BACKGROUND Early diabetic nephropathy(DN)is a complication of diabetes mellitus.It mainly affects kidney microvessels and glomerular function,and its timely and effective treatment is critical for early DN.However,the...BACKGROUND Early diabetic nephropathy(DN)is a complication of diabetes mellitus.It mainly affects kidney microvessels and glomerular function,and its timely and effective treatment is critical for early DN.However,the effects of treatments comprising simple Western medicine are not optimal.With the promotion and implementation of integrated Chinese and western medicine treatments,remarkable results have been achieved for many diseases.To this end,we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early DN.AIM To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early DN.METHODS Through a retrospective analysis,123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO.7 People’s Hospital from January 2021 to October 2022 and were selected as study subjects.After rigorous screening,100 patients with early DN were enrolled.The control group(CG,n=50)and the observation group(OG,n=50)were divided according to the treatment method.The CG were treated with sitagliptin,and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue decoction.Both groups were treated for 3 mo.For both groups,the baseline data and clinical efficacy were compared,and changes in blood glucose levels,lipid levels,renal function,and hematological indicators before(T0)and after(T1)treatment were assessed.RESULTS The total effective rate for the OG was 94.00%and that of the CG was 80.00%(P<0.05).After treatment(T1),the levels of fasting blood glucose,2 h postprandial glucose,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG(P<0.05),and cystatin C,homocysteine,urinary microalbumin,and blood creatinine values in OG patients were also obviously lower than those in the CG(P<0.05);erythrocyte deposition,plasma viscosity,whole blood high shear viscosity,and whole blood low shear viscosity were markedly lower in OG patients than in the CG(P<0.05).CONCLUSION Sitagliptin combined with Yiqi yangyin huoxue decoction has a remarkable effect when used to treat patients with early DN.Further,it is helpful in improving hemorheological indices and controlling disease progression.展开更多
Objective： To observe the effect of Yiqi Yangyin Decoction （益气养阴方, YQYYD） on the quality of life （QOL） of patients with unstable angina pectoris （UAP）. Methods： A total of 108 patients with UAP of qi-yin ...Objective： To observe the effect of Yiqi Yangyin Decoction （益气养阴方, YQYYD） on the quality of life （QOL） of patients with unstable angina pectoris （UAP）. Methods： A total of 108 patients with UAP of qi-yin deficiency syndrome confirmed by coronary angiography were enrolled and assigned to the treated group （treated with YQYYD and conventional therapy of Western medicine） and the control group （treated with conventional therapy of Western medicine）, by the use of the PROC PLAN of the SAS 6.12 software, in a prospective, randomized, controlled design. The clinical total effective rate, symptom score, QOL scale [Seattle Angina Questionnaire （SAQ）] and incidence of important clinical events were defined as the observation indices to evaluate the interventional effect of YQYYD on the QOL of patients with UAP of the qi-yin deficiency syndrome. Results： During the study, three cases dropped out in the treated group, one case dropped out in the control group, and 104 cases, including 51 cases in the treatment group and 53 cases in the control group, finished the trial. After four weeks of treatment, the total clinical effective rates in the treated group and the control group were 80.4% and 75.5% respectively, and there was no obvious difference between them （P〉0.05）. However, the symptom score of the treated group （9.31 ± 2.02） was significantly lesser than that of the control group （11.62 ± 3.04, P〈0.05）, and the total score of the QOI scale of the treated group （68.76 ± 5.74） was significantly higher than that of the control group （61.06 ±3.31, P〈0.01）. Among those in the treated group physical limitation, angina stability, angina frequency, and treatment satisfaction were significantly ameliorated when compared with the control group after treatment （P〈0.05, P〈0.01）. The incidence of important clinical events in the treated group （3.9%） was lower than that in the control group （5.7%） during the 8-month follow-up period, but the difference was insignificant （P〉0.05）. Conclusion： YQYYD could improve the clinical symptoms of patients with UAP of qi-yin deficiency syndrome and greatly improve their QOL.展开更多
Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 w...Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization.Patients received E+D,Zuogui Pill or BYHD for 12 months,respectively.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),anti-Mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after treatment.Results:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the study.After 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all P<0.01),BYHD also resulted in E2 elevation(P<0.05),ovary enlargement(P<0.05),AFC increase(P<0.01),and RI of ovarian arteries decrease(P<0.05).After 12 months,further improvements were observed in the Zuogui Pill and BYHD groups(all P<0.01),but BYHD showed better outcomes,with lower FSH,larger ovaries and a thicker endometrium compared with the Zuogui Pill group(all P<0.01).However,E+D only significantly increased endometrial thickness(P<0.01)and no significant improvements were observed in the RI of uterine arteries in the three groups.Conclusions:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin endometrium.The combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR.展开更多
Objective To evaluate the 8-week comprehensive effect of Yiqi Yangyin Hexue decoction (YYHD) in adult patients with chronic primary immune thrombocytopenia (cITP). Methods Totally 76 patients from the department of he...Objective To evaluate the 8-week comprehensive effect of Yiqi Yangyin Hexue decoction (YYHD) in adult patients with chronic primary immune thrombocytopenia (cITP). Methods Totally 76 patients from the department of hematology of Affiliated Hospital of Nanjing University of Chinese Medicine were enrolled.展开更多
目的探讨中西医结合治疗糖尿病心血管自主神经病变(DCAN)的临床疗效。方法选取2021年1月至2023年5月于石家庄市第二医院就诊的80例DCAN患者作为研究对象,采用随机数字表法分为对照组(40例)和观察组(40例),对照组采取常规西医治疗,观察...目的探讨中西医结合治疗糖尿病心血管自主神经病变(DCAN)的临床疗效。方法选取2021年1月至2023年5月于石家庄市第二医院就诊的80例DCAN患者作为研究对象,采用随机数字表法分为对照组(40例)和观察组(40例),对照组采取常规西医治疗,观察组在对照组基础上采用中医综合治疗(益气养阴活血汤+针灸),1个疗程为14 d,2个疗程宜间隔7 d,两组共治疗3个疗程。比较两组临床疗效;比较两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR);比较两组窦性RR间期标准差(SDNN)、全程NN节段的窦性RR间期标准差(SDANN)、全程相邻RR之差的均方根(RMSSD)、相邻RR间期差值>50 ms的个数占总窦性心搏个数的百分比(PNN50);比较两组不良反应发生率。结果观察组临床总有效率(90.00%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。两组治疗后FBG、2 h PBG、HbA1c、HOMA-IR均明显低于治疗前,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。两组治疗后SDNN、SDANN、RMSSD、PNN50均明显高于治疗前,且观察组均明显高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论中西医结合治疗DCAN临床疗效明显,能够有效改善血糖水平、心率变异性,且不增加不良反应,具有较高的临床参考价值。展开更多
文摘BACKGROUND Early diabetic nephropathy(DN)is a complication of diabetes mellitus.It mainly affects kidney microvessels and glomerular function,and its timely and effective treatment is critical for early DN.However,the effects of treatments comprising simple Western medicine are not optimal.With the promotion and implementation of integrated Chinese and western medicine treatments,remarkable results have been achieved for many diseases.To this end,we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early DN.AIM To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early DN.METHODS Through a retrospective analysis,123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO.7 People’s Hospital from January 2021 to October 2022 and were selected as study subjects.After rigorous screening,100 patients with early DN were enrolled.The control group(CG,n=50)and the observation group(OG,n=50)were divided according to the treatment method.The CG were treated with sitagliptin,and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue decoction.Both groups were treated for 3 mo.For both groups,the baseline data and clinical efficacy were compared,and changes in blood glucose levels,lipid levels,renal function,and hematological indicators before(T0)and after(T1)treatment were assessed.RESULTS The total effective rate for the OG was 94.00%and that of the CG was 80.00%(P<0.05).After treatment(T1),the levels of fasting blood glucose,2 h postprandial glucose,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG(P<0.05),and cystatin C,homocysteine,urinary microalbumin,and blood creatinine values in OG patients were also obviously lower than those in the CG(P<0.05);erythrocyte deposition,plasma viscosity,whole blood high shear viscosity,and whole blood low shear viscosity were markedly lower in OG patients than in the CG(P<0.05).CONCLUSION Sitagliptin combined with Yiqi yangyin huoxue decoction has a remarkable effect when used to treat patients with early DN.Further,it is helpful in improving hemorheological indices and controlling disease progression.
基金Supported by the National Basic Research Program of China (973 Program,No.2003CB517103)the Traditional Chinese Medicine-treated Characteristic and Dominant Diseases Program of China Academy of Chinese Medical Sciences(No. CACMS05Y0010)
文摘Objective： To observe the effect of Yiqi Yangyin Decoction （益气养阴方, YQYYD） on the quality of life （QOL） of patients with unstable angina pectoris （UAP）. Methods： A total of 108 patients with UAP of qi-yin deficiency syndrome confirmed by coronary angiography were enrolled and assigned to the treated group （treated with YQYYD and conventional therapy of Western medicine） and the control group （treated with conventional therapy of Western medicine）, by the use of the PROC PLAN of the SAS 6.12 software, in a prospective, randomized, controlled design. The clinical total effective rate, symptom score, QOL scale [Seattle Angina Questionnaire （SAQ）] and incidence of important clinical events were defined as the observation indices to evaluate the interventional effect of YQYYD on the QOL of patients with UAP of the qi-yin deficiency syndrome. Results： During the study, three cases dropped out in the treated group, one case dropped out in the control group, and 104 cases, including 51 cases in the treatment group and 53 cases in the control group, finished the trial. After four weeks of treatment, the total clinical effective rates in the treated group and the control group were 80.4% and 75.5% respectively, and there was no obvious difference between them （P〉0.05）. However, the symptom score of the treated group （9.31 ± 2.02） was significantly lesser than that of the control group （11.62 ± 3.04, P〈0.05）, and the total score of the QOI scale of the treated group （68.76 ± 5.74） was significantly higher than that of the control group （61.06 ±3.31, P〈0.01）. Among those in the treated group physical limitation, angina stability, angina frequency, and treatment satisfaction were significantly ameliorated when compared with the control group after treatment （P〈0.05, P〈0.01）. The incidence of important clinical events in the treated group （3.9%） was lower than that in the control group （5.7%） during the 8-month follow-up period, but the difference was insignificant （P〉0.05）. Conclusion： YQYYD could improve the clinical symptoms of patients with UAP of qi-yin deficiency syndrome and greatly improve their QOL.
基金Supported by the 2018 Program to Guide Medicine of the Shanghai Municipal Science and Technology Commission(No.18401902200)Special Project of the China Resources Sanjiu Medical and Pharmaceutical Co.and the Obstetrics&Gynecology Special Committee,the Chinese Association for the Integration of Traditional and Western Medicine(No.CR1901FC01)。
文摘Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization.Patients received E+D,Zuogui Pill or BYHD for 12 months,respectively.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),anti-Mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after treatment.Results:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the study.After 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all P<0.01),BYHD also resulted in E2 elevation(P<0.05),ovary enlargement(P<0.05),AFC increase(P<0.01),and RI of ovarian arteries decrease(P<0.05).After 12 months,further improvements were observed in the Zuogui Pill and BYHD groups(all P<0.01),but BYHD showed better outcomes,with lower FSH,larger ovaries and a thicker endometrium compared with the Zuogui Pill group(all P<0.01).However,E+D only significantly increased endometrial thickness(P<0.01)and no significant improvements were observed in the RI of uterine arteries in the three groups.Conclusions:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin endometrium.The combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR.
文摘Objective To evaluate the 8-week comprehensive effect of Yiqi Yangyin Hexue decoction (YYHD) in adult patients with chronic primary immune thrombocytopenia (cITP). Methods Totally 76 patients from the department of hematology of Affiliated Hospital of Nanjing University of Chinese Medicine were enrolled.
文摘目的探讨中西医结合治疗糖尿病心血管自主神经病变(DCAN)的临床疗效。方法选取2021年1月至2023年5月于石家庄市第二医院就诊的80例DCAN患者作为研究对象,采用随机数字表法分为对照组(40例)和观察组(40例),对照组采取常规西医治疗,观察组在对照组基础上采用中医综合治疗(益气养阴活血汤+针灸),1个疗程为14 d,2个疗程宜间隔7 d,两组共治疗3个疗程。比较两组临床疗效;比较两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR);比较两组窦性RR间期标准差(SDNN)、全程NN节段的窦性RR间期标准差(SDANN)、全程相邻RR之差的均方根(RMSSD)、相邻RR间期差值>50 ms的个数占总窦性心搏个数的百分比(PNN50);比较两组不良反应发生率。结果观察组临床总有效率(90.00%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。两组治疗后FBG、2 h PBG、HbA1c、HOMA-IR均明显低于治疗前,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。两组治疗后SDNN、SDANN、RMSSD、PNN50均明显高于治疗前,且观察组均明显高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论中西医结合治疗DCAN临床疗效明显,能够有效改善血糖水平、心率变异性,且不增加不良反应,具有较高的临床参考价值。
文摘目的 探讨益气养阴消癥通络汤治疗早期糖尿病肾病(DN)的临床效果。方法 64例早期糖尿病肾病患者,随机分为对照组和观察组,每组32例。对照组使用常规西药治疗,在此基础上,观察组使用益气养阴消癥通络汤治疗。比较两组临床疗效,血糖及肾功能指标[空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血肌酐(SCr)、尿素氮(BUN)、尿白蛋白排泄率(UAER)],中医证候积分,血液流变学指标[血浆粘度、全血高切粘度、全血低切粘度、纤维蛋白原(FIB)、D-二聚体(D-D)]。结果 观察组治疗总有效率为93.75%,明显高于对照组的75.00%(P<0.05)。观察组治疗后FBG、2 h PG、HbA1c、BUN、Scr、UAER分别为(6.35±0.90)mmol/L、(8.97±1.25)mmol/L、(6.71±0.86)%、(5.95±1.04)mmol/L、(120.73±17.68)μmol/L、(75.70±10.67)μg/min,均低于对照组的(7.84±1.21)mmol/L、(10.96±1.78)mmol/L、(8.10±0.93)%、(8.67±1.39)mmol/L、(135.06±19.28)μmol/L、(109.31±12.75)μg/min(P<0.05)。观察组治疗后咽干口渴、手足心热、神疲乏力、腰痛膝软、肢体水肿等中医证候积分分别为(0.98±0.16)、(0.92±0.15)、(1.01±0.21)、(0.96±0.18)、(0.95±0.20)分,均明显低于对照组的(1.53±0.21)、(1.49±0.20)、(1.75±0.24)、(1.50±0.23)、(1.48±0.23)分(P<0.05)。观察组治疗后血浆粘度、全血高切粘度、全血低切粘度、FIB、D-D分别为(1.23±0.21)mPa·s、(3.67±0.68)mPa·s、(8.74±1.36)mPa·s、(2.62±0.37)g/L、(1.90±0.35)μg/ml,均低于对照组的(1.88±0.25)mPa·s、(5.14±0.79)mPa·s、(11.08±1.93)mPa·s、(3.29±0.45)g/L、(2.68±0.40)μg/ml(P<0.05)。结论 益气养阴消癥通络汤治疗早期糖尿病肾病的临床效果显著,能提高血糖控制效果,改善肾功能,降低血液粘稠度,缓解证候。
