The deformation and fracture evolution mechanisms of the strata overlying mines mined using sublevel caving were studied via numerical simulations.Moreover,an expression for the normal force acting on the side face of...The deformation and fracture evolution mechanisms of the strata overlying mines mined using sublevel caving were studied via numerical simulations.Moreover,an expression for the normal force acting on the side face of a steeply dipping superimposed cantilever beam in the surrounding rock was deduced based on limit equilibrium theory.The results show the following:(1)surface displacement above metal mines with steeply dipping discontinuities shows significant step characteristics,and(2)the behavior of the strata as they fail exhibits superimposition characteristics.Generally,failure first occurs in certain superimposed strata slightly far from the goaf.Subsequently,with the constant downward excavation of the orebody,the superimposed strata become damaged both upwards away from and downwards toward the goaf.This process continues until the deep part of the steeply dipping superimposed strata forms a large-scale deep fracture plane that connects with the goaf.The deep fracture plane generally makes an angle of 12°-20°with the normal to the steeply dipping discontinuities.The effect of the constant outward transfer of strata movement due to the constant outward failure of the superimposed strata in the metal mines with steeply dipping discontinuities causes the scope of the strata movement in these mines to be larger than expected.The strata in the metal mines with steeply dipping discontinuities mainly show flexural toppling failure.However,the steeply dipping structural strata near the goaf mainly exhibit shear slipping failure,in which case the mechanical model used to describe them can be simplified by treating them as steeply dipping superimposed cantilever beams.By taking the steeply dipping superimposed cantilever beam that first experiences failure as the key stratum,the failure scope of the strata(and criteria for the stability of metal mines with steeply dipping discontinuities mined using sublevel caving)can be obtained via iterative computations from the key stratum,moving downward toward and upwards away from the goaf.展开更多
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.展开更多
The dipping process was recorded firstly by high-speed camera system; acceleration time, speed, and dipping time were set by the control system of dipping bed, respectively. By image processing of dipping process base...The dipping process was recorded firstly by high-speed camera system; acceleration time, speed, and dipping time were set by the control system of dipping bed, respectively. By image processing of dipping process based on Otsu's method, it was found that low-viscosity flux glue eliminates the micelle effectively, very low speed also leads to small micelle hidden between the bumps, and this small micelle and hidden phenomenon disappeared when the speed is ≥0.2 cm s-1. Dipping flux quantity of the bump decreases by about 100 square pixels when flux viscosity is reduced from4,500 to 3,500 mpa s. For the 3,500 mpa s viscosity glue, dipping flux quantity increases with the increase of the speed and decreases with the increase of the speed after the speed is up to 0.8 cm s-1. The stable time of dipping glue can be obtained by real-time curve of dipping flux quantity and is only 80–90 ms when dipping speed is from 1.6 to 4.0 cm s-1. Dipping flux quantity has an increasing trend for acceleration time and has a decreasing trend for acceleration. Dipping flux quantity increases with the increase of dipping time, and is becoming saturated when the time is ≥55 ms.展开更多
基金Financial support for this work was provided by the Youth Fund Program of the National Natural Science Foundation of China (No. 42002292)the General Program of the National Natural Science Foundation of China (No. 42377175)the General Program of the Hubei Provincial Natural Science Foundation, China (No. 2023AFB631)
文摘The deformation and fracture evolution mechanisms of the strata overlying mines mined using sublevel caving were studied via numerical simulations.Moreover,an expression for the normal force acting on the side face of a steeply dipping superimposed cantilever beam in the surrounding rock was deduced based on limit equilibrium theory.The results show the following:(1)surface displacement above metal mines with steeply dipping discontinuities shows significant step characteristics,and(2)the behavior of the strata as they fail exhibits superimposition characteristics.Generally,failure first occurs in certain superimposed strata slightly far from the goaf.Subsequently,with the constant downward excavation of the orebody,the superimposed strata become damaged both upwards away from and downwards toward the goaf.This process continues until the deep part of the steeply dipping superimposed strata forms a large-scale deep fracture plane that connects with the goaf.The deep fracture plane generally makes an angle of 12°-20°with the normal to the steeply dipping discontinuities.The effect of the constant outward transfer of strata movement due to the constant outward failure of the superimposed strata in the metal mines with steeply dipping discontinuities causes the scope of the strata movement in these mines to be larger than expected.The strata in the metal mines with steeply dipping discontinuities mainly show flexural toppling failure.However,the steeply dipping structural strata near the goaf mainly exhibit shear slipping failure,in which case the mechanical model used to describe them can be simplified by treating them as steeply dipping superimposed cantilever beams.By taking the steeply dipping superimposed cantilever beam that first experiences failure as the key stratum,the failure scope of the strata(and criteria for the stability of metal mines with steeply dipping discontinuities mined using sublevel caving)can be obtained via iterative computations from the key stratum,moving downward toward and upwards away from the goaf.
基金supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ)the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
文摘Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.
基金supported by National Natural Science Foundation of China (No. 51275536)the China High Technology R&D Program 973 (No. 2015CB057206)
文摘The dipping process was recorded firstly by high-speed camera system; acceleration time, speed, and dipping time were set by the control system of dipping bed, respectively. By image processing of dipping process based on Otsu's method, it was found that low-viscosity flux glue eliminates the micelle effectively, very low speed also leads to small micelle hidden between the bumps, and this small micelle and hidden phenomenon disappeared when the speed is ≥0.2 cm s-1. Dipping flux quantity of the bump decreases by about 100 square pixels when flux viscosity is reduced from4,500 to 3,500 mpa s. For the 3,500 mpa s viscosity glue, dipping flux quantity increases with the increase of the speed and decreases with the increase of the speed after the speed is up to 0.8 cm s-1. The stable time of dipping glue can be obtained by real-time curve of dipping flux quantity and is only 80–90 ms when dipping speed is from 1.6 to 4.0 cm s-1. Dipping flux quantity has an increasing trend for acceleration time and has a decreasing trend for acceleration. Dipping flux quantity increases with the increase of dipping time, and is becoming saturated when the time is ≥55 ms.
