In this paper,we offer a review of type-3 fuzzy logic systems and their applications in control.The main objective of this work is to observe and analyze in detail the applications in the control area using type-3 fuz...In this paper,we offer a review of type-3 fuzzy logic systems and their applications in control.The main objective of this work is to observe and analyze in detail the applications in the control area using type-3 fuzzy logic systems.In this case,we review their most important applications in control and other related topics with type-3 fuzzy systems.Intelligent algorithms have been receiving increasing attention in control and for this reason a review in this area is important.This paper reviews the main applications that make use of Intelligent Computing methods.Specifically,type-3 fuzzy logic systems.The aim of this research is to be able to appreciate,in detail,the applications in control systems and to point out the scientific trends in the use of Intelligent Computing techniques.This is done with the construction and visualization of bibliometric networks,developed with VosViewer Software,which it is a free Java-based program,mainly intended to be used for analyzing and visualizing bibliometric networks.With this tool,we can create maps of publications,authors,or journals based on a co-citation network or construct maps of keywords,countries based on a co-occurrence networks,research groups,etc.展开更多
As a promising ultra-wide bandgap semiconductor material,gallium oxide(Ga_(2)O_(3))is attracting extensive attention of researchers due to its feasible growth process,appropriate bandgap of 4.4 e V-5.3 e V allowing fo...As a promising ultra-wide bandgap semiconductor material,gallium oxide(Ga_(2)O_(3))is attracting extensive attention of researchers due to its feasible growth process,appropriate bandgap of 4.4 e V-5.3 e V allowing for deep-ultraviolet(deepUV)detection,good physical and chemical stability,high breakdown field strength and electron mobility,etc.Different from the strict processes for controllable crystalline Ga_(2)O_(3)(usually refer to as stable monoclinicβ-Ga_(2)O_(3)),amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))film can be prepared uniformly at low temperature on a large-area deposition substrate,suggesting great advantages such as low manufacturing cost and excellent flexibility,dispensing with high-temperature and high vacuum techniques.Thus,a-Ga_(2)O_(3)extremely facilitates important applications in various applied fields.Therefore,in this concise review,we summarize several major deposition methods for a-Ga_(2)O_(3)films,of which the characteristics are discussed.Additionally,potential methods to optimize the film properties are proposed by right of the inspiration from some recent studies.Subsequently,the applications of a-Ga_(2)O_(3)thin films,e.g.,in photodetectors,resistive random access memories(RRAMs)and gas sensors,are represented with a fruitful discussion of their structures and operating mechanisms.展开更多
目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学...目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。展开更多
Sb<sub>2</sub>S<sub>3</sub> has gained tremendous research recently for thin film solar cell absorber material because of their easy synthesis, unique electrical and optical properties. The sto...Sb<sub>2</sub>S<sub>3</sub> has gained tremendous research recently for thin film solar cell absorber material because of their easy synthesis, unique electrical and optical properties. The stoichiometry and composition of electroless Sb<sub>2</sub>S<sub>3</sub> thin films were analyzed using XPS depth profile studies. The surface layers were found nearly stoichiometric. On the other hand, the inner layer was rich in antimony composition making it more conductive electrically.展开更多
光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米...光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米材料进行XRD、SEM、TEM、XPS及UV-Vis DRS表征,并深入探讨其在可见光下灭活大肠杆菌(E.coli)的性能和机制。结果表明,Ag纳米粒均匀且牢固地负载在SCN表面,纳米材料表现出显著增强的可见光响应能力。当负载量为6%时,Ag/SCN-6呈现出最佳的光催化灭菌活性,60 min内能够将6.2 lg CFU·mL^(-1)的E.coli全部灭活。自由基捕获实验结果表明,超氧自由基(·O-2)是灭活过程中最主要活性物种,它协同光生空穴(h+)和羟基自由基(·OH)主导了光催化抗菌的进程。展开更多
Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s dis...Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s disease patients.Nonetheless,the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear.Evidence suggests that signal transduction and activator of transcription-3(STAT3)is associated with modulating synaptic plasticity,cell apoptosis,and cognitive function.Using luciferase reporter assays,electrophoretic mobility shift assays,western blotting,and immunofluorescence,we found that human tau-N368 accumulation inhibited STAT3 activity by suppressing STAT3 translocation into the nucleus.Overexpression of STAT3 improved tau-N368-induced synaptic deficits and reduced neuronal loss,thereby improving the cognitive deficits in tau-N368 mice.Moreover,in tau-N368 mice,activation of STAT3 increased N-methyl-D-aspartic acid receptor levels,decreased Bcl-2 levels,reversed synaptic damage and neuronal loss,and thereby alleviated cognitive deficits caused by tau-N368.Taken together,STAT3 plays a critical role in truncated tau-related neuropathological changes.This indicates a new mechanism behind the effect of tau-N368 on synapses and memory deficits.STAT3 can be used as a new molecular target to treat tau-N368-induced protein pathology.展开更多
文摘In this paper,we offer a review of type-3 fuzzy logic systems and their applications in control.The main objective of this work is to observe and analyze in detail the applications in the control area using type-3 fuzzy logic systems.In this case,we review their most important applications in control and other related topics with type-3 fuzzy systems.Intelligent algorithms have been receiving increasing attention in control and for this reason a review in this area is important.This paper reviews the main applications that make use of Intelligent Computing methods.Specifically,type-3 fuzzy logic systems.The aim of this research is to be able to appreciate,in detail,the applications in control systems and to point out the scientific trends in the use of Intelligent Computing techniques.This is done with the construction and visualization of bibliometric networks,developed with VosViewer Software,which it is a free Java-based program,mainly intended to be used for analyzing and visualizing bibliometric networks.With this tool,we can create maps of publications,authors,or journals based on a co-citation network or construct maps of keywords,countries based on a co-occurrence networks,research groups,etc.
基金Project supported by the National Key Research and Development Program of China(Grant No.2022YFB3605404)the National Natural Science Foundation of China(Grant Nos.62204126 and 62204125)+1 种基金the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(Grant Nos.XK1060921119,XK1060921002,and XK1060921115)the Open Fund of the Key Laboratory of Aerospace Information Materials and Physics(NUAA)MIIT。
文摘As a promising ultra-wide bandgap semiconductor material,gallium oxide(Ga_(2)O_(3))is attracting extensive attention of researchers due to its feasible growth process,appropriate bandgap of 4.4 e V-5.3 e V allowing for deep-ultraviolet(deepUV)detection,good physical and chemical stability,high breakdown field strength and electron mobility,etc.Different from the strict processes for controllable crystalline Ga_(2)O_(3)(usually refer to as stable monoclinicβ-Ga_(2)O_(3)),amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))film can be prepared uniformly at low temperature on a large-area deposition substrate,suggesting great advantages such as low manufacturing cost and excellent flexibility,dispensing with high-temperature and high vacuum techniques.Thus,a-Ga_(2)O_(3)extremely facilitates important applications in various applied fields.Therefore,in this concise review,we summarize several major deposition methods for a-Ga_(2)O_(3)films,of which the characteristics are discussed.Additionally,potential methods to optimize the film properties are proposed by right of the inspiration from some recent studies.Subsequently,the applications of a-Ga_(2)O_(3)thin films,e.g.,in photodetectors,resistive random access memories(RRAMs)and gas sensors,are represented with a fruitful discussion of their structures and operating mechanisms.
文摘目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。
文摘Sb<sub>2</sub>S<sub>3</sub> has gained tremendous research recently for thin film solar cell absorber material because of their easy synthesis, unique electrical and optical properties. The stoichiometry and composition of electroless Sb<sub>2</sub>S<sub>3</sub> thin films were analyzed using XPS depth profile studies. The surface layers were found nearly stoichiometric. On the other hand, the inner layer was rich in antimony composition making it more conductive electrically.
文摘光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米材料进行XRD、SEM、TEM、XPS及UV-Vis DRS表征,并深入探讨其在可见光下灭活大肠杆菌(E.coli)的性能和机制。结果表明,Ag纳米粒均匀且牢固地负载在SCN表面,纳米材料表现出显著增强的可见光响应能力。当负载量为6%时,Ag/SCN-6呈现出最佳的光催化灭菌活性,60 min内能够将6.2 lg CFU·mL^(-1)的E.coli全部灭活。自由基捕获实验结果表明,超氧自由基(·O-2)是灭活过程中最主要活性物种,它协同光生空穴(h+)和羟基自由基(·OH)主导了光催化抗菌的进程。
基金supported in parts by the National Natural Science Foundation of China,Nos.82101501(to QF),and 82201589(to XH)。
文摘Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s disease patients.Nonetheless,the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear.Evidence suggests that signal transduction and activator of transcription-3(STAT3)is associated with modulating synaptic plasticity,cell apoptosis,and cognitive function.Using luciferase reporter assays,electrophoretic mobility shift assays,western blotting,and immunofluorescence,we found that human tau-N368 accumulation inhibited STAT3 activity by suppressing STAT3 translocation into the nucleus.Overexpression of STAT3 improved tau-N368-induced synaptic deficits and reduced neuronal loss,thereby improving the cognitive deficits in tau-N368 mice.Moreover,in tau-N368 mice,activation of STAT3 increased N-methyl-D-aspartic acid receptor levels,decreased Bcl-2 levels,reversed synaptic damage and neuronal loss,and thereby alleviated cognitive deficits caused by tau-N368.Taken together,STAT3 plays a critical role in truncated tau-related neuropathological changes.This indicates a new mechanism behind the effect of tau-N368 on synapses and memory deficits.STAT3 can be used as a new molecular target to treat tau-N368-induced protein pathology.
