Elite Software-FIRE消防系统水力计算软件介绍及其与国产软件的比较

本文对Elite Software-FIRE软件的使用方法及计算原理进行了介绍,并使用该软件及国产软件对同一个消火栓系统和雨淋系统进行了计算,做了简要对比,对国产软件的发展及国际化之路提出了建议。

Barriers and Motivators of Young Dutch Elite Athletes for Optimizing Their Nutritional Intake

Many young elite athletes do not meet their daily energy and nutrient requirements. However, little research has been done on why these athletes do not meet their daily needs. The aim was to research the barriers and motivators of young Dutch elite athletes to optimize their nutritional intake. Quantitative and qualitative research was conducted among 8 handball and 4 volleyball players at the Dutch National Sports Center (17.2 ± 0.8 years). First, the nutritional intake was tracked through food diaries and analyzed in Nutritics. Thereupon, five semi-structured interviews based on the COM-B model were carried out. The interviews were transcribed and coded. The athletes had a reduced intake of energy, carbohydrates, vitamins A, C, E, D, calcium, potassium, zinc, and iron compared to their requirements. Seven themes for optimizing their nutritional intake emerged in the interviews: needs assessment, practical translation, portion size, lack of time, involvement, individuality, and food distribution. Barriers that the athletes experienced were that they did not know what their total daily nutritional needs were and how this translates into practice. In addition, the portion size at dinner was too small. They also had little time to eat a full meal due to time pressure from training and school. On the other hand, motivators were receiving meal options to translate their needs into practice with a distribution of moments when they need to eat. Covering these topics in nutritional workshops where athletes actively participate with more individual focus, could contribute to the optimization of their nutritional intake.

Elite capture,the“follow-up checks”policy,and the targeted poverty alleviation program:Evidence from rural western China

Decentralized methods for targeting poverty are widely adopted in developing countries to improve the performance of various poverty alleviation programs.A common challenge for implementing successful decentralized targeting is the existence of elite capture.China has recently implemented a nationwide decentralized poverty targeting program,the targeted poverty alleviation(TPA)policy,to achieve the national goal of eliminating absolute poverty by the end of 2020.As the largest decentralized poverty targeting program in the world,TPA's successful implementation was believed to be threatened by elite capture in some earlier reports.Since 2015,a targeting correction mechanism,called"follow-up checks"policy,has been introduced.With the"follow-up checks"policy,the elites and other ineligible households who receive benefits under TPA were removed from the program.This paper investigates the elite capture phenomenon in TPA using village census data from a poverty-stricken county in 2017-two years after implementing the"follow-up checks"policy.We find no evidence of elite capture in TPA.The elites are unlikely to become beneficiaries or receive more benefits than non-elites.Our results contradict earlier findings that reported elite capture in TPA.We argue that the reason is the accountability emphasized by the central government in the"follow-up checks"policy.Our findings imply that having proper accountability is critical for improving targeting performance by global antipoverty initiatives.

World Class Elite Breaststrokers Downward Kick EMG Muscle Activity of the Gluteus Maximus, Quadriceps Femoris, Hamstring, Gastrocnemius Medialis, Rectus Abdominal, and Erector Spinae

This study analyzed the difference between using a downward breaststroke kick and a horizontal breaststroke kick in a sample of world class elite swimmers.We compared average muscle activity of the gluteus maximus,quadriceps femoris(vastus medialis and rectus femoris),hamstring/long head of the biceps femoris,gastrocnemius medialis,rectus abdominal,and erector spinae when using the downward breaststroke kick technique.We find that when this sample of swimmers utilized the downward breaststroke kick,max speed and velocity per stroke increased,measured by 12,788 EMG samples,where the results are highly correlated to duration of the aerodynamic buoyant force in breaststroke kick technique.The increases in performance observed from measuring the world class elite swimmers is highly correlated to the duration of the kick aerodynamic buoyant force.Among this sample of elite swimmers,the longer a swimmer demonstrates a buoyant force breaststroke kick,the lower the time in a 100 breaststroke.

压力容器计算软件SW6与PV Elite开孔补强计算差异比较

通过运行SW6、PV Elite两软件分别计算一压力容器的接管开孔补强来比较两软件计算开孔补强的不同。在相同工况载荷下,通过实例比较,两软件在计算过程中,主要区别为SW6中开孔补强计算是依据于GB/T 150.3.6中计算公式,PV Elite的开孔补强计算则是依据于ASME Ⅷ-1中UG-37中计算公式。通过运行两软件,并结合工程实例,分析GB/T 150与ASMEⅧ-1中径向接管等面积补强计算的差异,为今后的压力容器设计提供参考。

A Research Conception on Indigenous Chinese Leadership:Based on Comparative Case Studies on Political Elites in Ancient China

Due to the complexity of leadership and its variability across situations,it is suggested that research on leadership should focus on attempts to understand leadership in specific situations or roles,and develop local knowledge about leadership in each situation or role.This paper validates the possibility and importance of building indigenous leadership theories from historical perspective.We demonstrated how to carry out research on indigenous Chinese leadership from a historical perspective by comparative case studies using historical data.Based on the principles of typicalness,representativeness,and comparativeness,we selected six counterparts of political elites in ancient China as comparative cases,which includes Guan Zhong&Shang Yang(organizational reformer),Liu Bang&Xiang Yu(entrepreneur),Li Shimin&Qin Shihuang(intergenerational transition successor),Zhuge Liang&Zeng Guofan(professional manager),Lu Su&Zhang Juzheng(mess-to-order maker),and Zuo Zongtang&Wang Anshi(national dream driver).The paper aims to develop indigenous leadership theory specific to Chinese mental states and culture.

Glia-to-neuron reprogramming to the rescue?

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

Neurocircuit regeneration by extracellular matrix reprogramming

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

小烧的HiFi进阶之路平衡电源PLiXiR净源ELITE BAC 1500试用报告

HiFi成长之路的又一次体验,这次体验的高端“食材”,由诚意满满的《视听前线》组织,漂流品为PLiXiR净源Elite BAC 1500特别版电源处理器和Elite BAC 3000标准版电源处理器。小弟有幸试用的是Elite BAC 1500特别版,收到产品的一刻有些惊呆,对于电源的理解,我深感自己之前的浅薄。

系统脱胎换骨,我沉浸在曼妙的音乐世界中PLiXiR净源Elite BAC 3000电源处理器试用有感

近两年来,随着自己的音响系统趋于稳定、听音取向逐渐明确,我开始关注之前我认为对音质的影响相对“不那么明显”的周边产品,包括电源、线材、机柜和脚架等。其中电源类产品引起了我较大的兴趣。无论从哪种渠道获取的信息,都强调电源对于音响系统的重要性。

Creating Prep to Play PRO for women playing elite Australian football:A how-to guide for developing injury-prevention programs

Background:Developing context-specific,evidence-informed,and implementable injury-prevention programs is challenging.Women playing in the elite Australian Football League for Women are at high risk of serious knee injuries,and no specific injury-prevention program exists.The objective of the study was to describe the collaborative process used to create a context-specific injury-prevention program.Methods:A previously used intervention-development process was modified to incorporate a partnership with the sport’s governing organization and focus on engaging program implementers.The Reach Effectiveness Adoption Implementation and Maintenance(RE-AIM)Sports Setting Matrix guided program development and implementation strategies.Results:The 7-step process,aligned with the RE-AIM Sports Setting Matrix,was applied to develop the injury-prevention program and was titled Prep to Play PRO.The steps were:(Step 1)gaining organizational support and establishing a project partnership;(Step 2)using research evidence and clinical experience;(Step 3)consulting content and context experts;(Step 4)engaging the organization,experts,program implementers,and end-users to concreate the intervention and develop implementation strategies;(Step 5)testing the intervention acceptability and feasibility;(Step 6)evaluating the intervention and implementation strategies against theory;and(Step 7)obtaining feedback from early implementers and end-users.Conclusion:Engaging critical stakeholders at multiple ecological levels(organization,team,and athlete)throughout program development and implementation planning support real-world use.The processes and activities described can guide future sports injury-prevention program development and implementation.

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves insufficient.Immunotherapy,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on PDAC.This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.AIM To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic adenocarcinoma.METHODS Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer therapy.Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable toxicity.Participants in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles.Between June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy alone.RESULTS The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy group.The incidence of severe adverse events did not differ significantly between the two groups(P>0.05).CONCLUSION The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC,meriting further investigation.

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor microenvir-onment.Inflammation regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy efficacy.Interleukin-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different tumors.We hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in HCC.The upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow cytometry.Mechanistic studies were conducted with gene knockout models and pathway inhibitors.The function of IL-17A in immune evasion was explored through coculture of T cells and HCC cells.The effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in vivo.RESULTS IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by IL-17A.IL-17A enhanced the survival of HCC cells in the coculture system.IL-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic index.Cyclin D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression decreased.The combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse model.CONCLUSION IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against decapenta-plegic 2 signaling pathway in HCC cells.Blocking IL-17A enhances the therapeutic efficacy of PD-L1 antibodies in HCC in vivo.

The Elite Strategies in the CIMS Subject of China 863 Program (1986-2000)

Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor.

ELITE PRO血凝仪2种测定纤维蛋白原方法结果的比较

目的:研究贝克曼库尔特ACL ELITE PRO全自动血凝仪,简称ELITE PRO。用凝血酶原时间(Prothrombin time,PT)衍算法(PT-Fib)测定纤维蛋白原(Fibrinogen,Fib)含量的精密度及其与凝血酶法(Clauss法)检测结果的相关性。方法:用Clauss法及PT-Fib法同时测定232例标本的Fib含量,对其结果的相关性进行分析,得出PT-Fib法测定Fib在ELITE PRO上的可信范围。结果:PT-Fib法检测结果精密度高,当Fib含量在1.5～4.5 g/L时,PT-Fib法与Clauss法的结果接近,两者测定结果正相关;当Fib<1.5 g/L或>4.5 g/L时,PT-Fib法的结果高于Clauss法。结论:当PT-Fib法测定的Fib含量在1.5～4.5 g/L时结果可靠,可直接用于临床报告;当PT-Fib法测定的Fib结果<1.5 g/L或>4.5 g/L时结果不稳定,应用Clauss法进一步复查。2种方法结合使用既可保证Fib检测速度的迅速、结果的准确,也可达到节约试剂的目的。

Philips Brilliance iCT Elite冠状动脉CTA低剂量扫描的研究与探讨

目的 :评价冠状动脉CT血管成像(CT angiography,CTA)低剂量扫描结合i Dose重建与常规剂量扫描结合滤波反投影(filtered back-projection,FBP)重建图像的图像质量,探讨Philips Brilliance i CT Elite冠状动脉成像中降低k Vp对减低辐射剂量的影响程度。方法:筛选73例行门控轴位扫描的患者,分为A、B、C、D 4组。其中A组采用常规剂量120 k Vp,B、C、D组均采用100 k Vp,应用软件i Dose4分别降噪,观察降低剂量的效果。结果 :应用Philips Brilliance i CT Elite的i Dose4迭代重建可以显著改善图像的质量,在CT剂量指数(CT dose index,CTDI)较常规剂量降低50%的条件下仍可以得到与常规剂量FBP重建相当甚至更好的图像,在非选择性人群中,其冠状动脉CTA辐射剂量降至55%是可行的。结论 :通过降低k Vp可以显著降低冠状动脉成像扫描的辐射剂量。

超声引导下Mammotome Elite活检系统在乳腺癌术前诊断中的应用

探讨和分析超声引导下Mammotome Elite活检系统在乳腺癌术前诊断中的应用效果。选取我院2014年6月~2015年12月乳腺外科收治的211例女性患者作为研究对象,所有患者均接受Mammotome Elite系统活检,对活检的结果进行分析。211例患者均顺利完成了系统活检,患者的病理符合率为97.6%,假阴性率为2.4%,在定性诊断上差异无统计学意义(P>0.05)。且刺病理与术后大体组织病理免疫组化检测指标表达略有差异,但无较大的差异性(P>0.05)。在超声引导下进行Mammotome Elite活检,具有术前穿刺活检取材方便、准确、活检时间短、确诊率高的优势,是一种非常理想的活检工具。

医用胸腹带的研制及其在乳腺麦默通elite穿刺活检中的应用

乳腺癌是女性常见的癌症及首要死亡原因[1]。空芯针穿刺活检是乳腺癌初步诊断的金标准[2]。以穿刺活检所取得的组织学结果为依据的精准初始疾病诊断,能够最大程度保障为患者提供最佳个体化综合诊疗方案[3]。乳腺Mammotome elite(麦默通elite)是一款无需反复置入穿刺针的真空辅助活检装置,在乳腺穿刺活检中具有获得组织量大、肿瘤低估率低的优点。

ELITEⅡ试验:AR拮抗剂与ACE抑制剂治疗心力衰竭的比较研究

1999年11月10日,Pitt等在亚特兰大举行的美国心脏学会72届学术年会上报告了“氯沙坦心力衰竭生存研究(ELITE Ⅱ试验)”的主要结果。稍后,默沙东公司在香港召开的亚太地区氯沙坦研讨会上也介绍了这一试验的有关内容。由于这是第一项对血管紧张素转换酶(ACE)抑制剂和血管紧张素Ⅱ受体(AR)拮抗剂治疗心力衰竭效果进行直接比较、以死亡率作为主要终点的大规模临床研究,因此受到人们的普遍关注。现将ELITE Ⅱ试验的初步结果介绍如下。

超声引导下真空辅助微创旋切系统(elite)旋切活检锁骨上淋巴结1例报告

锁骨上淋巴结是恶性肿瘤淋巴转移的主要部位之一。针对锁骨上淋巴结的活检手段主要分为开放活检及微创弹射式核心针穿刺活检两种。使用超声引导下真空辅助微创旋切系统（elite）旋切活检锁骨上淋巴结的手术方式尚未见到文献报道。现报道1例,并结合国内外文献评价此手术方式的优缺点。1临床资料患者,女,65岁,因＂左乳腺癌术后13月,发现左侧锁骨上淋巴结肿大1月＂入院。