The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/c...The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/cm3,μ(MoK)=1.44 mm-1,F(000)= 2040.0, (C39H31Cl6Fe3N7O2) and Mr = 1009.96. X-ray crystallographic studies reveal that the title compound contains complexes of [Fe(Phen)3]2+ and [Fe2(μ-oxo)Cl6]2- which consists of two [FeCl3] fragments connected by an oxo bridge,with the bond distances of Fe(3)O(1) 1.744(4) and Fe(2)O(1) 1.754(4)牛琣nd a bond angle Fe(2)O(1)Fe(3) of 162.9(3). In the [Fe2(μ-oxo)Cl6]2- complex, the two iron (Ⅲ) centres exhibit tetrahedral coordination, with the distorted tetrahedra formed by three Cl atoms and an oxo bridge. The bond lengths to the donor atoms lie in the range 2.211(1)～2.226(1)?for FeCl, and the non-bonded Fe…Fe distance is 3.459?展开更多
The title compound [Ni(bipy)3][(-oxo)Fe2Cl6] (bipy = 2, 2?bispyridine) was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in monoclinic, space group P2l/c with unit c...The title compound [Ni(bipy)3][(-oxo)Fe2Cl6] (bipy = 2, 2?bispyridine) was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in monoclinic, space group P2l/c with unit cell parameters: a = 9.7085(7),b = 26.409(2), c = 14.014(1) ,?= 100.237(3), V = 3535.9(2) 3,Z = 4,C30H24Cl6Fe2N6NiO,Mr = 867.66, Dc = 1.630 g/cm3,F(000) = 1744, (MoK? = 1.824 mm-1, the final R = 0.0394 and wR = 0.0475 for 2750 observed reflections with I ≥ 2(I). The title compound contains cation of [Ni(bipy)3]2+ and anion of [(-oxo)Fe2Cl6] 2- which consists of two [FeCl3] fragments connected by an oxo bridge with the bond distances of Fe(2)O(1) 1.752(2) and Fe(1)O(1) 1.763(2) , and the bond angle of Fe(2)O(1)Fe(1) 148.6(2)? In the [Fe2(-oxo)Cl6]2- complex, the two iron(Ⅲ) centers exhibit a tetrahedral coordination with the distorted tetrahedron formed by three Cl atoms and one oxo bridge.展开更多
Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the develo...Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.展开更多
A new method for the synthesis of substituted thiophenes was through intramolecular aldol condensation ofα-oxo ketene dibenzylthioacetals.All products were confirmed with IR, 1 H NMR and elemental analysis.
Pseudo-first order reaction rate constants of 5,10,15-tris（pentafluorophenyl）corrole Mn（V）-oxo （F_（15）CMn（V）-oxo）,5,15-bis（pentafluorophenyl）-10-（phenyl）corrole Mn（V）-oxo（F_（10）CMn（V）-oxo）,5,15- ...Pseudo-first order reaction rate constants of 5,10,15-tris（pentafluorophenyl）corrole Mn（V）-oxo （F_（15）CMn（V）-oxo）,5,15-bis（pentafluorophenyl）-10-（phenyl）corrole Mn（V）-oxo（F_（10）CMn（V）-oxo）,5,15- bis（phenyl）-10-（pentafluorophenyl）corrole Mn（V）-oxo（F_5CMn（V）-oxo） and 5,10,15-tris（phenyl）corrole Mn（V）-oxo（F_0CMn（V）-oxo） with a series of alkene substrates in different solvents were determined by UV-vis spectroscopy.The results indicated that the oxygen atom transfer pathway between Mn（V）-oxo corrole and alkene is solvent-dependent.展开更多
Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2（p-cymene）]（S,S）-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yie...Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2（p-cymene）]（S,S）-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields （up to 85%） and good enantioselectivities （up to 98% ee） were obtained.展开更多
A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol t...A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.展开更多
基金Supported by the foundation of Education Committee of Fujian Province (JB01045)
文摘The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/cm3,μ(MoK)=1.44 mm-1,F(000)= 2040.0, (C39H31Cl6Fe3N7O2) and Mr = 1009.96. X-ray crystallographic studies reveal that the title compound contains complexes of [Fe(Phen)3]2+ and [Fe2(μ-oxo)Cl6]2- which consists of two [FeCl3] fragments connected by an oxo bridge,with the bond distances of Fe(3)O(1) 1.744(4) and Fe(2)O(1) 1.754(4)牛琣nd a bond angle Fe(2)O(1)Fe(3) of 162.9(3). In the [Fe2(μ-oxo)Cl6]2- complex, the two iron (Ⅲ) centres exhibit tetrahedral coordination, with the distorted tetrahedra formed by three Cl atoms and an oxo bridge. The bond lengths to the donor atoms lie in the range 2.211(1)～2.226(1)?for FeCl, and the non-bonded Fe…Fe distance is 3.459?
基金Supported by the foundation of Education Committee of Fujian Province (JB01045)
文摘The title compound [Ni(bipy)3][(-oxo)Fe2Cl6] (bipy = 2, 2?bispyridine) was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in monoclinic, space group P2l/c with unit cell parameters: a = 9.7085(7),b = 26.409(2), c = 14.014(1) ,?= 100.237(3), V = 3535.9(2) 3,Z = 4,C30H24Cl6Fe2N6NiO,Mr = 867.66, Dc = 1.630 g/cm3,F(000) = 1744, (MoK? = 1.824 mm-1, the final R = 0.0394 and wR = 0.0475 for 2750 observed reflections with I ≥ 2(I). The title compound contains cation of [Ni(bipy)3]2+ and anion of [(-oxo)Fe2Cl6] 2- which consists of two [FeCl3] fragments connected by an oxo bridge with the bond distances of Fe(2)O(1) 1.752(2) and Fe(1)O(1) 1.763(2) , and the bond angle of Fe(2)O(1)Fe(1) 148.6(2)? In the [Fe2(-oxo)Cl6]2- complex, the two iron(Ⅲ) centers exhibit a tetrahedral coordination with the distorted tetrahedron formed by three Cl atoms and one oxo bridge.
文摘Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.
文摘A new method for the synthesis of substituted thiophenes was through intramolecular aldol condensation ofα-oxo ketene dibenzylthioacetals.All products were confirmed with IR, 1 H NMR and elemental analysis.
基金The financial support from the National Natural Science Foundation of China(Nos.20971046 and 21171057)
文摘Pseudo-first order reaction rate constants of 5,10,15-tris（pentafluorophenyl）corrole Mn（V）-oxo （F_（15）CMn（V）-oxo）,5,15-bis（pentafluorophenyl）-10-（phenyl）corrole Mn（V）-oxo（F_（10）CMn（V）-oxo）,5,15- bis（phenyl）-10-（pentafluorophenyl）corrole Mn（V）-oxo（F_5CMn（V）-oxo） and 5,10,15-tris（phenyl）corrole Mn（V）-oxo（F_0CMn（V）-oxo） with a series of alkene substrates in different solvents were determined by UV-vis spectroscopy.The results indicated that the oxygen atom transfer pathway between Mn（V）-oxo corrole and alkene is solvent-dependent.
文摘Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2（p-cymene）]（S,S）-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields （up to 85%） and good enantioselectivities （up to 98% ee） were obtained.
文摘A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.
