Objective:To systematically evaluate the clinical effect of pediatric massage on chronic persistent asthma in children.Methods:We searched relevant literatures through PubMed database,Embase database,Cochrane library,...Objective:To systematically evaluate the clinical effect of pediatric massage on chronic persistent asthma in children.Methods:We searched relevant literatures through PubMed database,Embase database,Cochrane library,Wanfang database,CNKI and VIP database to screen randomized controlled trials that met the inclusion criteria.According to Cochrane bias risk assessment criteria,the quality of the included literature was evaluated.Finally,Stata 15.1 software was used to analyze the extracted data.Results:A total of 18 studies,1656 participants were included in our Meta analysis.The pooled results showed that pediatric massage therapy could significantly increase clinical efficacy[OR=3.95(2.88,5.41),P<0.001],improve lung function[FEV1:SMD=0.90(0.20,1.61),P=0.012]and[PEF:SMD=0.74(0.58,0.91),P<0.001],reduce asthma attacks[SMD=1.25(-1.63,-0.87),P<0.001]and upper respiratory tract infections[SMD=-1.39(-1.63,-1.15),P<0.001];Conclusion:Pediatric massage therapy has a significant effect in the treatment of chronic persistent asthma in children.It can not only improve the pulmonary function,but also effectively prevent the onset of asthma.展开更多
目的探讨降气平喘固本汤联合穴位推拿治疗儿童支气管哮喘虚哮证的效果。方法选取2018年11月—2023年6月期间北京中医医院怀柔医院收治的支气管哮喘虚哮证患儿102例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各51例。对...目的探讨降气平喘固本汤联合穴位推拿治疗儿童支气管哮喘虚哮证的效果。方法选取2018年11月—2023年6月期间北京中医医院怀柔医院收治的支气管哮喘虚哮证患儿102例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各51例。对照组采取常规西医治疗,研究组在对照组基础上采取降气平喘固本汤联合穴位推拿,共治疗4周。观察比较两组患儿临床疗效、不良反应发生率,治疗前后中医证候积分、肺功能[最大呼气峰流速(Peak expiratory flow,PEF)、第1秒用力呼气量(Forced expiratory volume in one second,FEV1)、用力肺活量(Forced vital capacity,FVC)]、免疫功能[白细胞介素-13(Interleukin-13,IL-13)、白细胞介素-12(Interleukin-12,IL-12)、白细胞介素-4(Interleukin-4,IL-4)、干扰素-γ(Interferon-gamma,IFN-γ)]水平。结果治疗后研究组临床总有效率92.16%(47/51)明显高于对照组78.43%(40/51),差异有统计学意义(P<0.05)。治疗后两组患儿喉中哮鸣、形寒肢冷、咳痰无力、腰膝酸软、神疲乏力、声低气短分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿肺功能PEF、FEV1、FVC水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组肺功能PEF、FEV1、FVC水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿免疫功能IL-13、IL-4水平均较治疗前降低,IL-12、IFN-γ水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组免疫功能IL-13、IL-4水平均明显低于对照组,IL-12、IFN-γ水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率5.88%(3/51)与对照组3.92%(2/51)比较,差异无统计学意义(P>0.05)。结论采取降气平喘固本汤联合穴位推拿治疗支气管哮喘虚哮证,可有效缓解患儿临床症状,提升治疗效果,且具有安全性。展开更多
Objective:We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1,TLR2,and TLR4 on macrophages.Methods:One hundred sixty pediatric patients with...Objective:We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1,TLR2,and TLR4 on macrophages.Methods:One hundred sixty pediatric patients with persistent chronic asthma were col-lected,and divided into treatment and control groups of 80 each in strict accordance with the principle of random allocation.The patients in the control group received general nebulizer therapy,and the patients in the treatment group received infantile massage.Both groups of patients were observed for 3 months with respect to the following indicators:the frequency of asthmatic attacks;the frequency of respiratory tract infections(RTIs);C-ACT rating;and the PEF%of peripheral blood(PB)before and after treatment to detect macrophage TLR1,TLR2,and TLR4.Results:After treatment,the frequency of asthmatic attacks,frequency of RTIs,C-ACT rat-ing,and the PEF%and macrophage TLR1,TLR2,and TLR4 expression of fluorescence intensity in the treatment group showed a statistically significant increase when compared with the control group(P<0.05).Conclusion:Pediatric massage can improve the clinical symptoms of pediatric asthma by up-regulating the expression of macrophage TLR1,TLR2,and TLR4.展开更多
基金It was supported by Social Science and Technology Development Project of Dongguan with number Dongke[2018]no.95.
文摘Objective:To systematically evaluate the clinical effect of pediatric massage on chronic persistent asthma in children.Methods:We searched relevant literatures through PubMed database,Embase database,Cochrane library,Wanfang database,CNKI and VIP database to screen randomized controlled trials that met the inclusion criteria.According to Cochrane bias risk assessment criteria,the quality of the included literature was evaluated.Finally,Stata 15.1 software was used to analyze the extracted data.Results:A total of 18 studies,1656 participants were included in our Meta analysis.The pooled results showed that pediatric massage therapy could significantly increase clinical efficacy[OR=3.95(2.88,5.41),P<0.001],improve lung function[FEV1:SMD=0.90(0.20,1.61),P=0.012]and[PEF:SMD=0.74(0.58,0.91),P<0.001],reduce asthma attacks[SMD=1.25(-1.63,-0.87),P<0.001]and upper respiratory tract infections[SMD=-1.39(-1.63,-1.15),P<0.001];Conclusion:Pediatric massage therapy has a significant effect in the treatment of chronic persistent asthma in children.It can not only improve the pulmonary function,but also effectively prevent the onset of asthma.
文摘目的探讨降气平喘固本汤联合穴位推拿治疗儿童支气管哮喘虚哮证的效果。方法选取2018年11月—2023年6月期间北京中医医院怀柔医院收治的支气管哮喘虚哮证患儿102例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各51例。对照组采取常规西医治疗,研究组在对照组基础上采取降气平喘固本汤联合穴位推拿,共治疗4周。观察比较两组患儿临床疗效、不良反应发生率,治疗前后中医证候积分、肺功能[最大呼气峰流速(Peak expiratory flow,PEF)、第1秒用力呼气量(Forced expiratory volume in one second,FEV1)、用力肺活量(Forced vital capacity,FVC)]、免疫功能[白细胞介素-13(Interleukin-13,IL-13)、白细胞介素-12(Interleukin-12,IL-12)、白细胞介素-4(Interleukin-4,IL-4)、干扰素-γ(Interferon-gamma,IFN-γ)]水平。结果治疗后研究组临床总有效率92.16%(47/51)明显高于对照组78.43%(40/51),差异有统计学意义(P<0.05)。治疗后两组患儿喉中哮鸣、形寒肢冷、咳痰无力、腰膝酸软、神疲乏力、声低气短分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿肺功能PEF、FEV1、FVC水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组肺功能PEF、FEV1、FVC水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿免疫功能IL-13、IL-4水平均较治疗前降低,IL-12、IFN-γ水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组免疫功能IL-13、IL-4水平均明显低于对照组,IL-12、IFN-γ水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率5.88%(3/51)与对照组3.92%(2/51)比较,差异无统计学意义(P>0.05)。结论采取降气平喘固本汤联合穴位推拿治疗支气管哮喘虚哮证,可有效缓解患儿临床症状,提升治疗效果,且具有安全性。
基金Funded by International Science and Technology Cooperation Projects of China[2013DFG31080]National Natural Science Foundation of China[81303046]。
文摘Objective:We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1,TLR2,and TLR4 on macrophages.Methods:One hundred sixty pediatric patients with persistent chronic asthma were col-lected,and divided into treatment and control groups of 80 each in strict accordance with the principle of random allocation.The patients in the control group received general nebulizer therapy,and the patients in the treatment group received infantile massage.Both groups of patients were observed for 3 months with respect to the following indicators:the frequency of asthmatic attacks;the frequency of respiratory tract infections(RTIs);C-ACT rating;and the PEF%of peripheral blood(PB)before and after treatment to detect macrophage TLR1,TLR2,and TLR4.Results:After treatment,the frequency of asthmatic attacks,frequency of RTIs,C-ACT rat-ing,and the PEF%and macrophage TLR1,TLR2,and TLR4 expression of fluorescence intensity in the treatment group showed a statistically significant increase when compared with the control group(P<0.05).Conclusion:Pediatric massage can improve the clinical symptoms of pediatric asthma by up-regulating the expression of macrophage TLR1,TLR2,and TLR4.
