This study mainly investigates the mechanical mechanism of overlying strata breaking and the development of fractured zones during close-distance coal seam group mining in the Gaojialiang coal mine.First,a mechanical ...This study mainly investigates the mechanical mechanism of overlying strata breaking and the development of fractured zones during close-distance coal seam group mining in the Gaojialiang coal mine.First,a mechanical model for the second"activation"of broken overlying strata is established,and the related mechanical"activation"conditions are obtained.A recursive formula for calculating the separation distance of overlying strata is deduced.Second,a height determining method for predicting the height of fractured zones during close-distance coal seam group mining is proposed based on two values,namely,the separation distance and ultimate subsidence value of overlying strata.This method is applied to calculate the fractured zone heights in nos.20107 and 20307 mining faces.The calculated results are almost equal to the field observation results.Third,a modified formula for calculating the height of a waterflowing fractured zone is proposed.A comparison of the calculated and observed results shows that the errors are small.The height determining method and modified formula not only build a theoretical foundation for water conservation mining at the Gaojialiang coal mine,but also provide a reference for estimating the height of water-flowing fractured zones in other coal mines with similar conditions.展开更多
In light of the severe deformation and destruction of the district raise tunnel in the mining area at the northern part of the Lubanshan colliery, by the theoretic analysis and numerical simulation, both the mining st...In light of the severe deformation and destruction of the district raise tunnel in the mining area at the northern part of the Lubanshan colliery, by the theoretic analysis and numerical simulation, both the mining stress distribution in seams group and the deformation and destruction mechanism of floor district raise were investigated. The results show that, at the maximum vertical distance of 40 m, the abutment stress has an influence on the recovery of 2# and 3# coal seam and 8# coal seam at distance of 30 m. As a result, the recovery of 8# is rather than those of 2# or 3# coal seam, which contributes to the deformation and destruction of the district raise surrounding rock. The major factors affecting the abutment stress include the mining depth, mining height, residual gob space, adjacent working faces and short spacing coal seam recovery.展开更多
P21-activated kinases(PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group Ⅰ(PAK1-3) and group Ⅱ(PAK4-6). Focus is currently shifting from group Ⅰ ...P21-activated kinases(PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group Ⅰ(PAK1-3) and group Ⅱ(PAK4-6). Focus is currently shifting from group Ⅰ PAKs to group Ⅱ PAKs. Group Ⅱ PAKs play important roles in many fundamental cellular processes, some of which have particular significance in the development and progression of cancer. Because of their important functions, group Ⅱ PAKs have become popular potential drug target candidates. However, few group Ⅱ PAKs inhibitors have been reported, and most do not exhibit satisfactory kinase selectivity and "drug-like" properties. Isoform- and kinase-selective PAK inhibitors remain to be developed. This review describes the biological activities of group Ⅱ PAKs, the importance of group Ⅱ PAKs in the development and progression of gastrointestinal cancer, and smallmolecule inhibitors of group Ⅱ PAKs for the treatment of cancer.展开更多
Steeply dipping seam group, which has complex occurrence conditions, belongs to the steeply dipping seam. The research on the strata movement around the coal face not only improves safe production technology in practi...Steeply dipping seam group, which has complex occurrence conditions, belongs to the steeply dipping seam. The research on the strata movement around the coal face not only improves safe production technology in practice, but also develops the mining theory. By using physical simulation experiments, numerical simulation and site test, the deformation, failure and movement of surrounding rock in Iongwall working face were analyzed. According to the analysis, characteristics of the seam group were formed which is different from the single seam. Asymmetry mechanics, sequential changes and imbalance of strata movement along the tendency working face were summarized. Furthermore the features of upper and lower seams were different. The mining of the lower seam induced more complex strata movement along the strike. Multi-section mining disturbed surrounding rocks in larger areas than the single section mining did, which had an impact on and dynamic loading function to the support when mining the lower seam, and produced a great influence on the stability of support-rock system.展开更多
According to the influence of the combination of short-distance coal seam group on mining roadway, using numerical simulation software FLAG2D to draw the abutment pressure distribution ahead the working face and the a...According to the influence of the combination of short-distance coal seam group on mining roadway, using numerical simulation software FLAG2D to draw the abutment pressure distribution ahead the working face and the area of influence in fully-mechanized mining conditions, the variation rules of surrounding rock supporting pressure of floor roadway and the deformation rules were summarized. GYS-300 anchor dynamometer was used to measure the roadway surface displacement, and the conclusions of numerical simulation were verified.展开更多
The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds ...The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds present special properties upon mixing the d valence character. Our results provide explanations for the unexpected experimental observations based on the abnormal binding ordering of metal d electrons and their strong perturbation to the band edge states. The insights into the binary tellurides are useful for the study and control of the structural and chemical perturbation in their ternary alloys and heterostructures.展开更多
基于V isua l B asic 6.0的计算机动画仿真技术,实现平面低副连杆机构Ⅲ级杆组模块、原动件模块的计算和画图程序;在原动件运动给定后,任意连接Ⅱ级杆组构成平面低副连杆机构;调用相应的计算和画图程序,实现平面低副连杆机构的动画仿真...基于V isua l B asic 6.0的计算机动画仿真技术,实现平面低副连杆机构Ⅲ级杆组模块、原动件模块的计算和画图程序;在原动件运动给定后,任意连接Ⅱ级杆组构成平面低副连杆机构;调用相应的计算和画图程序,实现平面低副连杆机构的动画仿真和运动分析图形。展开更多
基金supported by the National Natural Science Foundation of China(Nos.51474137,and 51574154)Shandong Province Natural Science Fund(No.ZR201709180101)+1 种基金Tai’shan Scholar Engineering Construction Fund of Shandong Province of ChinaPostgraduate Technology Innovation Project of Shandong University of Science and Technology(No.SDKDYC 180103).
文摘This study mainly investigates the mechanical mechanism of overlying strata breaking and the development of fractured zones during close-distance coal seam group mining in the Gaojialiang coal mine.First,a mechanical model for the second"activation"of broken overlying strata is established,and the related mechanical"activation"conditions are obtained.A recursive formula for calculating the separation distance of overlying strata is deduced.Second,a height determining method for predicting the height of fractured zones during close-distance coal seam group mining is proposed based on two values,namely,the separation distance and ultimate subsidence value of overlying strata.This method is applied to calculate the fractured zone heights in nos.20107 and 20307 mining faces.The calculated results are almost equal to the field observation results.Third,a modified formula for calculating the height of a waterflowing fractured zone is proposed.A comparison of the calculated and observed results shows that the errors are small.The height determining method and modified formula not only build a theoretical foundation for water conservation mining at the Gaojialiang coal mine,but also provide a reference for estimating the height of water-flowing fractured zones in other coal mines with similar conditions.
基金Project(51104176)supported by the National Natural Science Foundation of China
文摘In light of the severe deformation and destruction of the district raise tunnel in the mining area at the northern part of the Lubanshan colliery, by the theoretic analysis and numerical simulation, both the mining stress distribution in seams group and the deformation and destruction mechanism of floor district raise were investigated. The results show that, at the maximum vertical distance of 40 m, the abutment stress has an influence on the recovery of 2# and 3# coal seam and 8# coal seam at distance of 30 m. As a result, the recovery of 8# is rather than those of 2# or 3# coal seam, which contributes to the deformation and destruction of the district raise surrounding rock. The major factors affecting the abutment stress include the mining depth, mining height, residual gob space, adjacent working faces and short spacing coal seam recovery.
基金Supported by National Natural Science Foundation of ChinaNo.90813038+2 种基金No.31271389No.31371424No.31171360 and No.81230077
文摘P21-activated kinases(PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group Ⅰ(PAK1-3) and group Ⅱ(PAK4-6). Focus is currently shifting from group Ⅰ PAKs to group Ⅱ PAKs. Group Ⅱ PAKs play important roles in many fundamental cellular processes, some of which have particular significance in the development and progression of cancer. Because of their important functions, group Ⅱ PAKs have become popular potential drug target candidates. However, few group Ⅱ PAKs inhibitors have been reported, and most do not exhibit satisfactory kinase selectivity and "drug-like" properties. Isoform- and kinase-selective PAK inhibitors remain to be developed. This review describes the biological activities of group Ⅱ PAKs, the importance of group Ⅱ PAKs in the development and progression of gastrointestinal cancer, and smallmolecule inhibitors of group Ⅱ PAKs for the treatment of cancer.
基金the New Century Excellent Talents in University of China(NCET-04-972)
文摘Steeply dipping seam group, which has complex occurrence conditions, belongs to the steeply dipping seam. The research on the strata movement around the coal face not only improves safe production technology in practice, but also develops the mining theory. By using physical simulation experiments, numerical simulation and site test, the deformation, failure and movement of surrounding rock in Iongwall working face were analyzed. According to the analysis, characteristics of the seam group were formed which is different from the single seam. Asymmetry mechanics, sequential changes and imbalance of strata movement along the tendency working face were summarized. Furthermore the features of upper and lower seams were different. The mining of the lower seam induced more complex strata movement along the strike. Multi-section mining disturbed surrounding rocks in larger areas than the single section mining did, which had an impact on and dynamic loading function to the support when mining the lower seam, and produced a great influence on the stability of support-rock system.
文摘According to the influence of the combination of short-distance coal seam group on mining roadway, using numerical simulation software FLAG2D to draw the abutment pressure distribution ahead the working face and the area of influence in fully-mechanized mining conditions, the variation rules of surrounding rock supporting pressure of floor roadway and the deformation rules were summarized. GYS-300 anchor dynamometer was used to measure the roadway surface displacement, and the conclusions of numerical simulation were verified.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10847111 and 61006091)the Startup Project for Ph. D. of Guangdong University of Technology (Grant No. 083034)the Fundamental Research Funds for the Central Universities of South China University of Technology (Grant No. 2009ZM0022)
文摘The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds present special properties upon mixing the d valence character. Our results provide explanations for the unexpected experimental observations based on the abnormal binding ordering of metal d electrons and their strong perturbation to the band edge states. The insights into the binary tellurides are useful for the study and control of the structural and chemical perturbation in their ternary alloys and heterostructures.
