The Relationship between Father-Love Absence and Loneliness:Based on the Perspective of the Social Functionalist Theory and the Social Needs Theory

Fathers play an important role in adolescents’development,which is significant for their development and influences their mental health,including feeling of loneliness.However,the effects and mechanisms of father-love absence on individual loneliness are not clear.Based on the social functionalist theory and the social needs theory,this study examines the influence of individual fatherlove absence on loneliness and its underlying mechanisms.A questionnaire survey was administered to 319 junior high school students and 1,476 high school students.The results showed that adolescents with father-love absence had higher levels of loneliness,and that father-love absence affected loneliness levels through mediating pathways of individual gratitude,peer relationships,and gratitude to peer relationships.This study not only confirms the negative effects of father-love absence on adolescents’loneliness,but also explains the mediate roles of individual gratitude and peer relationships.It enriches the theoretical system related to family education and has important theoretical and practical implications for further interventions on adolescents’mental health from the perspective of fatherless parenting.

IN VITRO CYTOGENETIC EFFECTS OF AGRIZIM AND BAYLETON ON HUMAN LYMPHOCYTES IN THE PRESENCE AND ABSENCE OF METABOLIC ACTIVATION

Agrizim and bayleton,two commonly usedagricultural fungicides in India,wereinvestigated for their genotoxicpotentialities on cultured humanlymphocytes by studying chromosomalaberrations and sister chromatid exchangesin the presence and absence of

Spatial Multi-Presence System to Increase Security Awareness for Remote Collaboration in an Extended Reality Environment

Enhancing the sense of presence of participants is an important issue in terms of security awareness for remote collaboration in extended reality.However,conventional methods are insufficient to be aware of remote situations and to search for and control remote workspaces.This study pro-poses a spatial multi-presence system that simultaneously provides multiple spaces while rapidly exploring these spaces as users perform collaborative work in an extended reality environment.The proposed system provides methods for arranging and manipulating remote and personal spaces by creating an annular screen that is invisible to the user.The user can freely arrange remote participants and their workspaces on the annular screen.Because users can simultaneously view various spaces arranged on the annular screen,they can perform collaborative work while simultaneously feeling the presence of multiple spaces and can be fully immersed in a specific space.In addition,the personal spaces where users work can also be arranged through the annular screen.According to the results of the performance evaluations,users participating in remote collaborative works can visualize the spaces of multiple users simultaneously and feel their presence,thereby increasing their understanding of the spaces.Moreover,the proposed system reduces the time to perform tasks and gain awareness of the emergency in remote workspaces.

Congenital Absence of Pericardium:The Largest Systematic Review in the Field on 247 Worldwide Cases(1977-Now)

Background:Congenital absence of pericardium(CAP),also known as pericardial agenesis,represents an uncommon cardiac abnormality and mostly incidental finding.It can be subdivided into complete and partial(left or right-sided)forms.Because of its infrequency,just case reports and a few case series have been released so far.This paper represents the largest systematic review in the field.Nine features(age at diagnosis,type,gender,clinical presentation,electrocardiography,imaging(ultrasounds,CT/MRI),concomitant cardiac defects,and outcome)were analysed.Methods:The electronic database PubMed was investigated from its establishment up to July 15th,2023.Just case reports and case series were included.Animal studies,papers that were not in English,Spanish,and Italian,and those manuscripts not reporting at least seven of the nine analysed features.were ruled out.The analysed data were reported mostly in terms of percentage.Results:One hundred eighty studies were included encompassing 247 patients.More than half of reviewed CAP cases were in males(63.2%).The mean age at diagnosis was 31.8±19.3 years;a range of 32 weeks of gestation-81 years).23.5%of the patients did not report any symptoms.The most common clinical presentations were chest pain(35.2%)and dyspnoea(29.2%).The most commonly seen ECG changes were right axis deviation(28.7%)and right bundle branch block(23.9%).CAP was suspected or diagnosed by echocardiography in 20.1%of cases.The diagnosis was made by CT and/or MRI in 61.9%of cases.CAP was left-sided in 71.2%,complete in 23.1%,and right-sided in 5.7%.A concomitant congenital heart defect was found in 22.7%,especially in the form of atrial septal defect(6.5%)and patency of ductus arteriosus(2.8%).The pericardial repair was required in 12.9% of the incomplete forms of the disease.Never did the complete form require surgical correction.The outcome appeared favourable in the vast majority of cases,with just 18 deaths(7.3%).Discussion:The main limitation of this systematic review is that it is based just on case reports and case series,due to the lack of large studies on CAP.However,it represents the largest analysis in the field.Due to the rarity of CAP establishing an International Registry is recommended.

Typical Zollinger-Ellison syndrome-atypical location of gastrinoma and absence of hypergastrinemia:A case report and review of literature

BACKGROUND Zollinger–Ellison syndrome(ZES)results from hypersecretion of gastrin from pancreatic or duodenal neuroendocrine tumors,commonly referred to as gastrinomas.The high levels of gastrin lead to a typical presentation involving watery diarrhea and multiple ulcers in the duodenum.Here,we have presented the rare case of a patient with ZES and absence of hypergastrinemia as well as an atypical location of gastrinoma.CASE SUMMARY A 72-year-old woman presented with the typical clinical manifestations of ZES,including upper abdominal pain,significant watery diarrhea,and acidic liquid vomitus.Surprisingly,however,she did not have an increased level of serum gastrin.In addition,there was no evidence of gastrinoma or any other ulcerogenic tumor.Esophagogastroduodenoscopy was conducted to examine the upper digestive tract.Revised diagnoses were considered,and an individualized treatment plan was developed.The patient responded to antacid medication while experiencing intermittent,recurring bouts of ZES.18F-AlF-NOTAoctreotide positron emission tomography(18F-OC PET)/computed tomography(CT)helped locate the tumor.Postoperative pathology and immunohistochemistry results suggested that the tumor was a gastrinoma located at an unconventional site.CONCLUSION This present case study demonstrates the possibility of ZES-like manifestation in patients with absence of hypergastrinemia.18F-OC PET/CT is a relatively new imaging technique that can be applied for diagnosing even tiny gastrinomas that are atypical in terms of location.

Beyond Video Quality:Evaluation of Spatial Presence in 360-Degree Videos

With the rapid development of immersive multimedia technologies,360-degree video services have quickly gained popularity and how to ensure sufficient spatial presence of end users when viewing 360-degree videos becomes a new challenge.In this regard,accurately acquiring users’sense of spatial presence is of fundamental importance for video service providers to improve their service quality.Unfortunately,there is no efficient evaluation model so far for measuring the sense of spatial presence for 360-degree videos.In this paper,we first design an assessment framework to clarify the influencing factors of spatial presence.Related parameters of 360-degree videos and headmounted display devices are both considered in this framework.Well-designed subjective experiments are then conducted to investigate the impact of various influencing factors on the sense of presence.Based on the subjective ratings,we propose a spatial presence assessment model that can be easily deployed in 360-degree video applications.To the best of our knowledge,this is the first attempt in literature to establish a quantitative spatial presence assessment model by using technical parameters that are easily extracted.Experimental results demonstrate that the proposed model can reliably predict the sense of spatial presence.

The Contribution Margin due to a Limiting Factor in the Presence of Several Sales Options: Actuality Is Not Always As It Appears at the Beginning of the Analysis

The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.

一种新的Presence建模方法

在分析Presence信息特征的基础上，提出了Presence模型的建模需求和功能目标，并指出：信息共享、隐私保护以及信息融合要求对信息提供一致的管理方式，可通过建立Presence信息模型来解决这一问题，信息模型的建立应该直观和易用。根据建模需求对适用的建模方法进行了比较，建立了一种新的面向普通应用开发者的混合建模方法，结合图形化建模和本体建模的优点，在建模过程引入了模型驱动结构（MDA）方法和工程化思想，标准化的表达方式和规范的建模步骤保证了建模的质量。

面向移动互联网的Presence/IM机制研究

以Presence/IM为代表的OTT业务具有实时在线、随时随地沟通的便利性成了移动互联网时代的应用热点.在当前电信标准体系中,Presence/IM实现机制分为SIMPLE和XMPP两大类,但这两类协议制定较早,在流量、功耗及传输上都没考虑移动互联网的特点,本文将在分析SIMPLE和XMPP协议的基础上,提出一种基于订阅/发布模型的移动互联网Presence/IM机制并给出具体实现,并重点阐述多终端同时在线情况时的消息路由机制.最后将本文提出的协议与SIMPLE和XMPP进行了对比分析.

基于SIP协议的Presence服务的研究

Presence服务是多媒体会议、即时消息等网络应用中的一项重要服务。SIP协议可以很好的作为一种Presence协议来实现presence服务,本文通过SIP协议的SUBSCRIBE、NOTIFY和扩展的PUBLISH方法,使用SIP协议的事件通知机制设计了一个基于SIP协议的Presence服务系统。

3G网络中的Presence业务

在介绍Presence业务总体特征的基础上,通过业务场景说明业务的具体应用,简单阐述了Presence业务的网络结构,最后介绍了目前国内外研究情况以及展望Presence业务发展前景。

Presence服务中授权机制的研究

随着IP通信业务的发展,Presence业务在通信系统中起着越来越重要的作用。用户发布的Presence信息包含越来越多的私人信息和敏感信息,Presence服务器需要经过发布者授权后才能把Presence信息发布给观察者。针对授权规则问题IETF提出了两种解决方法:Watcher Info机制和XCAP机制。本文主要介绍基于SIMPLE的Presence服务系统中两种机制的实现方法,对比分析两种机制的优缺点,在此基础上分析两者的发展前景。

基于P2P-SIP的Presence业务

即时通信作为一种通信形式受大众喜爱。本文简单说明了当前即时消息软件的不足,通过分析标准SIP协议的技术优势和P2P网络的良好特性。提出了较为稳定、安全、易于扩充的Presence业务模型。

基于IMS的Presence服务器的设计及实现

介绍了IMS中Presence业务体系架构,以及在该架构中的Presence服务器的位置和功能要求,并提出了一个设计方案,介绍了实现过程中的关键问题的解决思路和实现算法。

IMS中基于Presence生活导航系统的设计与实现

生活导航系统LPS(Life Presence System)是将Presence的机制扩展到呈现日常生活相关的事物状态变化的应用中,并提供交互式的操作完成用户行为的导航。文章描述了生活导航系统的主要应用场景以及应用的前景,介绍了IMS(IP Multimedia Subsystem)中基于Presence业务能力的生活导航系统的网络结构以及功能,提出了LPS系统的详细实现方案,并对系统实现的关键技术进行了分析。

基于SIP协议的Presence/IM技术研究与进展

随着互联网的迅速发展和IMS系统的逐渐成熟,基于SIP协议的Presence/IM业务研究和应用日趋增多.Presence/IM业务的需求带来了一系列的问题,而标准的制定工作更是首当其冲.IETF提供了很多规范来支持基于SIP协议的Presence/IM功能,这些规范被称为SIMPLE.本文详细分析了SIMPLE所涉及的规范和标准,并结合SIP事件扩展和IMPP协议总结了SIMPLE提供的具体功能,同时按照规范的功能进行了分类,并说明了这些规范之间的关系.论文还讨论了Presence/IM技术未来的研究方向和发展趋势.

Protein induced by vitamin K absence or antagonist-Ⅱ versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis

Background: As a promising biomarker of hepatocellular carcinoma(HCC), protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-Ⅱ with alpha-fetoprotein(AFP) in the diagnosis of HCC. Data sources: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-Ⅱ and AFP for HCC. The data were pooled using random effects model. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curve(ROC) was employed to evaluate the diagnostic accuracy of each marker. Results: Thirty-one studies were included. The pooled sensitivity(95% CI) of PIVKA-Ⅱ and AFP was 0.66(0.65–0.68) and 0.66(0.65–0.67), respectively in diagnosis of HCC; and the corresponding pooled specificity(95% CI) was 0.89(0.88–0.90) and 0.84(0.83–0.85), respectively. The area under the ROC curve(AUC) of PIVKA-Ⅱ and AFP was 0.856(0.817–0.895) and 0.770(0.728–0.811), respectively. Subgroup analysis showed that PIVKA-Ⅱ was superior to AFP in terms of the AUC for both small HCC( < 3 cm) [0.863(0.825–0.901) vs 0.717(0.658–0.776)] and large HCC( ≥ 3 cm) [0.854(0.811–0.897) vs 0.729(0.682–0.776)]; for American [0.926(0.897–0.955) vs 0.698(0.594–0.662)], European [0.772(0.743–0.801) vs 0.628(0.594–0.662)], Asian [0.838(0.812–0.864) vs 0.785(0.764–0.806)] and African [0.812(0.794–0.840) vs 0.721(0.675–0.767)] HCC patients; and for HBV-related [0.909(0.866–0.951) vs 0.714(0.673–0.755)] and mixed-etiology [0.847(0.821–0.873) vs 0.794(0.772–0.816)] HCC. Conclusion: This meta-analysis indicates that PIVKA-Ⅱ is better than AFP in terms of the accuracy for diagnosing HCC, regardless of tumor size, patient ethnic group, or HCC etiology.

Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma

BACKGROUND Researchers have investigated the diagnostic value of protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and obtained abundant clinical diagnostic data. However, PIVKA-II and AFP have unsatisfactory specificity and sensitivity in the diagnosis of early-stage HBV-related HCC. Gamma-glutamyltransferase (γ-GT) and aspartate aminotransferase (AST) are common biomarkers for evaluating liver function, and we hypothesized that the γ-GT/AST ratio in combination with PIVKA-II and AFP would improve the diagnosis of early-stage HBV-related HCC. AIM To evaluate the diagnostic value of γ-GT/AST ratio alone or in combination with PIVKA-II and AFP in HBV-related HCC. METHODS Serum levels of γ-GT, AST, PIVKA-II, and AFP were detected and analysed in 176 patients with HBV-related HCC and in 359 patients with chronic hepatitis B. According to tumour size and serum level of HBV DNA, HBV-related HCC patients were divided into the following categories: Early-stage HCC patients, HCC patients, HBV DNA positive (HBV DNA+) HCC patients, and HBV DNA negative (HBV DNA-) HCC patients. Receiver-operating characteristic (ROC) curves were used to analyse and compare the diagnostic value of the single and combined detection of various biomarkers in different types of HBV-related HCC. RESULTS Tumour size was positively correlated with serum levels of PIVKA-II and AFP in HCC patients (r = 0.529, aP < 0.001 and r = 0.270, bP < 0.001, respectively), but there was no correlation between tumour size and the γ-GT/AST ratio (r = 0.073, P = 0.336). The areas under the receiver-operating characteristic curves (AUROCs) of the γ-GT/AST ratio in early-stage HCC patients, HBV DNA+ HCC patients and HBV DNA- HCC patients were not significantly different from that in the total HCC patients (0.754, 0.802, and 0.705 vs 0.779, respectively;P > 0.05). When PIVKA-II was combined with the γ-GT/AST ratio in the diagnosis of earlystage HCC, HCC, and HBV DNA+ HCC, the AUROCs of PIVKA-II increased, with values of 0.857 vs 0.835, 0.925 vs 0.913, and 0.958 vs 0.954, respectively. When AFP was combined with the γ-GT/AST ratio in the diagnosis of early-stage HCC, HCC, HBV DNA+ HCC, and HBV DNA- HCC, the AUROCs of AFP increased, with values of 0.757 vs 0.621, 0.837 vs 0.744, 0.868 vs 0.757, and 0.840 vs 0.828, respectively. CONCLUSION The γ-GT/AST ratio may be better than PIVKA-II and AFP in the diagnosis of early-stage HBV-related HCC, and its combination with PIVKA-II and AFP can improve the diagnostic value for HBV-related HCC.

Small-Scale Self-Focusing of Intense Laser Beams In the Presence of Vector Effect

We extend Bespalov-Talanov (B-T) theory on small-scale self-focusing (SSSF) to include vector effect of a very narrow intense laser beam with application of the vector self-focusing model. The gain spectrum for perturbations is obtained by using the standard linear instability analysis. It is shown that the influence on SSSF of vector effect is closely related to the beam width. For a very narrow beam, the role played by vector effect becomes significant, it reduces the fastest growing frequency and the maximum growth rate, and shortens the frequency range for perturbation growing, and thus deviates the gain spectrum from that of B-T theory.

Protein induced by vitamin K absence or antagonist Ⅱ-producing gastric cancer

Protein induced by vitamin K absence or antagonist Ⅱ(PIVKA-Ⅱ) is a putative specific marker of hepatocellular carcinoma(HCC),but it may also be produced by asmall number of gastric cancers.To date,16 cases of PIVKA-Ⅱ-producing gastric cancer have been reported,2 of which were reported by us and all of which were identified in Japan.There are no symptoms specific to PIVKA-Ⅱ-producing gastric cancer,and the representative clinical symptoms are general fatigue,appetite loss,and upper abdominal pain.Serum alpha-feto-protein(AFP)levels are also increased in almost allcases.Liver metastasis is observed in approximately 80% of cases and portal vein tumor thrombus is ob-served in approximately 20% of cases.Differential diagnosis between metastatic liver tumor and HCC is often difficult.Grossly,almost all cases appear as advanced gastric cancer.Histologically,a hepatoid pattern is observed in many cases,in addition to a moderately to poorly differentiated adenocarcinoma component.The production of PIVKA-Ⅱ and AFP is usually confirmed using immunohistochemical staining.Treatment and prognosis largely depends on the existence of liver meta-stasis,and the prognosis of patients with liver metas-tasis is very poor.PIVKA-Ⅱ may be produced during the hepatocellular metaplasia of the tumor cells.