Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatur...Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatures T=(293.15 to 313.15)K.The van’t Hoff and(Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff,e-NRTL,UNIQUAC and Wilson)models were used to correlate the solubility data.The comparison of the models with temperature and solvent composition dependencies shows that the Wilson model has the minimum ARD which are relatively close to those obtained from Jouyban-Acree-van’t Hoff and E-Jouyban-Acree-van’t Hoff models and maximum ARD belonged to the UNIQUAC model.The order of ARDs for these models is:Wilson b Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff b e-NRTL b UNIQUAC.Moreover,the apparent thermodynamic functions,Gibbs free energy,enthalpy and entropy of dissolution and mixing were calculated based on the van’t Hoff and Gibbs free energy equations.The strong LTG-ILs interactions and enthalpic contribution of the dissolution process resulted from the calculated thermodynamic functions.展开更多
发育性和癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组临床和遗传异质的年龄依赖性神经系统疾病,其特征是在婴儿期或儿童早期出现难治性癫痫发作,且受影响的个体有精神运动发育迟缓或倒退。随着二代测序技术的发...发育性和癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组临床和遗传异质的年龄依赖性神经系统疾病,其特征是在婴儿期或儿童早期出现难治性癫痫发作,且受影响的个体有精神运动发育迟缓或倒退。随着二代测序技术的发展,尤其是全外显子测序技术的应用,越来越多的基因被发现与DEE相关。这些发现将为临床工作中DEE致病基因的检测提供依据,同时将有助于加深对DEE发病机制的理解。本文主要对DEE的遗传学病因及诊疗的相关研究进展展开综述,以期帮助临床医生早期识别相关基因突变,从而加快疾病诊断并及时实施最佳治疗。展开更多
目的建立基于骨质疏松症遗传相关基因的蛋白质相互作用网络,发现其中其中包含的分子复合物和未经研究或研究较少的与骨质疏松症相关的蛋白质。方法基于OMIM数据库中与骨质疏松症发生相关的177个遗传基因,应用Cytoscape软件及其插件Agile...目的建立基于骨质疏松症遗传相关基因的蛋白质相互作用网络,发现其中其中包含的分子复合物和未经研究或研究较少的与骨质疏松症相关的蛋白质。方法基于OMIM数据库中与骨质疏松症发生相关的177个遗传基因,应用Cytoscape软件及其插件Agilent Literature Search,进行PUBMED文献的文本数据挖掘,建立骨质疏松症的蛋白质相互作用网络;应用MCOMD算法,探测网络中的分子复合物,并对分子复合物包含的蛋白质进行GO分析,分析包括分子功能、生物学通路、细胞组分。结果骨质疏松症的蛋白质相互作用网络包含863个节点(蛋白质)、2925条边(相互作用关系)、4个高度关联的分子复合物。这些分子复合物内的18个蛋白质与骨质疏松症的关系未经研究或研究较少。结论基于OMIM数据库,可建立骨质疏松症的蛋白质相互作用网络,发现未经研究或研究较少的骨质疏松症关联蛋白质。展开更多
The Fe-based ionic liquid doped g-C_3N_4(Fee CN) photocatalyst was firstly prepared base on ultrathin g-C_3N_4 obtained by multiple calcination method with a metal-based reactive ionic liquid [Omim]FeCl_4 for the degr...The Fe-based ionic liquid doped g-C_3N_4(Fee CN) photocatalyst was firstly prepared base on ultrathin g-C_3N_4 obtained by multiple calcination method with a metal-based reactive ionic liquid [Omim]FeCl_4 for the degradation of Rhodamine B(RhB). Experimental results revealed that Fe3+species were doped into the framework of g-C_3N_4. The effect of the amount of Fe-doping on the catalytic activity was performed. The result showed that the Fee CN could effectively degrade RhB under the condition of visible light irradiation. The photocurrent analysis showed that the incorporation of Fe^(3+)into g-C_3N_4 material could accelerate the separation of the photogenerated carriers significantly.At the same time, the reactive species generated during the photodegradation process were tested by radicals trapping experiments and electron spin resonance(ESR). It was proposed that the synergistic effect of■ and ·OH contributed to degrade RhB efficiently.展开更多
基金a postdoctorate grant(693118)of Tabriz University of Medical Sciences,Iran for supporting this work.
文摘Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatures T=(293.15 to 313.15)K.The van’t Hoff and(Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff,e-NRTL,UNIQUAC and Wilson)models were used to correlate the solubility data.The comparison of the models with temperature and solvent composition dependencies shows that the Wilson model has the minimum ARD which are relatively close to those obtained from Jouyban-Acree-van’t Hoff and E-Jouyban-Acree-van’t Hoff models and maximum ARD belonged to the UNIQUAC model.The order of ARDs for these models is:Wilson b Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff b e-NRTL b UNIQUAC.Moreover,the apparent thermodynamic functions,Gibbs free energy,enthalpy and entropy of dissolution and mixing were calculated based on the van’t Hoff and Gibbs free energy equations.The strong LTG-ILs interactions and enthalpic contribution of the dissolution process resulted from the calculated thermodynamic functions.
文摘发育性和癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组临床和遗传异质的年龄依赖性神经系统疾病,其特征是在婴儿期或儿童早期出现难治性癫痫发作,且受影响的个体有精神运动发育迟缓或倒退。随着二代测序技术的发展,尤其是全外显子测序技术的应用,越来越多的基因被发现与DEE相关。这些发现将为临床工作中DEE致病基因的检测提供依据,同时将有助于加深对DEE发病机制的理解。本文主要对DEE的遗传学病因及诊疗的相关研究进展展开综述,以期帮助临床医生早期识别相关基因突变,从而加快疾病诊断并及时实施最佳治疗。
文摘目的建立基于骨质疏松症遗传相关基因的蛋白质相互作用网络,发现其中其中包含的分子复合物和未经研究或研究较少的与骨质疏松症相关的蛋白质。方法基于OMIM数据库中与骨质疏松症发生相关的177个遗传基因,应用Cytoscape软件及其插件Agilent Literature Search,进行PUBMED文献的文本数据挖掘,建立骨质疏松症的蛋白质相互作用网络;应用MCOMD算法,探测网络中的分子复合物,并对分子复合物包含的蛋白质进行GO分析,分析包括分子功能、生物学通路、细胞组分。结果骨质疏松症的蛋白质相互作用网络包含863个节点(蛋白质)、2925条边(相互作用关系)、4个高度关联的分子复合物。这些分子复合物内的18个蛋白质与骨质疏松症的关系未经研究或研究较少。结论基于OMIM数据库,可建立骨质疏松症的蛋白质相互作用网络,发现未经研究或研究较少的骨质疏松症关联蛋白质。
基金the financial support from the National Natural Science Foundation of China(No.21722604,21576122)Chinese Postdoctoral Science Foundation(No.2017M611726)
文摘The Fe-based ionic liquid doped g-C_3N_4(Fee CN) photocatalyst was firstly prepared base on ultrathin g-C_3N_4 obtained by multiple calcination method with a metal-based reactive ionic liquid [Omim]FeCl_4 for the degradation of Rhodamine B(RhB). Experimental results revealed that Fe3+species were doped into the framework of g-C_3N_4. The effect of the amount of Fe-doping on the catalytic activity was performed. The result showed that the Fee CN could effectively degrade RhB under the condition of visible light irradiation. The photocurrent analysis showed that the incorporation of Fe^(3+)into g-C_3N_4 material could accelerate the separation of the photogenerated carriers significantly.At the same time, the reactive species generated during the photodegradation process were tested by radicals trapping experiments and electron spin resonance(ESR). It was proposed that the synergistic effect of■ and ·OH contributed to degrade RhB efficiently.
