Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizati...Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizations,they have not been extensively studied in academia.We conducted a study grounded in workshops and interviews with 99 participants from 30 organizations,including organizations undergoing transformations(“final organizations”)and companies supporting these processes(“consultants”).The study aims to understand the motivations,objectives,and factors driving and challenging these transformations.Over 700 responses were collected to the question and categorized into 32 objectives.The findings show that organizations primarily aim to achieve customer centricity and adaptability,both with 8%of the mentions.Other primary important objectives,with above 4%of mentions,include alignment of goals,lean delivery,sustainable processes,and a flatter,more team-based organizational structure.We also detect discrepancies in perspectives between the objectives identified by the two kinds of organizations and the existing agile literature and models.This misalignment highlights the need for practitioners to understand with the practical realities the organizations face.展开更多
Under the background of digital transformation,the reform of the higher vocational mathematics curriculum faces urgent challenges and opportunities.This article explores the impact of digital transformation on the ref...Under the background of digital transformation,the reform of the higher vocational mathematics curriculum faces urgent challenges and opportunities.This article explores the impact of digital transformation on the reform of higher vocational mathematics curriculum and emphasizes the importance of improving teaching methods centered on learners.The article proposes specific reform methods and discusses the practical application of digital technology in the reform process.By combining digital technology with specific reform methods,further conducting innovative practice research,and continuously exploring the path of reform,we can effectively improve the quality of higher vocational mathematics classroom teaching and provide strong support for the cultivation of comprehensive qualities and employment abilities.展开更多
Starting from the characteristics of modernization in three different historical stages since the founding of the People’s Republic of China,this paper analyses the internal changes in the professional name,subordina...Starting from the characteristics of modernization in three different historical stages since the founding of the People’s Republic of China,this paper analyses the internal changes in the professional name,subordinate disciplines and categories,and professional mission of the environmental design profession,and summarizes the changes in the characteristics of the environmental design profession in 10 aspects such as subordinate disciplines,design objects,design types,cultural characteristics,and aesthetic values on the basis of the results of the analysis,and explores five transformations of the environmental design profession in the process of China’s development in the future.The five transformations in the future development of China are to serve the harmony and beauty of the three major urban and rural spaces with“small and micro-renewal and reconstruction”;to serve the transmission of Chinese culture and the spread of Chinese civilization with“spatial heritage and innovation”;to serve the balance and sufficiency of the four functions of urban and rural settlements with“friendliness and equilibrium”;to serve the intelligence,wisdom,and enjoyment of indoor and outdoor living environment space with“scientific and technological achievements”;and to serve the co-construction,co-management,and sharing of indoor and outdoor public space in urban and rural areas with“public participation.”展开更多
BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a ...BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.展开更多
The 19th century was a milestone for urban planning history of the Eastern Mediterranean region since the typology of the Ottoman city was reformed,more or less abruptly,by strong Western European influences as a cons...The 19th century was a milestone for urban planning history of the Eastern Mediterranean region since the typology of the Ottoman city was reformed,more or less abruptly,by strong Western European influences as a consequence of broader political,economic,and social transformations.From the very beginning of the 19th century,the Ottoman state confronted significant administrative issues that raised in the importance to institutionalise reforms over a long period of time,representing the foundation of later urban“modernisation reforms”.These challenges of the Ottoman cities at that period coincided with one crucial reform framework known as“Tanzimat”,which reflected the social willingness to inherit elements of European culture,technological innovations,and lifestyle.According to that direction,urban space was considered as a workshop of planning regulations and reforms adopting principles of contemporary,at that time,European urban planning,mostly applied in England and France.These social and urban reforms established by the Ottoman state marked the first attempt to relate Ottoman cities with European planning,urban infrastructures,building regulations,and public administration.During the period of Tanzimat(1839-1876),the economic role and impact of cities was strengthened reflecting a rising urbanisation of population.This article highlights this“Europeanisation”of Ottoman cities at the period of Tanzimat by investigating five case-study cities:Smyrna,Beirut,Alexandria,Thessaloniki,and Constantinople.All these cities were important ports-hubs of the Eastern Mediterranean whose urban development since the 1840s was a direct consequence of the modernisation reforms and,in general,an increase of European influence.These urban reforms,like in many European cities,included new transport infrastructures and communication networks,public services(water,gas,tramways,etc.),health and education,and new industrial patterns.展开更多
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.展开更多
The hydrogen-induced microstructure evolution and phase transformations in Ti-6Al-4V alloy during heating and cooling were studied.The specimens were heated to 1273 K and subsequently cooled to room temperature.The hy...The hydrogen-induced microstructure evolution and phase transformations in Ti-6Al-4V alloy during heating and cooling were studied.The specimens were heated to 1273 K and subsequently cooled to room temperature.The hydrogen content is up to 0.8%(mass fraction).The hydrogen-induced dynamic phase transformations and the corresponding mechanisms were analyzed.When the hydrogen content increases,the β transus temperature significantly decreases and the magnitude decreases,and the volume fraction of β phase increases.During heating,the phase transformations in hydrogenated Ti-6Al-4V alloys can be divided into three stages,and the phase transformation order is δ→α+H2↑?δ+α′→βH?α′→αH+βH?αH→α+H2↑?α→β?βH→β+H2↑.In addition,the relationship among hydrogenation and Ms and Mf of α′ martensite were determined.展开更多
针对主流Transformer网络仅对输入像素块做自注意力计算而忽略了不同像素块间的信息交互,以及输入尺度单一导致局部特征细节模糊的问题,本文提出一种基于Transformer并用于处理视觉任务的主干网络ConvFormer. ConvFormer通过所设计的多...针对主流Transformer网络仅对输入像素块做自注意力计算而忽略了不同像素块间的信息交互,以及输入尺度单一导致局部特征细节模糊的问题,本文提出一种基于Transformer并用于处理视觉任务的主干网络ConvFormer. ConvFormer通过所设计的多尺度混洗自注意力模块(Channel-Shuffle and Multi-Scale attention,CSMS)和动态相对位置编码模块(Dynamic Relative Position Coding,DRPC)来聚合多尺度像素块间的语义信息,并在前馈网络中引入深度卷积提高网络的局部建模能力.在公开数据集ImageNet-1K,COCO 2017和ADE20K上分别进行图像分类、目标检测和语义分割实验,ConvFormer-Tiny与不同视觉任务中同量级最优网络RetNetY-4G,Swin-Tiny和ResNet50对比,精度分别提高0.3%,1.4%和0.5%.展开更多
基金funding from the European Commission for the Ruralities Project(grant agreement no.101060876).
文摘Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizations,they have not been extensively studied in academia.We conducted a study grounded in workshops and interviews with 99 participants from 30 organizations,including organizations undergoing transformations(“final organizations”)and companies supporting these processes(“consultants”).The study aims to understand the motivations,objectives,and factors driving and challenging these transformations.Over 700 responses were collected to the question and categorized into 32 objectives.The findings show that organizations primarily aim to achieve customer centricity and adaptability,both with 8%of the mentions.Other primary important objectives,with above 4%of mentions,include alignment of goals,lean delivery,sustainable processes,and a flatter,more team-based organizational structure.We also detect discrepancies in perspectives between the objectives identified by the two kinds of organizations and the existing agile literature and models.This misalignment highlights the need for practitioners to understand with the practical realities the organizations face.
基金Classroom Revolution Special Project for Teaching Construction and Reform at Jiangsu Vocational College of Electronics and Information(JX-G-2023-04)。
文摘Under the background of digital transformation,the reform of the higher vocational mathematics curriculum faces urgent challenges and opportunities.This article explores the impact of digital transformation on the reform of higher vocational mathematics curriculum and emphasizes the importance of improving teaching methods centered on learners.The article proposes specific reform methods and discusses the practical application of digital technology in the reform process.By combining digital technology with specific reform methods,further conducting innovative practice research,and continuously exploring the path of reform,we can effectively improve the quality of higher vocational mathematics classroom teaching and provide strong support for the cultivation of comprehensive qualities and employment abilities.
基金Chongqing 2023 Undergraduate Colleges and Universities“Course Ideology and Politics Demonstration Course”and First-Class Undergraduate Course“Offline Course”“Environmental Space Design,”Chongqing College of Engineering 2022 Undergraduate“Course Civics and Politics Demonstration Course”and Gold Course“Offline Course”“Environmental Space Design,”Chongqing 2021 Higher Education Teaching Reform Research Project-Teaching Reform and Practice of Curriculum Civics and Politics Education Integrated into Environmental Design Professional Courses(Key Project)(202127)。
文摘Starting from the characteristics of modernization in three different historical stages since the founding of the People’s Republic of China,this paper analyses the internal changes in the professional name,subordinate disciplines and categories,and professional mission of the environmental design profession,and summarizes the changes in the characteristics of the environmental design profession in 10 aspects such as subordinate disciplines,design objects,design types,cultural characteristics,and aesthetic values on the basis of the results of the analysis,and explores five transformations of the environmental design profession in the process of China’s development in the future.The five transformations in the future development of China are to serve the harmony and beauty of the three major urban and rural spaces with“small and micro-renewal and reconstruction”;to serve the transmission of Chinese culture and the spread of Chinese civilization with“spatial heritage and innovation”;to serve the balance and sufficiency of the four functions of urban and rural settlements with“friendliness and equilibrium”;to serve the intelligence,wisdom,and enjoyment of indoor and outdoor living environment space with“scientific and technological achievements”;and to serve the co-construction,co-management,and sharing of indoor and outdoor public space in urban and rural areas with“public participation.”
文摘BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.
文摘The 19th century was a milestone for urban planning history of the Eastern Mediterranean region since the typology of the Ottoman city was reformed,more or less abruptly,by strong Western European influences as a consequence of broader political,economic,and social transformations.From the very beginning of the 19th century,the Ottoman state confronted significant administrative issues that raised in the importance to institutionalise reforms over a long period of time,representing the foundation of later urban“modernisation reforms”.These challenges of the Ottoman cities at that period coincided with one crucial reform framework known as“Tanzimat”,which reflected the social willingness to inherit elements of European culture,technological innovations,and lifestyle.According to that direction,urban space was considered as a workshop of planning regulations and reforms adopting principles of contemporary,at that time,European urban planning,mostly applied in England and France.These social and urban reforms established by the Ottoman state marked the first attempt to relate Ottoman cities with European planning,urban infrastructures,building regulations,and public administration.During the period of Tanzimat(1839-1876),the economic role and impact of cities was strengthened reflecting a rising urbanisation of population.This article highlights this“Europeanisation”of Ottoman cities at the period of Tanzimat by investigating five case-study cities:Smyrna,Beirut,Alexandria,Thessaloniki,and Constantinople.All these cities were important ports-hubs of the Eastern Mediterranean whose urban development since the 1840s was a direct consequence of the modernisation reforms and,in general,an increase of European influence.These urban reforms,like in many European cities,included new transport infrastructures and communication networks,public services(water,gas,tramways,etc.),health and education,and new industrial patterns.
基金supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS)the China Postdoctoral Science Foundation,No.2018M633091(to JS).
文摘Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.
基金Project(51275132)supported by the National Natural Science Foundation of China
文摘The hydrogen-induced microstructure evolution and phase transformations in Ti-6Al-4V alloy during heating and cooling were studied.The specimens were heated to 1273 K and subsequently cooled to room temperature.The hydrogen content is up to 0.8%(mass fraction).The hydrogen-induced dynamic phase transformations and the corresponding mechanisms were analyzed.When the hydrogen content increases,the β transus temperature significantly decreases and the magnitude decreases,and the volume fraction of β phase increases.During heating,the phase transformations in hydrogenated Ti-6Al-4V alloys can be divided into three stages,and the phase transformation order is δ→α+H2↑?δ+α′→βH?α′→αH+βH?αH→α+H2↑?α→β?βH→β+H2↑.In addition,the relationship among hydrogenation and Ms and Mf of α′ martensite were determined.
文摘针对主流Transformer网络仅对输入像素块做自注意力计算而忽略了不同像素块间的信息交互,以及输入尺度单一导致局部特征细节模糊的问题,本文提出一种基于Transformer并用于处理视觉任务的主干网络ConvFormer. ConvFormer通过所设计的多尺度混洗自注意力模块(Channel-Shuffle and Multi-Scale attention,CSMS)和动态相对位置编码模块(Dynamic Relative Position Coding,DRPC)来聚合多尺度像素块间的语义信息,并在前馈网络中引入深度卷积提高网络的局部建模能力.在公开数据集ImageNet-1K,COCO 2017和ADE20K上分别进行图像分类、目标检测和语义分割实验,ConvFormer-Tiny与不同视觉任务中同量级最优网络RetNetY-4G,Swin-Tiny和ResNet50对比,精度分别提高0.3%,1.4%和0.5%.