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Effects of gamma-aminobutyric acid receptors on muscarinic receptor-mediated free calcium ion levels in the facial nucleus following facial nerve injury
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作者 Guangfeng Jiang Dawei Sun +4 位作者 Rui Zhou Fugao Zhu Yanqing Wang Xiuming Wan Banghua Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第11期855-859,共5页
Muscarinic receptors and nicotine receptors can increase free calcium ion levels in the facial nucleus via different channels following facial nerve injury. In addition, γ-aminobutyric acid A (GABAA) receptors have... Muscarinic receptors and nicotine receptors can increase free calcium ion levels in the facial nucleus via different channels following facial nerve injury. In addition, γ-aminobutyric acid A (GABAA) receptors have been shown to negatively regulate free calcium ion levels in the facial nucleus by inhibiting nicotine receptors. The present study investigated the influence of GABAA, γ-aminobutyric acid B (GABAB) and C (GABAc) receptors on muscarinic receptors in rats with facial nerve injury by confocal laser microscopy. GABAA and GABAB receptors exhibited significant dose-dependent inhibitory effects on increased muscarinic receptor-mediated free calcium ion levels following facial nerve injury. Results showed that GABAA and GABAB receptors negatively regulate muscarinic receptor effects and interplay with cholinergic receptors to regulate free calcium ion levels for facial neural regeneration. 展开更多
关键词 injury of facial nerve γ-aminobutyric acid A receptor γ-aminobutyric acid b receptor muscarinic receptor facial nucleus calcium ion peripheral nerve injury neural regeneration
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Limbic Encephalitis Associated with Anti-y-aminobutyric Acid B Receptor Antibodies: A Case Series from China 被引量:41
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作者 Hong-Zhi Guan Hai-Tao Ren +7 位作者 Xun-Zhe Yang Qiang Lu Bin Peng Yi-Cheng Zhu Xiao-Qiu Shao Yong-Qiang Hu Dong Zhou Li-Ying Cui 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第22期3023-3028,共6页
Background: Autoimmune encephalitis associated with antibodies against γ-aminobutyric acid B receptor (GABABR) in patients with limbic encephalitis (LE) was first described in 2010. We present a series of klan C... Background: Autoimmune encephalitis associated with antibodies against γ-aminobutyric acid B receptor (GABABR) in patients with limbic encephalitis (LE) was first described in 2010. We present a series of klan Chinese patients tbr further clinical refinement. Methods: Serum and cerebrospinal fluid (CSF) samples from patients referred to the program of encephalitis and paraneoplastic syndrome of Peking Union Medical College Hospital were tested with indirect immunofluorescence. Clinical information of patients with anti-GABABR antibody positivity was retrospectively reviewed, and descriptive statistical analysis was performed. Results: All eighteen anti-GABABR antibody-positive cases had limbic syndromes, and electroencephalogram (EEG) or neuroimaging evidence fulfilled the diagnostic criteria of LE. Four patients had additional antibodies against Hu in serum and one had anti-N-methyl-d-aspartate receptor antibody in both sera and CSF. Seventeen (17/18) patients presented with new-onset refractory seizure or status epileptics. Twelve (12/18) patients had memory deficits, 11 (11/18) patients had personality change, 7 (7/18) patients had disturbance of consciousness, and 3 (3/18) patients showed cerebellar dysfunction. One patient with LE had progressive motor and sensory polyneuropathy. Lung cancer was detected in 6 (6/18) patients. Ten (10/18) patients showed abnormality in bilateral or unilateral mediotemporal region on magnetic resonance imaging. Ten (10/18) patients had temporal lobe epileptic activity with or without general slowing on EEG. Seventeen patients received immunotherapy and 15 of them showed neurological improvement. Four patients with lung cancer died within 1-12 months due to neoplastic complications. Conclusions: Our study demonstrates that most Han Chinese patients with anti-GABABR antibody-associated LE have prominent refractory epilepsy and show neurological improvement on immunotherapy. Patients with underlying lung tumor have a relatively poor prognosis. Testing for anti-GABABR antibodies is necessary for patients with possible LE or new-onset epilepsy with unknown etiology. 展开更多
关键词 Anti-γ-aminobutyric acid b receptor Antibody Autoimmune: Limbic Encephalitis SEIZURE
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巴氯芬缓减大鼠胫骨癌痛及可能机制 被引量:1
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作者 李伟 杨建平 +2 位作者 王丽娜 周静 任春光 《江苏医药》 CAS CSCD 北大核心 2010年第10期1188-1190,共3页
目的探讨巴氯芬对大鼠胫骨癌痛的作用及可能机制。方法使用Walker256乳腺癌细胞建立SD大鼠胫骨癌痛模型,第9天64只模型大鼠随机分8组(n=8):N1、N2组(生理盐水10μl),B1、B2组(巴氯芬0.1μg),C1、C2组[γ-氨基丁酸B型受体(GABAB)特异性... 目的探讨巴氯芬对大鼠胫骨癌痛的作用及可能机制。方法使用Walker256乳腺癌细胞建立SD大鼠胫骨癌痛模型,第9天64只模型大鼠随机分8组(n=8):N1、N2组(生理盐水10μl),B1、B2组(巴氯芬0.1μg),C1、C2组[γ-氨基丁酸B型受体(GABAB)特异性拮抗剂(CGP35348)60μg],D1、D2组(CGP3534860μg+巴氯芬0.1μg)。N1、B1、C1、D1组单次鞘内给药前0.5h、给药后0.5、1、2、4、8、24h使用VonFrey纤维测定患肢机械缩足阈值(MWT)。N2、B2、C2、D2组鞘内连续给药4d,每天给药1次,最后一次给药后6h处死,用免疫组织化学方法检测磷酸化细胞外信号调节激酶(p-ERK1/2)表达。结果与N1组比较,B1组大鼠MWT明显增加(P<0.05),持续时间为4h;与N2组比较,B2组大鼠脊髓背角p-ERK1/2阳性细胞数明显减少(P<0.05)。结论巴氯芬可能通过GABAB受体调控下游p-ERK1/2变化减缓胫骨癌痛,其作用可被CGP35348阻断。 展开更多
关键词 骨癌痛 γ-氨基丁酸b型(gabab)受体 巴氯芬 磷酸化细胞外信号调节激酶(p-ERK1/2)
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