“Common but differentiated responsibilities and respective capabilities”(CBDRRC) is the most significant guiding principle in the international climate change regime, created by the United Nations Framework Conventi...“Common but differentiated responsibilities and respective capabilities”(CBDRRC) is the most significant guiding principle in the international climate change regime, created by the United Nations Framework Convention on Climate Change in 1992 and inherited by the Paris Agreement 24 years later. This paper examines the operationalization of the CBDRRC principle in one of the cornerstone rules of the regimedits transparency provisions, both in existing practice under the convention and possible evolvement in negotiations under the Paris Agreement, from the perspectives of both international rule-making and domestic implementation. The authors have found a continuous enhancement of the transparency framework since the 1990s, and gradual consolidation of a bifurcated system between developed and developing countries into a common one. The authors argue that the transparency framework, as part of the procedural rules, should be designed to facilitate transparent information sharing in accordance with substantive commitments under international climate change laws. Thus, it indirectly reflects historical responsibilities for climate change, while the framework should also be designed as feasible and reflective of the respective capabilities of nations. Finally, the evolution of the transparency framework will aim to enact common and enhanced provisions while differentiating between developed and developing countries in the near term, and greater transparency-related capacity-building for developing countries.展开更多
Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study lever...Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study leverages computational tools to dissect the differential gene expression profiles in retinoblastoma. Methods: Employing an in silico approach, we analyzed gene expression data from public repositories by applying rigorous statistical models, including limma and de seq 2, for identifying differentially expressed genes DEGs. Our findings were validated through cross-referencing with independent datasets and existing literature. We further employed functional annotation and pathway analysis to elucidate the biological significance of these DEGs. Results: Our computational analysis confirmed the dysregulation of key retinoblastoma-associated genes. In comparison to normal retinal tissue, RB1 exhibited a 2.5-fold increase in expression (adjusted p Conclusions: Our analysis reinforces the critical genetic alterations known in retinoblastoma and unveils new avenues for research into the disease’s molecular basis. The discovery of chemoresistance markers and immune-related genes opens potential pathways for personalized treatment strategies. The study’s outcomes emphasize the power of in silico analyses in unraveling complex cancer genomics.展开更多
In this paper, we conduct research on the dynamic demand response problem in smart grid to control the energy consumption. The objective of the energy consumption control is constructed based on differential game, as ...In this paper, we conduct research on the dynamic demand response problem in smart grid to control the energy consumption. The objective of the energy consumption control is constructed based on differential game, as the dynamic of each users’ energy state in smart gird can be described based on a differential equation. Concept of electricity sharing is introduced to achieve load shift of main users from the high price hours to the low price hours. Nash equilibrium is given based on the Hamilton equation and the effectiveness of the proposed model is verified based on the numerical simulation results.展开更多
Bacterial blight of rice caused by Xanthomonas oryzae pv.oryzae（Xoo） is one of high nitrogen（N） responsive diseases.Rice plants became more disease resistant with decreasing N suggesting that the crosstalk between...Bacterial blight of rice caused by Xanthomonas oryzae pv.oryzae（Xoo） is one of high nitrogen（N） responsive diseases.Rice plants became more disease resistant with decreasing N suggesting that the crosstalk between disease resistance and N utilization pathways might exist.However,the co-regulatory components in such crosstalk have not been elucidated.Here,we comparatively analyzed the gene expression profiling of rice under Xoo inoculation,low N treatment,or a combination of both stresses,and identified the differentially-expressed genes（DEGs） in overlapping responses.These DEGs were involved in different biological processes,including innate immunity and nitrogen metabolism.The randomly-selected DEGs expression was validated by quantitative real-time PCR assays.Temporal expression of six genes from different functional categories suggested that N condition was the dominant factor when both stresses were present.These DEGs identified provide novel insights into the coordinated regulatory mechanism in biotic and abiotic stress responses in rice.展开更多
Unconditionally stable higher-order accurate time step integration algorithms based on the differential quadrature method (DQM) for second-order initial value problems were applied and the quadrature rules of DQM, com...Unconditionally stable higher-order accurate time step integration algorithms based on the differential quadrature method (DQM) for second-order initial value problems were applied and the quadrature rules of DQM, computing of the weighting coefficients and choices of sampling grid points were discussed. Some numerical examples dealing with the heat transfer problem, the second-order differential equation of imposed vibration of linear single-degree-of-freedom systems and double-degree-of-freedom systems, the nonlinear move differential equation and a beam forced by a changing load were computed, respectively. The results indicated that the algorithm can produce highly accurate solutions with minimal time consumption, and that the system total energy can remain conservative in the numerical computation.展开更多
Temperature is a key regulator of brown adipose tissue(BAT)function,acting through central sensory inputs to influence metabolism and energy storage.Although animal models have produced a wealth of information on the ...Temperature is a key regulator of brown adipose tissue(BAT)function,acting through central sensory inputs to influence metabolism and energy storage.Although animal models have produced a wealth of information on the pathways,effectors and responses mediating the physiological response of adipose tissue to temperature in vivo,the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes,in the absence of neural input.In particular,stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro.Here the basis for adipogenic responsiveness to low temperature is discussed,together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.展开更多
A cDNA subtractive library enriched for dark-induced up-regulated ESTs was constructed by suppression subtractive hybridization(SSH) from leaf tissues of soybean cultivar DongNong L13 treated with short-day(8-h light/...A cDNA subtractive library enriched for dark-induced up-regulated ESTs was constructed by suppression subtractive hybridization(SSH) from leaf tissues of soybean cultivar DongNong L13 treated with short-day(8-h light/16-h dark) and long-day(16-h light/8-h dark) conditions.A total of 148 clones were sequenced,representing 76 unique ESTs which corresponded to about 20% of 738 clones from the cDNA library and showed a significant up-regulation of at least three fold verified by dot blot hybridization.The putative functions of ESTs were predicted by Blastn and Blastx.The 43 differentially expressed genes identified by subtractions were classified according to their putative functions generated by Blast analysis.Genetic functional analysis indicated that putative proteins encoded by these genes were related to diverse functions during organism development,which include biological regulation pathways such as transcription,signal transduction and programmed cell death,protein,nucleic acid and carbohydrate macromolecule degradation,the cell wall modification,primary and secondary metabolism and stress response.Two soybean transcription factors enhanced in SD conditions,GAMYB-binding protein and DNA binding protein RAV cDNAs that may be involved in SD soybean photoperiod response,had been isolated using 5'-and 3'-rapid amplification of cDNA ends(RACE)(Genbank Accession numbers DQ112540 and DQ147914).展开更多
The accuracy of the measured current is a preeminent parameter for Current Control based Power Converter applications to ensure genuine operation of the designed converter.The current measurement accuracy can be affec...The accuracy of the measured current is a preeminent parameter for Current Control based Power Converter applications to ensure genuine operation of the designed converter.The current measurement accuracy can be affected by several parameters which includes the type of technology used,components used for the selected technology,aging,usage,operating and environmental conditions.The effect of gain resistors and their manufacturing tolerances on differential amplifier-based buck converter current measurement is investigated in this work.The analysis mainly focused on the output voltage variation and its accuracy with respect to the change in gain resistance tolerances.The gain resistors with 5%,1%,0.5%and 0.1%manufacturing tolerances taken for the worst-case analysis and the calculated performance results are compared and verified with the simula-tion results.The Operational amplifiers(Op-Amp)for high frequency power con-verter applications must operate in a high frequency noise environment and the intended current measuring system must manage common mode noise distur-bances paired with the signal to be measured.Based on the Common Mode Rejec-tion Ratio(CMRR)the common mode voltages and noise signals will effectively getfiltered out.Lesser CMRR results in lower common mode signal rejection,resulting in poor precision and noise rejection.In differential amplifiers,the CMRR predominantly depends on gain resistors.So,the variations in Common Mode Rejection Ratio due to gain resistor tolerances also analyzed and compared with the output voltage variations.Besides the effects of resistor tolerances,this paper also examines the effect of Op-Amp offset voltage on output accuracy spe-cifically for low magnitude input currents.The obtained results from this analysis clearly shows that the gain resistors with 0.1%tolerance gives maximum accuracy with improved CMRR and accuracy at low magnitude input currents will get well improved by using Op-Amps with Low Offset voltage specifications.展开更多
In this paper,we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric spaces.Furthermore,we study fixed point theorems for Reich a...In this paper,we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric spaces.Furthermore,we study fixed point theorems for Reich and Chatterjea nonexpansive mappings in a Banach space using the Krasnoselskii-Ishikawa iteration method associated withSλand consider some applications of our results to prove the existence of solutions for nonlinear integral and nonlinear fractional differential equations.We also establish certain interesting examples to illustrate the usability of our results.展开更多
文摘“Common but differentiated responsibilities and respective capabilities”(CBDRRC) is the most significant guiding principle in the international climate change regime, created by the United Nations Framework Convention on Climate Change in 1992 and inherited by the Paris Agreement 24 years later. This paper examines the operationalization of the CBDRRC principle in one of the cornerstone rules of the regimedits transparency provisions, both in existing practice under the convention and possible evolvement in negotiations under the Paris Agreement, from the perspectives of both international rule-making and domestic implementation. The authors have found a continuous enhancement of the transparency framework since the 1990s, and gradual consolidation of a bifurcated system between developed and developing countries into a common one. The authors argue that the transparency framework, as part of the procedural rules, should be designed to facilitate transparent information sharing in accordance with substantive commitments under international climate change laws. Thus, it indirectly reflects historical responsibilities for climate change, while the framework should also be designed as feasible and reflective of the respective capabilities of nations. Finally, the evolution of the transparency framework will aim to enact common and enhanced provisions while differentiating between developed and developing countries in the near term, and greater transparency-related capacity-building for developing countries.
文摘Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study leverages computational tools to dissect the differential gene expression profiles in retinoblastoma. Methods: Employing an in silico approach, we analyzed gene expression data from public repositories by applying rigorous statistical models, including limma and de seq 2, for identifying differentially expressed genes DEGs. Our findings were validated through cross-referencing with independent datasets and existing literature. We further employed functional annotation and pathway analysis to elucidate the biological significance of these DEGs. Results: Our computational analysis confirmed the dysregulation of key retinoblastoma-associated genes. In comparison to normal retinal tissue, RB1 exhibited a 2.5-fold increase in expression (adjusted p Conclusions: Our analysis reinforces the critical genetic alterations known in retinoblastoma and unveils new avenues for research into the disease’s molecular basis. The discovery of chemoresistance markers and immune-related genes opens potential pathways for personalized treatment strategies. The study’s outcomes emphasize the power of in silico analyses in unraveling complex cancer genomics.
基金supported by National Key R&D Program of China, No.2018YFB1003905the Fundamental Research Funds for the Central Universities, No.FRF-TP-18-008A3
文摘In this paper, we conduct research on the dynamic demand response problem in smart grid to control the energy consumption. The objective of the energy consumption control is constructed based on differential game, as the dynamic of each users’ energy state in smart gird can be described based on a differential equation. Concept of electricity sharing is introduced to achieve load shift of main users from the high price hours to the low price hours. Nash equilibrium is given based on the Hamilton equation and the effectiveness of the proposed model is verified based on the numerical simulation results.
基金supported by the grants from the National Basic Research Program of China(2011CB100701)
文摘Bacterial blight of rice caused by Xanthomonas oryzae pv.oryzae（Xoo） is one of high nitrogen（N） responsive diseases.Rice plants became more disease resistant with decreasing N suggesting that the crosstalk between disease resistance and N utilization pathways might exist.However,the co-regulatory components in such crosstalk have not been elucidated.Here,we comparatively analyzed the gene expression profiling of rice under Xoo inoculation,low N treatment,or a combination of both stresses,and identified the differentially-expressed genes（DEGs） in overlapping responses.These DEGs were involved in different biological processes,including innate immunity and nitrogen metabolism.The randomly-selected DEGs expression was validated by quantitative real-time PCR assays.Temporal expression of six genes from different functional categories suggested that N condition was the dominant factor when both stresses were present.These DEGs identified provide novel insights into the coordinated regulatory mechanism in biotic and abiotic stress responses in rice.
文摘Unconditionally stable higher-order accurate time step integration algorithms based on the differential quadrature method (DQM) for second-order initial value problems were applied and the quadrature rules of DQM, computing of the weighting coefficients and choices of sampling grid points were discussed. Some numerical examples dealing with the heat transfer problem, the second-order differential equation of imposed vibration of linear single-degree-of-freedom systems and double-degree-of-freedom systems, the nonlinear move differential equation and a beam forced by a changing load were computed, respectively. The results indicated that the algorithm can produce highly accurate solutions with minimal time consumption, and that the system total energy can remain conservative in the numerical computation.
基金the Biotechnology and Biological Sciences Research Council[Grant No.BB/M008770/1]a studentship from CONACyT.We are grateful to Dušan Radojević(U.of Belgrade)for his help with the illustrations.VS is supported by a grant from the Italian Ministry of Education,University and Research(MIUR)to the Department of Molecular Medicine of the University of Pavia under the initiative‘Dipartimenti di Eccellenza(2018-2022)’。
文摘Temperature is a key regulator of brown adipose tissue(BAT)function,acting through central sensory inputs to influence metabolism and energy storage.Although animal models have produced a wealth of information on the pathways,effectors and responses mediating the physiological response of adipose tissue to temperature in vivo,the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes,in the absence of neural input.In particular,stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro.Here the basis for adipogenic responsiveness to low temperature is discussed,together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.
文摘A cDNA subtractive library enriched for dark-induced up-regulated ESTs was constructed by suppression subtractive hybridization(SSH) from leaf tissues of soybean cultivar DongNong L13 treated with short-day(8-h light/16-h dark) and long-day(16-h light/8-h dark) conditions.A total of 148 clones were sequenced,representing 76 unique ESTs which corresponded to about 20% of 738 clones from the cDNA library and showed a significant up-regulation of at least three fold verified by dot blot hybridization.The putative functions of ESTs were predicted by Blastn and Blastx.The 43 differentially expressed genes identified by subtractions were classified according to their putative functions generated by Blast analysis.Genetic functional analysis indicated that putative proteins encoded by these genes were related to diverse functions during organism development,which include biological regulation pathways such as transcription,signal transduction and programmed cell death,protein,nucleic acid and carbohydrate macromolecule degradation,the cell wall modification,primary and secondary metabolism and stress response.Two soybean transcription factors enhanced in SD conditions,GAMYB-binding protein and DNA binding protein RAV cDNAs that may be involved in SD soybean photoperiod response,had been isolated using 5'-and 3'-rapid amplification of cDNA ends(RACE)(Genbank Accession numbers DQ112540 and DQ147914).
文摘The accuracy of the measured current is a preeminent parameter for Current Control based Power Converter applications to ensure genuine operation of the designed converter.The current measurement accuracy can be affected by several parameters which includes the type of technology used,components used for the selected technology,aging,usage,operating and environmental conditions.The effect of gain resistors and their manufacturing tolerances on differential amplifier-based buck converter current measurement is investigated in this work.The analysis mainly focused on the output voltage variation and its accuracy with respect to the change in gain resistance tolerances.The gain resistors with 5%,1%,0.5%and 0.1%manufacturing tolerances taken for the worst-case analysis and the calculated performance results are compared and verified with the simula-tion results.The Operational amplifiers(Op-Amp)for high frequency power con-verter applications must operate in a high frequency noise environment and the intended current measuring system must manage common mode noise distur-bances paired with the signal to be measured.Based on the Common Mode Rejec-tion Ratio(CMRR)the common mode voltages and noise signals will effectively getfiltered out.Lesser CMRR results in lower common mode signal rejection,resulting in poor precision and noise rejection.In differential amplifiers,the CMRR predominantly depends on gain resistors.So,the variations in Common Mode Rejection Ratio due to gain resistor tolerances also analyzed and compared with the output voltage variations.Besides the effects of resistor tolerances,this paper also examines the effect of Op-Amp offset voltage on output accuracy spe-cifically for low magnitude input currents.The obtained results from this analysis clearly shows that the gain resistors with 0.1%tolerance gives maximum accuracy with improved CMRR and accuracy at low magnitude input currents will get well improved by using Op-Amps with Low Offset voltage specifications.
文摘In this paper,we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric spaces.Furthermore,we study fixed point theorems for Reich and Chatterjea nonexpansive mappings in a Banach space using the Krasnoselskii-Ishikawa iteration method associated withSλand consider some applications of our results to prove the existence of solutions for nonlinear integral and nonlinear fractional differential equations.We also establish certain interesting examples to illustrate the usability of our results.
