Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes.This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes.Building on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the scaffolds.The latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are presented.Furthermore,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices

The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture formation.The healing process involves various phases:hemostasis and inflammation,proliferation,and remodeling.Mechanical staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic chemokines.Compression anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and efficacy.However,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary concern.Newer devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to stapling.Magnetic technology is also being explored for other medical treatments.While there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.

Editorial for advances in slope deformation and failure analysis methods

We are privileged to be invited by the Honorary Editor-in-Chief,Professor Qihu Qian,Editor-in-Chief,Professor Xia-Ting Feng,and the editorial staff of the Journal of Rock Mechanics and Geotechnical Engineering(JRMGE),to serve as Guest Editors for this Special Issue(SI).In literature there have been new advancements in monitoring techniques,advanced numerical modelling,optimization algorithms,artificial intelligence and data science introduced for slope engineering.The newly proposed approaches show great potential for improving slope design,construction,and risk assessment.

Conversion therapy for unresectable hepatocellular carcinoma:Advances and challenges

Recently,the World Journal of Gastrointestinal Oncology published an article entitled“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of the literature”,in which the authors shared their successful experience with complete surgical resection after multidisciplinary conversion therapy.The study by Chu et al demonstrates the great challenges that the advanced hepatocellular carcinoma(HCC)poses to surgical oncology,reveals the complexity of conversion therapy for unresectable HCC,emphasizes the important role of a multidisciplinary management model in conversion therapy,and enriches our understanding of the dynamics of personalized treatment for different patients.At present,conversion therapy is a hot research topic in the treatment of unresectable HCC,which has brought new hope to many patients with moderately advanced HCC.However,there are still many urgent problems to be solved in conversion therapy.Here,we would like to further discuss the advances and challenges of conversion therapy for unresectable HCC with the authors and the general readers.

Recent advances and perspectives of zinc metal-free anodes for zinc ion batteries

Zinc-ion batteries(ZIBs) are recognized as potential energy storage devices due to their advantages of low cost, high energy density, and environmental friendliness. However, zinc anodes are subject to unavoidable zinc dendrites, passivation, corrosion, and hydrogen evolution reactions during the charging and discharging of batteries, becoming obstacles to the practical application of ZIBs. Appropriate zinc metal-free anodes provide a higher working potential than metallic zinc anodes, effectively solving the problems of zinc dendrites, hydrogen evolution, and side reactions during the operation of metallic zinc anodes. The improvement in the safety and cycle life of batteries creates conditions for further commercialization of ZIBs. Therefore, this work systematically introduces the research progress of zinc metal-free anodes in “rocking chair” ZIBs. Zinc metal-free anodes are mainly discussed in four categories: transition metal oxides,transition metal sulfides, MXene(two dimensional transition metal carbide) composites, and organic compounds, with discussions on their properties and zinc storage mechanisms. Finally, the outlook for the development of zinc metal-free anodes is proposed. This paper is expected to provide a reference for the further promotion of commercial rechargeable ZIBs.

Advances in the study of epicanthus correction

Epicanthus is a half-moon-shaped skin fold diagonally or vertically distributed in front of the medial canthus.In mild cases,it affects aesthetics,whereas in severe cases,it may obscure the patient’s field of vision and even affect the functional development of the eyes in children.Until now,surgery has been the only corrective measure for epicanthus and a bewildering number of epicanthus-related surgical procedures have been reported;however,there is no standardized classification to guide inexperienced plastic surgeons in their study or case selection.Therefore,this review aimed to classify epicanthus accordingly and introduce its corresponding and appropriate surgical treatment modalities.

Advances of embedded resistive random access memory in industrial manufacturing and its potential applications

Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial applications.As the field of embedded memory continues to evolve,innovative strategies are emerging to enhance performance.Among them,resistive random access memory(RRAM)has gained significant attention due to its numerousadvantages over traditional memory devices,including high speed(<1 ns),high density(4 F^(2)·n^(-1)),high scalability(~nm),and low power consumption(~pJ).This review focuses on the recent progress of embedded RRAM in industrial manufacturing and its potentialapplications.It provides a brief introduction to the concepts and advantages of RRAM,discusses the key factors that impact its industrial manufacturing,and presents the commercial progress driven by cutting-edge nanotechnology,which has been pursued by manysemiconductor giants.Additionally,it highlights the adoption of embedded RRAM in emerging applications within the realm of the Internet of Things and future intelligent computing,with a particular emphasis on its role in neuromorphic computing.Finally,the review discusses thecurrent challenges and provides insights into the prospects of embedded RRAM in the era of big data and artificial intelligence.

Design strategies,advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease

Inflammatory bowel diseases(IBD)significantly contribute to high mortality globally and negatively affect patients’qualifications of life.The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations.Moreover,certain natural or synthetic anti-inflammatory drugs are associated with poor targeting,low drug accumulation at the lesion site,and other side effects,hindering them from exerting their therapeutic effects.Colon-targeted drug delivery systems represent attractive alternatives as novel carriers for IBD treatment.This review mainly discusses the treatment status of IBD,obstacles to drug delivery,design strategies of colon-targeted delivery systems,and perspectives on the existing complementary therapies.Moreover,based on recent reports,we summarized the therapeutic mechanism of colon-targeted drug delivery.Finally,we addressed the challenges and future directions to facilitate the exploitation of advanced nanomedicine for IBD therapy.

Advances in Research of Anti-tumor Effect of Aconiti Radix

In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.

Advances in beyond total mesorectal excision surgery: Behind the scenes

The management of locally advanced rectal cancer involving adjacent organs and extending beyond the surgical planes of total mesorectal excision has evolved over the past few decades both in terms of the effectiveness of preoperative treatments and surgical innovation.The use of a robotic platform is increasing,even in complex surgery such as pelvic exenteration together with the advantages of minimally invasive procedures.However,satisfactory surgical,oncological,and functional outcomes are achieved not only minimizing the impact of a demolitive surgery but also when a multidisciplinary specialized team focuses on experienced surgeons,mandatory rules of surgical oncology,appropriate medical treatments,accurate preoperative planning,and an acceptable quality of life.

Stroke:challenges and opportunities--Perspectives on clinical research advances and future outlook in 2024

Dear readers,In the field of stroke research and treatment,cutting-edge technologies and studies continue to emerge,providing new perspectives and strategies for exploring the mechanisms and treatment methods of stroke.According to the latest advancements,neuroimaging techniques play a crucial role in stroke research.MRI technology,for instance,is essential for evaluating stroke patients.

Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

This study examines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard treatments.The article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced HCC.Additionally,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced stages.As a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table method.The control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous sindilizumab.The observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei granules.Both groups underwent treatment cycles of 3 weeks,with a minimum of two cycles.The therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the groups.The objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P<0.05).After two treatment cycle,CD3+,CD4+,and CD4+/CD8+levels were higher in the observation group compared to the control group,while CD8+,regulatory T cells,and natural killer cells were lower(P<0.05).Additionally,the incidence of leukopenia,nausea,and vomiting was lower in observed group(P<0.05).No significant differences were observed in the incidence of other adverse reactions(P>0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

Research Advances in Spatio-Temporal Coupling of Water and Fertilizer in Sugarcane

The coupling of water and fertilizer is the only way for high yield, efficiency, sugar on sugarcane. On sugarcane production, the spatial and temporal controlling technology of fertigation is an important direction of the sustainable and healthy development of ecological agriculture in cane area of China. This paper reviews main achievements and advances on the coupling effect of water and fertilizer on sugarcane from time and space at home or abroad in recent years, analyzes the application prospects of the temporal and spatial coupling effect of water and fertilizer on sugarcane and puts forward some problems which need further research in future.

RSC Advances出版发行模式对中国学术期刊的启示

通过分析英国皇家化学学会旗下学术期刊RSC Advances的出版发行模式,为提高中国科技期刊质量和影响力提供建议。RSC Advances的出版发行模式启示中国学术期刊要提升发文的质和量,实行集团化管理和出版,并适时转变为OA期刊,免费开放存取。

Advances in Breeding of High-amylose Indica Hybrid Rice Combinations in Sichuan Province

During 2000-2013, totally ten high-amylose specific hybrid rice combinations approved and five combinations for production test were bred in Sichuan Province. In the paper, rice yield, economic traits, quality indicators and rice blast-resistance identification results of these 15 hybrid combinations were described and analyzed. Results show that Chuanxiangyou37 and Tianlongyou540 have relatively high amylose content, good yielding ability, high resistance and appropriate growth period, which are new hybrid rice varieties with organic combination of high amylase content, high gel consistency, high yield, stable yield and wide adaptability. Therefore, Chuanxiangyou37 and Tianlongyou540 are recommended as the main combination for rice production.

Research Advances in the Inhibition of Long Chain Fatty Acid to Methanogenic Activity in Anaeroic Digestion System

This article reviewed the inhibition mechanism of long chain fatty acid on the formation of anaerobic system, then thoroughly analyzed the inhibition factors of long chain fatty acid, and summarized the remission method to its inhibition, finally proposed some suggestions to further study on the influence of long chain fatty acid on anaerobic digestion system.

Advances in Manufacturing的创办和国际化发展探索

通过回顾Advances in Manufacturing(由Journal of Shanghai University(English Edition)专业化改版而来)自2013年创刊至今的工作实践和探索尝试,分别从依托编委会的大力支持、与Springer合作出版、全球多途径积极宣传推广期刊、加强编辑自身内涵建设等方面进行详细的阐述,以期对新创英文期刊的国际化水平的提升有所借鉴和参考。

地震学英文科技期刊国际影响力提升实践--以Earthquake Research Advances期刊为例

提升我国地震学英文科技期刊的国际影响力,对于增强我国地震学在国际学术领域的话语权具有重要意义,同时也能吸引更多国外优秀科研论文在我国期刊上发表。本文以中国地震局主管、中国地震台网中心主办的《地震研究进展(英文)》(Earthquake Research Advances)为例,详细探讨了提升英文科技期刊国际影响力的方法,旨在为推动我国地震学英文期刊的高质量发展提供参考。

Advances in Cloud Physics and Weather Modification in China

The capabilities of cloud-resolving numerical models, observational instruments and cloud seeding have improved greatly over recent years in China. The subject of this review focuses on the main progresses made in China in the areas of cloud modeling, field observations, aerosol–cloud interactions, the effects of urbanization on cloud and precipitation, and weather modification.Well-equipped aircraft and ground-based advanced Doppler and polarized radars have been rapidly applied in cloudseeding operations. The combined use of modern techniques such as the Global Positioning System, remote sensing, and Geographical Information Systems has greatly decreased the blindness and uncertainties in weather-modification activities.Weather-modification models based on state-of-the-art cloud-resolving models are operationally run at the National Weather Modification Centre in China for guiding weather-modification programs.Despite important progress having been made, many critical issues or challenges remain to be solved, or require stronger scientific evidence and support, such as the chain of physical events involved in the effects induced by cloud seeding. Current important progresses in measurements and seeding techniques provide the opportunity and possibility to reduce these deficiencies. Long-term scientific projects aimed at reducing these key uncertainties are extremely urgent and important for weather-modification activities in China.