Seven new lanthanide（Ⅲ） complexes with 4-hydroxyantipyrine were synthesized. These complexes were characterized by elemental analysis, molar conductance, magnetic moment measurements, FT-IR, electronic and 1HNMR sp...Seven new lanthanide（Ⅲ） complexes with 4-hydroxyantipyrine were synthesized. These complexes were characterized by elemental analysis, molar conductance, magnetic moment measurements, FT-IR, electronic and 1HNMR spectra, X-ray powder diffraction, and thermogravimetric studies. The ligand, 4-hydroxyantipyrine （hap）, contained carbonyl oxygen and hydroxyl oxygen as potential donor sites. On coordination, deprotonation occurred and as a result, hap acted as a monobasic bidentate ligand. A coordination number 6 was assigned to the lanthanide（Ⅲ） ions in these complexes with orthorhombic structure. All the complexes were thermally stable-150℃ and underwent decomposition in three stages with the formation of Ln2O3 as the final residues.展开更多
A new europium（Ⅲ） complex Eu2(C15H11O3)6(C12H8N2)2 has been synthesized with 2-（4-Methylbenzoyl）benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: monoclinic, space grou...A new europium（Ⅲ） complex Eu2(C15H11O3)6(C12H8N2)2 has been synthesized with 2-（4-Methylbenzoyl）benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: monoclinic, space group P21/n, a = 15.1238（5）, b = 13.5928（4）, c = 22.9840（7） ?, β = 104.132（3）o, V = 4582.0（2） ?3, Dc = 1.522 g/cm3, Z = 4, μ（Mo Kα） = 1.433 mm-1, F（000） = 2128, the final R = 0.0447 and wR = 0.0826. The Eu（Ⅲ） ion is coordinated by eight atoms to give a distorted square antiprism coordination geometry. The complex shows two intense fluorescence emission bands arising from the transitions of Eu3+: 5 D0 → 7 F1（594 nm） and 5 D0 → 7 F2（617 nm）. The complex is an antiferromagnetism system in the range of 150～300 K. Also reported in the paper is the thermal stability property of the title complex.展开更多
A new terbium(Ⅲ complex Tb(C20H14O3N)3(C12H8N2)（H2O）·H2O has been synthesized with 2-diphenylanine carbonyl benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: triclin...A new terbium(Ⅲ complex Tb(C20H14O3N)3(C12H8N2)（H2O）·H2O has been synthesized with 2-diphenylanine carbonyl benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: triclinic, space group P1, a =11.6034（6）, b = 16.2465（8）, c = 16.4427（8） ?, α = 73.168（5）o, β = 88.655（4）o, γ = 82.865（4）o, V = 2943.7（3） ?3, Dc = 1.494 g/cm3, Z = 2, μ（MoK α） = 1.272 mm-1, F（000） = 1348, the final R = 0.0535 and w R = 0.0809. The Tb（Ⅲ） ion is coordinated by nine atoms to give a monocapped square antiprism coordination geometry. The complex shows four fluorescence emission bands arising from the transitions of Tb3+: 5D4 → 7F6（491 nm）, 5D4 → 7F5（546 nm）, 5D4 → 7F4（585 nm） and 5D4→7F3（621 nm）. Also reported are the magnetic and thermal stability properties of the complex.展开更多
The coordination nature of a number of substituted sodiumphenoxides to iron （Ⅲ） ion has been studied. The o-nitrosodiumphenoxide was found to have different coordination behaviour from that the sodium salts of sali...The coordination nature of a number of substituted sodiumphenoxides to iron （Ⅲ） ion has been studied. The o-nitrosodiumphenoxide was found to have different coordination behaviour from that the sodium salts of salicylic acid and methylsalicylate showed. The structure of the complexes, the number of the ligands being coordinated to the metal ion, has also been determined by titration, uv-vis spectroscopy, atomic absorption and the flame test. In addition, other sodium phenoxides were also involved in this study for comparison. An electric conductivity study on the resulting complexes was carried out and all complexes were found to be semiconductors.展开更多
To elucidate the nature of low-lying triplet states and the effect of ligand modifica- tions on the excited-state properties of functional cationic iridium complexes, the solvent- dependent excited-state dynamics of t...To elucidate the nature of low-lying triplet states and the effect of ligand modifica- tions on the excited-state properties of functional cationic iridium complexes, the solvent- dependent excited-state dynamics of two phosphorescent cationic iridium（Ⅲ） complexes, namely [Ir（dph-oxd）2（bpy）]PF6 （1） and [Ir（dph-oxd）2（pzpy）]Pf6 （2）, were investigated by femtosecond and nanosecond transient absorption spectroscopy. Upon photoexcitation to the metal-to-ligand charge-transfer （MLCT） states, the excited-state dynamics shows a rapid process （τ-=0.7-3 ps） for the formation of solvent stabilized 3MLCT states, which significantly depends on the solvent polarity for both 1 and 2. Sequentially, a relatively slow process assigned to the vibrational cooling/geometrical relaxation and a long-lived phospho- rescent emissive state is identified. Due to the different excited-state electronic structures regulated by ancillary ligands, the solvation-induced stabilization of the 3MLCT state in 1 is faster than that in 2. The present results provide a better sight of excited-state relaxation dynamics of ligand-related iridium（Ⅲ） complexes and solvation effects on triplet manifolds.展开更多
A new luminescent europium complex [Eu(DBM)3dpq] (DBM = 1, 3-diphenyl-1, 3- propanedionate and dpq=dipyrido[2,3-f][2',3'-h]quinoxaline) has been synthesized and shows intense red emission under UV excitation. ...A new luminescent europium complex [Eu(DBM)3dpq] (DBM = 1, 3-diphenyl-1, 3- propanedionate and dpq=dipyrido[2,3-f][2',3'-h]quinoxaline) has been synthesized and shows intense red emission under UV excitation. With the device structure ITO/TPD/Eu(DBM)3dpq: TPD (1:2)/Gd(DBM)3bath/Mg:Ag, sharp-band red emissions with low turn-on voltage of 3V and high brightness of 304cd m-2 were achieved.展开更多
N-2-Thiazolylacrylamide （NTA） was polymerized by a radical route to obtain the polymer in good yield. The polymer with a pendent heterocyclic group is soluble in common organic solvents, which allow to prepare the c...N-2-Thiazolylacrylamide （NTA） was polymerized by a radical route to obtain the polymer in good yield. The polymer with a pendent heterocyclic group is soluble in common organic solvents, which allow to prepare the corresponding metal complexes with higher loads easily. FTIR, ^1H NMR, elemental analysis, and energy-dispersive X-Ray spectroscopy （EDX） were applied to characterize these materials. The magnetic behavior of Fe（Ⅱ） and Nd（Ⅲ） complexes of poly（N-2-thiazolylacrylamide） was examined by a PPMS-9T magnetometer, exhibiting the characteristics of a soft ferromagnet. It is found that the Nd（Ⅲ） complex has an extremely high relative saturation magnetization of 35 emu/g.展开更多
The study on the interaction between 2, 6- bis（benzimidazole- 2- yl） pyridine amino acidlanthanum （Ⅲ） complex and deoxyribonucleic acid （DNA） was performed by the analysis methods ofultraviolet visible spectros...The study on the interaction between 2, 6- bis（benzimidazole- 2- yl） pyridine amino acidlanthanum （Ⅲ） complex and deoxyribonucleic acid （DNA） was performed by the analysis methods ofultraviolet visible spectroscopy （UV）, fluorescence spectroscopy, viscosimetry and cyclic voltammetry.The results indicated after interaction between the complex and DNA, all of the UV absorption intensity,fluorescence intensity and viscosity decreased with the binding constant of 1.1×10^5 L/mol. And the peakpotential of oxidation and reduction peaks did not change but the redox peak currents reduced from thecyclic voltammetry. All above indicated that the complex and DNA were combined through the partialintercalation and electrostatic binding.展开更多
目的:基于网络药理学和分子对接方法,确定复方黄柏液治疗的Ⅲ度烧伤肉芽组织愈合的有效活性成分、关键靶点和潜在的药理学机制,并进行肉芽组织成纤维细胞的初步验证。方法:从公共数据库中药系统药理学分析平台(TCMSP)检索复方黄柏液组...目的:基于网络药理学和分子对接方法,确定复方黄柏液治疗的Ⅲ度烧伤肉芽组织愈合的有效活性成分、关键靶点和潜在的药理学机制,并进行肉芽组织成纤维细胞的初步验证。方法:从公共数据库中药系统药理学分析平台(TCMSP)检索复方黄柏液组成成分连翘、黄柏、金银花的有效成分和靶点;GeneCards、OMIM数据库检索“Ⅲ度烧伤”疾病相关靶点。通过生物信息学分析,包括蛋白质-蛋白质相互作用(Protein-proteininteraction,PPI)以及基因本体(Gene ontology,GO)和京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)分析,获得了关键的有效成分、核心靶点和相关信号通路;DiscoveryStudio分子对接分析有效成分化合物与靶蛋白的结合。0.5%的DMSO溶液处理的成纤维细胞记为对照组;槲皮素(40μmol/ml)处理的成纤维细胞记为槲皮素组。采用CCK8法、Transwell实验检测细胞增殖、迁移侵袭;WB试验检测细胞p-PI3K、p-Akt蛋白。结果:共筛选出74个有效成分,331个作用靶点,AKT1为潜在的治疗靶点,木犀草素、山柰酚、槲皮素、汉黄芩素、丹皮酚为潜在的候选药物。PI3K-AKT信号通路可能在复方黄柏液治疗Ⅲ度烧伤中发挥关键作用;分子对接表明槲皮素与AKT1结合最好。与对照组相比,槲皮素组成纤维细胞增殖、迁移侵袭均显著降低,p-PI3K、p-Akt蛋白表达也显著降低(P<0.05)。结论:复方黄柏液促进Ⅲ度烧伤患者肉芽组织形成的生物活性成分为槲皮素,潜在通路为PI3K-AKT信号通路,为复方黄柏液治疗Ⅲ度烧伤的研究提供了思路。展开更多
基金Project supported by Ph.D. programme at the Department of Chemistry, University of Kerala, Kariavattom Campus, Trivandrum-695 581 Kerala, India
文摘Seven new lanthanide（Ⅲ） complexes with 4-hydroxyantipyrine were synthesized. These complexes were characterized by elemental analysis, molar conductance, magnetic moment measurements, FT-IR, electronic and 1HNMR spectra, X-ray powder diffraction, and thermogravimetric studies. The ligand, 4-hydroxyantipyrine （hap）, contained carbonyl oxygen and hydroxyl oxygen as potential donor sites. On coordination, deprotonation occurred and as a result, hap acted as a monobasic bidentate ligand. A coordination number 6 was assigned to the lanthanide（Ⅲ） ions in these complexes with orthorhombic structure. All the complexes were thermally stable-150℃ and underwent decomposition in three stages with the formation of Ln2O3 as the final residues.
基金supported by the cooperative project of Hengyang Normal University with Hengyang Yile New Materials Co.,Ltd.(No.HXKJ201905)
文摘A new europium（Ⅲ） complex Eu2(C15H11O3)6(C12H8N2)2 has been synthesized with 2-（4-Methylbenzoyl）benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: monoclinic, space group P21/n, a = 15.1238（5）, b = 13.5928（4）, c = 22.9840（7） ?, β = 104.132（3）o, V = 4582.0（2） ?3, Dc = 1.522 g/cm3, Z = 4, μ（Mo Kα） = 1.433 mm-1, F（000） = 2128, the final R = 0.0447 and wR = 0.0826. The Eu（Ⅲ） ion is coordinated by eight atoms to give a distorted square antiprism coordination geometry. The complex shows two intense fluorescence emission bands arising from the transitions of Eu3+: 5 D0 → 7 F1（594 nm） and 5 D0 → 7 F2（617 nm）. The complex is an antiferromagnetism system in the range of 150～300 K. Also reported in the paper is the thermal stability property of the title complex.
基金supported by the cooperative project of Hengyang Normal University with Hengyang Yile New Materials Co.,Ltd.(HXKJ201905)the Natural Science Foundation of Hunan Province(2019JJ60021,2019JJ50013)+1 种基金the Scientific Research Found of Hunan Provincial Education Department of China(17A049)the Industry and Research Key Project of Hengyang City(2018k KJ016,2017KJ155,2017KJ193)
文摘A new terbium(Ⅲ complex Tb(C20H14O3N)3(C12H8N2)（H2O）·H2O has been synthesized with 2-diphenylanine carbonyl benzoic acid and 1,10-phenanthroline as ligands. Crystal data for the complex are as follows: triclinic, space group P1, a =11.6034（6）, b = 16.2465（8）, c = 16.4427（8） ?, α = 73.168（5）o, β = 88.655（4）o, γ = 82.865（4）o, V = 2943.7（3） ?3, Dc = 1.494 g/cm3, Z = 2, μ（MoK α） = 1.272 mm-1, F（000） = 1348, the final R = 0.0535 and w R = 0.0809. The Tb（Ⅲ） ion is coordinated by nine atoms to give a monocapped square antiprism coordination geometry. The complex shows four fluorescence emission bands arising from the transitions of Tb3+: 5D4 → 7F6（491 nm）, 5D4 → 7F5（546 nm）, 5D4 → 7F4（585 nm） and 5D4→7F3（621 nm）. Also reported are the magnetic and thermal stability properties of the complex.
文摘The coordination nature of a number of substituted sodiumphenoxides to iron （Ⅲ） ion has been studied. The o-nitrosodiumphenoxide was found to have different coordination behaviour from that the sodium salts of salicylic acid and methylsalicylate showed. The structure of the complexes, the number of the ligands being coordinated to the metal ion, has also been determined by titration, uv-vis spectroscopy, atomic absorption and the flame test. In addition, other sodium phenoxides were also involved in this study for comparison. An electric conductivity study on the resulting complexes was carried out and all complexes were found to be semiconductors.
文摘To elucidate the nature of low-lying triplet states and the effect of ligand modifica- tions on the excited-state properties of functional cationic iridium complexes, the solvent- dependent excited-state dynamics of two phosphorescent cationic iridium（Ⅲ） complexes, namely [Ir（dph-oxd）2（bpy）]PF6 （1） and [Ir（dph-oxd）2（pzpy）]Pf6 （2）, were investigated by femtosecond and nanosecond transient absorption spectroscopy. Upon photoexcitation to the metal-to-ligand charge-transfer （MLCT） states, the excited-state dynamics shows a rapid process （τ-=0.7-3 ps） for the formation of solvent stabilized 3MLCT states, which significantly depends on the solvent polarity for both 1 and 2. Sequentially, a relatively slow process assigned to the vibrational cooling/geometrical relaxation and a long-lived phospho- rescent emissive state is identified. Due to the different excited-state electronic structures regulated by ancillary ligands, the solvation-induced stabilization of the 3MLCT state in 1 is faster than that in 2. The present results provide a better sight of excited-state relaxation dynamics of ligand-related iridium（Ⅲ） complexes and solvation effects on triplet manifolds.
基金This work is supposed by the Natural Science Foundation of Henan,China(No.0312000700)
文摘A new luminescent europium complex [Eu(DBM)3dpq] (DBM = 1, 3-diphenyl-1, 3- propanedionate and dpq=dipyrido[2,3-f][2',3'-h]quinoxaline) has been synthesized and shows intense red emission under UV excitation. With the device structure ITO/TPD/Eu(DBM)3dpq: TPD (1:2)/Gd(DBM)3bath/Mg:Ag, sharp-band red emissions with low turn-on voltage of 3V and high brightness of 304cd m-2 were achieved.
基金This project is financially supported by the National Natural Science Foundation of China(No.20374044,20434020)
文摘N-2-Thiazolylacrylamide （NTA） was polymerized by a radical route to obtain the polymer in good yield. The polymer with a pendent heterocyclic group is soluble in common organic solvents, which allow to prepare the corresponding metal complexes with higher loads easily. FTIR, ^1H NMR, elemental analysis, and energy-dispersive X-Ray spectroscopy （EDX） were applied to characterize these materials. The magnetic behavior of Fe（Ⅱ） and Nd（Ⅲ） complexes of poly（N-2-thiazolylacrylamide） was examined by a PPMS-9T magnetometer, exhibiting the characteristics of a soft ferromagnet. It is found that the Nd（Ⅲ） complex has an extremely high relative saturation magnetization of 35 emu/g.
文摘The study on the interaction between 2, 6- bis（benzimidazole- 2- yl） pyridine amino acidlanthanum （Ⅲ） complex and deoxyribonucleic acid （DNA） was performed by the analysis methods ofultraviolet visible spectroscopy （UV）, fluorescence spectroscopy, viscosimetry and cyclic voltammetry.The results indicated after interaction between the complex and DNA, all of the UV absorption intensity,fluorescence intensity and viscosity decreased with the binding constant of 1.1×10^5 L/mol. And the peakpotential of oxidation and reduction peaks did not change but the redox peak currents reduced from thecyclic voltammetry. All above indicated that the complex and DNA were combined through the partialintercalation and electrostatic binding.
文摘目的:基于网络药理学和分子对接方法,确定复方黄柏液治疗的Ⅲ度烧伤肉芽组织愈合的有效活性成分、关键靶点和潜在的药理学机制,并进行肉芽组织成纤维细胞的初步验证。方法:从公共数据库中药系统药理学分析平台(TCMSP)检索复方黄柏液组成成分连翘、黄柏、金银花的有效成分和靶点;GeneCards、OMIM数据库检索“Ⅲ度烧伤”疾病相关靶点。通过生物信息学分析,包括蛋白质-蛋白质相互作用(Protein-proteininteraction,PPI)以及基因本体(Gene ontology,GO)和京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)分析,获得了关键的有效成分、核心靶点和相关信号通路;DiscoveryStudio分子对接分析有效成分化合物与靶蛋白的结合。0.5%的DMSO溶液处理的成纤维细胞记为对照组;槲皮素(40μmol/ml)处理的成纤维细胞记为槲皮素组。采用CCK8法、Transwell实验检测细胞增殖、迁移侵袭;WB试验检测细胞p-PI3K、p-Akt蛋白。结果:共筛选出74个有效成分,331个作用靶点,AKT1为潜在的治疗靶点,木犀草素、山柰酚、槲皮素、汉黄芩素、丹皮酚为潜在的候选药物。PI3K-AKT信号通路可能在复方黄柏液治疗Ⅲ度烧伤中发挥关键作用;分子对接表明槲皮素与AKT1结合最好。与对照组相比,槲皮素组成纤维细胞增殖、迁移侵袭均显著降低,p-PI3K、p-Akt蛋白表达也显著降低(P<0.05)。结论:复方黄柏液促进Ⅲ度烧伤患者肉芽组织形成的生物活性成分为槲皮素,潜在通路为PI3K-AKT信号通路,为复方黄柏液治疗Ⅲ度烧伤的研究提供了思路。
