A large-scale fine-grained Mg-Gd-Y-Zn-Zr alloy plate with high strength and ductility was successfully prepared by multi-pass friction stir processing(MFSP)technology in this work.The structure of grains and long peri...A large-scale fine-grained Mg-Gd-Y-Zn-Zr alloy plate with high strength and ductility was successfully prepared by multi-pass friction stir processing(MFSP)technology in this work.The structure of grains and long period stacking ordered(LPSO)phase were characterized,and the mechanical properties uniformity was investigated.Moreover,a quantitative relationship between the microstructure and tensile yield strength was established.The results showed that the grains in the processed zone(PZ)and interfacial zone(IZ)were refined from 50μm to 3μm and 4μm,respectively,and numerous original LPSO phases were broken.In IZ,some block-shaped 18R LPSO phases were transformed into needle-like 14H LPSO phases due to stacking faults and the short-range diffusion of solute atoms.The severe shear deformation in the form of kinetic energy caused profuse stacking fault to be generated and move rapidly,greatly increasing the transformation rate of LPSO phase.After MFSP,the ultimate tensile strength,yield strength and elongation to failure of the large-scale plate were 367 MPa,305 MPa and 18.0% respectively.Grain refinement and LPSO phase strengthening were the major strengthening mechanisms for the MFSP sample.In particularly,the strength of IZ was comparable to that of PZ because the strength contribution of the 14H LPSO phase offsets the lack of grain refinement strengthening in IZ.This result opposes the widely accepted notion that IZ is a weak region in MFSP-prepared large-scale fine-grained plate.展开更多
The layeredδ-MnO_(2)(dMO)is an excellent cathode material for rechargeable aqueous zinc-ion batteries owing to its large interlayer distance(~0.7 nm),high capacity,and low cost;however,such cathodes suffer from struc...The layeredδ-MnO_(2)(dMO)is an excellent cathode material for rechargeable aqueous zinc-ion batteries owing to its large interlayer distance(~0.7 nm),high capacity,and low cost;however,such cathodes suffer from structural degradation during the long-term cycling process,leading to capacity fading.In this study,a Co-doped dMO composite with reduced graphene oxide(GC-dMO)is developed using a simple cost-effective hydrothermal method.The degree of disorderness increases owing to the hetero-atom doping and graphene oxide composites.It is demonstrated that layered dMO and GC-dMO undergo a structural transition from K-birnessite to the Zn-buserite phase upon the first discharge,which enhances the intercalation of Zn^(2+)ions,H_(2)O molecules in the layered structure.The GC-dMO cathode exhibits an excellent capacity of 302 mAh g^(-1)at a current density of 100 mAg^(-1)after 100 cycles as compared with the dMO cathode(159 mAhg^(-1)).The excellent electrochemical performance of the GC-dMO cathode owing to Co-doping and graphene oxide sheets enhances the interlayer gap and disorderness,and maintains structural stability,which facilitates the easy reverse intercalation and de-intercalation of Zn^(2+)ions and H_(2)O molecules.Therefore,GC-dMO is a promising cathode material for large-scale aqueous ZIBs.展开更多
Photoacoustic imaging(PAI)is a noninvasive emerging imaging method based on the photoacoustic effect,which provides necessary assistance for medical diagnosis.It has the characteristics of large imaging depth and high...Photoacoustic imaging(PAI)is a noninvasive emerging imaging method based on the photoacoustic effect,which provides necessary assistance for medical diagnosis.It has the characteristics of large imaging depth and high contrast.However,limited by the equipment cost and reconstruction time requirements,the existing PAI systems distributed with annular array transducers are difficult to take into account both the image quality and the imaging speed.In this paper,a triple-path feature transform network(TFT-Net)for ring-array photoacoustic tomography is proposed to enhance the imaging quality from limited-view and sparse measurement data.Specifically,the network combines the raw photoacoustic pressure signals and conventional linear reconstruction images as input data,and takes the photoacoustic physical model as a prior information to guide the reconstruction process.In addition,to enhance the ability of extracting signal features,the residual block and squeeze and excitation block are introduced into the TFT-Net.For further efficient reconstruction,the final output of photoacoustic signals uses‘filter-then-upsample’operation with a pixel-shuffle multiplexer and a max out module.Experiment results on simulated and in-vivo data demonstrate that the constructed TFT-Net can restore the target boundary clearly,reduce background noise,and realize fast and high-quality photoacoustic image reconstruction of limited view with sparse sampling.展开更多
As a product of the Cold War,NATO did not disintegrate with the end of it,but rather,it has sought to become“global NATO”through continuous expansion and transformation,in order to hold wider sway in international s...As a product of the Cold War,NATO did not disintegrate with the end of it,but rather,it has sought to become“global NATO”through continuous expansion and transformation,in order to hold wider sway in international security.In its 75-year history,NATO has made numerous moves including adopting confrontational security thinking,building exclusive alliances,conducting humanitarian intervention and crisis management,expanding eastward and northward and involving in the Asia-Pacific.展开更多
Single-pixel imaging(SPI)can transform 2D or 3D image data into 1D light signals,which offers promising prospects for image compression and transmission.However,during data communication these light signals in public ...Single-pixel imaging(SPI)can transform 2D or 3D image data into 1D light signals,which offers promising prospects for image compression and transmission.However,during data communication these light signals in public channels will easily draw the attention of eavesdroppers.Here,we introduce an efficient encryption method for SPI data transmission that uses the 3D Arnold transformation to directly disrupt 1D single-pixel light signals and utilizes the elliptic curve encryption algorithm for key transmission.This encryption scheme immediately employs Hadamard patterns to illuminate the scene and then utilizes the 3D Arnold transformation to permutate the 1D light signal of single-pixel detection.Then the transformation parameters serve as the secret key,while the security of key exchange is guaranteed by an elliptic curve-based key exchange mechanism.Compared with existing encryption schemes,both computer simulations and optical experiments have been conducted to demonstrate that the proposed technique not only enhances the security of encryption but also eliminates the need for complicated pattern scrambling rules.Additionally,this approach solves the problem of secure key transmission,thus ensuring the security of information and the quality of the decrypted images.展开更多
BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal adenoma.Screening colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled muc...BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal adenoma.Screening colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent tumors.CSM-positive colorectal polyps are associated with various diseases;however,their prognosis varies greatly.Cold snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal polyps.Improved imaging is required to diagnose and treat CSM-positive colorectal polyps.METHODS This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using endoscopy.All patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record system.Based on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal carcinoma.RESULTS The diameters of NHGN and SM polyps were much smaller than those of neoplastic polyps.Most NHGN polyps had a deeper red mucosal color.On logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic polyps.Type 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic polyps.Logistic regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal cancer.Changes in the CSM mucosa surrounding neoplastic polyps and submucosal invasion of colorectal cancer disappeared within 12 months.No tumor recurrence was found during either partial or complete endoscopic resection of the CSM.CONCLUSION CSM-positive colorectal polyps>1 cm in diameter or with deeper red mucosa may be related to NHGN.Resection of CSM surrounding colorectal adenomas did not affect tumor recurrence.展开更多
The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the...The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the power grid. This paper advances an online CVT error state evaluation method, anchored in the in-phase relationship and outlier detection. Initially, this method leverages the in-phase relationship to obviate the influence of primary side fluctuations in the grid on assessment accuracy. Subsequently, Principal Component Analysis (PCA) is employed to meticulously disentangle the error change information inherent in the CVT from the measured values and to compute statistics that delineate the error state. Finally, the Local Outlier Factor (LOF) is deployed to discern outliers in the statistics, with thresholds serving to appraise the CVT error state. Experimental results incontrovertibly demonstrate the efficacy of this method, showcasing its prowess in effecting online tracking of CVT error changes and conducting error state assessments. The discernible enhancements in reliability, accuracy, and sensitivity are manifest, with the assessment accuracy reaching an exemplary 0.01%.展开更多
BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a ...BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.展开更多
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.展开更多
The S transform, which is a time-frequency representation known for its local spectral phase properties in signal processing, uniquely combines elements of wavelet transforms and the short-time Fourier transform (STF...The S transform, which is a time-frequency representation known for its local spectral phase properties in signal processing, uniquely combines elements of wavelet transforms and the short-time Fourier transform (STFT). The fractional Fourier transform is a tool for non-stationary signal analysis. In this paper, we define the concept of the fractional S transform (FRST) of a signal, based on the idea of the fractional Fourier transform (FRFT) and S transform (ST), extend the S transform to the time-fractional frequency domain from the time- frequency domain to obtain the inverse transform, and study the FRST mathematical properties. The FRST, which has the advantages of FRFT and ST, can enhance the ST flexibility to process signals. Compared to the S transform, the FRST can effectively improve the signal time- frequency resolution capacity. Simulation results show that the proposed method is effective.展开更多
In order to increase the hardware utilization and minimize the chip area a multi-transform coding architecture which includes 4 ×4 forward integer transform 4 ×4 inverse integer transform 4 ×4 Hadamard ...In order to increase the hardware utilization and minimize the chip area a multi-transform coding architecture which includes 4 ×4 forward integer transform 4 ×4 inverse integer transform 4 ×4 Hadamard transform and 2 ×2 Hadamard transform is proposed. By simplifying these transforms and exploring their similarities the proposed design merges the architectures processing individual transforms into a high-performance multi-transform coding architecture.Using a semiconductor manufacturing international corporation SMIC 0.18 μm complementary metal oxide semiconductor CMOS technology the proposed architecture achieves the maximum operating clock frequency of 200 MHz and the throughput rate of 800 ×106 pixel/s with the hardware cost of 3 704 gates.The results demonstrate that the data throughput rate per unit area DTUA of this design is at least 40.28%higher than that of the reference design.This design can meet the requirements of real-time decoding digital cinema video 4 096 ×2 048@30 Hz at 62.9 MHz which helps to reduce the power consumption.展开更多
基金supported by the National Key Research and Development Program of China(2021YFB3501002)State Key Program of National Natural Science Foundation of China(5203405)+3 种基金National Natural Science Foundation of China(51974220,52104383)National Key Research and Development Program of China(2021YFB3700902)Key Research and Development Program of Shaanxi Province(2020ZDLGY13-06,2017ZDXM-GY-037)Shaanxi Province National Science Fund for Distinguished Young Scholars(2022JC-24)。
文摘A large-scale fine-grained Mg-Gd-Y-Zn-Zr alloy plate with high strength and ductility was successfully prepared by multi-pass friction stir processing(MFSP)technology in this work.The structure of grains and long period stacking ordered(LPSO)phase were characterized,and the mechanical properties uniformity was investigated.Moreover,a quantitative relationship between the microstructure and tensile yield strength was established.The results showed that the grains in the processed zone(PZ)and interfacial zone(IZ)were refined from 50μm to 3μm and 4μm,respectively,and numerous original LPSO phases were broken.In IZ,some block-shaped 18R LPSO phases were transformed into needle-like 14H LPSO phases due to stacking faults and the short-range diffusion of solute atoms.The severe shear deformation in the form of kinetic energy caused profuse stacking fault to be generated and move rapidly,greatly increasing the transformation rate of LPSO phase.After MFSP,the ultimate tensile strength,yield strength and elongation to failure of the large-scale plate were 367 MPa,305 MPa and 18.0% respectively.Grain refinement and LPSO phase strengthening were the major strengthening mechanisms for the MFSP sample.In particularly,the strength of IZ was comparable to that of PZ because the strength contribution of the 14H LPSO phase offsets the lack of grain refinement strengthening in IZ.This result opposes the widely accepted notion that IZ is a weak region in MFSP-prepared large-scale fine-grained plate.
基金supported by the National Research Foundation of Korea(NRF)grants funded by the Korean Government(NRF-2021R1A4A1030318,NRF-2022R1C1C1011386,NRF-2020M3H4A1A03084258)supported by the"Regional Innovation Strategy(RIS)"through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(MOE)(2021RIS-003)
文摘The layeredδ-MnO_(2)(dMO)is an excellent cathode material for rechargeable aqueous zinc-ion batteries owing to its large interlayer distance(~0.7 nm),high capacity,and low cost;however,such cathodes suffer from structural degradation during the long-term cycling process,leading to capacity fading.In this study,a Co-doped dMO composite with reduced graphene oxide(GC-dMO)is developed using a simple cost-effective hydrothermal method.The degree of disorderness increases owing to the hetero-atom doping and graphene oxide composites.It is demonstrated that layered dMO and GC-dMO undergo a structural transition from K-birnessite to the Zn-buserite phase upon the first discharge,which enhances the intercalation of Zn^(2+)ions,H_(2)O molecules in the layered structure.The GC-dMO cathode exhibits an excellent capacity of 302 mAh g^(-1)at a current density of 100 mAg^(-1)after 100 cycles as compared with the dMO cathode(159 mAhg^(-1)).The excellent electrochemical performance of the GC-dMO cathode owing to Co-doping and graphene oxide sheets enhances the interlayer gap and disorderness,and maintains structural stability,which facilitates the easy reverse intercalation and de-intercalation of Zn^(2+)ions and H_(2)O molecules.Therefore,GC-dMO is a promising cathode material for large-scale aqueous ZIBs.
基金supported by National Key R&D Program of China[2022YFC2402400]the National Natural Science Foundation of China[Grant No.62275062]Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology[Grant No.2020B121201010-4].
文摘Photoacoustic imaging(PAI)is a noninvasive emerging imaging method based on the photoacoustic effect,which provides necessary assistance for medical diagnosis.It has the characteristics of large imaging depth and high contrast.However,limited by the equipment cost and reconstruction time requirements,the existing PAI systems distributed with annular array transducers are difficult to take into account both the image quality and the imaging speed.In this paper,a triple-path feature transform network(TFT-Net)for ring-array photoacoustic tomography is proposed to enhance the imaging quality from limited-view and sparse measurement data.Specifically,the network combines the raw photoacoustic pressure signals and conventional linear reconstruction images as input data,and takes the photoacoustic physical model as a prior information to guide the reconstruction process.In addition,to enhance the ability of extracting signal features,the residual block and squeeze and excitation block are introduced into the TFT-Net.For further efficient reconstruction,the final output of photoacoustic signals uses‘filter-then-upsample’operation with a pixel-shuffle multiplexer and a max out module.Experiment results on simulated and in-vivo data demonstrate that the constructed TFT-Net can restore the target boundary clearly,reduce background noise,and realize fast and high-quality photoacoustic image reconstruction of limited view with sparse sampling.
文摘As a product of the Cold War,NATO did not disintegrate with the end of it,but rather,it has sought to become“global NATO”through continuous expansion and transformation,in order to hold wider sway in international security.In its 75-year history,NATO has made numerous moves including adopting confrontational security thinking,building exclusive alliances,conducting humanitarian intervention and crisis management,expanding eastward and northward and involving in the Asia-Pacific.
基金Project supported by the National Natural Science Foundation of China(Grant No.62075241).
文摘Single-pixel imaging(SPI)can transform 2D or 3D image data into 1D light signals,which offers promising prospects for image compression and transmission.However,during data communication these light signals in public channels will easily draw the attention of eavesdroppers.Here,we introduce an efficient encryption method for SPI data transmission that uses the 3D Arnold transformation to directly disrupt 1D single-pixel light signals and utilizes the elliptic curve encryption algorithm for key transmission.This encryption scheme immediately employs Hadamard patterns to illuminate the scene and then utilizes the 3D Arnold transformation to permutate the 1D light signal of single-pixel detection.Then the transformation parameters serve as the secret key,while the security of key exchange is guaranteed by an elliptic curve-based key exchange mechanism.Compared with existing encryption schemes,both computer simulations and optical experiments have been conducted to demonstrate that the proposed technique not only enhances the security of encryption but also eliminates the need for complicated pattern scrambling rules.Additionally,this approach solves the problem of secure key transmission,thus ensuring the security of information and the quality of the decrypted images.
基金the Science and Technology Plan Project of Chengdu Municipal Health Commission,No.2019007.
文摘BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal adenoma.Screening colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent tumors.CSM-positive colorectal polyps are associated with various diseases;however,their prognosis varies greatly.Cold snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal polyps.Improved imaging is required to diagnose and treat CSM-positive colorectal polyps.METHODS This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using endoscopy.All patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record system.Based on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal carcinoma.RESULTS The diameters of NHGN and SM polyps were much smaller than those of neoplastic polyps.Most NHGN polyps had a deeper red mucosal color.On logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic polyps.Type 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic polyps.Logistic regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal cancer.Changes in the CSM mucosa surrounding neoplastic polyps and submucosal invasion of colorectal cancer disappeared within 12 months.No tumor recurrence was found during either partial or complete endoscopic resection of the CSM.CONCLUSION CSM-positive colorectal polyps>1 cm in diameter or with deeper red mucosa may be related to NHGN.Resection of CSM surrounding colorectal adenomas did not affect tumor recurrence.
文摘The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the power grid. This paper advances an online CVT error state evaluation method, anchored in the in-phase relationship and outlier detection. Initially, this method leverages the in-phase relationship to obviate the influence of primary side fluctuations in the grid on assessment accuracy. Subsequently, Principal Component Analysis (PCA) is employed to meticulously disentangle the error change information inherent in the CVT from the measured values and to compute statistics that delineate the error state. Finally, the Local Outlier Factor (LOF) is deployed to discern outliers in the statistics, with thresholds serving to appraise the CVT error state. Experimental results incontrovertibly demonstrate the efficacy of this method, showcasing its prowess in effecting online tracking of CVT error changes and conducting error state assessments. The discernible enhancements in reliability, accuracy, and sensitivity are manifest, with the assessment accuracy reaching an exemplary 0.01%.
文摘BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.
基金supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS)the China Postdoctoral Science Foundation,No.2018M633091(to JS).
文摘Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.
基金supported by Scientific Research Fund of Sichuan Provincial Education Departmentthe National Nature Science Foundation of China (No. 40873035)
文摘The S transform, which is a time-frequency representation known for its local spectral phase properties in signal processing, uniquely combines elements of wavelet transforms and the short-time Fourier transform (STFT). The fractional Fourier transform is a tool for non-stationary signal analysis. In this paper, we define the concept of the fractional S transform (FRST) of a signal, based on the idea of the fractional Fourier transform (FRFT) and S transform (ST), extend the S transform to the time-fractional frequency domain from the time- frequency domain to obtain the inverse transform, and study the FRST mathematical properties. The FRST, which has the advantages of FRFT and ST, can enhance the ST flexibility to process signals. Compared to the S transform, the FRST can effectively improve the signal time- frequency resolution capacity. Simulation results show that the proposed method is effective.
基金The National Key Technology R&D Program of China during the 12th Five Year Plan Period(No.2013BAJ05B03)
文摘In order to increase the hardware utilization and minimize the chip area a multi-transform coding architecture which includes 4 ×4 forward integer transform 4 ×4 inverse integer transform 4 ×4 Hadamard transform and 2 ×2 Hadamard transform is proposed. By simplifying these transforms and exploring their similarities the proposed design merges the architectures processing individual transforms into a high-performance multi-transform coding architecture.Using a semiconductor manufacturing international corporation SMIC 0.18 μm complementary metal oxide semiconductor CMOS technology the proposed architecture achieves the maximum operating clock frequency of 200 MHz and the throughput rate of 800 ×106 pixel/s with the hardware cost of 3 704 gates.The results demonstrate that the data throughput rate per unit area DTUA of this design is at least 40.28%higher than that of the reference design.This design can meet the requirements of real-time decoding digital cinema video 4 096 ×2 048@30 Hz at 62.9 MHz which helps to reduce the power consumption.