Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision...Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.展开更多
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c...Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.展开更多
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio...The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.展开更多
We will highlight the values Umicore's unique Process Excellence Model is based upon and how these do correlate with the overall culture of Umicore. Besides, we are going to explain about the benefits for the targ...We will highlight the values Umicore's unique Process Excellence Model is based upon and how these do correlate with the overall culture of Umicore. Besides, we are going to explain about the benefits for the target industries that come along with our approach. Here, we will not mainly focus on the usually mentioned cost saving potential, but how also other aspects do create substantial value for the industries.展开更多
Purpose: The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and te...Purpose: The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and technology management.Design/methodology/approach: This paper starts with a discussion of two critical questions about the significance and design of international peer review. A case study of international peer review of CAS Centers for Excellence is further analyzed. Findings: International peer review may provide a solution to address the problem of quantitative oriented research evaluation in China. The case study of research evaluation of CAS Centers for Excellence shows that it is possible and feasible to conduct an international peer review in China’s context. When applying this approach to other scenarios, there are still many issues to consider including individualized design of international peer review combined with practical demands, and further improvement of theories and methods of international peer review. Research limitation: 1) Only the case of international peer review of CAS Centers for Excellence is analyzed;2) A relatively small number of respondents were surveyed in the questionnaire. Practical implications: The work presented in this study can be used as a reference for future studies.Originality/value: Currently, there are no similarly detailed studies exploring the significance and methodology of international peer review in China.展开更多
近年来,使用恶意Excel 4.0宏(XLM)文档的攻击迎来了爆发,而XLM代码往往经过复杂的混淆,现有方法或检测系统难以分析海量样本的真实功能。因此,针对恶意样本中使用的各类混淆技术,基于抽象语法树和模拟执行,设计和实现了包含138个宏函数...近年来,使用恶意Excel 4.0宏(XLM)文档的攻击迎来了爆发,而XLM代码往往经过复杂的混淆,现有方法或检测系统难以分析海量样本的真实功能。因此,针对恶意样本中使用的各类混淆技术,基于抽象语法树和模拟执行,设计和实现了包含138个宏函数处理程序的自动化XLM反混淆与关键威胁指标(IOC,indicators of compromise)提取系统XLMRevealer;在此基础上,根据XLM代码特点提取Word和Token特征,通过特征融合能够捕获多层次细粒度特征,并在XLMRevealer中构造CNN-BiLSTM(convolution neural network-bidirectional long short term memory)模型,从不同维度挖掘家族样本的关联性和完成家族分类。最后,从5个来源构建包含2346个样本的数据集并用于反混淆实验和家族分类实验。实验结果表明,XLMRevealer的反混淆成功率达到71.3%,相比XLMMacroDeobfuscator和SYMBEXCEL工具分别提高了20.8%和15.8%;反混淆效率稳定,平均耗时仅为0.512 s。XLMRevealer对去混淆XLM代码的家族分类准确率高达94.88%,效果优于所有基线模型,有效体现Word和Token特征融合的优势。此外,为探索反混淆对家族分类的影响,并考虑不同家族使用的混淆技术可能有所不同,模型会识别到混淆技术的特征,分别对反混淆前和反混淆后再统一混淆的XLM代码进行实验,家族分类准确率为89.58%、53.61%,证明模型能够学习混淆技术特征,更验证了反混淆对家族分类极大的促进作用。展开更多
文摘Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.
基金supported by Canada First Research Excellence Fund,Medicine by Design(to CMM)。
文摘Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.
基金supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA)National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA)Department of Defense(DoD)grant AZ210089(to KMA)。
文摘The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.
文摘We will highlight the values Umicore's unique Process Excellence Model is based upon and how these do correlate with the overall culture of Umicore. Besides, we are going to explain about the benefits for the target industries that come along with our approach. Here, we will not mainly focus on the usually mentioned cost saving potential, but how also other aspects do create substantial value for the industries.
基金funded by NSFC grant(71771205)CASISD presidential fund(Y8X1171Q01)CAS Youth Innovation Promotion Association fund(Y9J0361601)
文摘Purpose: The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and technology management.Design/methodology/approach: This paper starts with a discussion of two critical questions about the significance and design of international peer review. A case study of international peer review of CAS Centers for Excellence is further analyzed. Findings: International peer review may provide a solution to address the problem of quantitative oriented research evaluation in China. The case study of research evaluation of CAS Centers for Excellence shows that it is possible and feasible to conduct an international peer review in China’s context. When applying this approach to other scenarios, there are still many issues to consider including individualized design of international peer review combined with practical demands, and further improvement of theories and methods of international peer review. Research limitation: 1) Only the case of international peer review of CAS Centers for Excellence is analyzed;2) A relatively small number of respondents were surveyed in the questionnaire. Practical implications: The work presented in this study can be used as a reference for future studies.Originality/value: Currently, there are no similarly detailed studies exploring the significance and methodology of international peer review in China.
文摘近年来,使用恶意Excel 4.0宏(XLM)文档的攻击迎来了爆发,而XLM代码往往经过复杂的混淆,现有方法或检测系统难以分析海量样本的真实功能。因此,针对恶意样本中使用的各类混淆技术,基于抽象语法树和模拟执行,设计和实现了包含138个宏函数处理程序的自动化XLM反混淆与关键威胁指标(IOC,indicators of compromise)提取系统XLMRevealer;在此基础上,根据XLM代码特点提取Word和Token特征,通过特征融合能够捕获多层次细粒度特征,并在XLMRevealer中构造CNN-BiLSTM(convolution neural network-bidirectional long short term memory)模型,从不同维度挖掘家族样本的关联性和完成家族分类。最后,从5个来源构建包含2346个样本的数据集并用于反混淆实验和家族分类实验。实验结果表明,XLMRevealer的反混淆成功率达到71.3%,相比XLMMacroDeobfuscator和SYMBEXCEL工具分别提高了20.8%和15.8%;反混淆效率稳定,平均耗时仅为0.512 s。XLMRevealer对去混淆XLM代码的家族分类准确率高达94.88%,效果优于所有基线模型,有效体现Word和Token特征融合的优势。此外,为探索反混淆对家族分类的影响,并考虑不同家族使用的混淆技术可能有所不同,模型会识别到混淆技术的特征,分别对反混淆前和反混淆后再统一混淆的XLM代码进行实验,家族分类准确率为89.58%、53.61%,证明模型能够学习混淆技术特征,更验证了反混淆对家族分类极大的促进作用。
