A High-Performance Liquid Chromatography Method for the Simultaneous Determination of Five Index Components in Danhong Injection

The purpose of this study was to establish a high-performance liquid chromatography (HPLC) method for the simultaneous determination of sodium danshensu, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, and 4-coumaric acid in Danhong injection. The chromatographic method employed was as follows: the column was a Welch Ultimate XB-C18 column (250 mm × 4.6 mm, 10 μm), the mobile phase was a gradient elution of 0.4% formic acid aqueous solution (A) and acetonitrile (B), the detection wavelengths were 280 nm for sodium danshensu, protocatechuic aldehyde, and salvianolic acid B and 326 nm for 4-coumaric acid and rosmarinic acid, the sample volume was 10 μL, the flow rate was 1.0 mL/min, and the column temperature was 35°C. This method can realize the separation and determination of sodium danshensu, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, and 4-coumaric acid within 50 minutes. The linear relationships of the five peak areas and their concentrations are good (R2> 0.9997). The precision RSD values are all less than 1.0%. The reproducibility RSD values are all less than 1.3%. The stability RSD values are all less than 2.2%. The recovery values ranged from 92.4% to 99.4%. This method is simple, accurate, and reproducible. It can be used for the determination of sodium danshensu, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, and 4-coumaric acid in Danhong injection.

Protective effect of Danhong injection in patients with acute myocardial infarction at a high risk of no-reflow during primary percutaneous coronary intervention

Objective To observe the effect of Danhong injection(DI)in patients with acute ST-segment elevation myocardial infarction(STEMI)at a high risk of no-reflow(NR)during primary percutaneous coronary intervention(PCI).Methods Patients were placed in a DI group and control group.The DI group was given DI and the control group was given physiologic saline.The administration lasted 4 to 6 days in both groups after PCI.Cardiac magnetic resonance(CMR)was carried out during the perioperative period(7±2 days).The primary endpoint of the study was myocardial infarct size(IS)imaged on delayed-enhancement CMR.The secondary endpoint was major adverse cardiac events observed 6 months after PCI.Results In total,160 high-risk NR patients were enrolled,and 110 patients completed the CMR examination.According to postoperative CMR,the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group(0.57±0.13 vs.0.48±0.17,P<0.01;49.3%±6.9%vs.46.2%±7.7%,P=0.03,respectively),whereas the IS was lower(19.7%±5.6%vs.22.2%±6.5%,P=0.04),compared with that in the control group.These differences were observed to be significant.After 6 months,the prevalence of major adverse cardiac events in the DI group decreased compared with that in the control group,but the differences were not observed to be significant(P>0.05).Conclusion The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI.

Pretreatment with Danhong injection protects the brain against ischemia-reperfusion injury

Danhong injection （DHI）, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is widely used in China for treating acute isch-emic stroke. In the present study, we explored the neuroprotective efficacy of DHI in a rat model of temporary middle cerebral artery ocdusion, and evaluated the potential mechanisms under-lying its effects. Pretreatment with DHI （0.9 and 1.8 mL/kg） resulted in a significantly smaller infarct volume and better neurological scores than pretreatment with saline. Furthermore, DHI significantly reduced the permeability of the blood-brain barrier, increased occludin protein expression and decreased neutrophil infiltration, as well as profoundly suppressing the upreg-ulation of matrix metallopeptidase-9 expression seen in rats that had received vehicle. Matrix metallopeptidase-2 expression was not affected by ischemia or DHI. Moreover, DHI （1.8 mL/kg） administered 3 hours after the onset of ischemia also improved neurological scores and reduced infarct size. Our results indicate that the neuroprotective efficacy of DHI in a rat model of cerebral ischemia-reperfusion injury is mediated by a protective effect on the blood-brain barrier and the reversal of neutrophil infiltration.

Danhong injection A modulator for Golgi structural stability after cerebral ischemiareperfusion injury

The cerebral ischemia-reperfusion model was established using the suture occlusion method, and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to model establishment Rat brain tissues were harvested at 6, 24, 48, 72 hours after reperfusion. Immunohistochemical staining showed that transforming growth factor-J31 expression increased, while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion. Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-131 and GM130, and expres- sion levels peaked at 7 days after reperfusion. At 7 days after cerebral ischemia-reperfusion, Golgi morphology was damaged in untreated rats, while Golgi morphology breakage was not observed after intervention with Danhong injection. These experimental findings indicate that Danhong injec- tion can up-regulate the expression of transforming growth factor-131 and GM130, and maintain Golgi stability, thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion.

Effects of adjuvant danhong injection therapy on nerve injury and platelet activation markers in patients with acute cerebral infarction

Objective:To investigate the effects of adjuvant danhong injection therapy on nerve injury and platelet activation markers in patients with acute cerebral infarction.Methods: A total of 102 patients with acute cerebral infarction who were treated in our hospital between January 2016 and September 2017 were reviewed and divided into the routine group (n=54) who received conventional therapy and the danhong injection group who received adjuvant danhong injection therapy. The differences in the contents of nerve injury indexes in serum and platelet activation markers in peripheral blood were compared between the two groups before treatment, after 3 d of treatment and after 7 d of treatment.Results: There was no statistically significant difference in the contents of nerve injury indexes in serum and platelet activation markers in peripheral blood between the two groups before treatment. After 3 d of treatment and after 7 d of treatment, copeptin, H-FABP and NSE contents in serum of danhong injection group were lower than those of routine group whereas BDNF and bFGF contents were higher than those of routine group;CD62p, CD42b, PAC-1 and PMA contents in peripheral blood were lower than those of routine group.Conclusion: Conventional therapy combined with adjuvant danhong injection therapy can effectively reduce the degree of nerve injury and inhibit the platelet activation in patients with acute cerebral infarction.

A Meta-Analysis of Danhong Injection in the Treatment of Vascular Dementia

Objectives: To evaluate the efficacy of Danhong injection in the treatment of vascular dementia. Methods: CNKI, VIP, CBM, MEDLINE, PubMed, and SCI Expanded databases were searched, and the clinical research literature of Danhong injection in the treatment of vascular dementia was collected. Literature screening and literature quality assessment were performed independently by two investigators based on inclusion criteria and the Cochrane System Evaluator’s Handbook version 5.0.0. Meta-analysis was performed using RevMan 5.0 software. Results: A total of 16 studies were included in a total of 1383 patients. Meta-analysis showed that Danhong injection combined with conventional chemotherapy can reduce the incidence of vascular dementia compared with conventional chemotherapy alone (odds ratio 3.13, 95% CI2.02 to 4.85, P < 0.0001), improved Mini-mental State Examination (MMSE)) score (SDD 1.76, 95% CI 0.67 to 2.85, P = 0.002). Conclusion: Danhong transfusion combined with chemical drugs for the treatment of vascular dementia is superior to the simple treatment of chemical drugs, which can improve the efficacy and quality of life of patients, indicating that Danhong injection has an auxiliary effect on the treatment of vascular dementia.

Effect of Danhong Injection Combined with Magnesium Polarization Solution and Nitrate in Treating Coronary Heart Disease

The objective of this study was to observe the effect of Danhong injection combined with magnesium polarized solution and nitrate on coronary heart disease.A total of 58 patients who had been diagnosed with coronary heart disease who participated in the voluntary study were selected and divided into observation group and control group.The number of patients in the two groups was 29,and the control group was mainly injected with nitroglycerin.The observation group was mainly treated with Danhong injection combined with magnesium polarized solution and nitrate ester.The main comparisons were the difference of clinical treatment effect,total cholesterol before and after treatment between the two groups of patients under different therapeutic drugs,and the differences in endothelin were recorded.The observation group was superior to the control group in terms of clinical treatment effect and total cholesterol and endothelin after treatment.Danhong injection combined with magnesium polarized solution and nitrate ester has a good effect in the treatment of coronary heart disease,which can be promoted and developed.

Effect of Danhong injection on neuroethology changes, cell injury and apoptosis in rats with cerebral infarction

Objective:To study the effect of Danhong injection on neuroethology changes, cell injury and apoptosis in rats with cerebral infarction.Methods: SD rats were selected as experimental animals and divided into control group, cerebral infarction group and Danhong group, control group received sham operation, cerebral infarction group were made into cerebral infarction animal models and Danhong group were made into cerebral infarction animal models and then received Danhong injection for intervention. After the intervention, water maze experiment was used to assess the neuroethology changes of rats, and the serum and brain tissue were collected to determine nerve injury molecules and apoptosis molecules.Results: 2 weeks, 4 weeks and 6 weeks after intervention, the escape latency and the course to find platform of cerebral infarction group were higher than those of control group and the number of platform crossing were lower than those of control group;the escape latency and the course to find platform of Danhong group were lower than those of cerebral infarction group, and the number of platform crossing were higher than those of cerebral infarction group;6 weeks after intervention, CK-BB, LDH, NSE and S100β levels in serum as well as ROS, MDA, JNK1, JNK2, c-Jun, ATF-2 and Bax levels in brain tissue of cerebral infarction group were significantly higher than those of control group while GSH-PX, T-SOD and CAT levels in brain tissue were significantly lower than those of control group;CK-BB, LDH, NSE and S100β levels in serum as well as ROS, MDA, JNK1, JNK2, c-Jun, ATF-2 and Bax levels in brain tissue of Danhong group were significantly lower than those of cerebral infarction group while GSH-PX, T-SOD and CAT levels in brain tissue were significantly higher than those of cerebral infarction group. Conclusion:Danhong injection can reduce the neurocyte damage and inhibit the neurocyte apoptosis to improve the neurological function of rats with cerebral infarction.

Effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure

Objective:To study the effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure.Methods: 80 cases of patients with ischemic cardiomyopathy heart failure who were treated in our hospital between March 2014 and December 2016 were collected and divided into control group (n=40) and observation group (n=40) according to random number table. The control group received regular treatment, the observation group received regular + Danhong injection treatment, and both therapies lasted for 14 d a course, two sessions. Serum contents of neuroendocrine molecules and ventricular remodeling-related indexes, Doppler ultrasonic ventricular remodeling parameter levels, and so on were compared between two groups of patients before and after treatment.Results: Before treatment, serum contents of neuroendocrine molecules and ventricular remodeling-related indexes as well as Doppler ultrasonic ventricular remodeling parameter levels were not statistically different between two groups of patients. After treatment, serum neuroendocrine molecules NT-proBNP, ANP, AngⅡ, ALD and NE contents of observation group were lower than those of control group, serum ventricular remodeling indexes TGF-β1, NF-κB, CysC and FGF23 contents were lower than those of control group, and ultrasonic ventricular remodeling parameters LVMI, LVRI, RVEDV and RVESV levels were lower than those of control group.Conclusion: Adjuvant Danhong injection therapy helps optimize the neuroendocrine molecule contents and inhibit the ventricular remodeling process in patients with ischemic cardiomyopathy heart failure.

Effect of danhong injection combined with sodium ozagrel on serum IL-8, TNF-α, VEGF, TBIL and NSE in old patients with acute cerebral infarction

Objective:To study the effect of danhong injection combined with sodium ozagrel on serum IL-8, TNF-α, VEGF, TBIL and NSE in old patients with acute cerebral infarction.Methods:A total of 100 old patients with acute cerebral infarction in our hospital from August 2014 to December 2016 were enrolled in this study. The subjects were divided into the control group (n=50) and the treatment group (n=50) randomly. The control group was treated with sodium ozagrel, the treatment group was treated with danhong injection combined with sodium ozagrel, and both the two groups were treated for 14 days. The serum IL-8, TNF-α, VEGF, TBIL and NSE of the two groups before and after treatment were compared.Results:There were no significantly differences of the serum IL-8, TNF-α, VEGF, TBIL and NSE of the two groups before treatment. The serum IL-8, TNF-α, NSE levels of the two groups after treatment were significantly lower than before treatment, the serum VEGF, TBIL levels of the two groups after treatment were significantly higher than before treatment, and that of the treatment group after treatment were significantly better than the control group.Conclusion:Danhong injection combined with sodium ozagrel can significantly reduce the serum IL-8, TNF-α, NSE levels, improve the serum VEGF, TBIL levels, and reduce inflammation, promote the nerve functional recovery of the old patients with acute cerebral infarction, and it was worthy clinical application.

Effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome

Objective: To study the effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome. Methods: A total of 80 patients with acute coronary syndrome in our hospital from July 2014 to July 2017 were enrolled in this study. The subjects were divided into the control group (n=40) and the treatment group (n=40) randomly. The control group was treated with xuesaitong injection combined with nadroparin calcium;the treatment group was treated with danhong injection combined with nadroparin calcium. The two groups were treated for 2 weeks. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before and after treatment were compared. Results: There were no significantly differences of the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before treatment. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group were significantly better than that of the control group. Conclusion: Danhong injection combined with nadroparin calcium can significantly reduce the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of patients with acute coronary syndrome, and it was worthy clinical application.

Efficacy and safety of Danhong injection in the treatment of arteriosclerosis obliterans:a meta-analysis of randomized controlled trials

目的:系统评价丹红注射液治疗动脉硬化闭塞症的临床有效性和安全性。方法:计算机检索中国知网(CNKI)、维普中文期刊数据库(VIP)、万方数据知识服务平台、中国生物医学文献数据库(CBM)、Pubmed、科学引文索引(SCI)数据库、Cochrane Library在内的8个中英文数据库,2位研究者对符合入选标准者采用Cochrane推荐的偏倚风险评估方法评价偏倚风险,提取资料,并应用Review Manager软件进行Meta分析和系统评价。结果:最终纳入13项研究,总病例数884例,结果显示,丹红注射液治疗动脉硬化闭塞症与常规治疗方式相比较,临床有效性更高,差异有统计学意义,[OR=3.08,95%CI(2.07,4.60),P<0.00001];对动脉硬化程度改善更加明显,[OR=0.15,95%CI(0.12,0.19),P<0.00001];对血流动力学改善更加明显,[OR=-0.19,95%CI(-0.33,-0.04),P=0.01];未有任何不良反应发生。结论:丹红注射液治疗动脉硬化闭塞症,临床有效性更高,对动脉硬化程度和血流动力学改善更加明显,且具有较高安全性。但由于文献研究质量偏低,需要更多高质量、大样本、随机对照双盲临床试验提供高级别证据,以进一步验证丹红注射液治疗动脉硬化闭塞症有效性和安全性。

丹红注射液联合肝素治疗脓毒症并发急性肾损伤的效果

目的探讨丹红注射液联合肝素治疗脓毒症并发急性肾损伤的临床疗效及对血清高迁移率族蛋白B1(high mobility group box 1,HMGB1)和可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1,sTREM-1)水平的影响。方法选取收治的80例脓毒症并发急性肾损伤患者作为研究对象,用随机数字表法分为2组,每组40例,2组均予以常规治疗,对照组加用低分子肝素,观察组加用低分子肝素和丹红注射液。对比2组的治疗效果,记录2组治疗前后的血清HMGB1、sTREM-1、肾功能指标及凝血功能指标等的变化。结果与治疗前比较,2组治疗后的各项生命指标、炎症指标、凝血功能指标、肾功能指标、HMGB1及sTREM-1水平均得到明显改善(P<0.05)。与对照组比较,观察组治疗后的体温、心率及急性生理学及慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分均明显更低,血清白细胞介素-6(interleutin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)、降钙素原(procall⁃citonin,PCT)、血肌酐(screatinine,Scr)、胱抑素C(cystatin C,CysC)、尿素氮(blood urea nitrogen,BUN)、纤维蛋白原(fibrinogen,FIB)及D-二聚体(D-dimer,D-D)的水平均更低,机械通气时间及ICU住院时间明显更短,凝血酶原时间(prothrombin time,PT)明显更长(P<0.05)。2组治疗后的存活率比较差异无统计学意义(P>0.05)。结论丹红注射液联合肝素治疗能够通过抑制sTREM-1、HMGB1的表达,减轻炎症反应,改善凝血功能,增大肾灌注,减轻肾组织损伤,从而治疗脓毒症并发急性肾损伤。

丹红注射液联合氨茶碱治疗慢性肺心病伴呼吸衰竭患者的效果

目的:观察丹红注射液联合氨茶碱治疗慢性肺源性心脏病(肺心病)伴呼吸衰竭患者的效果。方法:选取2019年1月至2023年1月该院收治的92例慢性肺心病伴呼吸衰竭患者进行前瞻性研究,依据随机数字表法将其分为研究组和对照组各46例。两组均给予常规治疗,在此基础上,对照组行氨茶碱治疗,研究组在对照组基础上联合丹红注射液治疗,比较两组治疗前后血气指标[动脉血氧分压(PaO_(2))、血氧饱和度(SpO_(2))]水平、心肺功能指标[左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、用力呼出50%肺活量的呼气流速(PEF50%)、肺总量(TLC)]水平、钠尿肽(BNP)水平、同型半胱氨酸(Hcy)水平和生命质量[健康调查简表(SF-36)]评分。结果:治疗后,研究组PaO_(2)、SpO_(2)水平均高于对照组,差异有统计学意义(P<0.05);治疗后,研究组LVESD、TLC水平均低于对照组,LVEF、PEF50%水平均高于对照组,差异有统计学意义(P<0.05);治疗后,研究组BNP、Hcy水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组精神健康、精力、社会功能、生理职能等SF-36评分均高于对照组,差异有统计学意义(P<0.05)。结论:丹红注射液联合氨茶碱治疗慢性肺心病伴呼吸衰竭患者可提高血气指标水平和生命质量评分,改善心肺功能指标水平,降低BNP和Hcy水平,效果优于单纯氨茶碱治疗。

丹红注射液联合缬沙坦在早期糖尿病肾病患者中的应用分析

目的分析丹红注射液联合缬沙坦在早期糖尿病肾病(DN)患者中的应用效果。方法103例早期DN患者,按照随机数字表分为对照组(51例)与研究组(52例)。对照组口服缬沙坦治疗,研究组在其基础上静脉滴注丹红注射液治疗。比较两组患者的临床疗效、不良反应发生情况以及治疗前后的肾功能指标[尿素氮(BUN)、血肌酐(SCr)、尿微量白蛋白/尿肌酐(ACR)]。结果研究组总有效率96.15%较对照组的82.35%高(P<0.05)。治疗后,研究组ACR(158.50±12.12)mg/mmol、SCr(106.66±25.50)μmol/L、BUN(7.27±1.35)mmol/L均较对照组的(174.65±13.56)mg/mmol、(140.68±25.64)μmol/L、(8.54±1.43)mmol/L低(P<0.05)。两组不良反应发生率对比,结果无差异性(P>0.05)。结论丹红注射液联合缬沙坦在早期DN患者中取得了较为满意的治疗效果,可以改善患者的肾功能,安全性佳,具有临床应用及推广价值。

丹红注射液联合丁苯酞注射液治疗急性脑梗死患者的临床效果及对氧化应激的影响

目的 分析丹红注射液联合丁苯酞注射液治疗急性脑梗死患者的临床效果及对氧化应激的影响。方法 将我院2020年12月至2022年12月收治的64例急性脑梗死患者以治疗方案不同分为常规组和观察组,每组32例。常规组在基础治疗基础上给予丁苯酞注射液治疗,观察组在常规组治疗基础上增加丹红注射液治疗。比较两组的治疗效果。结果 观察组的治疗总有效率显著高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、S100-β蛋白、8-羟基脱氧鸟苷(8-OHdG)及丙二醛(MDA)水平显著低于常规组,超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及谷胱甘肽(GSH)水平显著高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组基底动脉的最大血流速度(Vmax)、最小血流速度(Vmin)及平均血流量(Qmean)显著高于常规组,外周阻力(RV)显著低于常规组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论 丹红注射液联合丁苯酞注射液治疗急性脑梗死患者可取得安全高效的临床效果,并改善氧化应激反应。

丹红注射液联合丁苯酞注射液治疗对急性脑梗死神经功能及炎性因子水平的影响

目的 探讨丹红注射液联合丁苯酞注射液治疗对急性脑梗死患者神经功能及炎性因子水平的影响。方法 将100例急性脑梗死患者随机分为两组各50例。对照组采用丁苯酞注射液治疗,观察组在对照组基础上采用丁苯酞注射液治疗,两组均连续治疗14 d。比较两组的神经功能、炎性因子水平及不良反应。结果 治疗后,观察组NIHSS评分及TNF-α、 hs-CRP、 IL-6水平低于对照组(P <0.05)。治疗期间,两组不良反应发生率(10.00%vs. 16.00%)比较无统计学差异(P>0.05)。结论 丹红注射液联合丁苯酞注射液治疗可显著改善急性脑梗死患者神经功能损伤,减轻机体炎性反应,且安全性较高,值得临床推广。

基于网络药理学和分子对接技术探讨丹红注射液治疗肺纤维化的作用机制

目的 利用网络药理学和分子对接技术,探讨丹红注射液防治肺纤维化的作用靶点。方法 通过TCMSP数据库检索丹参和红花的有效成分,将各有效成分带入TCMSP数据库和Swiss TargetPrediction数据库获得有效成分的作用靶点,从GeneCards数据库获取肺纤维化的治疗靶点,把成分靶点和疾病靶点交集后,使用String数据库构建蛋白互作网络(PPI)并分析。利用R软件进行基因本体(GO)和京都基因与基因组百科全书(KEGG)通路分析。最后通过AutoDock软件对核心成分和靶点进行分子对接。结果 共获得172个交集靶点,GO富集分析显示对外源性刺激的反应、炎症反应、凋亡过程的负调控等可能参与到丹红注射液治疗肺纤维化进程。KEGG富集分析显示丹红注射液治疗肺纤维化的信号通路主要集中于10条,其中脂质和动脉粥样硬化(lipid and atherosclerosis)、糖尿病并发症中的AGE-RAGE信号通路(AGE-RAGE signaling pathway in diabetic complications)、流体剪切力与动脉粥样硬化(fluid shear stress and atherosclerosis)这3条通路最为关键。分子对接结果显示,丹红注射液的关键成分木犀草素(luteolin)和丹参酮ⅡA(tanshinone ⅡA)可与核心靶点EGFR、SRC匹配。结论 通过网络药理学及分子对接的方法,找到了丹红注射液治疗肺纤维化的可能潜在靶点,预测了其发挥药理作用的关键通路。

丹红注射液联合倍他司汀治疗急性眩晕患者的效果

目的:探究丹红注射液联合倍他司汀对急性眩晕患者脑血流动力学及凝血指标的影响。方法:于2021年2月—2023年2月选取本院诊治的急性眩晕患者60例为研究对象,以随机数字法将其分为观察组30例与对照组30例。两组入选患者均实施降压、降糖等常规治疗;对照组静脉注射45 min倍他司汀20 mg+氯化钠注射液250 ml;观察组在对照组用药基础上静脉注射45 min丹红注射液30 ml+氯化钠注射液250 ml。评价比较两组临床疗效,并比较两组治疗前后眩晕程度、脑血流动力学指标及凝血指标。结果:治疗1周后,观察组的总有效率为93.33%(28/30),对照组为73.33%(22/40),观察组显著高于对照组(P<0.05)。治疗前,两组患者的眩晕残碍程度评定量表(DHI)与Barthel量表(BI)评分无显著差异(P>0.05);治疗1周后,两组患者DHI评分降低,BI评分升高,且观察组DHI评分显著低于对照组,观察组BI评分显著高于对照组(P<0.05)。治疗前,两组急性眩晕症患者的基底动脉(BA)、左椎动脉(LVA)和右椎动脉(RVA)的血液流速均无显著差异(P>0.05);治疗1周后,两组患者BA、LVA和RVA的血液流速均明显加快,且观察组快于对照组(P<0.05)。治疗前,两组患者活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及纤维蛋白原(FIB)均无统计学差异(P>0.05);治疗1周后,两组患者APTT和PT均升高,且观察组显著高于对照组(P<0.05);FIB均降低,且观察组显著低于对照组(P<0.05)。结论:丹红注射液联合倍他司汀治疗急性眩晕患者临床疗效良好,可提高治疗效果与患者的生活自理能力,且改善脑血流状态与凝血状态。