不同的工艺试验条件对不良进行改善。实验结果表明:不良区域封框胶被金属走线遮挡,遮挡比例是边角白点不良的重要影响因素;TOF-SIMS(Time of Flight Secondary Ion Mass Spectrometry)进一步分析发现不良区有更高含量的封框胶成分(丙烯酸类、双酚A类)。封框胶被金属走线遮挡,造成该区域封框胶固化不完全,导致封框胶成分析出溶入液晶,继而影响液晶正常偏转,产生边角白点不良。通过调整边角处的封框胶画法,可以有效降低不良率。实验改善了边角白点不良,为A产品的顺利量产打下了坚实基础。展开更多
基金Supported by the National Natural Science Foundation of China(No.82171073No.82101147).
文摘●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS.However,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special characteristics.The associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular toxoplasmosis.The related retinal injury is laser photocoagulation,surgery,and trauma.Although primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and complications.Notably,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with corticosteroids.The possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s membrane.The MEWDS-related features in secondary MEWDS are still evanescent under most circumstances.Its prognosis and treatment depend on the severity of complications.Current studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal insults.More pathogenic studies should be conducted in the future.Accurate diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.
文摘Dear Editor,Multiple evanescent white dot syndrome （MEWDS） was first described in 1984 as a rare, acute, unilateral,multifocal retinochoroidal disorder, typically affecting young myopic women. Previous studies with fluorescein angiography （FA） and electrophysiology suggested that MEWDS to be a disease in the retinal pigment epithelium （RPE） or outer retina, while recent studies with spectral- domain optical coherence tomography （SD-OCT） suggested it may be an outer retinal disease due to observation of hyperreflective material in outer retina and subtle disruptionsof the ellipsoid zone without RPE disruption.
文摘To report the case of a patient who presented with idiopathic choroidal neovascularization(CNV)as the first sign of multiple evanescent white dot syndrome(MEWDS).A 25-year-old woman presented with recent onset of decreased vision and metamorphopsia in the right eye.The results of fundoscopic examination,fluorescein angiography,and optical coherence tomography(OCT) were compatible with a diagnosis of idiopathic CNV,which was treated with one intravitreal injection of bevacizumab.Five years later,the patient returned complaining of photopsia and decreased vision in the same eye.The fundoscopic examination showed typical signs of MEWDS.After 3 months,recurrence of CNV was observed in the same eye.In conclusion,idiopathic CNV might be the only manifestation of a subclinical occurrence of MEWDS.In this case,it was followed by a recurrence of MEWDS and subsequent reactivation of CNV.
文摘Purpose: To study the clinicopathological change on "Multiple Evanescent White-dot Syndrome (MEWDS)"through fundus angiogrphy analyses.Methods:Examing the case with fluorescein angiography (FFA) and indocyanine green angiography(ICGA), visual field and following up for 15 months.Results :There exist multiple white dots in the fundus photo and angiography. The changes on ICGA maintain longer than fundus photo and FFA. Papille may be edematous and macula could present with special hypofluorescent flecks.Conclusions:MEWDS has specific angiographic features. Its pathological changes involve deep retinal pigment epithelium(RPE) as well as choroidal capillaries. The prognosis of the visual acuity for MEWDS is very good.
基金supported by National Key R&D Program of China (2016YFB0400100)National Nature Science Foundation of China (61921005, 61674076, 61674081, 61605071, 61974062)+5 种基金Nature Science Foundation of Jiangsu Province (BY2013077, BK20141320, BE2015111)Six Talent Peaks Project of Jiangsu Province (XYDXX-081)Open Fund of the State Key Laboratory on Integrated Optoelectronics (IOSKL2017KF03)Innovation Project of Postgraduate Training in Jiangsu Province (KYCX18_0031)Fundamental Research Funds for the Central Universities (021014380096)Collaborative Innovation Center of Solid State Lighting and Energy-saving Electronics
文摘Hybrid white micro-pillar structure light emitting diodes(LEDs)have been manufacture utilizing blue micro-LEDs arrays integrated with 580 nm CIS((CuInS2-ZnS)/ZnS)core/shell quantum dots.The fabricated hybrid white micro-LEDs have good electrical properties,which are manifested in relatively low turn-on voltage and reverse leakage current.High-quality hybrid white light emission has been demonstrated by the hybrid white micro-LEDs after a systemic optimization,in which the corresponding color coordinates are calculated to be(0.3303,0.3501)and the calculated color temperature is 5596 K.This result indicates an effective way to achieve high-performance white LEDs and shows great promise in a large range of applications in the future including micro-displays,bioinstrumentation and visible light communication.
基金Project supported by the National Natural Science Foundation of China(Grant No.21302122)the Science and Technology Commission of Shanghai Municipality,China(Grant No.13ZR1416600)
文摘A bright white quantum dot light-emitting device （white-QLED） with 4-[4-（1-phenyl-lH-benzo[d]imidazol-2- yl）phenyl]-2- [3-（tri-phenylen-2-yl）phen-3-yl]quinazoline deposited on a thin film of mixed green/red-QDs as a bilayer emitter is fabricated. The optimized white-QLED exhibits a turn-on voltage of 3.2 V and a maximum brightness of 3660 cd/m2 @8 V with the Commission Internationale de l＇Eclairage （CIE） chromaticity in the region of white light. The ultra-thin layer of QDs is proved to be critical for the white light generation in the devices. Excitation mechanism in the white-QLEDs is investigated by the detailed analyses of electroluminescence （EL） spectral and the fluorescence lifetime of QDs. The results show that charge injection is a dominant mechanism of excitation in the white-QLED.
文摘We make a rigorous exploration of the profiles of a few diagonal and off-diagonal components of linear (αxx, αyy, αxy andαyx), first nonlinear (βxxx, βyyy, βxyy andβyxx), and second nonlinear (γxxxx, γyyyy, γxxyyandγyyxx) polarizabilities of quantum dots under the influence of external pulsed field. Simultaneous presence of additive white noise has also been considered. The quantum dot contains dopant described by a Gaussian potential. The numbers of pulse and the dopant location have been found to fabricate the said profiles jointly. The β components display greater complexity in their profiles in comparison with the α and γ counterparts. The presence of noise prominently enhances the influence of dopant coordinate on the polarizability profiles, particularly for α and γ components. However, for β components, the said influence becomes quite evident both in the presence and absence of additive noise. The study reveals some means of achieving stable, enhanced, and often maximized output of noise-driven linear and nonlinear polarizabilities.
文摘Optoelectronic applications require the development of new fluorescent and efficient luminescent materials, free of toxicity, low in cost, and easy to produce. In this way the synthesis of zinc-oxide (ZnO) quantum dots (QDs) has recently received special attention due to their good optical, electrical and chemical properties with low production costs and blue light emission. In this work ZnO QDs were successfully doped with europium in order to obtain a tunable emission luminescence from blue emission of ZnO to red emission of europium as a function of wavelength excitation. Results show an efficient blue to red tuning when the excitation wavelength was changed from 317 nm to 395 nm, respectively. This opens the possibility of having new optical devices to produce different color emission using the same material.
基金This research was supported by the National Natural Science Foundation of China under contract No.40276038the"863"Program of China under contract No.2003AA626020the Fujian Science Fundation under contract No.2003F001.
文摘A rebuilt vector pCANTAB 5 EE was obtained by inserting a 34 bp double-stranded oligonucleotide which contained a EcoRV recognition sequence into pCANTAB 5 E. White spot syndrome virus （WSSV） genome DNA was fragmented by sonication to isolate fragments mainly in the range of 0.8 ～2.0 kb, then the fragments were blunt-ended with T4 DNA polymerase and cloned into the EcoRV site of pCANTAB 5 EE. The primary recombinant clone of the library was 3.0 × 10^5.Colony PCR of random selected recombinants showed that the size of the inserts was 0.12 ～ 1.77 kb. After the whole library recombinant phages infected Escherichia coli HB2151 cells, the extracellular and periplasmic extracts were dropped on PVDF membranes to perform dot blot, using polyclonal mouse anti-VP24 serum,anti-WSV026 serum,anti-WSV063 serum,anti-WSV069 serum,anti-WSV112 serum, anti WSV238 serum,anti-WSV303 serum and anti-VP26 serum as the primary antibody, respectively. The results showed that the display library could express the viral proteins.
文摘研究了6世代线生产的A产品边角白点不良问题。首先针对不良进行实物分析,然后利用Minitab软件的二元逻辑回归方法进行了数据分析,最后通过不同的工艺试验条件对不良进行改善。实验结果表明:不良区域封框胶被金属走线遮挡,遮挡比例是边角白点不良的重要影响因素;TOF-SIMS(Time of Flight Secondary Ion Mass Spectrometry)进一步分析发现不良区有更高含量的封框胶成分(丙烯酸类、双酚A类)。封框胶被金属走线遮挡,造成该区域封框胶固化不完全,导致封框胶成分析出溶入液晶,继而影响液晶正常偏转,产生边角白点不良。通过调整边角处的封框胶画法,可以有效降低不良率。实验改善了边角白点不良,为A产品的顺利量产打下了坚实基础。
