Acoustic reflection imaging logging technology can detect and evaluate the development of reflection anomalies,such as fractures,caves and faults,within a range of tens of meters from the wellbore,greatly expanding th...Acoustic reflection imaging logging technology can detect and evaluate the development of reflection anomalies,such as fractures,caves and faults,within a range of tens of meters from the wellbore,greatly expanding the application scope of well logging technology.This article reviews the development history of the technology and focuses on introducing key methods,software,and on-site applications of acoustic reflection imaging logging technology.Based on the analyses of major challenges faced by existing technologies,and in conjunction with the practical production requirements of oilfields,the further development directions of acoustic reflection imaging logging are proposed.Following the current approach that utilizes the reflection coefficients,derived from the computation of acoustic slowness and density,to perform seismic inversion constrained by well logging,the next frontier is to directly establish the forward and inverse relationships between the downhole measured reflection waves and the surface seismic reflection waves.It is essential to advance research in imaging of fractures within shale reservoirs,the assessment of hydraulic fracturing effectiveness,the study of geosteering while drilling,and the innovation in instruments of acoustic reflection imaging logging technology.展开更多
Rock fracture mechanics and accurate characterization of rock fracture are crucial for understanding a variety of phenomena interested in geological engineering and geoscience.These phenomena range from very large-sca...Rock fracture mechanics and accurate characterization of rock fracture are crucial for understanding a variety of phenomena interested in geological engineering and geoscience.These phenomena range from very large-scale asymmetrical fault structures to the scale of engineering projects and laboratory-scale rock fracture tests.Comprehensive study can involve mechanical modeling,site or post-mortem investigations,and inspection on the point cloud of the source locations in the form of earthquake,microseismicity,or acoustic emission.This study presents a comprehensive data analysis on characterizing the forming of the asymmetrical damage zone around a laboratory mixed-mode rock fracture.We substantiate the presence of asymmetrical damage through qualitative analysis and demonstrate that measurement uncertainties cannot solely explain the observed asymmetry.The implications of this demonstration can be manifold.On a larger scale,it solidifies a mechanical model used for explaining the contribution of aseismic mechanisms to asymmetrical fault structures.On a laboratory scale,it exemplifies an alternative approach to understanding the observational difference between the source location and the in situ or post-mortem inspection on the rock fracture path.The mechanical model and the data analysis can be informative to the interpretations of other engineering practices as well,but may face different types of challenges.展开更多
We investigate the following inverse problem:starting from the acoustic wave equation,reconstruct a piecewise constant passive acoustic source from a single boundary temporal measurement without knowing the speed of s...We investigate the following inverse problem:starting from the acoustic wave equation,reconstruct a piecewise constant passive acoustic source from a single boundary temporal measurement without knowing the speed of sound.When the amplitudes of the source are known a priori,we prove a unique determination result of the shape and propose a level set algorithm to reconstruct the singularities.When the singularities of the source are known a priori,we show unique determination of the source amplitudes and propose a least-squares fitting algorithm to recover the source amplitudes.The analysis bridges the low-frequency source inversion problem and the inverse problem of gravimetry.The proposed algorithms are validated and quantitatively evaluated with numerical experiments in 2D and 3D.展开更多
In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic ...In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic emission technique was used to monitor the acoustic signal characteristics of composite rock specimens during the entire loading process. At the same time, an optical non-contact 3 D digital image correlation technique was used to study the evolution of axial strain field and the maximal strain field before and after the peak strength at different stress levels during the loading process. The effect of bedding plane inclination on the deformation and strength during uniaxial loading was analyzed. The methods of solving the elastic constants of hard and weak rock were described. The damage evolution process, deformation and failure mechanism, and failure mode during uniaxial loading were fully determined. The experimental results show that the θ = 0?–45?specimens had obvious plastic deformation during loading, and the brittleness of the θ = 60?–90?specimens gradually increased during the loading process. When the anisotropic angle θincreased from 0?to 90?, the peak strength, peak strain,and apparent elastic modulus all decreased initially and then increased. The failure mode of the composite rock specimen during uniaxial loading can be divided into three categories:tensile fracture across the discontinuities(θ = 0?–30?), slid-ing failure along the discontinuities(θ = 45?–75?), and tensile-split along the discontinuities(θ = 90?). The axial strain of the weak and hard rock layers in the composite rock specimen during the loading process was significantly different from that of the θ = 0?–45?specimens and was almost the same as that of the θ = 60?–90?specimens. As for the strain localization highlighted in the maximum principal strain field, the θ = 0?–30?specimens appeared in the rock matrix approximately parallel to the loading direction,while in the θ = 45?–90?specimens it appeared at the hard and weak rock layer interface.展开更多
Ultrasonic imaging logging provides continuous and oriented images of structures vs. depth. In the Chinese Continental Scientific Drilling (CCSD) Project, acoustic borehole images were recorded in the second pre-pilot...Ultrasonic imaging logging provides continuous and oriented images of structures vs. depth. In the Chinese Continental Scientific Drilling (CCSD) Project, acoustic borehole images were recorded in the second pre-pilot drillhole which penetrates the metamorphic rocks. This paper focuses on fracture evaluation of the drillhole with these images. Both least square fit and a modified Hough transform are used for fracture extraction, and 269 fractures were mapped in the interval from 69.5 to 1 020 m. Most fractures dip steeply, with an average angle of 54°. Fracture dip directions are dominantly in the range of 220°-280° above the depth of 267 m, but 80°-120° in the lower zones. These observations may indicate the differences in structural movements or in-situ stress fields between the upper and lower zones in the drillhole.展开更多
The anisotropy induced by rock bedding structures is usually manifested in the mechanical behaviors and failure modes of rocks.Brazilian tests are conducted for seven groups of shale specimens featuring different bedd...The anisotropy induced by rock bedding structures is usually manifested in the mechanical behaviors and failure modes of rocks.Brazilian tests are conducted for seven groups of shale specimens featuring different bedding angles. Acoustic emission (AE) and digital image correlation (DIC) technologies are used to monitor the in-situ failure of the specimens. Furthermore, the crack morphology of damaged samples is observed through scanning electron microscopy (SEM). Results reveal the structural dependence on the tensile mechanical behavior of shales. The shale disk exhibits compression in the early stage of the experiment with varying locations and durations. The location of the compression area moves downward and gradually disappears when the bedding angle increases. The macroscopic failure is well characterized by AE event location results, and the dominant frequency distribution is related to the bedding angle. The b-value is found to be stress-dependent.The crack turning angle between layers and the number of cracks crossing the bedding both increase with the bedding angle, indicating competition between crack propagations. SEM results revealed that the failure modes of the samples can be classified into three types:tensile failure along beddings with shear failure of the matrix, ladder shear failure along beddings with tensile failure of the matrix, and shear failure along multiple beddings with tensile failure of the matrix.展开更多
The forward-looking image sonar is a necessary vision device for Autonomous Underwater Vehicles (AUV). Based on the acoustic image received from forward-looking image sonar, AUV local path is planned. When the envir...The forward-looking image sonar is a necessary vision device for Autonomous Underwater Vehicles (AUV). Based on the acoustic image received from forward-looking image sonar, AUV local path is planned. When the environment model is made to adapt to local path planning, an iterative algorithm of binary conversion is used for image segmentation. Raw data of the acoustic image, which were received from serial port, are processed. By the use of "Mathematic Morphology" to filter noise, a mathematic model of environment for local path planning is established after coordinate transformation. The optimal path is searched by the distant transmission (Dt) algorithm. Simulation is conducted for the analysis of the algorithm. Experiment on the sea proves it reliable.展开更多
Acoustic emission ( AE ) features during the fracture process of notched wrought aluminum alloy 7N01 and weld were investigated under the three-point bending load. Wavelet transform is used to investigate the time-f...Acoustic emission ( AE ) features during the fracture process of notched wrought aluminum alloy 7N01 and weld were investigated under the three-point bending load. Wavelet transform is used to investigate the time-frequency features of AE signals during the test. The experimental results showed that AE energy was effective indicators to detect the crack initiation for 7N01 aluminum. The digital images from monitoring the notch tip region of 7 NO1 aluminum sample verify the prediction of AE signals. The weld emits low energy, weak signal strength, and low peak amplitude, while stronger AE energy, amplitude, and more AE event counts for the base metal. In short, the AE technique was more sensitive to the changes in the fracture mode and could be used to monitor the damage development in welded structures.展开更多
Borehole acoustic reflection logging can provide high resolution images of nearborehole geological structure. However, the conventional seismic migration and imaging methods are not effective because the reflected wav...Borehole acoustic reflection logging can provide high resolution images of nearborehole geological structure. However, the conventional seismic migration and imaging methods are not effective because the reflected waves are interfered with the dominant borehole-guided modes and there are only eight receiving channels per shot available for stacking. In this paper, we apply an equivalent offset migration method based on wave scattering theory to process the acoustic reflection imaging log data from both numerical modeling and recorded field data. The result shows that, compared with the routine post-stack depth migration method, the equivalent offset migration method results in higher stack fold and is more effective for near-borehole structural imaging with low SNR acoustic reflection log data.展开更多
Aim To research on a stable microbubble with good acoustic properties and excellent imaging enhancing effect, and to make it to be a promising agent for the enhancement of ultrasound imaging in the ultrasound diagnosi...Aim To research on a stable microbubble with good acoustic properties and excellent imaging enhancing effect, and to make it to be a promising agent for the enhancement of ultrasound imaging in the ultrasound diagnosis of cardiovascular system diseases. Methods The morphology, size and zeta potential of lipid-coated microbubbles (LCM), the acoustic properties of backscatter, and the second harmonic scatter of LCM were determined. Furthermore, the relationship between the concentrations and the amplitude values of the second harmonic was investigated by testing the intensities of the second harmonic at different concentrations. The imaging effect of LCM was also studied in vitro. Results The mean diameter of LCM was 3.38 μm with 95% of the bubbles under 5 μm. The scatter signal generated by microbubbles was observed under different concentrations in the bistatic modes while the position of transmitting transducer and receiving transducer was orthogonal. The intensity of the second harmonic scatter fell with the decrease of microbubble concentration. The increase rate of the second harmonic amplitude values generated by the microbubbles versus that by physiological saline was linear with the natural logarithm of bubble concentrations. The LCM could enhance the ultrasound image of thrombus. Conclusion The LCM exhibited good physical state and acoustic properties, which could increase the imaging quality.展开更多
AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in...AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.展开更多
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tis...BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.展开更多
AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirr...AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirrhosis secondary to primary biliary cirrhosis were selected as the observation group, with the degree of patient liver cirrhosis graded by Child-Pugh (CP) score. Sixty healthy individuals were selected as the control group. The four indicators of hepatic fibrosis were detected in all research objects, including hyaluronic acid (HA), laminin (LN), type III collagen (PC III), and type IV collagen (IV-C). The liver parenchyma hardness value (LS) was then measured by ARFI technique. LS and the four indicators of liver fibrosis (HA, LN, PC III, and IV-C) were observed in different grade CP scores. The diagnostic value of LS and the four indicators of liver fibrosis in determining liver cirrhosis degree with PBC, whether used alone or in combination, were analyzed by receiver operating characteristic (ROC) curve. RESULTS: LS and the four indicators of liver fibrosis within the three classes (A, B, and C) of CP scores in the observation group were higher than in the control group, with C class > B class > A class; the differences were statistically significant (P < 0.01). Although AUC values of LS within the three classes of CP scores were higher than in the four indicators of liver fibrosis, sensitivity and specificity were unstable. The ROC curves of LS combined with the four indicators of liver fibrosis revealed that: AUC and sensitivity in all indicators combined in the A class of CP score were higher than in LS alone, albeit with slightly decreased specificity; AUC and specificity in all indicators combined in the B class of CP score were higher than in LS alone, with unchanged sensitivity; AUC values (0.967), sensitivity (97.4%), and specificity (90%) of all indicators combined in the C class of CP score were higher than in LS alone (0.936, 92.1%, 83.3%). CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value.展开更多
AIM To image stomach wall blood vessels and tissue, layerby-layer.METHODS We built up the acoustic resolution photoacoustic microscopy(AR-PAM) system for imaging layered tissues, such as the stomach wall. A tunable dy...AIM To image stomach wall blood vessels and tissue, layerby-layer.METHODS We built up the acoustic resolution photoacoustic microscopy(AR-PAM) system for imaging layered tissues, such as the stomach wall. A tunable dye laser system was coupled to a fiber bundle. The fibers of the bundle were placed in nine directions with an incident angle of 45° around a high-frequency ultrasound transducer attached to the acoustic lens. This structure formed a dark field on the tissue surface under the acoustic lens and the nine light beams from the fibers to be combined near the focal point of the acoustic lens. The sample piece was cut from a part of the porcine stomach into a petri dish. In order to realize photoacoustic depth imaging of tumor, we designed a tumor model based on indocyanine green(ICG) dye. The ICG solution(concentration of 129 μM/m L)was mixed into molten gel, and then a gel mixture of ICG(concentration of 12.9 μM/mL) was injected into the stomach submucosa. The injection quantity was controlled by 0.1 mL to make a small tumor model. RESULTS An acoustic resolution photoacoustic microscopy based on fiber illumination was established and an axial resolution of 25 μm and a lateral resolution of 50 μm in its focal zone range of 500 μm has been accomplished. We tuned the laser wavelength to 600 nm. The photoacoustic probe was driven to do B-scan imaging in tissue thickness of 200 μm. The photoacoustic micro-image of mucosa and submucosa of the tissue have been obtained and compared with a pathological photograph of the tissue stained by hematoxylin-eosin staining. We have observed more detailed internal structure of the tissue. We also utilized this photoacoustic microscopy to image blood vessels inside the submucosa. High contrast imaging of the submucosa tumor model was obtained using ICG dye. CONCLUSION This AR-PAM is able to image layer-by-layer construction and some blood vessels under mucosa in the stomach wall without any contrast agents.展开更多
Microwave induced thermoacoustic imaging(MTAI)has emerged as a potential biomedical imaging modality with over 20-year growth.MTAI typically employs pulsed microwave as the pumping source,and detects the microwave-ind...Microwave induced thermoacoustic imaging(MTAI)has emerged as a potential biomedical imaging modality with over 20-year growth.MTAI typically employs pulsed microwave as the pumping source,and detects the microwave-induced ultrasound wave via acoustic transducers.Therefore,it features high acoustic resolution,rich elect romagnetic contrast,and large imaging depth.Benefiting from these unique advantages,MTAI has been extensively applied to various fields including pathology,biology,material and medicine.Till now,MTAI has been deployed for a wide range of biomedical applications,including cancer diagnosis,joint evaluation,brain in-vestigation and endoscopy.This paper provides a comprehensive review on(1)essential physics(endogenous/exogenous contrast mechanisms,penetration depth and resolution),(2)hardware configurations and software implementations(excit ation source,antenna,ultrasound detector and image recovery algorithm),(3)animal studies and clinical applications,and(4)future directions.展开更多
Photoacoustic imaging is a potential candidate for in vivo brain imaging,whereas,its imaging performance could be degraded by inhomogeneous multi-layered media,consisted of scalp and skull.In this work,we propose a lo...Photoacoustic imaging is a potential candidate for in vivo brain imaging,whereas,its imaging performance could be degraded by inhomogeneous multi-layered media,consisted of scalp and skull.In this work,we propose a low-artifact photoacoustic microscopy(LAPAM)scheme,which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers.Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes,the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images.Phantom experiment is used to validate the effectiveness of this method.Furthermore,LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull.Experimental results show that the proposed method successfully achieves the low-artifact brain image,which demonstrates the practical applicability of LAPAM.This work might improve the photoacoustic imaging quality in many biomedical applications which involve tissues with complex acoustic properties,such as brain imaging through scalp and skull.展开更多
A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The t...A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).展开更多
Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation be...Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation between benign and malignant solid breast masses, meanwhile evaluate the influences of ARFI with breast imaging reporting and data system (BI-RADS) of suspicious masses. Methods: Seventy-five women with 86 breast lesions underwent conventional breast ultra- sound examination. Then B-mode BI-RADS features and assessments were recorded and standard breast US supplemented by ARFI elastographic examination were repeated. The data were recorded and analyzed as following: area ratio of breast lesion, the shear-wave velocity, the ratio of the shear-wave velocity between lesions and surrounding normal tissues, and according to the elastographic data reconsidered the BI-RADS category, all the results have been correlated with pathological results and make statistical evaluations of ARFI for differentiation between benign and malignant solid breast masses. Meantime our study has correlated the adjusted BI-RADS category of suspicious breast lesions with the pathological results and made assessment. Results: Thirty-eight patients were malignant breast carcinoma (31 invasive ductal carcinoma, 5 intraductal carcinoma in situ, 2 medullary carcinoma, 2 invasive Iobular carcinoma), 48 patients were benign breast lesions (23 fibroadenoma, 12 benign nodular hyperplasia, 5 phyllodes tumor, 6 adenosis, 2 intraductal papilloma). Underwent conventional breast ultrasound exam, 42 cases were BI-RADS category 3, 23 cases were BI-RADS category 4. When adding elastographic data, 46 cases were BI-RADS category 3 and 20 cases were BI-RADS category 4. Compared with pathological results showed for both the specificity of BIRADS features and the area under ROC curve has risen. Virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) data showed the area ratio (AR) between elastographic lesions area and B-mode lesions area, SWV (maximal shear-wave velocity of lesions), R-SWV (shear-wave velocity ratio between lesions and surrounding normal tissues) in benign breast lesions were lower than those in malignant lesions which has statistical significance and the cut-off point were 1.1,4.65 m/s, 5.18 respectively. Conclusion: The ARFI elastography can provide the reliable qualitative and quantitative analysis about hardness of breast lesions, supply the new BI-RADS category features to suspicious breast masses and serve as an effective diagnostic tool for differentiation between benign and malignant solid masses.展开更多
Thermoacoustic imaging with current injection(TAI-CI) is a novel imaging technology that couples with electromagnetic and acoustic research, which combines the advantages of high contrast of the electrical impedance t...Thermoacoustic imaging with current injection(TAI-CI) is a novel imaging technology that couples with electromagnetic and acoustic research, which combines the advantages of high contrast of the electrical impedance tomography and the high spatial resolution of sonography, and therefore has the potential for early diagnosis. To verify the feasibility of TAI-CI for complex bone-containing biological tissues, the principle of TAI-CI and the coupling characteristics of fluid and solid were analyzed. Meanwhile, thermoacoustic(TA) effects for fluid model and fluid–solid coupling model were analyzed by numerical simulations. Moreover, we conducted experiments on animal cartilage, hard bone and biological soft tissue phantom with low conductivity(0.5 S/m). By injecting a current into the phantom, the thermoacoustic signal was detected by the ultrasonic transducer with a center frequency of 1 MHz, thereby the B-scan image of the objects was obtained. The B-scan image of the cartilage experiment accurately reflects the distribution of cartilage and gel, and the hard bone has a certain attenuation effect on the acoustic signal. However, compared with the ultrasonic imaging, the thermoacoustic signal is only attenuated during the outward propagation. Even in this case, a clear image can still be obtained and the images can reflect the change of the conductivity of the gel. This study confirmed the feasibility of TAI-CI for the imaging of biological tissue under the presence of cartilage and the bone. The novel TAI-CI method provides further evidence that it can be used in the diagnosis of human diseases.展开更多
Wideband acoustic imaging,which combines compressed sensing(CS)and microphone arrays,is widely used for locating acoustic sources.However,the location results of this method are unstable,and the computational efficien...Wideband acoustic imaging,which combines compressed sensing(CS)and microphone arrays,is widely used for locating acoustic sources.However,the location results of this method are unstable,and the computational efficiency is low.In this work,in order to improve the robustness and reduce the computational cost,a DCS-SOMP-SVD compressed sensing method,which combines the distributed compressed sensing using simultaneously orthogonal matching pursuit(DCS-SOMP)and singular value decomposition(SVD)is proposed.The performance of the DCS-SOMP-SVD is studied through both simulation and experiment.In the simulation,the locating results of the DCS-SOMP-SVD method are compared with the wideband BP method and the DCS-SOMP method.In terms of computational efficiency,the proposed method is as efficient as the DCS-SOMP method and more efficient than the wideband BP method.In terms of locating accuracy,the proposed method can still locate all sources when the signal to noise ratio(SNR)is−20 dB,while the wideband BP method and the DCS-SOMP method can only locate all sources when the SNR is higher than 0 dB.The performance of the proposed method can be improved by expanding the frequency range.Moreover,there is no extra source in the maps of the proposed method,even though the target sparsity is overestimated.Finally,a gas leak experiment is conducted to verify the feasibility of the DCS-SOMP-SVD method in the practical engineering environment.The experimental results show that the proposed method can locate both two leak sources in different frequency ranges.This research proposes a DCS-SOMP-SVD method which has sufficient robustness and low computational cost for wideband acoustic imaging.展开更多
基金Supported by the PetroChina Science and Technology Project(2021DJ4002,2022DJ3908)。
文摘Acoustic reflection imaging logging technology can detect and evaluate the development of reflection anomalies,such as fractures,caves and faults,within a range of tens of meters from the wellbore,greatly expanding the application scope of well logging technology.This article reviews the development history of the technology and focuses on introducing key methods,software,and on-site applications of acoustic reflection imaging logging technology.Based on the analyses of major challenges faced by existing technologies,and in conjunction with the practical production requirements of oilfields,the further development directions of acoustic reflection imaging logging are proposed.Following the current approach that utilizes the reflection coefficients,derived from the computation of acoustic slowness and density,to perform seismic inversion constrained by well logging,the next frontier is to directly establish the forward and inverse relationships between the downhole measured reflection waves and the surface seismic reflection waves.It is essential to advance research in imaging of fractures within shale reservoirs,the assessment of hydraulic fracturing effectiveness,the study of geosteering while drilling,and the innovation in instruments of acoustic reflection imaging logging technology.
文摘Rock fracture mechanics and accurate characterization of rock fracture are crucial for understanding a variety of phenomena interested in geological engineering and geoscience.These phenomena range from very large-scale asymmetrical fault structures to the scale of engineering projects and laboratory-scale rock fracture tests.Comprehensive study can involve mechanical modeling,site or post-mortem investigations,and inspection on the point cloud of the source locations in the form of earthquake,microseismicity,or acoustic emission.This study presents a comprehensive data analysis on characterizing the forming of the asymmetrical damage zone around a laboratory mixed-mode rock fracture.We substantiate the presence of asymmetrical damage through qualitative analysis and demonstrate that measurement uncertainties cannot solely explain the observed asymmetry.The implications of this demonstration can be manifold.On a larger scale,it solidifies a mechanical model used for explaining the contribution of aseismic mechanisms to asymmetrical fault structures.On a laboratory scale,it exemplifies an alternative approach to understanding the observational difference between the source location and the in situ or post-mortem inspection on the rock fracture path.The mechanical model and the data analysis can be informative to the interpretations of other engineering practices as well,but may face different types of challenges.
基金partially supported by the NSF(Grant Nos.2012046,2152011,and 2309534)partially supported by the NSF(Grant Nos.DMS-1715178,DMS-2006881,and DMS-2237534)+1 种基金NIH(Grant No.R03-EB033521)startup fund from Michigan State University.
文摘We investigate the following inverse problem:starting from the acoustic wave equation,reconstruct a piecewise constant passive acoustic source from a single boundary temporal measurement without knowing the speed of sound.When the amplitudes of the source are known a priori,we prove a unique determination result of the shape and propose a level set algorithm to reconstruct the singularities.When the singularities of the source are known a priori,we show unique determination of the source amplitudes and propose a least-squares fitting algorithm to recover the source amplitudes.The analysis bridges the low-frequency source inversion problem and the inverse problem of gravimetry.The proposed algorithms are validated and quantitatively evaluated with numerical experiments in 2D and 3D.
基金supported by the National Basic Research 973 Program of China (Grant 2014CB046905)the Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars (Grant BK20150005)+1 种基金the Fundamental Research Funds for the Central Universities (China University of Mining and Technology) (Grant 2014XT03)the innovation research project for academic graduate of Jiangsu Province (Grant KYLX16_0536)
文摘In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic emission technique was used to monitor the acoustic signal characteristics of composite rock specimens during the entire loading process. At the same time, an optical non-contact 3 D digital image correlation technique was used to study the evolution of axial strain field and the maximal strain field before and after the peak strength at different stress levels during the loading process. The effect of bedding plane inclination on the deformation and strength during uniaxial loading was analyzed. The methods of solving the elastic constants of hard and weak rock were described. The damage evolution process, deformation and failure mechanism, and failure mode during uniaxial loading were fully determined. The experimental results show that the θ = 0?–45?specimens had obvious plastic deformation during loading, and the brittleness of the θ = 60?–90?specimens gradually increased during the loading process. When the anisotropic angle θincreased from 0?to 90?, the peak strength, peak strain,and apparent elastic modulus all decreased initially and then increased. The failure mode of the composite rock specimen during uniaxial loading can be divided into three categories:tensile fracture across the discontinuities(θ = 0?–30?), slid-ing failure along the discontinuities(θ = 45?–75?), and tensile-split along the discontinuities(θ = 90?). The axial strain of the weak and hard rock layers in the composite rock specimen during the loading process was significantly different from that of the θ = 0?–45?specimens and was almost the same as that of the θ = 60?–90?specimens. As for the strain localization highlighted in the maximum principal strain field, the θ = 0?–30?specimens appeared in the rock matrix approximately parallel to the loading direction,while in the θ = 45?–90?specimens it appeared at the hard and weak rock layer interface.
文摘Ultrasonic imaging logging provides continuous and oriented images of structures vs. depth. In the Chinese Continental Scientific Drilling (CCSD) Project, acoustic borehole images were recorded in the second pre-pilot drillhole which penetrates the metamorphic rocks. This paper focuses on fracture evaluation of the drillhole with these images. Both least square fit and a modified Hough transform are used for fracture extraction, and 269 fractures were mapped in the interval from 69.5 to 1 020 m. Most fractures dip steeply, with an average angle of 54°. Fracture dip directions are dominantly in the range of 220°-280° above the depth of 267 m, but 80°-120° in the lower zones. These observations may indicate the differences in structural movements or in-situ stress fields between the upper and lower zones in the drillhole.
基金financially supported by the National Natural Science Foundation of China (No.51934003)the Major Science and Technology Special Project of Yunnan Province,China(Nos.202102AF080001 and 202102AG050024)。
文摘The anisotropy induced by rock bedding structures is usually manifested in the mechanical behaviors and failure modes of rocks.Brazilian tests are conducted for seven groups of shale specimens featuring different bedding angles. Acoustic emission (AE) and digital image correlation (DIC) technologies are used to monitor the in-situ failure of the specimens. Furthermore, the crack morphology of damaged samples is observed through scanning electron microscopy (SEM). Results reveal the structural dependence on the tensile mechanical behavior of shales. The shale disk exhibits compression in the early stage of the experiment with varying locations and durations. The location of the compression area moves downward and gradually disappears when the bedding angle increases. The macroscopic failure is well characterized by AE event location results, and the dominant frequency distribution is related to the bedding angle. The b-value is found to be stress-dependent.The crack turning angle between layers and the number of cracks crossing the bedding both increase with the bedding angle, indicating competition between crack propagations. SEM results revealed that the failure modes of the samples can be classified into three types:tensile failure along beddings with shear failure of the matrix, ladder shear failure along beddings with tensile failure of the matrix, and shear failure along multiple beddings with tensile failure of the matrix.
文摘The forward-looking image sonar is a necessary vision device for Autonomous Underwater Vehicles (AUV). Based on the acoustic image received from forward-looking image sonar, AUV local path is planned. When the environment model is made to adapt to local path planning, an iterative algorithm of binary conversion is used for image segmentation. Raw data of the acoustic image, which were received from serial port, are processed. By the use of "Mathematic Morphology" to filter noise, a mathematic model of environment for local path planning is established after coordinate transformation. The optimal path is searched by the distant transmission (Dt) algorithm. Simulation is conducted for the analysis of the algorithm. Experiment on the sea proves it reliable.
文摘Acoustic emission ( AE ) features during the fracture process of notched wrought aluminum alloy 7N01 and weld were investigated under the three-point bending load. Wavelet transform is used to investigate the time-frequency features of AE signals during the test. The experimental results showed that AE energy was effective indicators to detect the crack initiation for 7N01 aluminum. The digital images from monitoring the notch tip region of 7 NO1 aluminum sample verify the prediction of AE signals. The weld emits low energy, weak signal strength, and low peak amplitude, while stronger AE energy, amplitude, and more AE event counts for the base metal. In short, the AE technique was more sensitive to the changes in the fracture mode and could be used to monitor the damage development in welded structures.
基金supported by the National Natural Science Foundation of China (Grant No.50674098)the 863 Program (Grant No.2006AA06Z207 & 2006AA06Z213)the 973 Program (Grant No.2007CB209601)
文摘Borehole acoustic reflection logging can provide high resolution images of nearborehole geological structure. However, the conventional seismic migration and imaging methods are not effective because the reflected waves are interfered with the dominant borehole-guided modes and there are only eight receiving channels per shot available for stacking. In this paper, we apply an equivalent offset migration method based on wave scattering theory to process the acoustic reflection imaging log data from both numerical modeling and recorded field data. The result shows that, compared with the routine post-stack depth migration method, the equivalent offset migration method results in higher stack fold and is more effective for near-borehole structural imaging with low SNR acoustic reflection log data.
文摘Aim To research on a stable microbubble with good acoustic properties and excellent imaging enhancing effect, and to make it to be a promising agent for the enhancement of ultrasound imaging in the ultrasound diagnosis of cardiovascular system diseases. Methods The morphology, size and zeta potential of lipid-coated microbubbles (LCM), the acoustic properties of backscatter, and the second harmonic scatter of LCM were determined. Furthermore, the relationship between the concentrations and the amplitude values of the second harmonic was investigated by testing the intensities of the second harmonic at different concentrations. The imaging effect of LCM was also studied in vitro. Results The mean diameter of LCM was 3.38 μm with 95% of the bubbles under 5 μm. The scatter signal generated by microbubbles was observed under different concentrations in the bistatic modes while the position of transmitting transducer and receiving transducer was orthogonal. The intensity of the second harmonic scatter fell with the decrease of microbubble concentration. The increase rate of the second harmonic amplitude values generated by the microbubbles versus that by physiological saline was linear with the natural logarithm of bubble concentrations. The LCM could enhance the ultrasound image of thrombus. Conclusion The LCM exhibited good physical state and acoustic properties, which could increase the imaging quality.
文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.
文摘BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.
文摘AIM: To evaluate the assessment of primary biliary cirrhosis degree by acoustic radiation force impulse imaging (ARFI) and hepatic fibrosis indicators. METHODS: One hundred and twenty patients who developed liver cirrhosis secondary to primary biliary cirrhosis were selected as the observation group, with the degree of patient liver cirrhosis graded by Child-Pugh (CP) score. Sixty healthy individuals were selected as the control group. The four indicators of hepatic fibrosis were detected in all research objects, including hyaluronic acid (HA), laminin (LN), type III collagen (PC III), and type IV collagen (IV-C). The liver parenchyma hardness value (LS) was then measured by ARFI technique. LS and the four indicators of liver fibrosis (HA, LN, PC III, and IV-C) were observed in different grade CP scores. The diagnostic value of LS and the four indicators of liver fibrosis in determining liver cirrhosis degree with PBC, whether used alone or in combination, were analyzed by receiver operating characteristic (ROC) curve. RESULTS: LS and the four indicators of liver fibrosis within the three classes (A, B, and C) of CP scores in the observation group were higher than in the control group, with C class > B class > A class; the differences were statistically significant (P < 0.01). Although AUC values of LS within the three classes of CP scores were higher than in the four indicators of liver fibrosis, sensitivity and specificity were unstable. The ROC curves of LS combined with the four indicators of liver fibrosis revealed that: AUC and sensitivity in all indicators combined in the A class of CP score were higher than in LS alone, albeit with slightly decreased specificity; AUC and specificity in all indicators combined in the B class of CP score were higher than in LS alone, with unchanged sensitivity; AUC values (0.967), sensitivity (97.4%), and specificity (90%) of all indicators combined in the C class of CP score were higher than in LS alone (0.936, 92.1%, 83.3%). CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value.
基金Supported by the National Nature Science Foundation of China,No.61378060
文摘AIM To image stomach wall blood vessels and tissue, layerby-layer.METHODS We built up the acoustic resolution photoacoustic microscopy(AR-PAM) system for imaging layered tissues, such as the stomach wall. A tunable dye laser system was coupled to a fiber bundle. The fibers of the bundle were placed in nine directions with an incident angle of 45° around a high-frequency ultrasound transducer attached to the acoustic lens. This structure formed a dark field on the tissue surface under the acoustic lens and the nine light beams from the fibers to be combined near the focal point of the acoustic lens. The sample piece was cut from a part of the porcine stomach into a petri dish. In order to realize photoacoustic depth imaging of tumor, we designed a tumor model based on indocyanine green(ICG) dye. The ICG solution(concentration of 129 μM/m L)was mixed into molten gel, and then a gel mixture of ICG(concentration of 12.9 μM/mL) was injected into the stomach submucosa. The injection quantity was controlled by 0.1 mL to make a small tumor model. RESULTS An acoustic resolution photoacoustic microscopy based on fiber illumination was established and an axial resolution of 25 μm and a lateral resolution of 50 μm in its focal zone range of 500 μm has been accomplished. We tuned the laser wavelength to 600 nm. The photoacoustic probe was driven to do B-scan imaging in tissue thickness of 200 μm. The photoacoustic micro-image of mucosa and submucosa of the tissue have been obtained and compared with a pathological photograph of the tissue stained by hematoxylin-eosin staining. We have observed more detailed internal structure of the tissue. We also utilized this photoacoustic microscopy to image blood vessels inside the submucosa. High contrast imaging of the submucosa tumor model was obtained using ICG dye. CONCLUSION This AR-PAM is able to image layer-by-layer construction and some blood vessels under mucosa in the stomach wall without any contrast agents.
基金This work was supported in part by the National Natural Science Foundation of China(62022037,62105140,61775028,81571722 and 61528401)in part by Department of Science and Technology of Guangdong Province(2019ZT08Y191,SZBL2020090501013)+3 种基金Guangdong Provincial Key Laboratory of Advanced Biomaterials(2022B1212010003)Guangdong Provincial Department of Education(2021ZDZX1064)Shenzhen Science and Technology Program(JCYJ20200109141222892,KQTD20190-929172743294)in part by Startup grant from Southern University of Science and Technology.
文摘Microwave induced thermoacoustic imaging(MTAI)has emerged as a potential biomedical imaging modality with over 20-year growth.MTAI typically employs pulsed microwave as the pumping source,and detects the microwave-induced ultrasound wave via acoustic transducers.Therefore,it features high acoustic resolution,rich elect romagnetic contrast,and large imaging depth.Benefiting from these unique advantages,MTAI has been extensively applied to various fields including pathology,biology,material and medicine.Till now,MTAI has been deployed for a wide range of biomedical applications,including cancer diagnosis,joint evaluation,brain in-vestigation and endoscopy.This paper provides a comprehensive review on(1)essential physics(endogenous/exogenous contrast mechanisms,penetration depth and resolution),(2)hardware configurations and software implementations(excit ation source,antenna,ultrasound detector and image recovery algorithm),(3)animal studies and clinical applications,and(4)future directions.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12027808,11874217,11834008,81900875,and 81770973)Natural Science Foundation of Jiangsu Province,China(Grant No.BK 20181077)。
文摘Photoacoustic imaging is a potential candidate for in vivo brain imaging,whereas,its imaging performance could be degraded by inhomogeneous multi-layered media,consisted of scalp and skull.In this work,we propose a low-artifact photoacoustic microscopy(LAPAM)scheme,which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers.Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes,the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images.Phantom experiment is used to validate the effectiveness of this method.Furthermore,LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull.Experimental results show that the proposed method successfully achieves the low-artifact brain image,which demonstrates the practical applicability of LAPAM.This work might improve the photoacoustic imaging quality in many biomedical applications which involve tissues with complex acoustic properties,such as brain imaging through scalp and skull.
基金Supported by the National Key Scientific Instrument and Equipment Development Projects of China under Grant No 81127901the National Natural Science Foundation of China under Grant Nos 61372017 and 30970828
文摘A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).
文摘Objective: The aim of our study was to make the qualitative and quantitative analysis to breast lesions using acoustic radiation force impulses (ARFI), and assess the diagnostic value of ARFI for differentiation between benign and malignant solid breast masses, meanwhile evaluate the influences of ARFI with breast imaging reporting and data system (BI-RADS) of suspicious masses. Methods: Seventy-five women with 86 breast lesions underwent conventional breast ultra- sound examination. Then B-mode BI-RADS features and assessments were recorded and standard breast US supplemented by ARFI elastographic examination were repeated. The data were recorded and analyzed as following: area ratio of breast lesion, the shear-wave velocity, the ratio of the shear-wave velocity between lesions and surrounding normal tissues, and according to the elastographic data reconsidered the BI-RADS category, all the results have been correlated with pathological results and make statistical evaluations of ARFI for differentiation between benign and malignant solid breast masses. Meantime our study has correlated the adjusted BI-RADS category of suspicious breast lesions with the pathological results and made assessment. Results: Thirty-eight patients were malignant breast carcinoma (31 invasive ductal carcinoma, 5 intraductal carcinoma in situ, 2 medullary carcinoma, 2 invasive Iobular carcinoma), 48 patients were benign breast lesions (23 fibroadenoma, 12 benign nodular hyperplasia, 5 phyllodes tumor, 6 adenosis, 2 intraductal papilloma). Underwent conventional breast ultrasound exam, 42 cases were BI-RADS category 3, 23 cases were BI-RADS category 4. When adding elastographic data, 46 cases were BI-RADS category 3 and 20 cases were BI-RADS category 4. Compared with pathological results showed for both the specificity of BIRADS features and the area under ROC curve has risen. Virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) data showed the area ratio (AR) between elastographic lesions area and B-mode lesions area, SWV (maximal shear-wave velocity of lesions), R-SWV (shear-wave velocity ratio between lesions and surrounding normal tissues) in benign breast lesions were lower than those in malignant lesions which has statistical significance and the cut-off point were 1.1,4.65 m/s, 5.18 respectively. Conclusion: The ARFI elastography can provide the reliable qualitative and quantitative analysis about hardness of breast lesions, supply the new BI-RADS category features to suspicious breast masses and serve as an effective diagnostic tool for differentiation between benign and malignant solid masses.
基金Project supported by the National Natural Science Foundation of China(Grant No.51477161)the National Key Research and Development Program of China(Grant No.2018YFC0115200)the Fund from the Chinese Academy of Sciences(Grant No.YZ201507)
文摘Thermoacoustic imaging with current injection(TAI-CI) is a novel imaging technology that couples with electromagnetic and acoustic research, which combines the advantages of high contrast of the electrical impedance tomography and the high spatial resolution of sonography, and therefore has the potential for early diagnosis. To verify the feasibility of TAI-CI for complex bone-containing biological tissues, the principle of TAI-CI and the coupling characteristics of fluid and solid were analyzed. Meanwhile, thermoacoustic(TA) effects for fluid model and fluid–solid coupling model were analyzed by numerical simulations. Moreover, we conducted experiments on animal cartilage, hard bone and biological soft tissue phantom with low conductivity(0.5 S/m). By injecting a current into the phantom, the thermoacoustic signal was detected by the ultrasonic transducer with a center frequency of 1 MHz, thereby the B-scan image of the objects was obtained. The B-scan image of the cartilage experiment accurately reflects the distribution of cartilage and gel, and the hard bone has a certain attenuation effect on the acoustic signal. However, compared with the ultrasonic imaging, the thermoacoustic signal is only attenuated during the outward propagation. Even in this case, a clear image can still be obtained and the images can reflect the change of the conductivity of the gel. This study confirmed the feasibility of TAI-CI for the imaging of biological tissue under the presence of cartilage and the bone. The novel TAI-CI method provides further evidence that it can be used in the diagnosis of human diseases.
基金Supported by National Natural Science Foundation of China(Grant Nos.51675425,52075441)Shaanxi Provincial Key Research Program Project of China(Grant No.2020ZDLGY06-09)+1 种基金Dongguan Municipal Social Science and Technology Development(key)Project of China(Grant No.20185071021600)Science and Technology on Micro-system Laboratory Foundation of China(Grant No.6142804200405).
文摘Wideband acoustic imaging,which combines compressed sensing(CS)and microphone arrays,is widely used for locating acoustic sources.However,the location results of this method are unstable,and the computational efficiency is low.In this work,in order to improve the robustness and reduce the computational cost,a DCS-SOMP-SVD compressed sensing method,which combines the distributed compressed sensing using simultaneously orthogonal matching pursuit(DCS-SOMP)and singular value decomposition(SVD)is proposed.The performance of the DCS-SOMP-SVD is studied through both simulation and experiment.In the simulation,the locating results of the DCS-SOMP-SVD method are compared with the wideband BP method and the DCS-SOMP method.In terms of computational efficiency,the proposed method is as efficient as the DCS-SOMP method and more efficient than the wideband BP method.In terms of locating accuracy,the proposed method can still locate all sources when the signal to noise ratio(SNR)is−20 dB,while the wideband BP method and the DCS-SOMP method can only locate all sources when the SNR is higher than 0 dB.The performance of the proposed method can be improved by expanding the frequency range.Moreover,there is no extra source in the maps of the proposed method,even though the target sparsity is overestimated.Finally,a gas leak experiment is conducted to verify the feasibility of the DCS-SOMP-SVD method in the practical engineering environment.The experimental results show that the proposed method can locate both two leak sources in different frequency ranges.This research proposes a DCS-SOMP-SVD method which has sufficient robustness and low computational cost for wideband acoustic imaging.