Ytterbium triflate hydrate catalyzed Michael addition and cyclocondensation of α,β-unsaturated ketones with active methylene compounds

Catalyzed by ytterbium（III） triflate hydrate [Yb（OTf）3.xH20], the Michael addition and cyclocondensation of α,β-unsaturated ketones with active methylene compounds to afford the 1,4-adducts and benzo[b]pyran derivatives, respectively were studied.

A NEW ROUTE FROM HETEROAROMATIC BORON COMPOUNDS TO CORRESPONDING KETONES VIA DICHLOROCARBENE INSERTION UNDER PHASE TRANSFER CONDITIONS

The reactions of tri-2-benzofuranylborane or aminoethyl di-2-thienylborinate and 2-thienylphenylborinate with dichlorocarbene generated in situ from chloroform under phase transfer conditions were explored as a new route for the preparation of heteroaromatic ketones. It was found that a good yield of the ketones can be obtained by solid-liquid system.

CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction

Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure.

Ceric Ammonium Nitrate-mediated Oxidative Cycloaddition of 1,3-Dicarbonyls to β-Aryl-α, β-unsaturated Ketones

Regio and stereoselective synthesis of substituted dihydrofurans were accomplished by eeric ammonium nitrate mediated oxidative cycloaddition of 1,3-dicarbonyls to β-aryl-α,β-unsaturated ketones in moderate yields.

Novel and Efficient One Pot Condensation Reactions between Ketones and Aromatic Alcohols in the Presence of CrO3 Producing α,β-Unsaturated Carbonyl Compounds

We report a new, effective and simple method for preparing a,fl-unsaturated carbonyl compounds by reacting ketones and aromatic alcohols at 56 ℃ in the presence of CrO3 （CrO3 acts as an oxidant and also a catalyst） for around 10 h. The condensation reactions occurred effectively among a wide combination of ketones and alcohols. The procedure is simple and the yields can be high up to 98%. And a probable mechanism is proposed.

Dendritic compound of triphenylene-2,6,10-trione ketal-tri-{2,2-di-[(N-methyl-N-(4-pyridinyl) amino) methyl]-1,3-propanediol}: an easily recyclable catalyst for Morita-Baylis-Hillman reactions

A novel Dendritic Compound (2) of triphenylene- 2,6,10-trione ketal-tri-{2,2-di-[(N-methyl-N-(4-py- ridinyl) amino)methyl]-1,3-propanediol} was conveniently synthesized by aromatization of cyclohexanedione mono-ketal, ketal-exchange reaction with 2,2-dibromomethyl-1,3-propane- diol and nuclophilic substitution with N-methy- laminopyridine as nuclophilic reagent. The Mo-rita-Baylis-Hillman reaction of various aryl al-dehydes with methyl vinyl ketone and acryloni-trile in (DMF/cyclohexane, 1/1, v/v) has been investigated by using Dendritic Compound (2) as catalyst. The corresponding Morita-Baylis- Hillman adducts was obtained in good yields by using the recycled and reactivated dendritic catalyst.

Chemical Interaction UO2Cl2 with α-and β-Amino Acids in Aqueous and Organic Solution

This paper presents the results of the search of biologically active uranium compounds such as amino acids. We first received and examined X-ray and IR （infrared radiation） spectroscopy of uranium complexes with α- and β-amino acids in aqueous and organic solution. We proposed a method for direct synthesis of complex organic compounds of uranium chloride UO2Cl2 with α- andβ-amino acids for the synthesis of drugs for the treatment of cancer.

Low-valent titanium induced reductive cyclization of nitro compounds and aliphatic ketones:facile synthesis of 3,4-dihydro-(2H) -1,2,4-benzothiadiazine-1,1-dioxides

The intermolecular reductive cyclization of o-nitrobenzene-sulfonamides with aliphatic ketones induced by TiCl4/Sm system was studied and a series of 3, 3-disubstituted-3,4-dihydro(2H)-1,2, 4-benzothiadiazine-1,1-dioxides were synthesized in moderate to high yields under mild and neutral conditions.

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of [3-amino ketones containing a p-aminobenzoic acid moiety （TM.1 and TM-2） using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by ~H NMR, 1~C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The c^-glucodase inhibition （c^-GI） activity of compound le reached a remarkable level of 66.50%. The peroxisome proliferator- activated receptor （PPAR） relative activation activities of six compounds are above 80%, and in particular 2i displays an un- precedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also sub- ject to further in-depth investigation.

PEG-OSO_3H as an efficient and recyclable catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction in PEG-H_2O

Sulfuric acid-modified polyethylene glycol 6000（PEG-OSO_3H） was applied as an efficient and recyclable catalyst for the synthesis ofβ-amino carbonyl compounds via the Mannich reaction between aldehydes,aromatic ketones and aromatic amines at room temperature using PEG400-H_2O（1：1） as environment-friendly solvents.The reactions were completed in short times and mild reaction conditions with good to excellent yields.

Entirely green protocol for the synthesis of β-aminoketones using saccharose as a homogenous catalyst

Saccharose was applied as an efficient and homogenous catalyst for a one-pot,three-component Mannich reaction for the formation ofβ-aminoketones from aromatic aldehydes,anilines,and acetophenone at ambient temperature in excellent yields.This protocol has the following advantages： mild conditions,high yields,clean reaction profiles,operational simplicity,and environmentally benign and simple work-up procedures.

渭南市大气中醛酮类化合物的污染特征分析

2022年6月—2023年5月在渭南市师范学院挥发性有机物组分站获得醛酮类项目的监测数据,围绕渭南市醛酮类化合物的浓度水平、组成特征、变化趋势进行探究,用PMF模型识别和量化出醛酮类化合物在臭氧前体物中的贡献。对识别出的组份进行排序并逐一分析高组分物质的主要来源,找到污染源头,为VOCs污染减排提供相关科学技术支持。

A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot strategy

A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot cascade strategy is described. A variety of α-amino ketones are obtained in moderate to good yields under mild conditions. To overcome the multi-step synthesis, N-bromosuccinimide is involved in multiple tasks, playing a key role in the reaction course.

Chiral Cinchona Alkaloid-Thiourea Catalyzed Mannich Reaction for Enantioselective Synthesis of β-Amino Ketones Bearing Benzothiazol Moiety

Mannich reactions of imine with acetylacetone were effectively catalyzed by the modified chiral cinchona alka-loid-derived thiourea. The reactions led to chiral r-amino carbonyl compounds in high yields and good enantiose-lectivities. The study demonstrated for the first time that Mannich reactions of unmodified acetylacetone with het-erocyclic imine derived from benzothiazole can be promoted by chiral bifunctional organocatalyst.

Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Titanium（IV） Complexes of N-Sulfonylated β-Amino Alcohols

The easily prepared and recoverable chiral N-sulfonylated fl-amino alcohol 2 in combination with Ti（OPr-i）4 was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, i.e. chiral tertiary propargyl alcohols, with the ee up to 92%.

无机粒子填充改性聚醚醚酮复合材料研究进展

聚醚醚酮(PEEK)作为一种综合性能优良的特种材料,其具有优异的耐热性和生物相容性,广泛应用于航空航天、电子电器和生物医学等高精尖领域。为进一步改善PEEK的耐磨性能、力学性能和表面生物活性,常利用无机纳米填料的尺寸效应对基体材料进行协同改性或引入合适的官能团对PEEK复合材料进行界面改性,以扩大其应用范围和应用深度。本文首先概述了PEEK复合材料常用的改性方法,着重论述了硅化合物、金属化合物和新型纳米材料对PEEK改性的研究进展,并对PEEK纳米复合材料的发展前景和研发方向进行展望,为开发高性能、多功能化纳米填充PEEK复合材料提供新思路。

复方α-酮酸联合血液透析、血液灌流治疗CRF患者的效果分析

目的探讨复方α-酮酸联合血液透析(hemodialysis,HD)、血液灌流(hemoperfusion,HP)治疗慢性肾衰竭(chronic renal failure,CRF)患者的效果。方法将本院2018年3月—2020年12月收治的103例CRF患者按照计算机分组法分为对照组(51例)和观察组(52例),对照组给予HD联合HP治疗,观察组在对照组基础上给予复方α-酮酸治疗,观察两组治疗效果及氧化应激反应[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、丙二醛(MDA)以及超前氧化蛋白产物(AOPP)]。结果治疗后,观察组总有效率高于对照组,组间差异有统计学意义(P<0.05);观察组超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)水平均高于对照组,丙二醛(MDA)、超前氧化蛋白产物(AOPP)水平均低于对照组,组间差异有统计学意义(P<0.05)。结论复方α-酮酸联合HD、HP治疗CRF患者可降低氧化应激水平,提高治疗效果。

沙棘黄酮提取进展

沙棘黄酮是食药两用植物沙棘主要的保健与药用成分,具有重要的生理活性,能够清除体内的自由基,防治心血管疾病和抗衰老的作用。本文概述了国内外对沙棘资源的开发利用研究状况,综述了沙棘黄酮类化合物提取方法的最新研究进展,为充分利用沙棘资源和开发沙棘黄酮提供科学研究基础。

酸性沸石分子筛催化Knoevenagel缩合反应

在高硅 /铝比的酸性沸石分子筛HY上实现了Knoevenagel缩合反应 .Br nsted酸和Lewis酸均可催化Knoevenagel缩合反应 .考察了羰基化合物和活泼亚甲基化合物的反应活性顺序 .结果表明 ,羰基化合物的羰基极化程度越高 ,反应越容易进行 ;不同于碱催化时的Knoevenagel缩合反应 ,活泼亚甲基化合物的活泼氢的酸性并不是影响其反应活性的重要因素 .

钯配合物催化烯烃氧化合成酮类物质的研究进展

本文系统地评述了钯配合物催化烯烃氧化合成酮类物质的研究进展。综述了改进 Wacker类催化剂催化活性的几种方法。总结了烯烃氧化合成酮类物质反应的几种典型催化体系及其作用机理。着重介绍了 Pd( ) /HPA(杂多酸 )、Pd( ) /Fe Pc(酞菁铁 )、 Pd( ) /HQ(氢醌 ) /Fe Pc、Pd( ) /HQ /HPA、Pd( ) /Cu SO4 /HPA等 Wacker类催化体系在烯烃氧化合成酮类物质中的应用 ;对 Pd( ) /LCo NO2 、Pd Cl2 ( Me CN) 2 /Cu Cl、Pd( OAc) 2 /吡啶、氟两相等非