In the maintenance work of highway and bridge engineering structures,the fracture delay of high-strength bolts is a content that needs to be focused on and researched.Based on this,the paper analyzes the fracture dela...In the maintenance work of highway and bridge engineering structures,the fracture delay of high-strength bolts is a content that needs to be focused on and researched.Based on this,the paper analyzes the fracture delay of high-strength bolts in highway bridge maintenance,including an overview of the fundamental research on fracture delay and related specific studies.It is hoped that this study can provide scientific reference for the reasonable maintenance of high-strength bolts,so as to ensure the overall maintenance effect of highway bridge projects.展开更多
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex...High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.展开更多
In deep underground mining, the surrounding rocks are very soft with high stress. Their deformation and destruction are serious, and frequent failures occur on the bolt support. The failure mechanism of bolt support i...In deep underground mining, the surrounding rocks are very soft with high stress. Their deformation and destruction are serious, and frequent failures occur on the bolt support. The failure mechanism of bolt support is proposed to solve these problems. A calculation theory is established on the bond strength of the interface between the anchoring agent and surrounding rocks. An analysis is made on the influence law of different mechanical parameters of surrounding rocks on the interfacial bond strength. Based on the research, a new high-strength bolt-grouting technology is developed and applied on site. Besides, some helpful engineering suggestions and measures are proposed. The research shows that the serious deformation and failure, and the lower bond strength are the major factors causing frequent failures of bolt support. So, the bolt could not give full play to its supporting potential. It is also shown that as the integrity, strength, interface dilatancy and stress of surrounding rocks are improved, the bond strength will increase. So, the anchoring force on surrounding rocks can be effectively improved by employing an anchoring agent with high sand content, mechanical anchoring means, or grouting reinforcement. The new technology has advantages in a high strength, imposing pre-tightening force, and giving full play to the bolt supporting potential. Hence, it can improve the control effect on surrounding rocks. All these could be helpful references for the design of bolt support in deep underground mines.展开更多
Expandable rock bolts are widely used in hard rock mines as an efficient ground control product.However, capacity and service life can be significantly reduced if the metallic body is subjected to corrosion.In some ha...Expandable rock bolts are widely used in hard rock mines as an efficient ground control product.However, capacity and service life can be significantly reduced if the metallic body is subjected to corrosion.In some hard rock mines in the U.S., highly corrosive ground conditions exist, and it has been reported that inflatable rock bolts have corroded within a few months after installation.To provide mining industry a cost-effective inflatable bolt and combat the corrosion issues, Jennmar Corporation, Inc.,and its subsidiary Keystone Mining Services, LLC(KMS), analyzed corroded bolt samples, identified root causes, evaluated properties of various coating materials, and developed a new inflatable rock bolt,Python M3^(TM), that is protected with an innovative PyFlexU2^(TM)coating.The new generation Python M3^(TM) features improved steel chemistry for reliable performance, modified profile for better inflation, and surface preparation and coating application.The PyFlexU2^(TM)is impervious to liquid and air, durable, and UV resistant.With a flexible, adhesive, and highly corrosion-resistant undercoating, and a very hard sacrificial surface coating, the PyFlexU2^(TM)coating system provides the Python M3^(TM)superior protection against chemical corrosion and physical scratch damage.The under-coating has exceptional flexibility and adhesion to prevent coating micro-cracks or fractures after bolt inflation and possesses excellent corrosion resistance to acids(pH < 3), alkalis(p H > 11), fuels, and salt solvents.The corrosion and scratch resistant PyFlexU2^(TM)coating offers very effective bolt protection for extra longevity in highly corrosive environments.The Python M3^(TM)coated with PyFlexU2^(TM)has been tested in the most challenging conditions,including laboratory corrosion tests in extreme acidic and basic solvents, rock slurry, and borehole scratch insertion tests.With demonstrated corrosion and scratch resistance, the product has been greatly welcomed by hard rock mines in the West and is currently installed in large scale.This paper identifies the root causes of the bolt corrosion, discusses the analysis process, and details laboratory and underground tests carried out on the Python M3^(TM)coated with PyFlexU2^(TM).The Python M3^(TM)and PyFlexU2^(TM) are subjects covered by pending U.S.Patent Applications assigned to FCI Holdings Delaware, LLC.展开更多
By the increase in Mo content,the addition of microalloying elements V and Nb and by reducing the contents of Mn,P and S based on the composition of steel 42 CrMo,we have developed a 1 300 MPa-grade high strength stee...By the increase in Mo content,the addition of microalloying elements V and Nb and by reducing the contents of Mn,P and S based on the composition of steel 42 CrMo,we have developed a 1 300 MPa-grade high strength steel(ADF1)for bolts.The sustained load bending test,sustained load tensile test and stress corrosion cracking test have been carried out to evaluate the delayed fracture resistance of steel ADFl and commercial steel 42 CrMo.The results showed that steel ADF1 has superior delayed fracture resistance to that of 42 CrMo steel.It's concluded that the superior delayed fracture resistance of ADF1 is mainly due to the increase of tempering temperature,fine homogeneously distributed MC carbide and fine prior austenite grain size.展开更多
Stress relaxation behavior of two turbine bolt steels was evaluated by the manual-controlled tensile stress relaxation test (TSRT) at high temperature. First, feasibility and the procedure of the manual-controlled ten...Stress relaxation behavior of two turbine bolt steels was evaluated by the manual-controlled tensile stress relaxation test (TSRT) at high temperature. First, feasibility and the procedure of the manual-controlled tensile stress relaxation test (TSRT) is discussed and carried out on a general creep testing machine. And then, the experimental results from such type of test were compared to the existing data provided by certain Laboratory U.K. Overall good agreement between the results of manual-controlled TSRT method and the existing data provides confidence in the use of the proposed method in practice. Finally, the experimental results of turbine bolt steels from TSRT were compared with that of bending test. It is observed that great difference exists between the results from two different type stress relaxation tests. It is therefore suggested that the results from TSRT method be adopted in turbine bolt design in engineering.展开更多
The bubbles rise up and burst at the free surface is a complex two-phase process.A free energy lattice Boltzmann method(LBM)model is adopted in this paper to study this phenomenon.The interface capturing technique[Zhe...The bubbles rise up and burst at the free surface is a complex two-phase process.A free energy lattice Boltzmann method(LBM)model is adopted in this paper to study this phenomenon.The interface capturing technique[Zheng et al.,2006]is used to deal with the high density ratio problem.The Laplace law and the air-water interface capturing ability are validated for the multiphase model.The interaction between the single bubble or multiple bubbles and the free surface are studied by the multiphase model.The force acting on the bubble and the evolution of the free surface is studied.Meanwhile,effect of the initial distance between two adjacent bubbles on interaction effects of multiple bubbles is investigated as well.展开更多
In deep ground engineering,the use of high-strength and high-toughness steels for rock bolt can significantly improve its energy absorption capacity.However,the mechanisms and effects of rock loading conditions on thi...In deep ground engineering,the use of high-strength and high-toughness steels for rock bolt can significantly improve its energy absorption capacity.However,the mechanisms and effects of rock loading conditions on this kind of high energy-absorbing steel for rock bolt remain immature.In this study,taking Muzhailing highway tunnel as the background,physically based crystal plasticity simulations were performed to understand the effect of rock loading rate and pretension on the deformation behaviors of twinning induced plasticity(TWIP)steel used for rock bolt.The material physical connecting to the underlying microscopic mechanisms of dislocation glide and deformation twinning were incorporated in numerical modeling.The rock loading conditions were mimicked by the real-time field monitoring data of the NPR bolt/cable equipment installed on the tunnel surrounding rock surface.The results indicate that the bolt rod exhibits pronounced deformation-softening behavior with decrease of the loading rate.There is also a sound deformation-relaxation phenomenon induced by the dramatic decrease of loading rate after pre-tensioning.The high pretension(>600 MPa or 224 k N)can help bolt rod steel resist deformation-softening behavior,especially at low loading rate(<10~(-1)MPa/s or 10~(-2)kN/s).The loading rate was found to be a significant factor affecting deformation-softening behavior while the pretension was found to be the major parameter accounting for the deformation-relaxation scenario.The results provide the theoretical basis and technical support for practical applications.展开更多
By coupling the non-equilibrium extrapolation scheme for boundary condition with the multi-relaxation-time lattice Boltzmann method, this paper finds that the stability of the multi-relaxation-time model can be improv...By coupling the non-equilibrium extrapolation scheme for boundary condition with the multi-relaxation-time lattice Boltzmann method, this paper finds that the stability of the multi-relaxation-time model can be improved greatly, especially on simulating high Reynolds number (Re) flow. As a discovery, the super-stability analysed by Lallemand and Luo is verified and the complex structure of the cavity flow is also exhibited in our numerical simulation when Re is high enough. To the best knowledge of the authors, the maximum of Re which has been investigated by direct numerical simulation is only around 50 000 in the literature; however, this paper can readily extend the maximum to 1000 000 with the above combination.展开更多
In order to establish the design method for T-shaped tensile connector with high strength bolt,the theoretical analysis is carried out. Firstly,it analyzes the performance of the connector and establishes prying force...In order to establish the design method for T-shaped tensile connector with high strength bolt,the theoretical analysis is carried out. Firstly,it analyzes the performance of the connector and establishes prying force calculation model. Based on the model,prying force equation and function between bolt prying force and flange thickness is derived,and the min and max thickness requirement of flange plate under a certain tension load is then obtained. Finally,two simplified design methods of the connector are proposed,which are bolt pulling capacity method and flange plate bending capacity method.展开更多
Rock bolts are extensively utilized in underground engineering as a means of offering support and stability to rock masses in tunnels,mines,and other underground structures.In environments of high ground stress,faults...Rock bolts are extensively utilized in underground engineering as a means of offering support and stability to rock masses in tunnels,mines,and other underground structures.In environments of high ground stress,faults or weak zones can frequently arise in rock formations,presenting a significant challenge for engineering and potentially leading to underground engineering collapse.Rock bolts serve as a crucial structural element for the transmission of tensile stress and are capable of withstanding shear loads to prevent sliding of weak zones within rock mass.Therefore,a complete understanding of the behavior of rock bolts subjected to shear loads is essential.This paper presents a state-of-the-art review of the research progress of rock bolts subjected to shear load in three categories:experiment,numerical simulation,and analytical model.The review focuses on the research studies and developments in this area since the 1970s,providing a comprehensive overview of numerous factors that influence the anchorage performance of rock bolts.These factors include the diameter and angle of the rock bolt installation,rock strength,grouting material,bolt material,borehole diameter,rock bolt preload,normal stress,joint surface roughness and joint expansion angle.The paper reviews the improvement of mechanical parameter setting in numerical simulation of rock bolt shear.Furthermore,it delves into the optimization of the analytical model concerning rock bolt shear theory,approached from the perspectives of both Elastic foundation beam theory coupled with Elastoplasticity theory and Structural mechanic methods.The significance of this review lies in its ability to provide insights into the mechanical behavior of rock bolts.The paper also highlights the limitations of current research and guidelines for further research of rock bolts.展开更多
This study explores the effects of dynamic and static loading on rock bolt performance a key factor in maintaining the structural safety of coal mine roadways susceptible to coal bursts.Employing a housemade load fram...This study explores the effects of dynamic and static loading on rock bolt performance a key factor in maintaining the structural safety of coal mine roadways susceptible to coal bursts.Employing a housemade load frame to simulate various failure scenarios,pretension-impact-pull tests on rock bolts were conducted to scrutinize their dynamic responses under varied static load conditions and their failure traits under combined loads.The experimental results denote that with increased impact energy,maximum and average impact loads on rock bolts escalate significantly under pretension,initiating plastic deformation beyond a certain threshold.Despite minor reductions in the yield load due to impactinduced damage,pretension aids in constraining post-impact deformation rate and fluctuation degree of rock bolts.Moreover,impact-induced plastic deformation causes internal microstructure dislocation,fortifying the stiffness of the rock bolt support system.The magnitude of this fortification is directly related to the plastic deformation induced by the impact.These findings provide crucial guidance for designing rock bolt support in coal mine roadway excavation,emphasizing the necessity to consider both static and dynamic loads for improved safety and efficiency.展开更多
Confining stresses serve as a pivotal determinant in shaping the behavior of grouted rock bolts.Nonetheless,prior investigations have oversimplified the three-dimensional stress state,primarily assuming hydrostatic st...Confining stresses serve as a pivotal determinant in shaping the behavior of grouted rock bolts.Nonetheless,prior investigations have oversimplified the three-dimensional stress state,primarily assuming hydrostatic stress conditions.Under these conditions,it is assumed that the intermediate principal stress(σ_(2))equals the minimum principal stress(σ_(3)).This assumption overlooks the potential variations in magnitudes of in situ stress conditions along all three directions near an underground opening where a rock bolt is installed.In this study,a series of push tests was meticulously conducted under triaxial conditions.These tests involved applying non-uniform confining stresses(σ_(2)≠σ_(3))to cubic specimens,aiming to unveil the previously overlooked influence of intermediate principal stresses on the strength properties of rock bolts.The results show that as the confining stresses increase from zero to higher levels,the pre-failure behavior changes from linear to nonlinear forms,resulting in an increase in initial stiffness from 2.08 kN/mm to 32.51 kN/mm.The load-displacement curves further illuminate distinct post-failure behavior at elevated levels of confining stresses,characterized by enhanced stiffness.Notably,the peak load capacity ranged from 27.9 kN to 46.5 kN as confining stresses advanced from σ_(2)=σ_(3)=0 to σ_(2)=20 MPa and σ_(3)=10 MPa.Additionally,the outcomes highlight an influence of confining stress on the lateral deformation of samples.Lower levels of confinement prompt overall dilation in lateral deformation,while higher confinements maintain a state of shrinkage.Furthermore,diverse failure modes have been identified,intricately tied to the arrangement of confining stresses.Lower confinements tend to induce a splitting mode of failure,whereas higher loads bring about a shift towards a pure interfacial shear-off and shear-crushed failure mechanism.展开更多
A series of direct shear tests under constant normal loading conditions were carried out on specimens of bolted sandstone single-joint treated with different numbers of dryewet cycles.The experimental results show tha...A series of direct shear tests under constant normal loading conditions were carried out on specimens of bolted sandstone single-joint treated with different numbers of dryewet cycles.The experimental results show that the peak shear strength and shear stiffness of bolted sandstone joints were significantly reduced after 12 dryewet cycles.The decrease in the shear strength of rough joints is more significant than that of flat joints.Due to the decrease in the strength of the surrounding rock,the deformation characteristics of the bolts are significantly affected by the number of dryewet cycles performed.With an increase in the number of dryewet cycles,the plastic hinge length of the bolt gradually increases,resulting in an increase in the corresponding shear displacement when the bolt breaks.Compared with the tensileeshear failure mode of the bolts in flat joints,the tensileebending failure mode arises for bolts in rough joints.A shear curve model describing the whole process of bolted rock joints is established based on the deterioration of rock mechanical parameters caused by dry‒wet cycles.The model proposed considers the change in the friction angle of the joint surface with the shear displacement,which is applied to the derivation of the model by introducing the dynamic evolutionary friction angle parameter.The reasonably good agreement between a predicted curve and the corresponding experimental curve indicates that this method can effectively predict the shear strength of a bolted rock joint involving rough joint under dryewet cycling conditions.展开更多
Corrosion is a primary cause of the slippage of friction⁃type high⁃strength bolted(FHSB)T⁃stub connections.This paper attempts to quantify the residual capacity of FHSB T⁃stub connections with corroded nuts.Firstly,co...Corrosion is a primary cause of the slippage of friction⁃type high⁃strength bolted(FHSB)T⁃stub connections.This paper attempts to quantify the residual capacity of FHSB T⁃stub connections with corroded nuts.Firstly,corrosion simulation tests were conducted on 48 manually cut nuts to find out the relationship between the damage degree of nut section and the residual clamping force(RCF)of bolt.Then,static load tests were carried out on 24 FHSB T⁃stub connections with nuts of different degrees of damage to obtain the failure modes.By finite⁃element(FE)models,a comparative analysis was performed on the initial friction load(IFL)and ultimate strength(US)of each connection with corroded nuts.Finally,the parameters of 96 FE models for FHSB T⁃stub connections were analyzed and used to derive the calculation formulas for the degree of damage for each nut and the IFL and US of each connection.The results show that the RCF decay of a bolt is a quadratic function of the equivalent radius loss ratio and the shear failure after nut corrosion;the IFL of each connection had a clear linear correlation with the RCF of the corresponding bolts,and the correlation depends on the applied load and static friction on connecting plate interface induced by the clamping force;the static friction had little impact on the US of the connection;the proposed IFL and US formulas can effectively derive the residual anti⁃slip capacity of FHSB T⁃stub connections from the degree of damage of the corroded nut section.The research results provide a scientific basis for the replacement and maintenance of corroded bolts of FHSB T⁃stub connections.展开更多
In current practice of bolt reaming and anchoring of roadways in soft coal and rock mass,resin cartridges bend easily under the strong pushing and stirring of bolts,and the resin accumulates in the bolt-reamed area an...In current practice of bolt reaming and anchoring of roadways in soft coal and rock mass,resin cartridges bend easily under the strong pushing and stirring of bolts,and the resin accumulates in the bolt-reamed area and does not participate in the stirring.As a result,bolts encounter high drilling resistance and cannot reach the bottom of drillholes.The effective anchorage length is far less than the actual anchorage length.Bolts are not centered,and the shear is misaligned at the joint surface in the reaming area,which leads to cracking of the whole anchoring solid and large shear deformation of bolts.This study systematically analyzes the characteristics of roadway bolt reaming and anchoring.The influences of resin stirring force,bolt pull-out force,and reamingeanchoring solid strength on reamingeanchoring performance were analyzed theoretically.The main purpose is to develop a device that enhances reaming and anchoring.The mechanism through which the device strengthens the reamingeanchoring solid was analyzed theoretically.Numerical simulation and experiments were carried out to verify the improved performance of the small-pore reaming and anchoring using the proposed technology.The results showed that the stirring migration rate of the resin cartridge is greatly improved by adding the device to bolts.The reaction rate of the anchoring mixture,stirring pressure,pull-out force of the reaming and anchoring system,bolt concentricity,and shear and compressive strengths of the anchoring solid are also enhanced in the reaming area.This ensures that the resin cartridge in the reaming area is completely stirred,which greatly improves the shear resistance of the reamingeanchoring solid.Meanwhile,the drilling performance,torsional force,and stirring efficiency of bolts are maximized and prevail over those of conventional bolts.展开更多
High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. How...High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell activity.The Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal conditions.Furthermore, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results provide important insights into the heat response mechanism of CsSPT in cucumber and its potential as a target for breeding heat-resistant crops.展开更多
High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillim...High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.展开更多
This article reviews the current status on the dynamic behavior of highly stressed rocks under disturbances.Firstly,the experimental apparatus,methods,and theories related to the disturbance dynamics of deep,high-stre...This article reviews the current status on the dynamic behavior of highly stressed rocks under disturbances.Firstly,the experimental apparatus,methods,and theories related to the disturbance dynamics of deep,high-stress rock are reviewed,followed by the introduction of scholars’research on deep rock deformation and failure from an energy perspective.Subsequently,with a backdrop of highstress phenomena in deep hard rock,such as rock bursts and core disking,we delve into the current state of research on rock microstructure analysis and residual stresses from the perspective of studying the energy storage mechanisms in rocks.Thereafter,the current state of research on the mechanical response and the energy dissipation of highly stressed rock formations is briefly retrospected.Finally,the insufficient aspects in the current research on the disturbance and failure mechanisms in deep,highly stressed rock formations are summarized,and prospects for future research are provided.This work provides new avenues for the research on the mechanical response and damage-fracture mechanisms of rocks under high-stress conditions.展开更多
Following publication of the original article[1],the authors noticed a mistake in the Supplementary file,more specifically in figures S11 and S12 where they used by mistake the same sub-figures.The original article[1]...Following publication of the original article[1],the authors noticed a mistake in the Supplementary file,more specifically in figures S11 and S12 where they used by mistake the same sub-figures.The original article[1]has been corrected.展开更多
文摘In the maintenance work of highway and bridge engineering structures,the fracture delay of high-strength bolts is a content that needs to be focused on and researched.Based on this,the paper analyzes the fracture delay of high-strength bolts in highway bridge maintenance,including an overview of the fundamental research on fracture delay and related specific studies.It is hoped that this study can provide scientific reference for the reasonable maintenance of high-strength bolts,so as to ensure the overall maintenance effect of highway bridge projects.
基金supported by a grant of the M.D.-Ph.D./Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(to HK)+3 种基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSITMinistry of Science and ICT)(NRF2019R1A5A2026045 and NRF-2021R1F1A1061819)a grant from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(HR21C1003)New Faculty Research Fund of Ajou University School of Medicine(to JYC)。
文摘High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.
基金Projects(51304125,51379114)supported by the National Natural Science Foundation of ChinaProject(BS2013NJ004)supported by Award Fund for Outstanding Young and Middle-Aged Scientist of Shangdong Province,ChinaProject(201301004)supported by the Innovation Fund for Postdoctor of Shandong Province,China
文摘In deep underground mining, the surrounding rocks are very soft with high stress. Their deformation and destruction are serious, and frequent failures occur on the bolt support. The failure mechanism of bolt support is proposed to solve these problems. A calculation theory is established on the bond strength of the interface between the anchoring agent and surrounding rocks. An analysis is made on the influence law of different mechanical parameters of surrounding rocks on the interfacial bond strength. Based on the research, a new high-strength bolt-grouting technology is developed and applied on site. Besides, some helpful engineering suggestions and measures are proposed. The research shows that the serious deformation and failure, and the lower bond strength are the major factors causing frequent failures of bolt support. So, the bolt could not give full play to its supporting potential. It is also shown that as the integrity, strength, interface dilatancy and stress of surrounding rocks are improved, the bond strength will increase. So, the anchoring force on surrounding rocks can be effectively improved by employing an anchoring agent with high sand content, mechanical anchoring means, or grouting reinforcement. The new technology has advantages in a high strength, imposing pre-tightening force, and giving full play to the bolt supporting potential. Hence, it can improve the control effect on surrounding rocks. All these could be helpful references for the design of bolt support in deep underground mines.
文摘Expandable rock bolts are widely used in hard rock mines as an efficient ground control product.However, capacity and service life can be significantly reduced if the metallic body is subjected to corrosion.In some hard rock mines in the U.S., highly corrosive ground conditions exist, and it has been reported that inflatable rock bolts have corroded within a few months after installation.To provide mining industry a cost-effective inflatable bolt and combat the corrosion issues, Jennmar Corporation, Inc.,and its subsidiary Keystone Mining Services, LLC(KMS), analyzed corroded bolt samples, identified root causes, evaluated properties of various coating materials, and developed a new inflatable rock bolt,Python M3^(TM), that is protected with an innovative PyFlexU2^(TM)coating.The new generation Python M3^(TM) features improved steel chemistry for reliable performance, modified profile for better inflation, and surface preparation and coating application.The PyFlexU2^(TM)is impervious to liquid and air, durable, and UV resistant.With a flexible, adhesive, and highly corrosion-resistant undercoating, and a very hard sacrificial surface coating, the PyFlexU2^(TM)coating system provides the Python M3^(TM)superior protection against chemical corrosion and physical scratch damage.The under-coating has exceptional flexibility and adhesion to prevent coating micro-cracks or fractures after bolt inflation and possesses excellent corrosion resistance to acids(pH < 3), alkalis(p H > 11), fuels, and salt solvents.The corrosion and scratch resistant PyFlexU2^(TM)coating offers very effective bolt protection for extra longevity in highly corrosive environments.The Python M3^(TM)coated with PyFlexU2^(TM)has been tested in the most challenging conditions,including laboratory corrosion tests in extreme acidic and basic solvents, rock slurry, and borehole scratch insertion tests.With demonstrated corrosion and scratch resistance, the product has been greatly welcomed by hard rock mines in the West and is currently installed in large scale.This paper identifies the root causes of the bolt corrosion, discusses the analysis process, and details laboratory and underground tests carried out on the Python M3^(TM)coated with PyFlexU2^(TM).The Python M3^(TM)and PyFlexU2^(TM) are subjects covered by pending U.S.Patent Applications assigned to FCI Holdings Delaware, LLC.
基金Sponsored by National Key Fundamental Research Project(G1998061503)
文摘By the increase in Mo content,the addition of microalloying elements V and Nb and by reducing the contents of Mn,P and S based on the composition of steel 42 CrMo,we have developed a 1 300 MPa-grade high strength steel(ADF1)for bolts.The sustained load bending test,sustained load tensile test and stress corrosion cracking test have been carried out to evaluate the delayed fracture resistance of steel ADFl and commercial steel 42 CrMo.The results showed that steel ADF1 has superior delayed fracture resistance to that of 42 CrMo steel.It's concluded that the superior delayed fracture resistance of ADF1 is mainly due to the increase of tempering temperature,fine homogeneously distributed MC carbide and fine prior austenite grain size.
文摘Stress relaxation behavior of two turbine bolt steels was evaluated by the manual-controlled tensile stress relaxation test (TSRT) at high temperature. First, feasibility and the procedure of the manual-controlled tensile stress relaxation test (TSRT) is discussed and carried out on a general creep testing machine. And then, the experimental results from such type of test were compared to the existing data provided by certain Laboratory U.K. Overall good agreement between the results of manual-controlled TSRT method and the existing data provides confidence in the use of the proposed method in practice. Finally, the experimental results of turbine bolt steels from TSRT were compared with that of bending test. It is observed that great difference exists between the results from two different type stress relaxation tests. It is therefore suggested that the results from TSRT method be adopted in turbine bolt design in engineering.
基金supported by the National Natural Science Foundation of China (11672081)
文摘The bubbles rise up and burst at the free surface is a complex two-phase process.A free energy lattice Boltzmann method(LBM)model is adopted in this paper to study this phenomenon.The interface capturing technique[Zheng et al.,2006]is used to deal with the high density ratio problem.The Laplace law and the air-water interface capturing ability are validated for the multiphase model.The interaction between the single bubble or multiple bubbles and the free surface are studied by the multiphase model.The force acting on the bubble and the evolution of the free surface is studied.Meanwhile,effect of the initial distance between two adjacent bubbles on interaction effects of multiple bubbles is investigated as well.
基金the National Natural Science Foundation of China(Grant No.41941018)the Science and Technology Major Project of Gansu Province(Grant No.19ZD2GA005)the Research Institute for Deep Underground Science and Engineering Foundation(Grant No.XD2021023)。
文摘In deep ground engineering,the use of high-strength and high-toughness steels for rock bolt can significantly improve its energy absorption capacity.However,the mechanisms and effects of rock loading conditions on this kind of high energy-absorbing steel for rock bolt remain immature.In this study,taking Muzhailing highway tunnel as the background,physically based crystal plasticity simulations were performed to understand the effect of rock loading rate and pretension on the deformation behaviors of twinning induced plasticity(TWIP)steel used for rock bolt.The material physical connecting to the underlying microscopic mechanisms of dislocation glide and deformation twinning were incorporated in numerical modeling.The rock loading conditions were mimicked by the real-time field monitoring data of the NPR bolt/cable equipment installed on the tunnel surrounding rock surface.The results indicate that the bolt rod exhibits pronounced deformation-softening behavior with decrease of the loading rate.There is also a sound deformation-relaxation phenomenon induced by the dramatic decrease of loading rate after pre-tensioning.The high pretension(>600 MPa or 224 k N)can help bolt rod steel resist deformation-softening behavior,especially at low loading rate(<10~(-1)MPa/s or 10~(-2)kN/s).The loading rate was found to be a significant factor affecting deformation-softening behavior while the pretension was found to be the major parameter accounting for the deformation-relaxation scenario.The results provide the theoretical basis and technical support for practical applications.
基金Project supported by the National Natural Science Foundation of China (Grant No 70271069).
文摘By coupling the non-equilibrium extrapolation scheme for boundary condition with the multi-relaxation-time lattice Boltzmann method, this paper finds that the stability of the multi-relaxation-time model can be improved greatly, especially on simulating high Reynolds number (Re) flow. As a discovery, the super-stability analysed by Lallemand and Luo is verified and the complex structure of the cavity flow is also exhibited in our numerical simulation when Re is high enough. To the best knowledge of the authors, the maximum of Re which has been investigated by direct numerical simulation is only around 50 000 in the literature; however, this paper can readily extend the maximum to 1000 000 with the above combination.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51408620)the Major Science and Technology Project during the Third Five-Year Plan Period of China MCC(Grant No.0012013010)
文摘In order to establish the design method for T-shaped tensile connector with high strength bolt,the theoretical analysis is carried out. Firstly,it analyzes the performance of the connector and establishes prying force calculation model. Based on the model,prying force equation and function between bolt prying force and flange thickness is derived,and the min and max thickness requirement of flange plate under a certain tension load is then obtained. Finally,two simplified design methods of the connector are proposed,which are bolt pulling capacity method and flange plate bending capacity method.
基金The Project(52174101)supported by the National Natural Science Foundation of ChinaThe Project(2023A1515011634)supported by Guangdong Basic and Applied Basic Research Foundation.
文摘Rock bolts are extensively utilized in underground engineering as a means of offering support and stability to rock masses in tunnels,mines,and other underground structures.In environments of high ground stress,faults or weak zones can frequently arise in rock formations,presenting a significant challenge for engineering and potentially leading to underground engineering collapse.Rock bolts serve as a crucial structural element for the transmission of tensile stress and are capable of withstanding shear loads to prevent sliding of weak zones within rock mass.Therefore,a complete understanding of the behavior of rock bolts subjected to shear loads is essential.This paper presents a state-of-the-art review of the research progress of rock bolts subjected to shear load in three categories:experiment,numerical simulation,and analytical model.The review focuses on the research studies and developments in this area since the 1970s,providing a comprehensive overview of numerous factors that influence the anchorage performance of rock bolts.These factors include the diameter and angle of the rock bolt installation,rock strength,grouting material,bolt material,borehole diameter,rock bolt preload,normal stress,joint surface roughness and joint expansion angle.The paper reviews the improvement of mechanical parameter setting in numerical simulation of rock bolt shear.Furthermore,it delves into the optimization of the analytical model concerning rock bolt shear theory,approached from the perspectives of both Elastic foundation beam theory coupled with Elastoplasticity theory and Structural mechanic methods.The significance of this review lies in its ability to provide insights into the mechanical behavior of rock bolts.The paper also highlights the limitations of current research and guidelines for further research of rock bolts.
基金supported by the National Natural Science Foundation of China(Nos.52074151,51927807,and 52274123)Tiandi Science and Technology Co.,Ltd.(No.2022-2-TDMS012)。
文摘This study explores the effects of dynamic and static loading on rock bolt performance a key factor in maintaining the structural safety of coal mine roadways susceptible to coal bursts.Employing a housemade load frame to simulate various failure scenarios,pretension-impact-pull tests on rock bolts were conducted to scrutinize their dynamic responses under varied static load conditions and their failure traits under combined loads.The experimental results denote that with increased impact energy,maximum and average impact loads on rock bolts escalate significantly under pretension,initiating plastic deformation beyond a certain threshold.Despite minor reductions in the yield load due to impactinduced damage,pretension aids in constraining post-impact deformation rate and fluctuation degree of rock bolts.Moreover,impact-induced plastic deformation causes internal microstructure dislocation,fortifying the stiffness of the rock bolt support system.The magnitude of this fortification is directly related to the plastic deformation induced by the impact.These findings provide crucial guidance for designing rock bolt support in coal mine roadway excavation,emphasizing the necessity to consider both static and dynamic loads for improved safety and efficiency.
文摘Confining stresses serve as a pivotal determinant in shaping the behavior of grouted rock bolts.Nonetheless,prior investigations have oversimplified the three-dimensional stress state,primarily assuming hydrostatic stress conditions.Under these conditions,it is assumed that the intermediate principal stress(σ_(2))equals the minimum principal stress(σ_(3)).This assumption overlooks the potential variations in magnitudes of in situ stress conditions along all three directions near an underground opening where a rock bolt is installed.In this study,a series of push tests was meticulously conducted under triaxial conditions.These tests involved applying non-uniform confining stresses(σ_(2)≠σ_(3))to cubic specimens,aiming to unveil the previously overlooked influence of intermediate principal stresses on the strength properties of rock bolts.The results show that as the confining stresses increase from zero to higher levels,the pre-failure behavior changes from linear to nonlinear forms,resulting in an increase in initial stiffness from 2.08 kN/mm to 32.51 kN/mm.The load-displacement curves further illuminate distinct post-failure behavior at elevated levels of confining stresses,characterized by enhanced stiffness.Notably,the peak load capacity ranged from 27.9 kN to 46.5 kN as confining stresses advanced from σ_(2)=σ_(3)=0 to σ_(2)=20 MPa and σ_(3)=10 MPa.Additionally,the outcomes highlight an influence of confining stress on the lateral deformation of samples.Lower levels of confinement prompt overall dilation in lateral deformation,while higher confinements maintain a state of shrinkage.Furthermore,diverse failure modes have been identified,intricately tied to the arrangement of confining stresses.Lower confinements tend to induce a splitting mode of failure,whereas higher loads bring about a shift towards a pure interfacial shear-off and shear-crushed failure mechanism.
基金the Natural Science Foundation of China(Grant Nos.42302314 and 52078427)the Open foundation of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Grant No.SKLGP2022K001).
文摘A series of direct shear tests under constant normal loading conditions were carried out on specimens of bolted sandstone single-joint treated with different numbers of dryewet cycles.The experimental results show that the peak shear strength and shear stiffness of bolted sandstone joints were significantly reduced after 12 dryewet cycles.The decrease in the shear strength of rough joints is more significant than that of flat joints.Due to the decrease in the strength of the surrounding rock,the deformation characteristics of the bolts are significantly affected by the number of dryewet cycles performed.With an increase in the number of dryewet cycles,the plastic hinge length of the bolt gradually increases,resulting in an increase in the corresponding shear displacement when the bolt breaks.Compared with the tensileeshear failure mode of the bolts in flat joints,the tensileebending failure mode arises for bolts in rough joints.A shear curve model describing the whole process of bolted rock joints is established based on the deterioration of rock mechanical parameters caused by dry‒wet cycles.The model proposed considers the change in the friction angle of the joint surface with the shear displacement,which is applied to the derivation of the model by introducing the dynamic evolutionary friction angle parameter.The reasonably good agreement between a predicted curve and the corresponding experimental curve indicates that this method can effectively predict the shear strength of a bolted rock joint involving rough joint under dryewet cycling conditions.
文摘Corrosion is a primary cause of the slippage of friction⁃type high⁃strength bolted(FHSB)T⁃stub connections.This paper attempts to quantify the residual capacity of FHSB T⁃stub connections with corroded nuts.Firstly,corrosion simulation tests were conducted on 48 manually cut nuts to find out the relationship between the damage degree of nut section and the residual clamping force(RCF)of bolt.Then,static load tests were carried out on 24 FHSB T⁃stub connections with nuts of different degrees of damage to obtain the failure modes.By finite⁃element(FE)models,a comparative analysis was performed on the initial friction load(IFL)and ultimate strength(US)of each connection with corroded nuts.Finally,the parameters of 96 FE models for FHSB T⁃stub connections were analyzed and used to derive the calculation formulas for the degree of damage for each nut and the IFL and US of each connection.The results show that the RCF decay of a bolt is a quadratic function of the equivalent radius loss ratio and the shear failure after nut corrosion;the IFL of each connection had a clear linear correlation with the RCF of the corresponding bolts,and the correlation depends on the applied load and static friction on connecting plate interface induced by the clamping force;the static friction had little impact on the US of the connection;the proposed IFL and US formulas can effectively derive the residual anti⁃slip capacity of FHSB T⁃stub connections from the degree of damage of the corroded nut section.The research results provide a scientific basis for the replacement and maintenance of corroded bolts of FHSB T⁃stub connections.
基金supported by the National Natural Science Foundation of China-Liaoning Joint Fund Key Project(Grant No.U1908222)the National Natural Science Foundation of China Youth Science Fund(Grant No.52104087).
文摘In current practice of bolt reaming and anchoring of roadways in soft coal and rock mass,resin cartridges bend easily under the strong pushing and stirring of bolts,and the resin accumulates in the bolt-reamed area and does not participate in the stirring.As a result,bolts encounter high drilling resistance and cannot reach the bottom of drillholes.The effective anchorage length is far less than the actual anchorage length.Bolts are not centered,and the shear is misaligned at the joint surface in the reaming area,which leads to cracking of the whole anchoring solid and large shear deformation of bolts.This study systematically analyzes the characteristics of roadway bolt reaming and anchoring.The influences of resin stirring force,bolt pull-out force,and reamingeanchoring solid strength on reamingeanchoring performance were analyzed theoretically.The main purpose is to develop a device that enhances reaming and anchoring.The mechanism through which the device strengthens the reamingeanchoring solid was analyzed theoretically.Numerical simulation and experiments were carried out to verify the improved performance of the small-pore reaming and anchoring using the proposed technology.The results showed that the stirring migration rate of the resin cartridge is greatly improved by adding the device to bolts.The reaction rate of the anchoring mixture,stirring pressure,pull-out force of the reaming and anchoring system,bolt concentricity,and shear and compressive strengths of the anchoring solid are also enhanced in the reaming area.This ensures that the resin cartridge in the reaming area is completely stirred,which greatly improves the shear resistance of the reamingeanchoring solid.Meanwhile,the drilling performance,torsional force,and stirring efficiency of bolts are maximized and prevail over those of conventional bolts.
基金supported by grants from the Key Project of Guangzhou (Grant No.202103000085)National Natural Science Foundation of China (Grant No.31902014)+1 种基金Guangzhou Science and Technology Project (Grant No.202102020502)Fruit and Vegetable Industry System Innovation Team Project of Guangdong (Grant No.2021KJ110)。
文摘High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell activity.The Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal conditions.Furthermore, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results provide important insights into the heat response mechanism of CsSPT in cucumber and its potential as a target for breeding heat-resistant crops.
基金support of the National Natural Science Foundation of China(Nos.U20A6001,12002190,11972207,and 11921002)the Fundamental Research Funds for the Central Universities,China(No.SWUKQ22029)the Chongqing Natural Science Foundation of China(No.CSTB2022NSCQ-MSX1635).
文摘High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.
基金supported by the National Natural Science Foundation of China(Nos.52004015,51874014,and 52311530070)the fellowship of China National Postdoctoral Program for Innovative Talents(No.BX2021033)+1 种基金the fellowship of China Postdoctoral Science Foundation(Nos.2021M700389 and 2023T0025)the Fundamental Research Funds for the Central Universities of China(No.FRF-IDRY-20-003,Interdisciplinary Research Project for Young Teachers of USTB).
文摘This article reviews the current status on the dynamic behavior of highly stressed rocks under disturbances.Firstly,the experimental apparatus,methods,and theories related to the disturbance dynamics of deep,high-stress rock are reviewed,followed by the introduction of scholars’research on deep rock deformation and failure from an energy perspective.Subsequently,with a backdrop of highstress phenomena in deep hard rock,such as rock bursts and core disking,we delve into the current state of research on rock microstructure analysis and residual stresses from the perspective of studying the energy storage mechanisms in rocks.Thereafter,the current state of research on the mechanical response and the energy dissipation of highly stressed rock formations is briefly retrospected.Finally,the insufficient aspects in the current research on the disturbance and failure mechanisms in deep,highly stressed rock formations are summarized,and prospects for future research are provided.This work provides new avenues for the research on the mechanical response and damage-fracture mechanisms of rocks under high-stress conditions.
文摘Following publication of the original article[1],the authors noticed a mistake in the Supplementary file,more specifically in figures S11 and S12 where they used by mistake the same sub-figures.The original article[1]has been corrected.