An aromatization reaction was found when 18--methyl--estra--4(5), 9(10)--dien--3, 17--dione(6) was treated with triethyl orthoforrnate in dioxane in the presence of catalytic amount of p--toluenesulfonic acid (TsOH), ...An aromatization reaction was found when 18--methyl--estra--4(5), 9(10)--dien--3, 17--dione(6) was treated with triethyl orthoforrnate in dioxane in the presence of catalytic amount of p--toluenesulfonic acid (TsOH), and 18--methyl--9(11) --dehydroestrone--3--ethyl ether (8) was obtained in 70% yield. The mechanism was found to be a process of etherification--oxidation reaction.展开更多
文摘An aromatization reaction was found when 18--methyl--estra--4(5), 9(10)--dien--3, 17--dione(6) was treated with triethyl orthoforrnate in dioxane in the presence of catalytic amount of p--toluenesulfonic acid (TsOH), and 18--methyl--9(11) --dehydroestrone--3--ethyl ether (8) was obtained in 70% yield. The mechanism was found to be a process of etherification--oxidation reaction.
