Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for t...Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for this holiday?展开更多
In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the ...In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the teaching of the course Environmental Engineering Microbiology,and put forward some corresponding curriculum reform schemes.According to the target points of professional graduation requirements,the scheme proposes revising the syllabus of Environmental Engineering Microbiology,clarifying the curriculum objectives,updating the teaching content,and reforming the teaching methods.Through these measures,it is intended to achieve the unity of teachers way of"teaching"and students way of"learning",construct a new teaching mode,fully stimulate students subjective initiative,and enhance students innovative consciousness and practical ability.Besides,in this study,a"whole process-diversification"evaluation system is established to comprehensively evaluate students performance in theoretical knowledge learning and practical application,comprehensively evaluate students learning situation,and analyze the teaching effect in real time,so as to achieve continuous improvement,and ultimately achieve the goal of improving classroom quality.展开更多
Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis ...Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.展开更多
Labor quality evaluation,an important part for carrying out labor education,plays the role as“baton”for labor education.This paper will figure out the reasons for labor quality evaluation from its importance.The pap...Labor quality evaluation,an important part for carrying out labor education,plays the role as“baton”for labor education.This paper will figure out the reasons for labor quality evaluation from its importance.The paper will also classify key evaluation indicators for labor qualities as cognition,emotion,ability and qualities of labor,dividing dynamic indicators to figure out“what to evaluate”.Meanwhile,the author will solve the problem of“how to evaluate”and“who will evaluate”by promoting evaluation subjects diversities and innovating evaluation methods.When labor quality evaluation,the“baton”,guides the direction and strategy,attention should be paid to integrated education to cultivate labor quality in an all-round way.The“baton”will also guide characteristic education with collaborative innovation of labor education,professional education and vocational education.Moreover,labor quality evaluation guides the optimization of resources to create integrated labor qualities and lead innovation education to nurture innovative talents.展开更多
Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opport...Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.展开更多
This study explores the framework of developmental welfare through means of literature review and case study, analyzes the mode of supply of social housing for youth in New Taipei City of Taiwan, with a view to provid...This study explores the framework of developmental welfare through means of literature review and case study, analyzes the mode of supply of social housing for youth in New Taipei City of Taiwan, with a view to providing a reference for the inclusive and sustainable social housing mode in Taiwan.展开更多
When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status...When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status, and rights deeply. New Youth provided a forum for women to express their ideas, and its existence was a reflection of its advancement. However, from the discussion and promotion of “virtuous mother”, it’s easy to see that the intellectuals at that time had a biased perception of women’s identity and emphasized the intersection of women’s consciousness with the state’s thinking.展开更多
The rapid development of communication technology, have changed the landscape of information searching especially among youth. Youth are increasingly inclined to seek information using the new media such as mobile new...The rapid development of communication technology, have changed the landscape of information searching especially among youth. Youth are increasingly inclined to seek information using the new media such as mobile news. Nevertheless, the massive information flows have caused difficulties in finding quality, relevance and credibility of information. Hence, this study was undertaken to identify the problems encountered by the youth when searching for information through mobile news; to recognize the motivational factors in searching information through mobile news; and to find out the acceptance factor in searching information through mobile news. The underlying theory in this research is using Diffusion of Innovation Theory (DOI). Employing a quantitative approach, a total of 400 respondents from higher learning institutes were selected to be the respondents of this study. The data were analyzed using Statistical Package for Social Science (SPSS) version 21.0. Results of the study show that the problems faced when seeking information through mobile news is information disorder. Further, motivational factors that encourage information seeking through mobile news by youth are related to advantage and observability. At the same time, seeking information through mobile news is accepted by the youth due to their perceived ease of use. In conclusion, it is hoped that the mobile news could be one of the leading learning medium among the youth in the future.展开更多
Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly charact...Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and potioles.The phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of B.nivea var.strigosa formed a monophyletic group.The conservation status of B.nivea var.strigosa is assessed as“Near Threatened”(NT)according to IUCN evaluation criteria.The discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.展开更多
In recent years, public diplomacy experienced a steady and prosperous development in China. The objective of this paper is to map out the role of public diplomacy in China playing in the process of China's national i...In recent years, public diplomacy experienced a steady and prosperous development in China. The objective of this paper is to map out the role of public diplomacy in China playing in the process of China's national image construction overseas and the necessity of public diplomacy literacy education of youth especially those college students in higher education institutions. To be aware of these, it is significant and valuable in terms of the public diplomacy literacy education in college teaching in the era of new media sphere.展开更多
The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm...The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm because of its lesser invasiveness.However,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients post-operation.Thus,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.展开更多
The“New Youth,New Future”Asian Youth Music Festival kicked off in Nanjing,capital of east China’s Jiangsu Province,on October 28.Talented young artists,bands,and singers from China,Japan,the ROK,and ASEAN countries...The“New Youth,New Future”Asian Youth Music Festival kicked off in Nanjing,capital of east China’s Jiangsu Province,on October 28.Talented young artists,bands,and singers from China,Japan,the ROK,and ASEAN countries gathered to share a stage and be part of a youth musical and cultural feast dedicated to peace and friendship.The festival attracted more than 20,000 spectators.展开更多
Socialism with Chinese characteristics has entered a new era,marking the beginning of a new era of youth.In contemporary China,the new era has given young people the historical mission of seeking happiness for the Chi...Socialism with Chinese characteristics has entered a new era,marking the beginning of a new era of youth.In contemporary China,the new era has given young people the historical mission of seeking happiness for the Chinese people,the rejuvenation of the Chinese nation,and for the progress of the people in the world.Cultivating the mission and responsibility of youth is not only the requirement for national development,but also for young people to be qualified in the new era.Therefore,youth of the new era should clarify their status and mission,cultivate responsibility,and strive to become builders and successors of socialist modernization.展开更多
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis...Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.展开更多
BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE S...BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.展开更多
The Communist Manifesto,as the initial comprehensive exposition of scientific socialist theory,encapsulates the scientific spirit of Marxism.As socialism with Chinese characteristics enters a new epoch,and the world i...The Communist Manifesto,as the initial comprehensive exposition of scientific socialist theory,encapsulates the scientific spirit of Marxism.As socialism with Chinese characteristics enters a new epoch,and the world is in the throes of an unprecedented century-long transformation,the importance of young talent in bolstering national scientific and technological progress grows ever more apparent.It is of paramount significance to profoundly understand and elucidate the theoretical heritage,practical guidance,and directional leadership that The Communist Manifesto provides to scientific education for the young talent of this new era from three perspectives:theory,practice,and history.This understanding is vital for young talents to further deepen their accurate comprehension of the governing laws of the Communist Party,the construction laws of socialism,and the development laws of human society.The nurturing of scientific spirit and scientific literacy in young talents has critical implications for providing talent support in building a world scientific and technological powerhouse.展开更多
An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinc...An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinct aspects of adaptability,ornamental characteristics and use traits,in order to establish a comprehensive evaluation model.The results demonstrate that grade I(J≥2.685)exhibits excellent application value,encompassing six species of plants,such asHydrangeamacrophylla‘Endless Summer’;grade II(2.684≤J≤2.420)is also of notable application value,encompassing five species of plants,such asCallistemonrigidus;grade III(2.419≤J≤2.615)is of average application value,including five species of plants,such asCrocosmiacrocosmiflora;grade IV(J≤2.16)is of relatively poor application value.The evaluation results may be utilized as a theoretical reference for the promotion of new and superior varieties in the flower border of Hefei.展开更多
文摘Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for this holiday?
基金Supported by Higher Education Teaching Reform Project of Zhaoqing University (zlgc2024058&zlgc202242)Curriculum Ideological and Political Reform Demonstration Project of Zhaoqing University.
文摘In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the teaching of the course Environmental Engineering Microbiology,and put forward some corresponding curriculum reform schemes.According to the target points of professional graduation requirements,the scheme proposes revising the syllabus of Environmental Engineering Microbiology,clarifying the curriculum objectives,updating the teaching content,and reforming the teaching methods.Through these measures,it is intended to achieve the unity of teachers way of"teaching"and students way of"learning",construct a new teaching mode,fully stimulate students subjective initiative,and enhance students innovative consciousness and practical ability.Besides,in this study,a"whole process-diversification"evaluation system is established to comprehensively evaluate students performance in theoretical knowledge learning and practical application,comprehensively evaluate students learning situation,and analyze the teaching effect in real time,so as to achieve continuous improvement,and ultimately achieve the goal of improving classroom quality.
文摘Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.
基金Phased findings from the 2020 Higher Education Research Project:“Research on Integrated Development Mechanism for Colleges and Universities’Labor Education and Professional Education from the Perspective of Business Start-ups and Innovation in the New Era”(KT2020137).
文摘Labor quality evaluation,an important part for carrying out labor education,plays the role as“baton”for labor education.This paper will figure out the reasons for labor quality evaluation from its importance.The paper will also classify key evaluation indicators for labor qualities as cognition,emotion,ability and qualities of labor,dividing dynamic indicators to figure out“what to evaluate”.Meanwhile,the author will solve the problem of“how to evaluate”and“who will evaluate”by promoting evaluation subjects diversities and innovating evaluation methods.When labor quality evaluation,the“baton”,guides the direction and strategy,attention should be paid to integrated education to cultivate labor quality in an all-round way.The“baton”will also guide characteristic education with collaborative innovation of labor education,professional education and vocational education.Moreover,labor quality evaluation guides the optimization of resources to create integrated labor qualities and lead innovation education to nurture innovative talents.
基金the Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University,No.CMER202305the Program for Youth Innovation in Future Medicine,Chongqing Medical University,No.W0138.
文摘Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.
文摘This study explores the framework of developmental welfare through means of literature review and case study, analyzes the mode of supply of social housing for youth in New Taipei City of Taiwan, with a view to providing a reference for the inclusive and sustainable social housing mode in Taiwan.
基金贵州省2018年度哲学社会科学规划国学单列课题阶段性成果,宋元时期宋人别集的编纂与刊刻研究,Serial Number 18GZGX25《新青年》“译介”类栏目规划与内容判断力研究,Serial Number 22150322016)《点石斋画报》(1884-1898)的图文艺术性、现代性传播与出版研究,Serial Number Eb202008.
文摘When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status, and rights deeply. New Youth provided a forum for women to express their ideas, and its existence was a reflection of its advancement. However, from the discussion and promotion of “virtuous mother”, it’s easy to see that the intellectuals at that time had a biased perception of women’s identity and emphasized the intersection of women’s consciousness with the state’s thinking.
文摘The rapid development of communication technology, have changed the landscape of information searching especially among youth. Youth are increasingly inclined to seek information using the new media such as mobile news. Nevertheless, the massive information flows have caused difficulties in finding quality, relevance and credibility of information. Hence, this study was undertaken to identify the problems encountered by the youth when searching for information through mobile news; to recognize the motivational factors in searching information through mobile news; and to find out the acceptance factor in searching information through mobile news. The underlying theory in this research is using Diffusion of Innovation Theory (DOI). Employing a quantitative approach, a total of 400 respondents from higher learning institutes were selected to be the respondents of this study. The data were analyzed using Statistical Package for Social Science (SPSS) version 21.0. Results of the study show that the problems faced when seeking information through mobile news is information disorder. Further, motivational factors that encourage information seeking through mobile news by youth are related to advantage and observability. At the same time, seeking information through mobile news is accepted by the youth due to their perceived ease of use. In conclusion, it is hoped that the mobile news could be one of the leading learning medium among the youth in the future.
文摘Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and potioles.The phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of B.nivea var.strigosa formed a monophyletic group.The conservation status of B.nivea var.strigosa is assessed as“Near Threatened”(NT)according to IUCN evaluation criteria.The discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.
文摘In recent years, public diplomacy experienced a steady and prosperous development in China. The objective of this paper is to map out the role of public diplomacy in China playing in the process of China's national image construction overseas and the necessity of public diplomacy literacy education of youth especially those college students in higher education institutions. To be aware of these, it is significant and valuable in terms of the public diplomacy literacy education in college teaching in the era of new media sphere.
基金Supported by National Key R&D Programs of China,No.2022YFC2503600.
文摘The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm because of its lesser invasiveness.However,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients post-operation.Thus,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.
文摘The“New Youth,New Future”Asian Youth Music Festival kicked off in Nanjing,capital of east China’s Jiangsu Province,on October 28.Talented young artists,bands,and singers from China,Japan,the ROK,and ASEAN countries gathered to share a stage and be part of a youth musical and cultural feast dedicated to peace and friendship.The festival attracted more than 20,000 spectators.
文摘Socialism with Chinese characteristics has entered a new era,marking the beginning of a new era of youth.In contemporary China,the new era has given young people the historical mission of seeking happiness for the Chinese people,the rejuvenation of the Chinese nation,and for the progress of the people in the world.Cultivating the mission and responsibility of youth is not only the requirement for national development,but also for young people to be qualified in the new era.Therefore,youth of the new era should clarify their status and mission,cultivate responsibility,and strive to become builders and successors of socialist modernization.
基金supported by the National Natural Science Foundation of China(32141003 and 82330110)the CAMS Innovation Fund for Medical Sciences(CIFMS+2 种基金2021-I2M-1-039)the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Fundamental Research Funds for the Central Universities(2021-PT350-001).
文摘Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.
基金Key Health Science and Technology Development Project of Nanjing City,Jiangsu Province,No.ZKX19038.
文摘BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.
文摘The Communist Manifesto,as the initial comprehensive exposition of scientific socialist theory,encapsulates the scientific spirit of Marxism.As socialism with Chinese characteristics enters a new epoch,and the world is in the throes of an unprecedented century-long transformation,the importance of young talent in bolstering national scientific and technological progress grows ever more apparent.It is of paramount significance to profoundly understand and elucidate the theoretical heritage,practical guidance,and directional leadership that The Communist Manifesto provides to scientific education for the young talent of this new era from three perspectives:theory,practice,and history.This understanding is vital for young talents to further deepen their accurate comprehension of the governing laws of the Communist Party,the construction laws of socialism,and the development laws of human society.The nurturing of scientific spirit and scientific literacy in young talents has critical implications for providing talent support in building a world scientific and technological powerhouse.
基金by Undergraduate Innovation and Entrepreneurship Training Program of Anhui Province(S202312216042)Natural Science Key Research Project of Colleges and Universities in Anhui Province(2023AH051816)General Teaching Research Project of Anhui Province(2022jyxm665).
文摘An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinct aspects of adaptability,ornamental characteristics and use traits,in order to establish a comprehensive evaluation model.The results demonstrate that grade I(J≥2.685)exhibits excellent application value,encompassing six species of plants,such asHydrangeamacrophylla‘Endless Summer’;grade II(2.684≤J≤2.420)is also of notable application value,encompassing five species of plants,such asCallistemonrigidus;grade III(2.419≤J≤2.615)is of average application value,including five species of plants,such asCrocosmiacrocosmiflora;grade IV(J≤2.16)is of relatively poor application value.The evaluation results may be utilized as a theoretical reference for the promotion of new and superior varieties in the flower border of Hefei.