Modem medical treatment of viral myocarditis by suppressing viral replication and improving cardiomyocyte metabolism has a good effect on the acute infectious period of viral myocarditis,but the curative rate is poor,...Modem medical treatment of viral myocarditis by suppressing viral replication and improving cardiomyocyte metabolism has a good effect on the acute infectious period of viral myocarditis,but the curative rate is poor,especially the sequelae of viral myocarditis,which often lingers for years to decades.The use of traditional Chinese medicine can achieve a certain curative effect by promoting the positive and dispelling evil spirits as well as balancing yin and yang.After long-term observation,it is found to have clear eff ect on improving myocardial injury caused by viral myocarditis.展开更多
OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided ...OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided into normal(10 rats) and DCM(150 rats)groups. DCM was induced by an intraperitoneal injection of adriamycin. Then, DCM baseline group was randomly selected sixteen DCM rats. The remaining DCM rats were randomly divided into DCM control, perindopril, metoprolol, and SQYXD groups. Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP), and inflammatory factors were measured. The mRNA and protein expression levels of high-mobility group box 1(HMGB1), Toll-like receptor 4(TLR-4), receptor for advanced glycation end products(RAGE), and nuclear factor-κB(NF-κB) were determined. Myocardial metabolism imaging was performed on the normal, SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS: Rats in the DCM control group exhibited dilated left ventricular diameter, impaired cardiac function, disorganized sarcomere, impaired glucose metabolism, increased heart weight index,and increased levels of BNP, which were improved by treatment with SQYXD. In addition, hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1, TLR-4, RAGE, NF-κB,tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-10, compared with the normal group. Interestingly, the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4, RAGE, NF-κB, BNP, and LVEDD,but negatively correlated with LVEF. SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION: Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy. The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.展开更多
文摘Modem medical treatment of viral myocarditis by suppressing viral replication and improving cardiomyocyte metabolism has a good effect on the acute infectious period of viral myocarditis,but the curative rate is poor,especially the sequelae of viral myocarditis,which often lingers for years to decades.The use of traditional Chinese medicine can achieve a certain curative effect by promoting the positive and dispelling evil spirits as well as balancing yin and yang.After long-term observation,it is found to have clear eff ect on improving myocardial injury caused by viral myocarditis.
基金Supported by the Projects of Medical Technology of Management Center of Wuxi Hospital,Jiangsu Province(No.YGZXM14047:Application of Standardized Diagnosis and Treatment Scheme for Dilated Cardiomyopathy Combined with Staging)the Projects of Jiangsu Province Chinese Medicine Leading Personnel Training Target Fund(Treatment of Dilated Cardiomyopathy with Classic Compound)
文摘OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided into normal(10 rats) and DCM(150 rats)groups. DCM was induced by an intraperitoneal injection of adriamycin. Then, DCM baseline group was randomly selected sixteen DCM rats. The remaining DCM rats were randomly divided into DCM control, perindopril, metoprolol, and SQYXD groups. Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP), and inflammatory factors were measured. The mRNA and protein expression levels of high-mobility group box 1(HMGB1), Toll-like receptor 4(TLR-4), receptor for advanced glycation end products(RAGE), and nuclear factor-κB(NF-κB) were determined. Myocardial metabolism imaging was performed on the normal, SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS: Rats in the DCM control group exhibited dilated left ventricular diameter, impaired cardiac function, disorganized sarcomere, impaired glucose metabolism, increased heart weight index,and increased levels of BNP, which were improved by treatment with SQYXD. In addition, hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1, TLR-4, RAGE, NF-κB,tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-10, compared with the normal group. Interestingly, the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4, RAGE, NF-κB, BNP, and LVEDD,but negatively correlated with LVEF. SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION: Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy. The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.
文摘目的:探讨针刺配合养心汤治疗血管性认知功能障碍(vascular cognitive impairment,VCI)的临床效果。方法:选取2021年8月—2023年2月阳江市中医医院收治的66例VCI患者。根据随机数表法将其分为对照组与观察组,各33例。对照组给予认知训练,观察组在对照组基础上给予针刺联合养心汤。比较两组临床疗效,治疗前后认知功能、日常生活能力及安全性。结果:对照组脱落1例,观察组脱落3例。观察组总有效率为83.33%(25/30),高于对照组的62.50%(20/32),差异有统计学意义(P<0.05)。治疗后,两组蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)、简易智力状态检查量表(mini-mental state examination,MMSE)评分均高于治疗前,观察组MoCA评分、MMSE评分均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组日常生活能力(activities of daily living,ADL)评分高于治疗前,观察组ADL评分高于对照组,差异有统计学意义(P<0.05)。两组均未发生安全性事件。结论:针刺联合养心汤治疗VCI效果显著,能有效改善患者认知功能及日常生活能力,安全性高。
文摘目的研究养心健脾汤对心力衰竭(heart failure,HF)患者的疗效及心率变异性、血清因子的影响。方法选取2022年1月至2023年10月我院收治的100例HF患者为研究对象,根据治疗方案分为对照组和研究组,各50例。对照组采用曲美他嗪治疗,研究组在对照组基础上加用养心健脾汤治疗。比较两组临床疗效、治疗前后中医证候积分、心率变异性指标[正常窦性心搏间期标准差(SDNN)、正常相邻窦性心搏间期差值的均方根(RMSSD)、全程每5 min NN节段的窦性RR间期标准差(SDANN)、相邻窦性心搏间期差值>50 ms心搏数百分比(PNN50)]、血清细胞因子[超敏C反应蛋白(hs-CRP)、B型脑利钠肽(BNP)、组蛋白脱乙酰酶2(HDAC2)、分泌型卷曲相关蛋白2(SFRP2)]水平、不良反应发生率。结果研究组临床总有效率(96.00%)高于对照组(82.00%)(P<0.05);治疗1个月后,研究组水肿、气喘、心悸、畏寒肢冷评分低于对照组(P<0.05);治疗1个月后,研究组SDNN、RMSSD、SDANN、PNN50高于对照组(P<0.05);治疗1个月后,研究组血清hs-CRP、BNP、HDAC2水平低于对照组,SFRP2水平高于对照组(P<0.05);研究组不良反应总发生率(12.00%)与对照组(8.00%)相比,差异无统计学意义(P>0.05)。结论采用养心健脾汤与曲美他嗪联合治疗可有效促进HF患者心率变异性改善,缓解炎症状态及临床症状,增强疗效,安全性良好。
