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A Real-Time Small Target Vehicle Detection Algorithm with an Improved YOLOv5m Network Model
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作者 Yaoyao Du Xiangkui Jiang 《Computers, Materials & Continua》 SCIE EI 2024年第1期303-327,共25页
To address the challenges of high complexity,poor real-time performance,and low detection rates for small target vehicles in existing vehicle object detection algorithms,this paper proposes a real-time lightweight arc... To address the challenges of high complexity,poor real-time performance,and low detection rates for small target vehicles in existing vehicle object detection algorithms,this paper proposes a real-time lightweight architecture based on You Only Look Once(YOLO)v5m.Firstly,a lightweight upsampling operator called Content-Aware Reassembly of Features(CARAFE)is introduced in the feature fusion layer of the network to maximize the extraction of deep-level features for small target vehicles,reducing the missed detection rate and false detection rate.Secondly,a new prediction layer for tiny targets is added,and the feature fusion network is redesigned to enhance the detection capability for small targets.Finally,this paper applies L1 regularization to train the improved network,followed by pruning and fine-tuning operations to remove redundant channels,reducing computational and parameter complexity and enhancing the detection efficiency of the network.Training is conducted on the VisDrone2019-DET dataset.The experimental results show that the proposed algorithmreduces parameters and computation by 63.8% and 65.8%,respectively.The average detection accuracy improves by 5.15%,and the detection speed reaches 47 images per second,satisfying real-time requirements.Compared with existing approaches,including YOLOv5m and classical vehicle detection algorithms,our method achieves higher accuracy and faster speed for real-time detection of small target vehicles in edge computing. 展开更多
关键词 Vehicle detection YOLOv5m small target channel pruning CARAFE
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Improved YOLOv5-Based Inland River Floating Garbage Detection Model
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作者 HU Wen-hao SI Zhan-jun +1 位作者 SHI Jin-yu YANG Ke 《印刷与数字媒体技术研究》 CAS 北大核心 2024年第5期195-204,共10页
Detection of floating garbage in inland rivers is crucial for water environmental protection,as it effectively reduces ecological damage and ensures the safety of water resources.To address the inefficiency of traditi... Detection of floating garbage in inland rivers is crucial for water environmental protection,as it effectively reduces ecological damage and ensures the safety of water resources.To address the inefficiency of traditional cleanup methods and the challenges in detecting small targets,an improved YOLOv5 object detection model was proposed in this study.In order to enhance the model’s sensitivity to small targets and mitigate the impact of redundant information on detection performance,a bi-level routing attention mechanism was introduced and embedded into the backbone network.Additionally,a multi-scale detection head was incorporated into the model,allowing for more comprehensive coverage of floating garbage of various sizes through multi-scale feature extraction and detection.The Focal-EIoU loss function was also employed to optimize the model parameters,improving localization accuracy.Experimental results on the publicly available FloW_Img dataset demonstrated that the improved YOLOv5 model outperforms the original YOLOv5 model in terms of precision and recall,achieving a mAP(mean average precision)of 86.12%,with significant improvements and faster convergence. 展开更多
关键词 Floatinggarbage YOLOv5 Attentionmechanism Multi-scale detection head Focal-EIoU
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Benchmarking YOLOv5 models for improved human detection in search and rescue missions
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作者 Namat Bachir Qurban Ali Memon 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第1期70-80,共11页
Drone or unmanned aerial vehicle(UAV)technology has undergone significant changes.The technology allows UAV to carry out a wide range of tasks with an increasing level of sophistication,since drones can cover a large ... Drone or unmanned aerial vehicle(UAV)technology has undergone significant changes.The technology allows UAV to carry out a wide range of tasks with an increasing level of sophistication,since drones can cover a large area with cameras.Meanwhile,the increasing number of computer vision applications utilizing deep learning provides a unique insight into such applications.The primary target in UAV-based detection applications is humans,yet aerial recordings are not included in the massive datasets used to train object detectors,which makes it necessary to gather the model data from such platforms.You only look once(YOLO)version 4,RetinaNet,faster region-based convolutional neural network(R-CNN),and cascade R-CNN are several well-known detectors that have been studied in the past using a variety of datasets to replicate rescue scenes.Here,we used the search and rescue(SAR)dataset to train the you only look once version 5(YOLOv5)algorithm to validate its speed,accuracy,and low false detection rate.In comparison to YOLOv4 and R-CNN,the highest mean average accuracy of 96.9%is obtained by YOLOv5.For comparison,experimental findings utilizing the SAR and the human rescue imaging database on land(HERIDAL)datasets are presented.The results show that the YOLOv5-based approach is the most successful human detection model for SAR missions. 展开更多
关键词 Unmanned aerial vehicle(UAV) Search and rescue(SAR) You look only once(YOLO)model You only look once version 5 (YOLOv5)
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A Novel YOLOv5s-Based Lightweight Model for Detecting Fish’s Unhealthy States in Aquaculture
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作者 Bing Shi Jianhua Zhao +2 位作者 Bin Ma Juan Huan Yueping Sun 《Computers, Materials & Continua》 SCIE EI 2024年第11期2437-2456,共20页
Real-time detection of unhealthy fish remains a significant challenge in intensive recirculating aquaculture.Early recognition of unhealthy fish and the implementation of appropriate treatment measures are crucial for... Real-time detection of unhealthy fish remains a significant challenge in intensive recirculating aquaculture.Early recognition of unhealthy fish and the implementation of appropriate treatment measures are crucial for preventing the spread of diseases and minimizing economic losses.To address this issue,an improved algorithm based on the You Only Look Once v5s(YOLOv5s)lightweight model has been proposed.This enhanced model incorporates a faster lightweight structure and a new Convolutional Block Attention Module(CBAM)to achieve high recognition accuracy.Furthermore,the model introduces theα-SIoU loss function,which combines theα-Intersection over Union(α-IoU)and Shape Intersection over Union(SIoU)loss functions,thereby improving the accuracy of bounding box regression and object recognition.The average precision of the improved model reaches 94.2%for detecting unhealthy fish,representing increases of 11.3%,9.9%,9.7%,2.5%,and 2.1%compared to YOLOv3-tiny,YOLOv4,YOLOv5s,GhostNet-YOLOv5,and YOLOv7,respectively.Additionally,the improved model positively impacts hardware efficiency,reducing requirements for memory size by 59.0%,67.0%,63.0%,44.7%,and 55.6%in comparison to the five models mentioned above.The experimental results underscore the effectiveness of these approaches in addressing the challenges associated with fish health detection,and highlighting their significant practical implications and broad application prospects. 展开更多
关键词 Intensive recirculating aquaculture unhealthy fish detection improved YOLOv5s lightweight structure
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Assessment of the Southern Ocean Sea Surface Temperature Biases in CMIP5 and CMIP6 Models
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作者 GAO Zhen ZHAO Shichang +2 位作者 LIU Qinyu LONG Shang-Min SUN Shantong 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第5期1135-1150,共16页
This work evaluates the performances of climate models in simulating the Southern Ocean(SO)sea surface temperature(SST)by a large ensemble from phases 5 and 6 of the Coupled Model Intercomparison Project(CMIP5 and CMI... This work evaluates the performances of climate models in simulating the Southern Ocean(SO)sea surface temperature(SST)by a large ensemble from phases 5 and 6 of the Coupled Model Intercomparison Project(CMIP5 and CMIP6).By combining models from the same community sharing highly similar SO SST biases and eliminating the effect of global-mean biases on local SST biases,the results reveal that the ensemble-mean SO SST bias at 70°-30°S decreases from 0.38℃ in CMIP5 to 0.28℃ in CMIP6,together with increased intermodel consistency.The dominant mode of the intermodel variations in the zonal-mean SST biases is characterized as a meridional uniform warm bias pattern,explaining 79.1% of the intermodel variance and exhibiting positive principal values for most models.The ocean mixed layer heat budget further demonstrates that the SST biases at 70°-50°S primarily result from the excessive summertime heating effect from surface net heat flux.The biases in surface net heat flux south of 50°S are largely impacted by surface shortwave radiation from cloud and clear sky components at different latitudes.North of 50°S,the underestimated westerlies reduce the northward Ekman transport and hence northward cold advection in models,leading to warm SST biases year-round.In addition,the westerly biases are primarily traced back to the atmosphere-alone model simulations forced by the observed SST and sea ice.These results disclose the thermal origin at the high latitude and dynamical origin at the low latitude of the SO SST biases and underscore the significance of the deficiencies of atmospheric models in producing the SO SST biases. 展开更多
关键词 Southern Ocean CMIP5 CMIP6 SST biases surface heat flux WESTERLIES atmospheric biases cloud simulation
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MiR-219a-5p exerts a protective function in a mouse model of myocardial infarction
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作者 ZULONG SHENG YANRU HE +3 位作者 JUNYAN CAI YUQIN JI YUYU YAO GENSHAN MA 《BIOCELL》 SCIE 2024年第9期1369-1377,共9页
Background:Myocardial infarction(MI)is known worldwide for its important disabling features,including myocarditis and cardiomyocyte apoptosis.It is believed that microRNA(miRNA)has a role in the cellular processes of ... Background:Myocardial infarction(MI)is known worldwide for its important disabling features,including myocarditis and cardiomyocyte apoptosis.It is believed that microRNA(miRNA)has a role in the cellular processes of apoptosis and myocarditis,and miR-219a-5p has been found to suppress the inflammatory response.However,unknown is the precise mechanism by which miR-219a-5p contributes to MI.Methods:We measured the expression of miR-219a-5p and evaluated its effects on target proteins,inflammatory factors,and apoptosis in a mouse model of MI.Echocardiography was utilized to examine the MI clinical index,and triphenyl tetrazolium chloride staining was employed to analyze the infarcted region.Enzyme-linked immunosorbent assay and Western blotting measured serum and molecular markers in heart tissues.To quantify the association with miR-219a-5p and ATPase sarcoplasmic/endoplasmic reticulum Ca^(2+) transporting 2(ATP2A2),the luciferase activity assay and Pearson’s correlation analysis were employed.Results:MiR-219a-5p exhibited low expression in a mouse model of MI,and its amplification prevented both apoptotic and inflammatory reactions.Specifically,miR-219a-5p targeted ATP2A2.Conclusion:In a mouse model of MI,miR-219a-5p exerted a potent protective effect via direct targeting of ATP2A2. 展开更多
关键词 MiR-219a-5p Ca^(2+) transporting 2 Myocardial infarction Inflammatory response APOPTOSIS
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Artificial Neural Network and Fuzzy Logic Based Techniques for Numerical Modeling and Prediction of Aluminum-5%Magnesium Alloy Doped with REM Neodymium
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作者 Anukwonke Maxwell Chukwuma Chibueze Ikechukwu Godwills +1 位作者 Cynthia C. Nwaeju Osakwe Francis Onyemachi 《International Journal of Nonferrous Metallurgy》 2024年第1期1-19,共19页
In this study, the mechanical properties of aluminum-5%magnesium doped with rare earth metal neodymium were evaluated. Fuzzy logic (FL) and artificial neural network (ANN) were used to model the mechanical properties ... In this study, the mechanical properties of aluminum-5%magnesium doped with rare earth metal neodymium were evaluated. Fuzzy logic (FL) and artificial neural network (ANN) were used to model the mechanical properties of aluminum-5%magnesium (0-0.9 wt%) neodymium. The single input (SI) to the fuzzy logic and artificial neural network models was the percentage weight of neodymium, while the multiple outputs (MO) were average grain size, ultimate tensile strength, yield strength elongation and hardness. The fuzzy logic-based model showed more accurate prediction than the artificial neutral network-based model in terms of the correlation coefficient values (R). 展开更多
关键词 Al-5%Mg Alloy NEODYMIUM Artificial Neural Network Fuzzy Logic Average Grain Size and Mechanical Properties
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Application of Structured Health Education and Combined 5A Nursing Model in Self-control of Vulnerable Chronic Diseases: Take Coronary Heart Disease as an Example
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作者 Fan Li Shun Yuan +3 位作者 Chen Zhang Yan Li Qun Kong Qingjun Ding 《Journal of Clinical and Nursing Research》 2024年第6期206-213,共8页
Objective:To explore the intervention effect of the Structured Health Education course and 5A nursing model for self-control of elderly patients with coronary heart disease.Methods:Using the random sampling method,124... Objective:To explore the intervention effect of the Structured Health Education course and 5A nursing model for self-control of elderly patients with coronary heart disease.Methods:Using the random sampling method,124 elderly CAD patients admitted to the First Affiliated Hospital of Bengbu Medical University were randomly divided into an experimental group and a control group.The control group line routine health education,experimental group take structured health education combined with 5A nursing before and after the intervention using a coronary heart disease assessment questionnaire,coronary heart disease self-control scale evaluation of two groups of intervention,compare two groups before and after intervention blood pressure,blood sugar,body mass index,lipid index level and complications within 8 months after discharge.Results:After the course intervention,the disease cognition and self-behavior of the experimental group were higher than that of the control group,and the differences were statistically significant(all P<0.1).Conclusion:This course is suitable for elderly patients with coronary heart disease.The 5A model improves the cognitive and management ability of elderly patients to a certain extent,which is worthy of clinical application. 展开更多
关键词 Old age Coronary heart disease SELF-CONTROL Structured health education 5A nursing
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The construction and practice of humanistic care teaching model based on 5C care theory
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作者 Xi-Peng liu Qing-Qing Li +3 位作者 Yu-Zi Zhong Fei-Fei Hong Yan Li Yi-Jing Wang 《Nursing Communications》 2024年第8期1-9,共9页
Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on ... Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention group.Before and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using SPSS.Results:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P<0.05).There were no significant difference in the control group(P>0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring ability.In the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring ability.Actively guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work. 展开更多
关键词 5C caring theory humanistic caring ability undergraduate nursing students teaching model
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Application and Effect Evaluation of the Integrated“5A and 3+3”Management Model in the Safe Medication Use for Chemotherapy Patients
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作者 Li He Tingting Huo +3 位作者 Na Yao Yi Liu Yingdi Wei Yan Zhang 《Journal of Clinical and Nursing Research》 2024年第9期14-23,共10页
Objective:To explore the application and effect evaluation of the integrated“5A and 3+3”management model in ensuring safe medication use for chemotherapy patients.Methods:A total of 100 intravenous chemotherapy pati... Objective:To explore the application and effect evaluation of the integrated“5A and 3+3”management model in ensuring safe medication use for chemotherapy patients.Methods:A total of 100 intravenous chemotherapy patients admitted to the oncology department of Shaanxi Provincial People’s Hospital were randomly divided into two groups using a random number list method.Both groups received conventional nursing management during chemotherapy,while the study group additionally received the integrated“5A and 3+3”safety management model.The nursing intervention effects between the two groups were compared.Results:After the intervention,the study group showed higher levels of self-management ability,compliance,and nursing satisfaction compared to the control group.The overall incidence of adverse events during hospitalization was lower in the study group,with statistically significant differences(P<0.05).The knowledge scores of medical staff in the study group,related to the prevention and treatment of chemotherapy drug side effects,daily symptom management,and daily life management,were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Implementing the integrated“5A and 3+3”model in the safe medication management of intravenous chemotherapy patients can effectively enhance patients’self-management abilities and compliance,improve medical staff’s ability to safely administer chemotherapy drugs,reduce adverse events caused by chemotherapy,and increase patient satisfaction. 展开更多
关键词 Intravenous chemotherapy Safe medication Adverse drug reactions 5A”management “3+3”management
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无有机模板法制备Cu-ZSM-5催化剂及其选择性催化氧化苯乙烯 被引量:1
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作者 刘献锋 张晨芳 +2 位作者 张方 张东平 孔岩 《石油学报(石油加工)》 EI CAS CSCD 北大核心 2024年第1期93-102,共10页
不使用任何有机模板剂,硝酸铜和正硅酸四乙酯(TEOS)经过酸性水解、碱性陈化和水热晶化,制备得到四配位铜修饰ZSM-5沸石(Cu-ZSM-5)。考察凝胶的Si/Al摩尔比、pH值、晶化温度和晶化时间对Cu-ZSM-5的晶型和相对结晶度的影响。采用X射线衍射... 不使用任何有机模板剂,硝酸铜和正硅酸四乙酯(TEOS)经过酸性水解、碱性陈化和水热晶化,制备得到四配位铜修饰ZSM-5沸石(Cu-ZSM-5)。考察凝胶的Si/Al摩尔比、pH值、晶化温度和晶化时间对Cu-ZSM-5的晶型和相对结晶度的影响。采用X射线衍射(XRD)、红外光谱(FT-IR)、紫外漫反射谱和X-射线光电子能谱等手段对Cu-ZSM-5进行分析表征。结果表明:Cu-ZSM-5沸石具有MFI结构,结晶度高,无其他杂晶;铜原子以四配位为主。四配位铜是催化氧化苯乙烯的活性位点;在m(Cu-ZSM-5-50)=0.1 g、n(TBHP)/n(Styrene)=1.5、T=60℃、t=5 h条件下,苯乙烯转化率和苯甲醛选择性分别为76.5%和69.4%,表明Cu-ZSM-5-50具有较高的催化活性和较好的重复利用性。该制备方法不使用有机模板剂,无需高温焙烧,Cu-ZSM-5催化剂的制备成本大大降低。 展开更多
关键词 ZSM-5 无有机模板 催化氧化 苯乙烯 苯甲醛
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龟羚帕安丸对帕金森病大鼠血清NSE、Cys-C、5-HT、5-HIAA及NE水平的影响 被引量:2
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作者 常学辉 陈帅杰 +2 位作者 张良芝 王冬莲 张创业 《中华中医药学刊》 CAS 北大核心 2024年第2期1-4,共4页
目的观察龟羚帕安丸对帕金森病(Parkinson’s disease,PD)大鼠血清神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、胱抑素C(Cystatin C,Cys-C)、5-羟色胺(5-Hydroxytryptamine,5-HT)、5-羟基吲哚乙酸(5-Hydroxyindoleacetic acid,... 目的观察龟羚帕安丸对帕金森病(Parkinson’s disease,PD)大鼠血清神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、胱抑素C(Cystatin C,Cys-C)、5-羟色胺(5-Hydroxytryptamine,5-HT)、5-羟基吲哚乙酸(5-Hydroxyindoleacetic acid,5-HIAA)及去甲肾上腺素(Norepinephrine,NE)水平的影响。方法采用6-羟基多巴胺(6-OHDA)立体定向注射法制作PD大鼠模型,造模成功的PD大鼠随机分为模型组,西药组,中药高、中、低剂量组,中西药合用组,每组15只,另设假手术组15只。模型组及假手术组给予等容积生理盐水灌胃,其余组给予相应药物灌胃,连续给药28 d。大鼠腹主动脉取血,用酶联免疫吸附测定法(Enzyme linked immunosorbent assay,ELISA)检测各组大鼠血清NSE、Cys-C、5-HT、5-HIAA及NE的水平。结果模型组大鼠血清NSE及Cys-C水平均明显升高,血清5-HT、5-HIAA及NE水平均明显降低;中药各剂量组、中西药合用组、西药组血清NSE及Cys-C水平均明显降低,5-HT、5-HIAA及NE水平均明显升高。结论龟羚帕安丸具有明显神经保护作用,作用机制与降低NSE及Cys-C水平,增加5-HT、5-HIAA及NE水平,降低脑实质损伤、神经炎症损伤及提高单胺类神经递质有关。 展开更多
关键词 帕金森病 龟羚帕安丸 神经元特异性烯醇化酶 胱抑素C 5-羟色胺 5-羟基吲哚乙酸
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萝卜硫素通过调节ALOX5/NF-κB信号通路调控巨噬细胞糖酵解抑制糖尿病肾病进展 被引量:1
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作者 乌日娜 丁海东 +2 位作者 常宏 孙娜娜 张磊 《安徽医科大学学报》 CAS 北大核心 2024年第3期390-397,共8页
目的探讨萝卜硫素(SFN)调节花生四烯酸5-脂氧合酶基因(arachidonic acid 5-lipoxygenase,ALOX5)/核因子kappa B(NF-κB)信号通路调节巨噬细胞糖酵解对糖尿病肾病(DN)进展的影响。方法生物信息学分析SFN治疗DN的靶基因。使用30 mmol/L高... 目的探讨萝卜硫素(SFN)调节花生四烯酸5-脂氧合酶基因(arachidonic acid 5-lipoxygenase,ALOX5)/核因子kappa B(NF-κB)信号通路调节巨噬细胞糖酵解对糖尿病肾病(DN)进展的影响。方法生物信息学分析SFN治疗DN的靶基因。使用30 mmol/L高葡萄糖(HG)处理人近端肾小管上皮细胞系(HK-2细胞)诱导体外DN模型。将HK-2细胞分为如下组:正常糖(NG)组、HG组、HG+SFN(3 mmol/L)组、HG+ALOX5组、HG+SFN(3 mmol/L)+ALOX5组、HG处理的巨噬细胞+HK-2细胞组、HG+SFN(3 mmol/L)处理的巨噬细胞+HK-2细胞组、HG+ALOX5转染处理的巨噬细胞+HK-2细胞组、HG+SFN(3 mmol/L)+ALOX5转染处理的巨噬细胞+HK-2细胞组。CCK-8检测细胞活力,原位末端脱氧核苷酸转移酶标记(TUNEL)法检测细胞凋亡;葡萄糖和乳酸试剂盒检测各组细胞中葡萄糖和乳酸水平;Western blot检测各组细胞中ALOX5、NF-κB以及糖酵解相关蛋白己糖激酶-2(HK2)、丙酮酸激酶M2(PKM2)、葡萄糖转运蛋白1(GLUT1)的表达;使用链脲佐菌素(STZ)构建DN小鼠模型,DN小鼠给与SFN(0.5 mg/kg)治疗;检测小鼠各项生化指标,HE染色检测肾组织病理变化;Western blot检测小鼠肾脏巨噬细胞中糖酵解相关蛋白己糖激酶-2(HK2)、丙酮酸激酶M2(PKM2)、葡萄糖转运蛋白1(GLUT1)的表达。结果生物信息学分析结果显示ALOX5是SFN治疗DN的靶基因。与HG组相比,SFN处理增强HK-2细胞活力并抑制细胞凋亡(P<0.05);同时,SFN处理抑制HG诱导的巨噬细胞糖酵解相关蛋白的表达,减弱巨噬细胞介导的HK-2细胞损伤(P<0.05);Western blot结果表明SFN抑制ALOX5和NF-κB的表达(P<0.05);小鼠实验结果显示,SFN治疗改善DN小鼠肾功能和肾组织病理学改变,抑制肾组织中巨噬细胞糖酵解相关蛋白的表达(P<0.05)。结论SFN通过抑制ALOX5/NF-κB信号通路抑制巨噬细胞糖酵解从而改善DN进展。 展开更多
关键词 萝卜硫素 糖尿病肾病 巨噬细胞 糖酵解 花生四烯酸5-脂氧合酶 NF-ΚB信号通路
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大荚大粒鲜食大豆新品种‘兴化豆5号’的选育及特征特性 被引量:2
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作者 李清华 林海峰 +4 位作者 顾智炜 颜墩炜 严生仁 陈子琳 柯庆明 《中国农学通报》 2024年第15期37-43,共7页
本研究旨在开发适合福建省及其相似生态区种植条件的高产优质鲜食大豆新品种,以促进地区内品种更新、提高产业效率,并支持乡村振兴计划。通过使用‘浙98002’作为母本和‘毛豆389’作为父本进行杂交,采用系谱选择法成功培育出优良品种... 本研究旨在开发适合福建省及其相似生态区种植条件的高产优质鲜食大豆新品种,以促进地区内品种更新、提高产业效率,并支持乡村振兴计划。通过使用‘浙98002’作为母本和‘毛豆389’作为父本进行杂交,采用系谱选择法成功培育出优良品种‘兴化豆5号’。该品种于2020年入选参加福建省鲜食大豆区域试验。在2020—2021年的两年区域试验中,‘兴化豆5号’表现出色,平均鲜荚产量达到11522.7 kg/hm^(2),比对照品种‘毛豆3号’(CK)增产5.67%。其标准荚产量为8261.7 kg/hm^(2),较‘毛豆3号’(CK)增产5.11%,且标准荚率为71.70%。‘兴化豆5号’以其大荚大粒特性及清煮后香甜柔糯的口感而受到好评,属于中晚熟型鲜食大豆品种,适宜于福建省春季播种。2022年7月,‘兴化豆5号’经过福建省农作物品种审定委员会的审定。这一研究成果预示着福建省及类似生态区鲜食大豆种植业的一大步前进,有望为当地农业发展带来积极影响。 展开更多
关键词 鲜食大豆 新品种 ‘兴化豆5号’ 选育 特征特性
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柴贝止痫汤对癫痫—抑郁共病模型大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R表达的影响 被引量:2
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作者 王越 刘金民 +1 位作者 王凯悦 徐薇薇 《环球中医药》 CAS 2024年第2期196-202,共7页
目的 观察柴贝止痫汤对氯化锂—匹罗卡品慢性颞叶癫痫—抑郁共病模型大鼠大脑皮层及海马中5-羟色胺转运体(5-hydroxytryptamine transporter, 5-HTT)、5-羟色胺受体(5-hydroxytryptamine repreceptor, 5-HTR)(5-HT_(1A)R、5-HT_(2A)R)... 目的 观察柴贝止痫汤对氯化锂—匹罗卡品慢性颞叶癫痫—抑郁共病模型大鼠大脑皮层及海马中5-羟色胺转运体(5-hydroxytryptamine transporter, 5-HTT)、5-羟色胺受体(5-hydroxytryptamine repreceptor, 5-HTR)(5-HT_(1A)R、5-HT_(2A)R)和多巴胺(dopamine, DA)受体(DA_(2)R)表达的影响,探讨柴贝止痫汤对癫痫—抑郁共病的干预机制。方法 建立氯化锂—匹罗卡品慢性颞叶癫痫—抑郁共病大鼠模型。造模成功后,将大鼠随机分为6组:正常组、模型组、西药组(西酞普兰给药)和柴贝止痫汤低、中、高剂量组,连续灌胃给药14天,每天2次。干预后,通过糖水偏好及强迫游泳实验进行抑郁行为学监测;酶联免疫吸附法检测大鼠大脑皮层及海马中5-HT、DA含量;实时定量PCR法检测大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R基因的mRNA表达水平;蛋白免疫印迹法检测大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R的蛋白表达水平。结果 药物干预后,与模型组相比,柴贝止痫汤中、高剂量组大鼠糖水消耗量显著增加(P<0.01),不动时间显著减少(P<0.01);与模型组比较,柴贝止痫汤中(P<0.05)、高剂量组(P<0.01)大鼠大脑皮层及海马中5-HT含量、皮层中DA含量升高,高剂量组(P<0.05)大鼠大脑海马中DA含量升高;与模型组相比,柴贝止痫汤高剂量组大鼠大脑皮层5-HTT mRNA表达降低(P<0.01),而海马中5-HTT mRNA表达升高(P<0.05);同时,柴贝止痫汤高剂量组大鼠大脑皮层和海马中5-HT_(1A)R mRNA表达明显升高(P<0.05),蛋白表达水平与mRNA水平表达一致。5-HT_(2A)R和DA_(2)R的mRNA和蛋白表达水平在处理前后均无变化。结论 柴贝止痫汤能够通过下调慢性颞叶癫痫—抑郁共病模型大鼠大脑皮层5-HTT,上调海马5-HTT,以及上调大脑皮层和海马中5-HT_(1A)R的表达水平,改善抑郁行为。 展开更多
关键词 柴贝止痫汤 癫痫—抑郁共病 5-羟色胺转运体 5-羟色胺受体 多巴胺受体
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CdS/Nb_(2)O_(5)异质结材料的制备、表征及光催化降解环丙沙星研究 被引量:1
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作者 陈玲霞 朱蓓蓓 +1 位作者 李百裕 周杰 《化学试剂》 CAS 2024年第3期49-55,共7页
采用水热法制备了CdS/Nb_(2)O_(5)纳米复合材料,利用X-射线衍射光谱(XRD)、透射电镜(TEM)、红外光谱(FT-IR)、X-射线光电子能谱(XPS)和紫外-可见漫反射(UV-Vis DRS)对制备的材料进行表征。通过可见光下降解环丙沙星评价材料的光催化活... 采用水热法制备了CdS/Nb_(2)O_(5)纳米复合材料,利用X-射线衍射光谱(XRD)、透射电镜(TEM)、红外光谱(FT-IR)、X-射线光电子能谱(XPS)和紫外-可见漫反射(UV-Vis DRS)对制备的材料进行表征。通过可见光下降解环丙沙星评价材料的光催化活性。结果表明,制备的CdS/Nb_(2)O_(5)纳米复合材料由CdS纳米颗粒分散于Nb_(2)O_(5)纳米笼表面,二者形成紧密的Ⅱ型异质结;CdS的引入增强了Nb_(2)O_(5)的可见光吸收性能,同时提高了光生载流子的分离效率;当CdS的含量为15%时,CdS/Nb_(2)O_(5)可在60 min实现环丙沙星的高效降解,其反应速率常数是CdS的7.5倍,Nb_(2)O_(5)的20倍,空穴是该降解反应的主要活性物种,研究结果为抗生素废水的高效治理提供了一条新思路。 展开更多
关键词 CDS Nb_(2)O_(5) 异质结 光催化 环丙沙星
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下调METTL5通过Wnt/β-catenin信号通路抑制三阴乳腺癌细胞增殖、迁移与侵袭 被引量:1
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作者 吴坤琳 严乾壹 +2 位作者 王德星 缪秀英 张惠灏 《中国药理学通报》 CAS CSCD 北大核心 2024年第2期285-291,共7页
目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的s... 目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的shRNA(shRNA-METTL5)转染TNBC细胞后,用CCK-8、集落形成、伤口愈合以及Transwell实验分别检测细胞增殖活性、迁移与侵袭,Western blot检测Wnt/β-catenin信号关键蛋白的表达。构建异种移植瘤模型,验证敲降METTL5对TNBC细胞在体内生长以及Wnt/β-catenin信号活性的影响。结果METTL5在TNBC肿瘤组织和细胞系中表达上调(P<0.01)。敲降METTL5可抑制TNBC细胞的增殖、迁移和侵袭并降低了Wnt/β-catenin信号分子β-catenin、细胞周期蛋白(Cyclin)D1、基质金属蛋白酶(MMP)-2和MMP-7的表达(均P<0.01)。体内实验显示,敲降METTL5减缓了移植瘤生长和Wnt/β-catenin信号活性。结论敲降METTL5能抑制TNBC细胞的增殖、迁移与侵袭,其作用可能与抑制Wnt/β-catenin信号通路有关。 展开更多
关键词 三阴乳腺癌 甲基转移酶5 m6A甲基化 WNT/Β-CATENIN 增殖 迁移 侵袭
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基于5G多接入边缘计算的云化PLC系统架构设计与应用 被引量:6
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作者 冯毅雄 杨晨 +5 位作者 胡炳涛 赖颢善 石莹 宋光敏 汪勇 谭建荣 《计算机辅助设计与图形学学报》 EI CSCD 北大核心 2024年第1期33-46,共14页
随着工业控制系统对柔性化、扁平化的要求不断提升,以PLC为构建基础的传统工业控制网络在大规模接入、算力提升和部署灵活性方面均受到限制.针对这些问题,融合5G网络和边缘计算技术,设计了基于5G多接入边缘计算的云化PLC系统架构,阐述... 随着工业控制系统对柔性化、扁平化的要求不断提升,以PLC为构建基础的传统工业控制网络在大规模接入、算力提升和部署灵活性方面均受到限制.针对这些问题,融合5G网络和边缘计算技术,设计了基于5G多接入边缘计算的云化PLC系统架构,阐述了该架构的运行机制和所涉及的关键技术;在此基础上,进行PLC系统的云化部署和调试,实现了工业现场、企业数据中心、5G网络和边缘网络的集成;最后,通过在某汽车制造公司产线改造过程中的应用,验证了所提架构的有效性. 展开更多
关键词 5G 边缘计算 云化PLC(可编程逻辑控制器) 架构设计
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薏苡仁油联合5-FU对结肠癌HCT-116细胞株增殖、凋亡的影响 被引量:1
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作者 王韬 费建东 +1 位作者 聂双发 李磊 《西部中医药》 2024年第1期9-12,共4页
目的:分析薏苡仁油联合5-氟尿嘧啶(5-fluorouracil,5-FU)对结肠癌HCT-116细胞株增殖、凋亡的影响及其作用机制。方法:采用四甲基偶氮唑盐(methyl thiazolyl tetrazdium,MTT)法测定不同浓度薏苡仁油、5-FU以及薏苡仁油+5-FU对人结肠癌HCT... 目的:分析薏苡仁油联合5-氟尿嘧啶(5-fluorouracil,5-FU)对结肠癌HCT-116细胞株增殖、凋亡的影响及其作用机制。方法:采用四甲基偶氮唑盐(methyl thiazolyl tetrazdium,MTT)法测定不同浓度薏苡仁油、5-FU以及薏苡仁油+5-FU对人结肠癌HCT-116细胞株的生长抑制效应;采用流式细胞术检测细胞凋亡情况;采用逆转录聚合酶链反应(RT-PCR)检测生存蛋白(Survivin)mRNA表达水平。结果:薏苡仁油、5-FU、5-FU+薏苡仁油均对人结肠癌HCT-116细胞增殖产生一定抑制作用,且薏苡仁油浓度越高,作用时间越长,细胞增殖抑制率越高,3组比较差异有统计学意义(P<0.05);与薏苡仁油组及5-FU组相比,5-FU+薏苡仁油组细胞增殖抑制率更高,差异有统计学意义(P<0.05)。薏苡仁油组、5-FU组、5-FU+薏苡仁油组的细胞凋亡率均高于空白对照组,差异有统计学意义(P<0.05);薏苡仁油浓度越高,细胞凋亡率也越高,差异有统计学意义(P<0.05);5-FU+薏苡仁油组细胞凋亡率高于5-FU组及薏苡仁油组,差异有统计学意义(P<0.05)。与空白对照组相比,不同浓度薏苡仁油组Survivin mRNA表达降低,差异有统计学意义(P<0.05);5-FU组Survivin mRNA表达升高,差异有统计学意义(P<0.05);5-FU+薏苡仁油组Survivin mRNA表达较5-FU组降低,差异有统计学意义(P<0.05)。结论:薏苡仁油能抑制结肠癌HCT-116细胞增殖,诱导细胞凋亡,与5-FU联合应用能发挥药物协同作用,其作用机制可能与调控Survivin mRNA表达有关。 展开更多
关键词 结肠癌 增殖 凋亡 薏苡仁油 5-氟尿嘧啶
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基于融合MBAM与YOLOv5的PCB缺陷检测方法 被引量:5
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作者 胡欣 胡帅 +3 位作者 马丽军 司利云 肖剑 袁晔 《图学学报》 CSCD 北大核心 2024年第1期47-55,共9页
随着电子信息产业迅速发展,PCB行业作为电子信息产业的基础,其产品质量对后续生产的电子产品有着决定性影响。针对PCB缺陷目标较小,缺陷类型多,特征不明显,在实际生产过程中易产生误检、漏检等问题,提出了一种多分支注意力MBAM模块方法,... 随着电子信息产业迅速发展,PCB行业作为电子信息产业的基础,其产品质量对后续生产的电子产品有着决定性影响。针对PCB缺陷目标较小,缺陷类型多,特征不明显,在实际生产过程中易产生误检、漏检等问题,提出了一种多分支注意力MBAM模块方法,在3个不同维度对特征图进行关注,以增强特征提取的能力,对缺陷区域给予更多的注意力表示。通过改进YOLOv5结构,将MBAM与YOLOv5网络结合,有效的提升了对PCB中小目标的检测性能。最后通过在网络不同位置添加MBAM模块进行对比实验,选取了最佳的添加位置。通过在PCB缺陷数据集上的实验结果表明,改进后的PCB缺陷检测算法具有良好的检测性能,优于其他对比算法,最终的AP达到了96.7%,对比标准YOLOv5的94.7%提高了2个百分点,其他项指标均有涨点,在保持检测速度基本不变的情况下,精准地识别PCB缺陷类型。 展开更多
关键词 目标检测 PCB缺陷 小目标缺陷 YOLOv5 多分支注意力模块
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