China stroke surveillance report 2021

Since 2015,stroke has become the leading cause of death and disability in China,posing a significant threat to the health of its citizens as a major chronic non-communicable disease.According to the China Stroke High-risk Population Screening and Intervention Program,an estimated 17.8 million[95%confidence interval(CI)17.6–18.0million]adults in China had experienced a stroke in 2020,with 3.4 million(95%CI 3.3–3.5 million)experiencing their first-ever stroke and another 2.3 million(95%CI 2.2–2.4 million)dying as a result.Additionally,approximately 12.5%(95%CI 12.4%–12.5%)of stroke survivors were left disabled,as defined by a modified Rankin Scale score greater than 1,equating to 2.2 million(95%CI 2.1–2.2 million)stroke-related disabilities in 2020.As the population ages and the prevalence of risk factors like diabetes,hypertension,and hyperlipidemia continues to rise and remains poorly controlled,the burden of stroke in China is also increasing.A large national epidemiological survey initiated by the China Hypertension League in 2017 showed that the prevalence of hypertension was 24.7%;the awareness,treatment,and control rates in hypertensive patients were:60.1%,42.5%,and 25.4%,respectively.A nationally representative sample of the Chinese mainland population showed that the weighted prevalence of total diabetes diagnosed by the American Diabetes Association criteria was 12.8%,suggesting there are 120 million adults with diabetes in China,and the awareness,treatment,and control rates in diabetic patients were:43.3%,49.0%,and 49.4%,respectively.The“Sixth National Health Service Statistical Survey Report in 2018”showed that the proportion of the obese population in China was 37.4%,an increase of 7.2 points from 2013.Data from 1599 hospitals in the Hospital Quality Monitoring System and Bigdata Observatory Platform for Stroke of China(BOSC)showed that a total of 3,418,432 stroke cases[mean age±standard error(SE)was(65.700±0.006)years,and 59.1%were male]were admitted during 2020.Of those,over 80.0%(81.9%)were ischemic stroke(IS),14.9%were intracerebral hemorrhage(ICH)strokes,and 3.1%were subarachnoid hemorrhage(SAH)strokes.The mean±SE of hospitalization expenditures was Chinese Yuan(CNY)(16,975.6±16.3),ranging from(13,310.1±12.8)in IS to(81,369.8±260.7)in SAH,and out-of-pocket expenses were(5788.9±8.6),ranging from(4449.0±6.6)in IS to(30,778.2±156.8)in SAH.It was estimated that the medical cost of hospitalization for stroke in 2020 was CNY 58.0 billion,of which the patient pays approximately CNY 19.8 billion.In-hospital death/discharge against medical advice rate was 9.2%(95%CI 9.2%–9.2%),ranging from 6.4%(95%CI 6.4%–6.5%)for IS to 21.8%(95%CI 21.8%–21.9%)for ICH.From 2019 to 2020,the information about 188,648 patients with acute IS receiving intravenous thrombolytic therapy(IVT),49,845 patients receiving mechanical thrombectomy(MT),and 14,087 patients receiving bridging(IVT+MT)were collected through BOSC.The incidence of intracranial hemorrhage during treatment was 3.2%(95%CI 3.2%–3.3%),7.7%(95%CI 7.5%–8.0%),and 12.9%(95%CI 12.3%–13.4%),respectively.And in-hospital death/discharge against medical advice rate was 8.9%(95%CI 8.8%–9.0%),16.5%(95%CI 16.2%–16.9%),and 16.8%(95%CI 16.2%–17.4%),respectively.A prospective nationwide hospital-based study was conducted at 231 stroke base hospitals(Level III)from 31 provinces in China through BOSC from January 2019to December 2020 and 136,282 stroke patients were included and finished 12-month follow-up.Of those,over 86.9%were IS,10.8%were ICH strokes,and 2.3%were SAH strokes.The disability rate[%(95%CI)]in survivors of stroke at 3-month and 12-month was 14.8%(95%CI 14.6%–15.0%)and 14.0%(95%CI 13.8%–14.2%),respectively.The mortality rate[%(95%CI)]of stroke at 3-month and 12-month was 4.2%(95%CI 4.1%–4.3%)and 8.5%(95%CI 8.4%–8.6%),respectively.The recurrence rate[%(95%CI)]of stroke at 3-month and 12-month was 3.6%(95%CI 3.5%–3.7%)and 5.6%(95%CI 5.4%–5.7%),respectively.The Healthy China 2030 Stroke Action Plan was launched as part of this review,and the above data provide valuable guidelines for future stroke prevention and treatment efforts in China.

Synergistic Interdecadal Evolution of Precipitation over Eastern China and the Pacific Decadal Oscillation during 1951-2015

By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationship with the North Pacific sea surface temperature(SST).Two significant interdecadal signals,one with an 11-year cycle and the other with a 23-year cycle,are identified in both the precipitation and SST fields.Results show that the North Pacific SST forcing modulates the precipitation distribution over China through the effects of the Pacific Decadal Oscillation(PDO)-related anomalous Aleutian low on the western Pacific subtropical high(WPSH)and Mongolia high(MH).During the development stage of the PDO cold phase associated with the 11-year cycle,a weakened WPSH and MH increased the precipitation over the Yangtze River Basin,whereas an intensified WPSH and MH caused the enhanced rain band to move northward to North China during the decay stage.During the development stage of the PDO cold phase associated with the 23-year cycle,a weakened WPSH and MH increased the precipitation over North China,whereas an intensified WPSH and the weakened MH increased the precipitation over South China during the decay stage.The 11-year and 23-year variabilities contribute differently to the precipitation variations in the different regions of China,as seen in the 1998flooding case.The 11-year cycle mainly accounts for precipitation increases over the Yangtze River Basin,while the 23-year cycle is responsible for the precipitation increase over Northeast China.These results have important implications for understanding how the PDO modulates the precipitation distribution over China,helping to improve interdecadal climate prediction.

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.Methods Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the CRIMS.Trend tests and spatial analyses were also conducted.Results Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in China.The main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in women.The proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for CHC.The spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.Conclusion In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual transmission.The primary modes of infection were CHC and NMNCHC.There were variations in the sex ratio among different age groups,infected through various sexual behaviors.HIV/AIDS cases exhibited spatial clustering.Based on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

Trend of Storm Surge Induced by Typical Landfall Super Typhoons During 1975–2021 in the Eastern China Sea

Climate change affects the activity of global and regional tropical cyclones(TCs).Among all TCs,typical super typhoons(STYs)are particularly devastating because they maintain their intensity when landing on the coast and thus cause casualties,economic losses,and environmental damage.Using a 3D tidal model,we reconstructed the typhoon(TY)wind field to simulate the storm surge induced by typical STYs.The TY activity was then analyzed using historical data.Results showed a downtrend of varying degrees in the annual frequency of STYs and TCs in the Western North Pacific(WNP)Basin,with a significant trend change observed for TCs from 1949 to 2021.A large difference in the interannual change in frequency was found between STYs and TCs in the WNP and Eastern China Sea(ECS).Along the coast of EC,the frequency of landfall TCs showed a weak downtrend,and the typical STYs showed reverse micro growth with peak activity in August.Zhejiang,Fujian,and Taiwan were highly vulnerable to the frontal hits of typical STYs.Affected by climate change,the average lifetime maximum intensity(LMI)locations and landfall locations of typical STYs in the ECS basin showed a significant poleward migration trend.In addition,the annual average LMI and accumulated cyclone energy showed an uptrend,indicating the increasing severity of the disaster risk.Affected by the typical STY activity in the ECS,the maximum storm surge area also showed poleward migration,and the coast of North China faced potential growth in high storm surge risks.

Monitoring Surface Water Change in Northeast China in 1999–2020:Evidence from Satellite Observation and Refined Classification

As a typical region with high water demand for agricultural production,understanding the spatiotemporal surface water changes in Northeast China is critical for water resources management and sustainable development.However,the long-term variation characteristics of surface water of different water body types in Northeast China remain rarely explored.This study investigated how surface water bodies of different types(e.g.,lake,reservoir,river,coastal aquaculture,marsh wetland,ephemeral water) changed during1999–2020 in Northeast China based on various remote sensing-based datasets.The results showed that surface water in Northeast China grew dramatically in the past two decades,with an equivalent area increasing from 24 394 km^(2) in 1999 to 34 595 km^(2) in 2020.The surge of ephemeral water is the primary driver of surface water expansion,which could ascribe to shifted precipitation pattern.Marsh wetlands,rivers,and reservoirs experienced a similar trend,with an approximate 20% increase at the interdecadal scale.By contrast,coastal aquacultures and natural lakes remain relatively stable.This study is expected to provide a more comprehensive investigation of the surface water variability in Northeast China and has important practical significance for the scientific management of different types of surface water.

Magmatic-tectonic response of the South China Craton to the Paleo-Pacific subduction during the Triassic:a new viewpoint based on Well NK-1

The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic transformation.To reveal the essence of western Paleo-Pacific subduction during the Triassic period,Well NK-1 in this block was selected for petrographic study,and published research data from other cooperative teams were compared.A double-cycle pattern of basic to neutral magmatic volcanism was established,and 36 lithological rhythmic layers and representative cryptoexplosive breccia facies and welded tuff bands were identified.Combined with a reanalysis of published geochronological data,geochemical elements,and isotope geochemistry,we found that the rock assemblages could be divided into an intermediate-acid dacite(DA)series(SiO_(2)>65%)and basaltic(BA)series(Co<40μg/g),which was formed during the early Late Triassic((218.6±3.2)–(217.9±3.5)Ma).BA exhibits obvious calc-alkaline island-arc magmatic properties:(^(87)Sr/^(86)Sr)_i ratio ranging 0.70377–0.71118(average:0.70645),^(147)Sm/^(144)Nd ratio ranging 0.119–0.193(average:0.168),and chondrite-normalized rare earth element(REE)curves being flat,while DA exhibits remarkable characteristics of subducted island-arc andesitic magma:(^(87)Sr/^(86)Sr)_i ratio(0.70939–0.71129;average:0.71035),εNd(t)value(-6.2–-4.8;average:-5.6)andε_(Hf)(t)value(-2.9–-1.7,average:-2.2)show obvious crust-mantle mixing characteristics.BA and DA reveal typical characteristics of island-arc magma systems and typeⅡenriched mantle(EM-Ⅱ)magma.BA magma was likely resulted from the process whereby the continental crust frontal accretionary wedge was driven by the Paleo-Pacific slab subduction into the deep and began to melt,resulting in a large amount of melt(fluid)joined the asthenosphere on the side of the continental margin.In contrast,DA magma was likely resulted from the process whereby the plate front was forced to bend with increasing subduction distance,which triggered the upwelling of the asthenosphere near the continent and subsequently led to the partial melting of the lithospheric mantle and lower crust due to continuous underplating.The lithospheric thinning environment in the study area at the end of Triassic created suitable conditions for the separation between the NB and SCC,which provided an opportunity for the formation of the early intracontinental rift during the later expansion of the South China Sea(SCS).

A case study of continental shelf waves in the northwestern South China Sea induced by winter storms in 2021

This study aims to investigate characteristics of continental shelf wave(CSW)on the northwestern continental shelf of the South China Sea(SCS)induced by winter storms in 2021.Mooring and cruise observations,tidal gauge data at stations Hong Kong,Zhapo and Qinglan and sea surface wind data from January 1 to February 28,2021 are used to examine the relationship between along-shelf wind and sea level fluctuation.Two events of CSWs driven by the along-shelf sea surface wind are detected from wavelet spectra of tidal gauge data.The signals are triply peaked at periods of 56 h,94 h and 180 h,propagating along the coast with phase speed ranging from 6.9 m/s to18.9 m/s.The dispersion relation shows their property of the Kelvin mode of CSW.We develop a simple method to estimate amplitude of sea surface fluctuation by along-shelf wind.The results are comparable with the observation data,suggesting it is effective.The mode 2 CSWs fits very well with the mooring current velocity data.The results from rare current help to understand wave-current interaction in the northwestern SCS.

Spatiotemporal Changes of Snow Depth in Western Jilin,China from 1987 to 2018

Seasonal snow cover is a key global climate and hydrological system component drawing considerable attention due to glob-al warming conditions.However,the spatiotemporal snow cover patterns are challenging in western Jilin,China due to natural condi-tions and sparse observation.Hence,this study investigated the spatiotemporal patterns of snow cover using fine-resolution passive mi-crowave(PMW)snow depth(SD)data from 1987 to 2018,and revealed the potential influence of climate factors on SD variations.The results indicated that the interannual range of SD was between 2.90 cm and 9.60 cm during the snowy winter seasons and the annual mean SD showed a slightly increasing trend(P>0.05)at a rate of 0.009 cm/yr.In snowmelt periods,the snow cover contributed to an increase in volumetric soil water,and the change in SD was significantly affected by air temperature.The correlation between SD and air temperature was negative,while the correlation between SD and precipitation was positive during December and March.In March,the correlation coefficient exceeded 0.5 in Zhenlai,Da’an,Qianan,and Qianguo counties.However,the SD and precipitation were neg-atively correlated over western Jilin in October,and several subregions presented a negative correlation between SD and precipitation in November and April.

Analysis of the Haze Weather Process in the East of China from January 21 to 28, 2021

Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather that happened in eastern China in late January 2021. The research uses multi-party data and synoptic analysis methods to analyze the occurrence, evolution, and end of the haze weather. The polar vortex, the change of the atmospheric circulation, the change of the cold air force, the temperature and humidity, and the rain and snow weather are the important reasons for this weathering process. It can be used for reference in future research on haze weather.

Drivers,Trends,and Patterns of Changing Vegetation-greenness in Nansha Islands,China from 2016 to 2022

Changes in vegetation status generally also represents changes in the ecological health of islands and reefs(IRs).However,studies are limited of drivers and trends of vegetation change of Nansha Islands,China and how they relate to climate change and human activities.To resolve this limitation,we studied changes to the Normalized Difference Vegetation Index(NDVI)vegetation-greenness index for 22 IRs of Nansha Islands during normal and extreme conditions.Trends of vegetation greenness were analyzed using Sen's slope and Mann-Kendall test at two spatial scales(pixel and island),and driving factor analyses were performed by time-lagged partial correlation analyses.These were related to impacts from human activities and climatic factors under normal(temperature,precipitation,radiation,and Normalized Difference Built-up Index(NDBI))and extreme conditions(wind speed and latitude of IRs)from 2016 to 2022.Results showed:1)among the 22 IRs,NDVI increased/decreased significantly in 15/4 IRs,respectively.Huayang Reef had the highest NDVI change-rate(0.48%/mon),and Zhongye Island had the lowest(–0.29%/mon).Local spatial patterns were in one of two forms:dotted-form,and degradation in banded-form.2)Under normal conditions,human activities(characterized by NDBI)had higher impacts on vegetation-greenness than other factors.3)Under extreme conditions,wind speed(R^(2)=0.2337,P<0.05)and latitude(R^(2)=0.2769,P<0.05)provided limited explanation for changes from typhoon events.Our results provide scientific support for the sustainable development of Nansha Islands and the United Nations‘Ocean Decade’initiative.

Analysis of New Senior English for China Student’s Book 1

This article will firstly discuss the context overview of English teaching and learning in China. Under thiscircumstance, a problematic element will be examined of the New Senior English for China Student’s Book 1 and critical appraisal ofhow this element relates to other elements of curriculum development will be analyzed. The recommended changes and demonstrationmechanisms for evaluating the changes are put forward in the last two parts.

Mesoscale and Microphysical Characteristics of a Double Rain Belt Event in South China on May 10–13,2022

A second rain belt sometimes occurs ahead of a frontal rain belt in the warm sector over coastal South China,leading to heavy precipitation.We examined the differences in the mesoscale characteristics and microphysics of the frontal and warm sector rain belts that occurred in South China on May 10–13,2022.The southern rain belt occurred in an environment with favorable mesoscale conditions but weak large-scale forcing.In contrast,the northern rain belt was related to low-level horizontal shear and the surface-level front.The interaction between the enhanced southeasterly winds and the rainfall-induced cold pool promoted the persistent growth of convection along the southern rain belt.The convective cell propagated east over the coastal area,where there was a large temperature gradient.The bow-shaped echo in this region may be closely related to the rear-inflow jet.By contrast,the initial convection of the northern rain belt was triggered along the front and the region of low-level horizontal shear,with mesoscale interactions between the enhanced warm-moist southeasterly airflow and the cold dome associated with the earlier rain.The terrain blocked the movement of the cold pool,resulting in the stagnation of the frontal convective cell at an early stage.Subsequently,a meso-γ-scale vortex formed during the rapid movement of the convective cell,corresponding to an enhancement of precipitation.The representative raindrop spectra for the southern rain belt were characterized by a greater number and higher density of raindrops than the northern rain belt,even though both resulted in comparable hourly rainfalls.These results help us better understand the characteristics of double rain belts over South China.

Spatio-temporal Evaluation of Multi-scale Cultivated Land System Resilience in Black Soil Region from 2000 to 2019:A Case Study of Liaoning Province,Northeast China

It is of great significance to systematically analyze the cultivated land system resilience(CLSR) for the black soil protection and national food security.The CLSR is impacted by planting structure adjustment and cultivated land quality decline,posing major hidden dangers to food security.It is urgent to evaluate the CLSR at multiple spatio-temporal scales.This study took Liaoning Province in the black soil region of Northeast China as an example.Based on the resilience theory,this study constructed the CLSR evaluation system from the input-feedback perspective at the provincial-scale and the city-scale,and used the rank-sum ratio comprehensive evaluation method(RSR) to analyze the key influencing factors of CLSR in Liaoning Province and its 14 cities from 2000 to 2019.The results showed that:1) the time series changes of CLSR at the provincial-scale and the city-scale in Liaoning Province were similar,both showing an increasing trend.2) The CLSR in Liaoning Province presented a spatial pattern of ‘high in the west and low in the east’ at the city-scale.3) There were seven and six main influencing factors of CLSR at the provincial-scale and the city-scale,respectively.In addition to the net income per capita of rural households,other influencing factors of CLSR were different at the provincial-scale and the city-scale.The feedback factors were dominant at the provincial-scale,and the input factors and feedback factors were dominant at the city-scale.The results could provide a reference for the utilization of black soil and draw on the experience of regional agricultural planning and adjustment.

Progress in neurorehabilitation research and the support by the National Natural Science Foundation of China from 2010 to 2022

The National Natural Science Foundation of China is one of the major funding agencies for neuro rehabilitation research in China.This study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo rldwide.We used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science Foundation of China to analyze funding information.In addition,the prospects for neurorehabilitation research in China are discussed.From 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward tendency.During this period,the National Natural Science Foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in China.With the support of the National Natural Science Foundation of China,China has made some achievements in neurorehabilitation research.Research related to neurorehabilitation is believed to be making steady and significant progress in China.

Geological reservoir and resource potential(10^(13)m^(3))of gas hydrates in the South China Sea

A detailed understanding of the distribution and potential of natural gas hydrate(NGHs)resources is crucial to fostering the industrialization of those resources in the South China Sea,where NGHs are abundant.In this study,this study analyzed the applicability of resource evaluation methods,including the volumetric,genesis,and analogy methods,and estimated NGHs resource potential in the South China Sea by using scientific resource evaluation methods based on the factors controlling the geological accumulation and the reservoir characteristics of NGHs.Furthermore,this study compared the evaluation results of NGHs resource evaluations in representative worldwise sea areas via rational analysis.The results of this study are as follows:(1)The gas hydrate accumulation in the South China Sea is characterized by multiple sources of gas supply,multi-channel migration,and extensive accumulation,which are significantly different from those of oil and gas and other unconventional resources.(2)The evaluation of gas hydrate resources in the South China Sea is a highly targeted,stratified,and multidisciplinary evaluation of geological resources under the framework of a multi-type gas hydrate resource evaluation system and focuses on the comprehensive utilization of multi-source heterogeneous data.(3)Global NGHs resources is n×10^(15)m^(3),while the NGHs resources in the South China Sea are estimated to be 10^(13)m^(3),which is comparable to the abundance of typical marine NGHs deposits in other parts of the world.In the South China Sea,the NGHs resources have a broad prospect and provide a substantial resource base for production tests and industrialization of NGHs.

Spatio-temporal variability of surface chlorophyll a in the Yellow Sea and the East China Sea based on reconstructions of satellite data of 2001-2020

Chlorophyll-a(Chl-a)concentration is a primary indicator for marine environmental monitoring.The spatio-temporal variations of sea surface Chl-a concentration in the Yellow Sea(YS)and the East China Sea(ECS)in 2001-2020 were investigated by reconstructing the MODIS Level 3 products with the data interpolation empirical orthogonal function(DINEOF)method.The reconstructed results by interpolating the combined MODIS daily+8-day datasets were found better than those merely by interpolating daily or 8-day data.Chl-a concentration in the YS and the ECS reached its maximum in spring,with blooms occurring,decreased in summer and autumn,and increased in late autumn and early winter.By performing empirical orthogonal function(EOF)decomposition of the reconstructed data fields and correlation analysis with several potential environmental factors,we found that the sea surface temperature(SST)plays a significant role in the seasonal variation of Chl a,especially during spring and summer.The increase of SST in spring and the upper-layer nutrients mixed up during the last winter might favor the occurrence of spring blooms.The high sea surface temperature(SST)throughout the summer would strengthen the vertical stratification and prevent nutrients supply from deep water,resulting in low surface Chl-a concentrations.The sea surface Chl-a concentration in the YS was found decreased significantly from 2012 to 2020,which was possibly related to the Pacific Decadal Oscillation(PDO).

Spatio-temporal Variation Characteristics of Extreme Climate Events and Their Teleconnections to Large-scale Ocean-atmospheric Circulation Patterns in Huaihe River Basin,China During 1959–2019

Huaihe River Basin(HRB) is located in China’s north-south climatic transition zone,which is very sensitive to global climate change.Based on the daily maximum temperature,minimum temperature,and precipitation data of 40 meteorological stations and nine monthly large-scale ocean-atmospheric circulation indices data during 1959–2019,we present an assessment of the spatial and temporal variations of extreme temperature and precipitation events in the HRB using nine extreme climate indices,and analyze the teleconnection relationship between extreme climate indices and large-scale ocean-atmospheric circulation indices.The results show that warm extreme indices show a significant(P < 0.05) increasing trend,while cold extreme indices(except for cold spell duration) and diurnal temperature range(DTR) show a significant decreasing trend.Furthermore,all extreme temperature indices show significant mutations during 1959-2019.Spatially,a stronger warming trend occurs in eastern HRB than western HRB,while maximum 5-d precipitation(Rx5day) and rainstorm days(R25) show an increasing trend in the southern,central,and northwestern regions of HRB.Arctic oscillation(AO),Atlantic multidecadal oscillation(AMO),and East Atlantic/Western Russia(EA/WR) have a stronger correlation with extreme climate indices compared to other circulation indices.AO and AMO(EA/WR) exhibit a significant(P < 0.05) negative(positive)correlation with frost days and diurnal temperature range.Extreme warm events are strongly correlated with the variability of AMO and EA/WR in most parts of HRB,while extreme cold events are closely related to the variability of AO and AMO in eastern HRB.In contrast,AMO,AO,and EA/WR show limited impacts on extreme precipitation events in most parts of HRB.

Genetic and pathogenic characterization of new infectious bronchitis virus strains in the GVI-1 and GI-19 lineages isolated in central China

Avian infectious bronchitis(IB)is a highly contagious infectious disease caused by infectious bronchitis virus(IBV),which is prevalent in many countries worldwide and causes serious harm to the poultry industry.At present,many commercial IBV vaccines have been used for the prevention and control of IB;however,IB outbreaks occur frequently.In this study,two new strains of IBV,SX/2106 and SX/2204,were isolated from two flocks which were immunized with IBV H120 vaccine in central China.Phylogenetic and recombination analysis indicated that SX/2106,which was clustered into the GI-19 lineage,may be derived from recombination events of the GI-19 and GI-7 strains and the LDT3-A vaccine.Genetic analysis showed that SX/2204 belongs to the GVI-1 lineage,which may have originated from the recombination of the GI-13 and GVI-1 strains and the H120 vaccine.The virus cross-neutralization test showed that the antigenicity of SX/2106 and SX/2204 was different from H120.Animal experiments found that both SX/2106 and SX/2204 could replicate effectively in the lungs and kidneys of chickens and cause disease and death,and H120 immunization could not provide effective protection against the two IBV isolates.It is noteworthy that the pathogenicity of SX/2204 has significantly increased compared to the GVI-1 strains isolated previously,with a mortality rate up to 60%.Considering the continuous mutation and recombination of the IBV genome to produce new variant strains,it is important to continuously monitor epidemic strains and develop new vaccines for the prevention and control of IBV epidemics.

Geology and mineralization of the Dongping supergiant alkalic-hosted Au-Te deposit(>100 t Au)in Northern Hebei Province,China:A review

The Dongping deposit is the largest alkalic-hosted gold deposit in China containing>100 t of Au.This paper presents a new understanding for Dongping ore system,based on the previous studies.The mineralization originally occurred at 400-380 Ma,simultaneous with emplacement of the Shuiquangou alkaline complex,and was overprinted by the hydrothermal activity in the Yanshanian.Isotope compositions of ores indicate metals of the deposit are mainly provided by the Shuiquangou complex.Ore-forming fluids are characterized by increasing oxygen fugacity and decreasing sulfur fugacity,while tellurium fugacity increased in the Stage II-2 and decreased in Stage II-3.These systematic changes are closely related to the processes of mineral precipitation and fluid evolution.Sulfide precipitation from Stage Ⅰ to Stage Ⅱ was triggered by fluid boiling,which leads to the precipitation of Pb-Bi-Te,due to decrement of sulfur fugacity.Condensation of gas phase containing high concentration of H_2Te leads to precipitation of Te-Au-Ag minerals and native tellurium.Based on these hypotheses,this paper present a polyphase metallogenic model as follow.During the Devonian,fluids were released from alkaline magmas,which carried ore-forming materials form the surrounding rocks and precipitate the early ores.During the Jurassic-Cretaceous,fluorine-rich fluids exsolved from highly factionated Shangshuiquan granite,which extracted and concentrated Au from the Shuiquangou complex and the Sanggan Group metamorphic rocks,and finally formed the Dongping gold deposit.

Historical review and reflections on the participation of acupuncture and moxibustion in the treatment of epidemics in the People’s Republic of China (from 1950 until now)

Since the establishment of the People’s Republic of China, both the Communist Party and the government have placed great emphasis on the advancement of traditional Chinese medicine. Acupuncture and moxibustion have been actively involved in combating major epidemics such as malaria, schistosomiasis, and COVID-19. This article conducts a historical review of these three significant cases to elucidate how the acupuncture community has effectively utilized its unique advantages and characteristics through theoretical discussions, clinical practices, experimental research, as well as receiving administrative leadership and political support from the Communist Party of China and government. We provide an objective evaluation of their effectiveness while summarizing historical experiences to serve as a reference for future utilization of acupuncture and moxibustion therapy in epidemic relief efforts. Additionally, propose four suggestions: strengthening Party leadership and enhancing political support;timely summarization of experiences to establish programs and systems;deepening scientific research by integrating experimental findings with clinical practice;focusing on public awareness campaigns and education to solidify grassroots foundations.