Understanding the educational inequalities in suicide attempts and their mediators:a Mendelian randomisation study

Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.

Mapping and measuring urban-rural inequalities in accessibility to social infrastructures

Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.

STRONGLY CONVERGENT INERTIAL FORWARD-BACKWARD-FORWARD ALGORITHM WITHOUT ON-LINE RULE FOR VARIATIONAL INEQUALITIES

This paper studies a strongly convergent inertial forward-backward-forward algorithm for the variational inequality problem in Hilbert spaces.In our convergence analysis,we do not assume the on-line rule of the inertial parameters and the iterates,which have been assumed by several authors whenever a strongly convergent algorithm with an inertial extrapolation step is proposed for a variational inequality problem.Consequently,our proof arguments are different from what is obtainable in the relevant literature.Finally,we give numerical tests to confirm the theoretical analysis and show that our proposed algorithm is superior to related ones in the literature.

THE LOGARITHMIC SOBOLEV INEQUALITY FOR A SUBMANIFOLD IN MANIFOLDS WITH ASYMPTOTICALLY NONNEGATIVE SECTIONAL CURVATURE

In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality,this inequality contains a term involving the mean curvature.

Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week:An analysis with 707,616 adolescents

Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important information.For instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate levels.Also,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity practice.Thus,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender inequalities.Methods:We used representative datasets from 146 countries/territories collected between 2003 and 2019.MVPA was self-reported.Participants were grouped into younger(≤14 years old)and older(>14 years old)adolescents.Crude Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled estimates.Analyses were stratified by country and region.Results:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per week.This prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions were<77%.The prevalence of≥60 min of MVPA≥1 days per week was higher among boys than girls,with the largest differences occurring among the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)vs.Prevalence ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between regions.Gender differences were observed in several countries,especially among the oldest adolescents.Priorities for physical activity promotion among adolescents should include increasing access/opportunities for physical activity among those who do not achieve≥60 min of MVPA≥1 days per week and reducing gender inequalities.

Does digitalization mitigate regional inequalities?Evidence from China

Regional inequality significantly influences sustainable development and human well-being.In China,there exists pronounced regional disparities in economic and digital advancements;however,scant research delves into the interplay between them.By analyzing the economic development and digitalization gaps at regional and city levels in China,extending the original Cobb-Douglas production function,this study aims to evaluate the impact of digitalization on China's regional inequality using seemingly unrelated regression.The results indicate a greater emphasis on digital inequality compared to economic disparity,with variable coefficients of 0.59 for GDP per capita and 0.92 for the digitalization index over the past four years.However,GDP per capita demonstrates higher spatial concentration than digitalization.Notably,both disparities have shown a gradual reduction in recent years.The southeastern region of the Hu Huanyong Line exhibits superior levels and rates of economic and digital advancement in contrast to the northwestern region.While digitalization propels economic growth,it yields a nuanced impact on achieving balanced regional development,encompassing both positive and negative facets.Our study highlights that the marginal utility of advancing digitalization is more pronounced in less developed regions,but only if the government invests in the digital infrastructure and education in these areas.This study's methodology can be utilized for subsequent research,and our findings hold the potential to the government's regional investment and policy-making.

Weak and Strong Convergence of Self Adaptive Inertial Subgradient Extragradient Algorithms for Solving Variational Inequality Problems

Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious advantages.Two different algorithms are given for solving variational inequality problem in this paper.The problem we study is defined in a real Hilbert space and has L-Lipschitz and pseudomonotone condition.Two new algorithms adopt inertial technology and non-monotonic step size rule,and their convergence can still be proved when the value of L is not given in advance.Finally,some numerical results are designed to demonstrate the computational efficiency of our two new algorithms.

A Study of Triangle Inequality Violations in Social Network Clustering

Clustering a social network is a process of grouping social actors into clusters where intra-cluster similarities among actors are higher than inter-cluster similarities. Clustering approaches, i.e. , k-medoids or hierarchical, use the distance function to measure the dissimilarities among actors. These distance functions need to fulfill various properties, including the triangle inequality (TI). However, in some cases, the triangle inequality might be violated, impacting the quality of the resulting clusters. With experiments, this paper explains how TI violates while performing traditional clustering techniques: k-medoids, hierarchical, DENGRAPH, and spectral clustering on social networks and how the violation of TI affects the quality of the resulting clusters.

AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

A RELAXED INERTIAL FACTOR OF THE MODIFIED SUBGRADIENT EXTRAGRADIENT METHOD FOR SOLVING PSEUDO MONOTONE VARIATIONAL INEQUALITIES IN HILBERT SPACES

In this paper,we investigate pseudomonotone and Lipschitz continuous variational inequalities in real Hilbert spaces.For solving this problem,we propose a new method that combines the advantages of the subgradient extragradient method and the projection contraction method.Some very recent papers have considered different inertial algorithms which allowed the inertial factor is chosen in[0;1].The purpose of this work is to continue working in this direction,we propose another inertial subgradient extragradient method that the inertial factor can be chosen in a special case to be 1.Under suitable mild conditions,we establish the weak convergence of the proposed algorithm.Moreover,linear convergence is obtained under strong pseudomonotonicity and Lipschitz continuity assumptions.Finally,some numerical illustrations are given to confirm the theoretical analysis.

Verification of the Landau Equation and Hardy’s Inequality

We prove the L estimate for the isotropic version of the homogeneous landau problem, which was explored by M. Gualdani and N. Guillen. As shown in a region of the smooth potentials range under values of the interaction exponent (2), a weighted Poincaré inequality is a natural consequence of the traditional weighted Hardy inequality, which in turn implies that the norms of solutions propagate in the L1 space. Now, the L estimate is based on the work of De Giorgi, Nash, and Moser, as well as a few weighted Sobolev inequalities.

NOTES ON THE LOG-BRUNN-MINKOWSKI INEQUALITY

Böröczky-Lutwak-Yang-Zhang proved the log-Brunn-Minkowski inequality for two origin-symmetric convex bodies in the plane in a way that is stronger than for the classical Brunn-Minkowski inequality.In this paper,we investigate the relative positive center set of planar convex bodies.As an application of the relative positive center,we prove the log-Minkowski inequality and the log-Brunn-Minkowski inequality.

Knowledge of Tuberculosis, Services of TB Control Programme and Associated Socio-Demographic Inequity among Rural Participants of Jaipur, Rajasthan, India: A Cross Sectional Study

Background: Tuberculosis (TB) is one of the top 10 causes of death worldwide. India is still the highest TB burden country. There is a scarcity of data on TB knowledge from Rajasthan state of India. Objective: The objective of this study was to estimate the prevalence of knowledge about TB and services of TB control programme and to determine its correlates among rural population of Jaipur, Rajasthan. Methods: Cross-sectional community based study was carried out at Model Rural Health Research Unit, Jaipur, a unit of Department of Health Research, Ministry of Health & Family Welfare, Government of India. Results: Study reports the result from 1993 adult participants from 10 villages of 2 sub-districts of district Jaipur. About 88.9% of studied participants knew that TB is an infectious disease and it spreads from TB patient to healthy person in close contact. Only 22.3% of participants knew “DOTS is the treatment for TB”. While, only 58.9% knew “sputum is used for diagnosis of TB” at health centers. Scheduled castes, scheduled tribes and backward classes social groups knew less than the mainstream “General” social group. The observed difference was statistically significant (p 0.05). Logistic regression analysis estimated the relative contribution to knowledge status. Conclusion: The knowledge of study participants on transmission of tuberculosis was similar to knowledge of population in country wide study. They poorly knew sputum is used for diagnosing tuberculosis disease;socio-demographic inequity exists in this knowledge too. People from older age groups, underprivileged social groups and minority need extra educational activities.

The Bell Inequality, Inviolable by Data Used Consistently with Its Derivation, Is Satisfied by Quantum Correlations Whose Probabilities Satisfy the Wigner Inequality

It is not generally known that the inequality that Bell derived using three random variables must be identically satisfied by any three corresponding data sets of ±1’s that are writable on paper. This surprising fact is not immediately obvious from Bell’s inequality derivation based on causal random variables, but follows immediately if the same mathematical operations are applied to finite data sets. For laboratory data, the inequality is identically satisfied as a fact of pure algebra, and its satisfaction is independent of whether the processes generating the data are local, non-local, deterministic, random, or nonsensical. It follows that if predicted correlations violate the inequality, they represent no three cross-correlated data sets that can exist, or can be generated from valid probability models. Reported data that violate the inequality consist of probabilistically independent data-pairs and are thus inconsistent with inequality derivation. In the case of random variables as Bell assumed, the correlations in the inequality may be expressed in terms of the probabilities that give rise to them. A new inequality is then produced: The Wigner inequality, that must be satisfied by quantum mechanical probabilities in the case of Bell experiments. If that were not the case, predicted quantum probabilities and correlations would be inconsistent with basic algebra.

Some Refinement of Holder’s and Its Reverse Inequality

Holder’s inequality, its refinement, and reverse have received considerable attention in the theory of mathematical analysis and differential equations. In this paper, we give some refinements of Holder’s inequality and its reverse using a simple analytical technique of algebra and calculus. Our results show many results related to holder’s inequality as special cases of the inequalities presented.

NEW DOOB'S MAXIMAL INEQUALITIES FOR MARTINGALES

Let 1≤q≤∞,b be a slowly varying function and letΦ:[0,∞)■[0,∞)be an increasing convex function withΦ(0)=0 and■Φ(r)=∞.In this paper,we present a new class of Doob’s maximal inequality on Orlicz-Lorentz-Karamata spaces LΦ,q,b.The results are new,even for the Lorentz-Karamata spaces withΦ(t)=tp,the Orlicz-Lorentz spaces with b≡1,and weak Orlicz-Karamata spaces with q=∞in the framework of LΦ,q,b-Moreover,we obtain some even stronger qualitative results that can remove the△2-condition of Liu,Hou and Wang(Sci China Math,2010,53(4):905-916).

Generalization of Inequalities in Metric Spaces with Applications

In this paper, which serves as a continuation of earlier work, we generalize the idea of inequalities in metric spaces and use them to demonstrate that the incomplete metric space can be used to obtain a Banach space.

TRANSPORTATION COST-INFORMATION INEQUALITY FOR A STOCHASTIC HEAT EQUATION DRIVEN BY FRACTIONAL-COLORED NOISE

In this paper,we prove Talagrand’s T2 transportation cost-information inequality for the law of stochastic heat equation driven by Gaussian noise,which is fractional for a time variable with the Hurst index H∈(1/2,1),and is correlated for the spatial variable.The Girsanov theorem for fractional-colored Gaussian noise plays an important role in the proof.

What in Fact Proves the Violation of the Bell-Type Inequalities?

A. Peres constructed an example of particles entangled in the state of spin singlet. He claimed to have obtained the CHSH inequality and concluded that the violation of this inequality shows that in a measurement in which some variables are tested, other variables, not tested, have no defined value. In the present paper is proved that the correct conclusion of the violation of the CHSH inequality is different. It is proved that the classical calculus of probabilities of test results, obeying the Kolmogorov axioms, is unfit for the quantum formalism, dominated by probability amplitudes.

HARNACK TYPE INEQUALITIES FOR SDES DRIVEN BY FRACTIONAL BROWNIAN MOTION WITH MARKOVIAN SWITCHING

In this paper, by constructing a coupling equation, we establish the Harnack type inequalities for stochastic differential equations driven by fractional Brownian motion with Markovian switching. The Hurst parameter H is supposed to be in(1/2, 1). As a direct application, the strong Feller property is presented.